WO2000050465A3 - Styrene/divinylbenzene copolymers functionalized with a high degree of aminomethyl groups - Google Patents
Styrene/divinylbenzene copolymers functionalized with a high degree of aminomethyl groups Download PDFInfo
- Publication number
- WO2000050465A3 WO2000050465A3 PCT/BR2000/000023 BR0000023W WO0050465A3 WO 2000050465 A3 WO2000050465 A3 WO 2000050465A3 BR 0000023 W BR0000023 W BR 0000023W WO 0050465 A3 WO0050465 A3 WO 0050465A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- resin
- epm
- groups
- styrene
- aminomethyl
- Prior art date
Links
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 title abstract 2
- 239000011347 resin Substances 0.000 abstract 7
- 229920005989 resin Polymers 0.000 abstract 7
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000129 anionic group Chemical group 0.000 abstract 2
- 238000007614 solvation Methods 0.000 abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 238000007813 chromatographic assay Methods 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/12—Macromolecular compounds
- B01J41/14—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/12—Hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Abstract
Resins containing apolar styrene-divinylbenzenc-type matrices may solvate in aqueous medium, depending on the amount of positively charged ammonium groups incorporated in its structure. Experiments with a resin containing 4.9 mmol/g aminomethyl groups and denominated aminomethyl-resin (hereafter referred as to EPM-1) showed that this resin presents a good solvation in polar organic solvents and even in water. Based on a special strategy already developed for estimation of pKa of ionizable groups of the resin, it was found a value around 5,5 for the EPM-1 amine group. As model of anionic solutes for chromatographic assays with EPM-1, differently negatively charged peptide fragments were synthesized and tested in chromatographic purification thus demonstrating that EPM-1 can be considered an alternative anion exchange resin also for other anionic solutes. Besides, for containing easily reactive primary amine groups in its structure, this resin can be also precursor for other resins with different chromatographic potentialities. In the same trend, chemical variation involving the divinylbenzene degree of crosslinking of this copolymer may affect its solvation characteristics, porosity, etc., hence modifying the use of this polymeric material.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9904682-2A BR9904682A (en) | 1999-02-24 | 1999-02-24 | Copolymer of styrene and functionalized divinylbenzene with a high degree of amino-metal groups (epm-1) and its use as a new type of anion exchange resin |
| BRPI9904682 | 1999-02-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2000050465A2 WO2000050465A2 (en) | 2000-08-31 |
| WO2000050465A3 true WO2000050465A3 (en) | 2000-11-30 |
Family
ID=4073705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/BR2000/000023 WO2000050465A2 (en) | 1999-02-24 | 2000-02-23 | Styrene/divinylbenzene copolymers functionalized with a high degree of aminomethyl groups |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BR9904682A (en) |
| WO (1) | WO2000050465A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2259950C2 (en) * | 2003-10-22 | 2005-09-10 | Тихомиров Георгий Иванович | Coalescent material for separating oil/water mixture |
| WO2017178593A2 (en) * | 2016-04-13 | 2017-10-19 | Castrol Limited | Removing aromatic compounds from a hydrocarbon fluid |
| CN111437891A (en) * | 2020-03-03 | 2020-07-24 | 东华理工大学 | Anion exchange resin and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093567A (en) * | 1977-01-17 | 1978-06-06 | Rohm And Haas Company | Aminated crosslinked copolymers of bis(chloromethyl) styrene which exhibit improved anion exchange properties |
| US4177140A (en) * | 1977-01-26 | 1979-12-04 | Akzona Inc. | Method for removing a weak acid from an aqueous solution |
| US5464875A (en) * | 1993-08-20 | 1995-11-07 | Bayer Aktiengesellschaft | Process for preparing weakly-basic anion exchangers and reagents suitable for this purpose |
-
1999
- 1999-02-24 BR BR9904682-2A patent/BR9904682A/en not_active IP Right Cessation
-
2000
- 2000-02-23 WO PCT/BR2000/000023 patent/WO2000050465A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093567A (en) * | 1977-01-17 | 1978-06-06 | Rohm And Haas Company | Aminated crosslinked copolymers of bis(chloromethyl) styrene which exhibit improved anion exchange properties |
| US4177140A (en) * | 1977-01-26 | 1979-12-04 | Akzona Inc. | Method for removing a weak acid from an aqueous solution |
| US5464875A (en) * | 1993-08-20 | 1995-11-07 | Bayer Aktiengesellschaft | Process for preparing weakly-basic anion exchangers and reagents suitable for this purpose |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000050465A2 (en) | 2000-08-31 |
| BR9904682A (en) | 2000-09-26 |
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