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WO1999032174A1 - Distributeur de medicament portatif pour administration differee de preparations pour injection ou perfusion - Google Patents

Distributeur de medicament portatif pour administration differee de preparations pour injection ou perfusion Download PDF

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Publication number
WO1999032174A1
WO1999032174A1 PCT/DE1998/003767 DE9803767W WO9932174A1 WO 1999032174 A1 WO1999032174 A1 WO 1999032174A1 DE 9803767 W DE9803767 W DE 9803767W WO 9932174 A1 WO9932174 A1 WO 9932174A1
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
liquid
sensor
medium
medicament
Prior art date
Application number
PCT/DE1998/003767
Other languages
German (de)
English (en)
Inventor
Ok Kyung Cho
Original Assignee
Arithmed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19756775A external-priority patent/DE19756775A1/de
Priority claimed from DE1998153035 external-priority patent/DE19853035A1/de
Application filed by Arithmed Gmbh filed Critical Arithmed Gmbh
Publication of WO1999032174A1 publication Critical patent/WO1999032174A1/fr
Priority to PCT/DE1999/003678 priority Critical patent/WO2000029047A1/fr
Priority to KR1020017006317A priority patent/KR20010081028A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272—Electro-active or magneto-active materials
    • A61M2205/0294—Piezoelectric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure

Definitions

  • Portable medication dispenser for the delayed administration of injection or infusion preparations
  • the invention relates to a device according to the preamble of claim 1 and a method according to the preamble of claim 65.
  • Devices of this type are used as portable medication dispensers in order to dispense smaller quantities of medication one time at a time, in several doses or continuously over a certain period of time.
  • No. 5,090,963 describes a portable medication dispenser which has a detachable reservoir with a cannula for dispensing medication located thereon.
  • the reservoir consists of two bell-shaped halves, one rigid and the other flexible, i.e. movable membrane is designed.
  • the reservoir can be fastened on the side of the membrane to a basic device of the device, which itself has a membrane of the same size, which closes a volume filled with an electrolyte.
  • both membranes touch; their common position and thus the volume of the electrolyte or the reservoir are variable. Initially, the reservoir is completely filled and the volume of the electrolyte fluid is minimal. To displace the drug, gas is generated by electrolysis, which presses the device membrane against the reservoir membrane and thus presses the drug from the reservoir through the cannula into the human body.
  • WO 95/13838 describes a similar medicament dispenser which uses electrolytic gas generation to exert pressure on a membrane and thereby displace a medicament from a reservoir.
  • This medication dispenser is attached directly to the skin via an adhesive surface on its underside and pierces it with a hollow needle through which the medication is dispensed. Points on its outside the donor includes an electrolysis cell and various electronic control elements.
  • Both medication dispensers have in common that a controlled deformation or expansion of a flexible membrane reduces a reservoir volume, the electrolytic gas generation in each case causing the deformation of the membrane.
  • the membrane or the membranes each separate the electrolysis liquid from the medicament to be administered as a deformable partition.
  • All medication dispensers contain at least one membrane for separating the medication to be administered from the medium of a pressure chamber and differ only in the type of pressure build-up.
  • the task is to provide a medication dispenser which excludes from the outset the dangers of liquid leakage or air leakage mentioned by a novel, simple and inexpensive construction.
  • the invention provides that the reservoir is shaped such that at each filling level of the liquid to be administered, an interface between the liquid and one already emptied volume of the reservoir is small. This requires a substantial channel-like shape of the interior of the reservoir, in which the liquid is received in the form of a liquid column.
  • the small diameter of the reservoir or the liquid column of, for example, one millimeter or less requires a correspondingly large channel length.
  • this form which initially appears to be unrealistic for a storage container, has the advantage that a minimal area - namely the surface of the liquid level in the channel - is available as the point of application of the pump pressure to the liquid at any filling level during the liquid discharge.
