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WO2000043750A3 - Imaging of tissue using polarized light - Google Patents

Imaging of tissue using polarized light Download PDF

Info

Publication number
WO2000043750A3
WO2000043750A3 PCT/US2000/001764 US0001764W WO0043750A3 WO 2000043750 A3 WO2000043750 A3 WO 2000043750A3 US 0001764 W US0001764 W US 0001764W WO 0043750 A3 WO0043750 A3 WO 0043750A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
light
imaging
backscattered
polarized light
Prior art date
Application number
PCT/US2000/001764
Other languages
French (fr)
Other versions
WO2000043750A2 (en
WO2000043750A9 (en
Inventor
Stephen F Fulghum
Original Assignee
Newton Lab Inc
Stephen F Fulghum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newton Lab Inc, Stephen F Fulghum filed Critical Newton Lab Inc
Priority to CA002371782A priority Critical patent/CA2371782A1/en
Priority to EP00904542A priority patent/EP1153280A2/en
Priority to JP2000595125A priority patent/JP2002535645A/en
Priority to NZ513118A priority patent/NZ513118A/en
Priority to KR1020017009360A priority patent/KR20010110346A/en
Priority to AU26282/00A priority patent/AU2628200A/en
Publication of WO2000043750A2 publication Critical patent/WO2000043750A2/en
Publication of WO2000043750A3 publication Critical patent/WO2000043750A3/en
Publication of WO2000043750A9 publication Critical patent/WO2000043750A9/en
Priority to HK02103359.7A priority patent/HK1041727A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4792—Polarisation of scatter light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
  • Eye Examination Apparatus (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)

Abstract

The present invention relates to the differential detection of directly backscattered light from epithelial tissues in order to determine the cell nuclear size distribution for the purpose of detecting tissue dysplasia. Light directly backscattered from surface tissue is differentiated from the light backscattered from underlying tissue by means of polarization, angular distribution or both. Both point measurement embodiments and imaging embodiments are presented. Optical systems for delivery and collection of light include endoscopic and fiber optic systems.
PCT/US2000/001764 1999-01-25 2000-01-25 Imaging of tissue using polarized light WO2000043750A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002371782A CA2371782A1 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
EP00904542A EP1153280A2 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
JP2000595125A JP2002535645A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
NZ513118A NZ513118A (en) 1999-01-25 2000-01-25 Imaging of a tissue by detecting polarized and unpolarized images to form a processed image of a region of interest
KR1020017009360A KR20010110346A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
AU26282/00A AU2628200A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
HK02103359.7A HK1041727A1 (en) 1999-01-25 2002-05-03 Imaging of tissue using polarized light

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11722199P 1999-01-25 1999-01-25
US60/117,221 1999-01-25

Publications (3)

Publication Number Publication Date
WO2000043750A2 WO2000043750A2 (en) 2000-07-27
WO2000043750A3 true WO2000043750A3 (en) 2000-11-23
WO2000043750A9 WO2000043750A9 (en) 2001-08-30

Family

ID=22371613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001764 WO2000043750A2 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light

Country Status (9)

Country Link
EP (1) EP1153280A2 (en)
JP (1) JP2002535645A (en)
KR (1) KR20010110346A (en)
CN (1) CN1341209A (en)
AU (1) AU2628200A (en)
CA (1) CA2371782A1 (en)
HK (1) HK1041727A1 (en)
NZ (1) NZ513118A (en)
WO (1) WO2000043750A2 (en)