  • This eliminates the need for large-area membranes for the first time; in addition, due to the small area of the liquid level, a separating element between the pumping medium and the liquid can be dispensed with entirely.
  • the membrane holder the other walls of the reservoir, the connection between the reservoir and the cannula, there is now only a channel-like interior of the reservoir, which offers no point of attack for leaks. The inside of the reservoir is thus protected from all sides against leaks caused by production or handling. Wear-prone parts are not required.
  • the reservoir is a hose or a tube, which can optionally be wound up or bent in some other way.
  • This simple and yet unused form of the medication reservoir is also much cheaper than conventional chambers with large-area membranes.
  • a conventional membrane equivalent is completely unnecessary, so that the pressure of a medium for conveying the liquid is transferred directly to the liquid column, for example by means of media such as compressed gases or gas mixtures, liquid media or a gas generated by chemical reactions or in some other way.
  • the use according to the invention of the capillary forces or the adhesion and cohesion forces ensures that the liquid is completely dig remains in the area between the fill level and the outlet opening, whereas in a conventionally compact reservoir chamber an inclined position of the device would already be sufficient to pump compressed air into the body together with it in the reservoir, unless additional protective mechanisms are provided.
  • the reservoir can be inserted directly into the body.
  • the reservoir is connected on the outlet side to a hollow needle or cannula which is inserted into the body. Due to the massive construction of the medication dispenser, damage is most likely to be expected at the point of contact between the reservoir and the insertion cannula or hollow needle, for example, when the cannula is pulled or in other rough handling.
  • the circadian rhythm is understood to mean an endogenously controlled approximately 24-hour rhythmicity, which all biological functions caused by the daily fluctuations in geophysical environmental factors in the Senses of timer effects are synchronized.
  • the circadian rhythm controls, among other things, the periodic body temperature.
  • the device has, on the one hand, a pneumatic control and administration of the liquid, and a flow sensor with regard to monitoring and controlling the metering. Furthermore, the device has means for temperature or heat measurement which, like extensive specific research by the applicant have shown in the meantime, beyond the applications mentioned in DE 43 42 105 AI and in US Pat. No. 5,795,305, suitable for determining the individual circadian rhythm by frequent measurements on an individual over a sufficient period of time (for example several days, weeks or months) . At the same time, additional parameters such as pulse rate and / or blood pressure, etc. are measured. This data is evaluated electronically.
  • the point in time at which the liquid is dispensed is achieved by a timing control which is based on the fact that a limited amount of a buffer medium passes through a passage per unit of time.
  • the liquid is then dispensed using the same force used to force the buffer medium through the passage. Without restricting the generality, this force can be applied by compressed air, i.e. it can be pneumatic in nature.
  • the metering is controlled on the one hand by means of a sensor which measures the flow of the dispensed liquid or a driving pump medium and uses it to control the dispensing of the liquid.
  • this can be, for example, a differential pressure sensor that measures the pressure drop in said liquid or a conveying medium via a capillary or other suitable constriction.
  • the course of the individual body temperature is recorded over a sufficiently long period of time by at least one temperature and / or heat sensor, so that the circadian rhythm of an individual is recorded, and deviations from this rhythm can be determined.
  • the temperature sensor can be, for example, a semiconductor (for example a PTC or NTC), a thermocouple or a resistance thermometer.
  • the sensor (s) can be internal or externally connected to the device according to the invention directly, for example via cables, or indirectly, ie wirelessly, for example by radio, infrared, ultrasound, etc.
  • the reservoir is essentially tubular or tubular or is formed from a tube or a tube.
  • a flexible tube or a rigid tube as a reservoir is the simplest way to provide a reservoir that has a minimal liquid surface at every filling level of the medication.
  • Conventional, commercially available hoses can be used. In this way, a particularly inexpensive reservoir is provided.
  • the waveguide used can also be shaped and in particular curved, which creates a compact and easy-to-use reservoir.
  • the reservoir is wound in a spiral or coil-like manner or appropriately arranged in another way.
  • An example of a circular cylindrical reservoir shape made of one or more spirals lying one above the other len can be worn well on the body and leaves space in the middle for a dispensing unit which effects or initiates the liquid delivery.
  • a further embodiment provides that the reservoir is tapered or tapered at an end that can be inserted into the body. This enables the reservoir to be inserted directly into the body without the need for a hollow needle or a prior puncture.
  • a further embodiment provides that the reservoir is bent or angled at the end that can be inserted into the body. A reservoir permitted in this way can, for example, be wound spirally and open directly into the body from the center of the spiral.
  • Another embodiment provides a puncture aid and a septum, which is partially inside the reservoir.
  • the septum serves to seal the hose of the reservoir after removal of the internal puncture aid.
  • a limiting element such as a ball, which is movable with the filling level
  • the movable limiting element serves to further reduce the already small surface of the liquid level, namely to the ring area between the ball diameter and the inner reservoir diameter. This prevents even the smallest interaction of the pump medium with liquid.
  • a pump gas such as air
  • the ball which moves with the filling level, permits a visible control of the filling state of the reservoir in the case of a transparent reservoir hose.
  • the dose administered can only be indicated indirectly, for example with the aid of a display.
  • the reservoir can still be one Residual volume of liquid included. This ensures that the inflowing pump medium never reaches the body. As soon as the fill level and thus the ball has reached the obstacle, the ball automatically closes the reservoir; the pump medium that follows it cannot enter the body.
  • the obstacle can be, for example, an annular reduction in the reservoir diameter, but can also consist in the bend in front of the angled reservoir end. Finally, the obstacle itself prevents the ball or the limiting element from entering the body. Depending on the reservoir size and length, a dose reading scale can be provided.
  • Another embodiment provides that the reservoir for dispensing several liquids or quantities of liquids is branched or otherwise subdivided. In this way, multiple drugs or multiple drug doses can be administered.
  • the type of branching is basically arbitrary; it is only essential that the diameter of all hollow channels is sufficiently small everywhere.
  • the reservoir has a flat, compact or three-dimensional shape and is provided with a large number of intermediate walls on the inside.
  • a reservoir has a labyrinth-like channel system with preferably a single, alternatively also a branched, multiple winding channel. In this way, a medical patient can be accommodated in a reservoir of conventional size and still ensure that a minimal contact surface is available for direct pressure transmission at any filling level within the channel.
  • a preferred embodiment provides that chemicals, for example one or more self-foaming plastic components such as polyurethane or volatile substances or also biologically active substances such as enzymes or microorganisms, are provided for the displacement of the medicament from the reservoir or for the temporal dissolution or speed control of this displacement. are seen.
  • chemicals for example one or more self-foaming plastic components such as polyurethane or volatile substances or also biologically active substances such as enzymes or microorganisms, are provided for the displacement of the medicament from the reservoir or for the temporal dissolution or speed control of this displacement.
  • These substances can be provided at a rear end of the reservoir and can undergo volume-increasing reactions alone or through the action of the dispensing unit; the drug is thus pushed out of the reservoir tube.
  • Such a hydraulic or pneumatic process depending on the substance, can equally be provided for time control.
  • a further embodiment provides that the reservoir is closed at a rear end.
  • thermo decomposition of a chemical substance is provided for displacing the medicament from the reservoir or for timing or speed control of this displacement. This is used for the irreversible decomposition of a small amount e.g. of a relatively large gas volume released by an organic or inorganic blowing agent.
  • Another alternative embodiment provides that the thermal expansion of a gas or the evaporation of a liquid is provided for displacement of the medicament from the reservoir or for timing or for speed control of this displacement.
  • the irreversible expansion of a small amount caused by the internal pressure is used e.g. 5 gas-filled hollow microspheres made of a thermoplastic.
  • the reservoir has a gas-permeable but liquid-impermeable element in front of the end which can be inserted into the body and which allows a residual amount of a pump gas to escape.