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WO2002018658A1 (en) * 2000-08-14 2002-03-07 Oralscan Laboratories, Inc. Detection of epithelial dysplasia
US7404929B2 (en) 2002-01-18 2008-07-29 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system based on scattering of polarized light
EP1472517A1 (en) 2002-01-18 2004-11-03 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system
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CN1826512B (en) * 2003-06-04 2013-05-22 突慧公司 Measurements of optical inhomogeneity and other properties in substances using propagation modes of light
JP4535697B2 (en) * 2003-07-23 2010-09-01 オリンパス株式会社 Endoscope device for light scattering observation of biological tissue
AU2004273992B2 (en) * 2003-09-19 2010-01-21 The General Hospital Corporation Fluorescence polarization imaging devices and methods
CN100443041C (en) * 2004-05-26 2008-12-17 吴冈 Endoscope system with measuring function and measuring method thereof
US20070167835A1 (en) * 2005-07-25 2007-07-19 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
ES2402796T3 (en) * 2005-10-11 2013-05-09 Duke University Systems and method for endoscopic interferometry of low coherence resolved at an angle
RU2469639C2 (en) * 2007-02-20 2012-12-20 Конинклейке Филипс Электроникс Н.В. Optical device for estimating optical depth in sample
WO2008110968A1 (en) * 2007-03-12 2008-09-18 Koninklijke Philips Electronics N.V. A system, computer-readable medium, method, and use for combined epithelial early cancer diagnosis and staging
CN100506150C (en) * 2007-04-28 2009-07-01 马剑文 Optical detection device and working method for tissue of living body
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JP4575474B2 (en) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 Biological tissue identification apparatus and method
JP5191831B2 (en) * 2008-07-23 2013-05-08 オリンパスメディカルシステムズ株式会社 Subject observation device and method of operating subject observation device
JP2010025867A (en) * 2008-07-23 2010-02-04 Olympus Medical Systems Corp Subject observation apparatus and subject observation method
KR101109968B1 (en) 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 Subject observation apparatus and subject observation method
WO2010064170A1 (en) * 2008-12-02 2010-06-10 Koninklijke Philips Electronics N.V. Sensor device for detecting target particles by frustrated total internal reflection
JP5532479B2 (en) * 2010-03-31 2014-06-25 住友化学株式会社 Mold inspection method, antiglare product haze prediction method, and antiglare product reflection image sharpness prediction method
JPWO2012057150A1 (en) 2010-10-29 2014-05-12 オリンパス株式会社 Optical measuring device and probe
JP5390045B2 (en) * 2011-07-15 2014-01-15 オリンパスメディカルシステムズ株式会社 probe
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WO2013132400A1 (en) * 2012-03-08 2013-09-12 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
JP5596870B2 (en) * 2012-05-25 2014-09-24 オリンパスメディカルシステムズ株式会社 Measuring probe
WO2014042156A1 (en) * 2012-09-13 2014-03-20 オリンパス株式会社 Measurement probe and biological optical measurement system
DE102012221527A1 (en) * 2012-11-26 2014-06-12 Heine Optotechnik Gmbh & Co Kg Optical diagnostic tool, particularly dermatoscope for investigating examination area of patient, has first polarizing filter unit downstream in illumination beam path of illumination unit in illuminating direction
AP2016009037A0 (en) * 2013-04-21 2016-02-29 Mobileoct Ltd Polarized light imaging apparatus and methods thereof for separating light from a surface of a sample its deeper diffuse layers
CN104280350B (en) * 2013-07-03 2018-06-01 庞小峰 A kind of early diagnosis of cancer of special sharpening and the device of therapeutic effect inspection
KR101503272B1 (en) 2013-07-26 2015-03-18 연세대학교 원주산학협력단 Multi-modal imaging device for arthritis diagnosis
CN106725250A (en) * 2017-01-09 2017-05-31 清华大学深圳研究生院 Polarized imaging system and measuring method are peeped in a kind of head end modulation
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Also Published As

Publication number Publication date
WO2000043750A2 (en) 2000-07-27
EP1153280A2 (en) 2001-11-14
CA2371782A1 (en) 2000-07-27
CN1341209A (en) 2002-03-20
WO2000043750A9 (en) 2001-08-30
HK1041727A1 (en) 2002-07-19
KR20010110346A (en) 2001-12-13
JP2002535645A (en) 2002-10-22
AU2628200A (en) 2000-08-07
NZ513118A (en) 2004-02-27

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