  • a window prevents gas from entering the body.
  • a micropump for example a micromembrane pump, which can be operated piezoelectrically, electrostatically or thermoelectrically.
  • a further embodiment provides a pressure container for displacing the medication from the reservoir, for triggering it in time and / or for controlling the speed of this displacement.
  • This pressure vessel can be a gas-filled pressure or vacuum vessel or a vacuum vessel. The latter is suitable for bringing two liquids into contact with one another, for example, by sucking in a piston and triggering a volume-increasing reaction.
  • a timely precise control of the start of dispensing can be achieved by means of a critical nozzle.
  • a cylinder or a similarly suitable form in which a piston is located at the end, which is made of solid, liquid, sol or gel-like material can exist and, for example, by means of gas pressure acts on a chamber at the opposite end of which there is a passage (for example nozzles, diaphragms, membrane filters, in particular micro or nano nozzles, materials suitable for diffusion or active biomembranes or others active membranes), which is suitable for slowly letting out a buffer medium located in the said chamber and in this way allows a desired time control.
  • Said piston is designed such that after a certain stroke determined by the timing control, it opens a further outlet which acts as a connection between the cylinder and the reservoir and enables said gas pressure to administer the liquid.
  • a further development of this embodiment provides that said cylinder Linder and the reservoir are one and the same component, the cross section corresponding to that of the previous reservoir, and the liquid to be administered itself serves as a piston for displacing the buffer medium.
  • the passage at the end of the cylinder is divided into two and has selectively permeable devices which each pass only the buffer medium or only the liquid, which is then released directly or indirectly into the body.
  • Said selectively permeable devices are, for example, membrane filters or materials suitable for diffusion or other active membranes, e.g. B. Biomembranes.
  • a sensor in particular a glucose sensor, is provided.
  • the time, duration and scope of administration can be individually controlled.
  • a flow sensor for controlling the amount of said liquid to be dispensed, for example a differential pressure sensor, which measures a pressure drop across a defined capillary.
  • a further provided suitable electronic component for example a microcontroller, determines the amount of liquid dispensed per time or the total amount of liquid dispensed and, if necessary, controls or interrupts the dispensing of the liquid, for example by controlling said micro-membrane pump.
  • the device is designed to deliver the smallest amounts of insulin in the range from a few to a few hundred microliters.
  • One embodiment of the invention provides that a suitable selectively permeable device is attached to the outlet end of the reservoir, which device allows the liquid to pass through, but completely or largely retains the subsequent said medium.
  • This embodiment also provides that at the input end of the re- servoirs on which said medium enters, a suitable selectively permeable device is attached, which allows said entering medium to pass through, but retains all or most of said liquid.
  • Said selectively permeable devices consist of membrane filters or of materials suitable for diffusion or of active biomembranes or corresponding other active membranes.
  • the object of the invention described at the outset is achieved with respect to the method in that the liquid is stored in a reservoir with a small cross section at each filling level and is conveyed by direct action on the filling level without a substantial change in volume or shape of the reservoir.
  • a preferred embodiment provides that the liquid is pumped using a medium, in particular air. By feeding the ambient air into the rear end of the reservoir, there is no need for a separate pump medium container.
  • An alternative embodiment provides that at least two substances are mixed to trigger a pumping process. These substances are preferably in liquid or solid form in or near the rear end of the reservoir.
  • an invented embodiment according to the invention that the reservoir is first inserted into the body with the aid of a puncture aid and this is then removed.
  • Another embodiment of the invention provides that the administration of the liquid is controlled with the aid of a sensor.
  • the use of such sensors with which the concentration of the administered medicament in the body is measured is particularly expedient, or such sensors with which the amount of liquid administered is measured directly or indirectly.
  • one embodiment provides that the concentration of a substance in the body is measured, for the change of which the respective medication is released.
  • This substance can be blood glucose without restricting the general inventive concept.
  • a time control of the liquid delivery is achieved by the movement of a piston in a cylinder.
  • a driving force acts on the piston, for example through compressed air, in such a way that the piston acts on a buffer medium, for example air, located in the cylinder and presses it outwards through a passage at the opposite end of the cylinder.
  • the passage is designed in such a way that a limited amount of the buffer medium escapes per unit of time.
  • This passage consists of one or more openings, such as nozzles, orifices, or membrane filters, in particular of micro or nano nozzles, or of materials suitable for diffusion or of active biomembranes or corresponding other active membranes.
  • the piston is made of solid material.
  • the piston consists of a sol- or gel-like substance or a liquid.
  • said cylinder is a capillary, possibly wound.
  • a further development of this embodiment provides that the piston initially keeps a connection between the cylinder and the reservoir closed and releases it through its movement in said cylinder after a certain time and enables the driving force to administer the liquid.
  • a suitable selectively permeable membrane prevents the piston substance from escaping from the cylinder and in particular prevents the piston substance from entering the reservoir.
  • the piston itself consists of the liquid to be administered, as a result of which a separate reservoir is unnecessary.
  • said passage for said buffer medium is protected against the passage of the liquid by means of a suitable selectively permeable membrane, while another selectively permeable membrane in the immediate vicinity of the aforementioned membrane allows the liquid to pass through, but retains the buffer medium.
  • the liquid then enters the body directly through a suitable device, for example an injection needle.
  • liquid is administered in an electronically controlled manner by means of a dispensing unit, for example by means of a micro membrane pump.
  • the pumped quantity of pumped medium or the quantity of liquid administered is measured by means of a flow sensor, the measured values of which for controlling the dose delivered are expanded / developed by means of suitable electronics.
  • this embodiment provides that both said electronics and said flow sensor and optionally said delivery unit are combined into a unit on a suitable substrate using hybrid technology.
  • a further embodiment has external sensors which measure the body temperature or heat (e.g. thermistors or thermopiles) and the pulse frequency (e.g. microphones or electrodes), possibly also the blood circulation (e.g. optical sensors for measurement in transmission and / or scattered light geometry) and the Blood pressure of an individual Record duums, record over a sufficiently long period of time and determine the individual circadian rhythm using a programmable electronic component, for example a microcontroller. Certain deviations from the long-term behavior of the circadian rhythm can be recognized in this way and compensated for by administration of an appropriate liquid medication. Without limiting the generality, the said certain deviations can be fluctuations in the blood glucose concentration.
  • the body temperature or heat e.g. thermistors or thermopiles
  • the pulse frequency e.g. microphones or electrodes
  • the blood circulation e.g. optical sensors for measurement in transmission and / or scattered light geometry
  • the Blood pressure of an individual Record duums record over a sufficiently long period of time and determine the individual circadian rhythm using
  • a further development of this embodiment provides that the sensory part of the device is wholly or partially internal, i.e. is integrated into the device itself.
  • the reservoir has a selectively permeable membrane on the outlet side (i.e. on the side facing the body), which allows the liquid to pass through, but retains a pumping or other pumping medium.
  • the reservoir has a selectively permeable membrane on the inlet side (i.e. on the side facing the acting force) which allows a pumping or other pumping medium to pass through, but which retains the liquid.
  • liquid is conveyed directly or indirectly by means of a solid, liquid or gaseous conveying medium.
  • the device contains several reservoirs and several identical or different drives for conveying one or more identical or different liquids, which can be combined with one another as desired.
  • the device is programmed and / or remotely controlled via an internal or external input unit, wherein the input unit can be worn on the body and has, for example, the shape of a wristwatch. Both said input unit and the device itself have transmitting and receiving units via which they can communicate with one another.
  • the device can be programmed with complex dispensing patterns for the liquid to be administered, for example continuously, discontinuously with uniform or non-uniform intervals.
  • a preferred embodiment also includes one or more trigger devices, e.g. Push buttons, for additional spontaneous administration of defined amounts of liquid.
  • trigger devices e.g. Push buttons
  • Further preferred designs of the device and its attachment to the body are waterproof or water-resistant, in particular also against perspiration, and thus enable the user to perform normal daily activities or sports, such as e.g. Bathing, showering, swimming, etc.
  • FIG. 1a shows a cross section
  • FIG. 1b shows a plan view of the medicament dispenser according to the invention.
  • the same components of the dispenser are provided with the same reference numerals.
  • the medication reservoir 2 and the delivery unit are connected to a plaster 1 with which they are attached to the human body.
  • the reservoir 2 is a medicament-filled cannula tube which is spirally wound in several planes and is therefore arranged in a space-saving manner. It is inserted through the skin into the subcutis at its angled, pointed end 6.
  • a delivery unit which, depending on the embodiment, has various elements.
  • FIGS. 1a and 1b playfully refers to an operation intended to receive programming data, such as a photodiode 3, an active pump drive, such as a micromembrane pump 4, and an energy source 5.
  • the delivery unit designed in this way serves to displace the medication from the reservoir or to trigger this displacement in time or to control its speed.
  • the medication or medications administered can be administered once or in several adjustable doses.
  • the mode of administration is by no means limited to subcutaneous introduction, it also extends to intramuscular, intravenous or intraperitoneal administration.
  • a puncture aid can be used to facilitate the direct insertion of the reservoir, for example the hose. This is then removed again while the reservoir remains in the puncture opening.
  • the reservoir can, for example, be dimensioned for medicament doses from 10 to 120 and possibly up to 500 or more microliters and can be designed as an individually replaceable disposable part.
  • a wide variety of media for example noble gases such as argon, or air or a saline solution can be used to displace the medicament from the reservoir.
  • the entire device can be a single unit to be attached to the body, but can also consist of a separately carried control module and an exchangeable or partially exchangeable medication unit and, if necessary, have an additional separate programming unit.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif portatif pour l'administration différée de médicaments liquides. Ce dispositif comprend un réservoir pouvant contenir au moins un médicament et pouvant être appliqué sur un corps pour l'administration dudit médicament. Ce dispositif comprend en outre une unité de distribution provoquant l'administration du médicament. L'invention est caractérisée en ce que le réservoir peut être introduit directement dans le corps et est formé de sorte qu'à chaque niveau de remplissage du médicament, soit créée une surface limite, entre le médicament et un volume déjà vide du réservoir, de faible dimension par rapport aux distributeurs de médicaments classiques dans lesquels un réservoir est vidé sous l'effet de la déformation d'une membrane, et dans lesquels la membrane et les adaptateurs de canule côté évacuation peuvent être endommagés en cas de manipulation incorrecte. L'invention permet d'obtenir un fonctionnement parfait, grâce à ce nouveau type de réservoir. Selon un aspect de l'invention, on décrit un dispositif pneumatique et un procédé correspondant pour une distribution de liquide automatisée, différée. Les matériaux utilisés sont perméables de façon sélective, c'est-à-dire qu'ils laissent passer le liquide mais retiennent un matériau gonflant. Dans un autre mode de réalisation, la distribution d'un liquide est provoquée de façon régulée électroniquement ou la quantité de liquide est dosée électroniquement. Pour la détermination de la dose et du moment de la distribution, on se fonde sur le rythme circadien individuel qui est détecté avant et après l'application, au moyen de détecteurs appropriés, sur une période suffisamment longue.
PCT/DE1998/003767 1997-12-19 1998-12-21 Distributeur de medicament portatif pour administration differee de preparations pour injection ou perfusion WO1999032174A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/DE1999/003678 WO2000029047A1 (fr) 1998-11-18 1999-11-18 Dispositif portable et procede d'administration medicamenteuse mobile par transmission radio de donnees a des fins de commande et de programmation
KR1020017006317A KR20010081028A (ko) 1998-11-18 1999-11-18 제어 또는 프로그래밍을 위한 데이터의 무선 전송으로약제를 이동식으로 공급하는 휴대용 장치 및 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19756775.4 1997-12-19
DE19756775A DE19756775A1 (de) 1997-08-01 1997-12-19 Tragbarer Medikamentenspender zur zeitverzögerten Verabreichung von Injektions- oder Infusionspräparaten
DE19853035.8 1998-11-18
DE1998153035 DE19853035A1 (de) 1998-11-18 1998-11-18 Tragbares Mikrodosiersystem zur zeitverzögerten Abgabe von Flüssigkeiten

Publications (1)

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DE10010208A1 (de) * 2000-02-25 2001-09-13 Inst Physikalische Hochtech Ev Mikrodosiervorrichtung zur definierten Abgabe kleiner in sich geschlossener Flüssigkeitsvolumina
EP1170024A2 (fr) * 2000-02-02 2002-01-09 Meonic System Engineering GmbH Méthode et dispositif pour l'injection d'un médicament
WO2003059421A1 (fr) * 2002-01-03 2003-07-24 Baxter International Inc. Procede et appareil permettant de fournir un traitement medical sur la base du calcul de la demande
EP1386626A1 (fr) * 2002-07-31 2004-02-04 Novo Nordisk A/S Dispositif d'administration pour le traitement de diabète mellitus
US20070023037A1 (en) * 2005-07-27 2007-02-01 The Curators Of The University Of Missouri Focused droplet nebulizer for evaporative light scattering detector
US8040509B2 (en) 2004-02-17 2011-10-18 The Curators Of The University Of Missouri Light scattering detector
US8397553B2 (en) 2006-12-06 2013-03-19 The Curators Of The University Of Missouri Liquid chromatography detector and flow controller therefor
RU2643346C2 (ru) * 2007-06-19 2018-02-01 Годо Кайся АйПи Бридж 1 Устройство беспроводной связи и способ расширения ответных сигналов
JP2020110667A (ja) * 2012-07-10 2020-07-27 ベクトン ディキンソン フランス 統合された注射システムおよび通信装置
WO2023114413A1 (fr) * 2021-12-17 2023-06-22 Becton, Dickinson And Company Générateur thermoélectrique pour alimenter un auto-injecteur

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US4525164A (en) * 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4735619A (en) * 1982-09-13 1988-04-05 Sperry C R Syringe and syringe actuator
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US5090963A (en) 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
WO1995013838A1 (fr) 1993-11-18 1995-05-26 Elan Medical Technologies Limited Dispositif d'administration intradermique de medicaments
DE4342105A1 (de) 1993-12-12 1995-06-14 Cho Ok Kyung Verfahren und Vorrichtung zur noninvasiven Bestimmung der Konzentration der Glucose in Teilen des menschlichen Körpers, inbesondere im menschlichen Blut, unter Durchführung höchstgenauer Temperaturmessungen des menschlichen Körpers
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1170024A2 (fr) * 2000-02-02 2002-01-09 Meonic System Engineering GmbH Méthode et dispositif pour l'injection d'un médicament
EP1170024A3 (fr) * 2000-02-02 2002-01-16 Meonic System Engineering GmbH Méthode et dispositif pour l'injection d'un médicament
DE10010208C2 (de) * 2000-02-25 2002-02-07 Inst Physikalische Hochtech Ev Mikrodosiervorrichtung zur definierten Abgabe kleiner in sich geschlossener Flüssigkeitsvolumina
DE10010208A1 (de) * 2000-02-25 2001-09-13 Inst Physikalische Hochtech Ev Mikrodosiervorrichtung zur definierten Abgabe kleiner in sich geschlossener Flüssigkeitsvolumina
AU2002351242B2 (en) * 2002-01-03 2008-06-19 Baxter International Inc. Method and apparatus for providing medical treatment therapy based on calculated demand
WO2003059421A1 (fr) * 2002-01-03 2003-07-24 Baxter International Inc. Procede et appareil permettant de fournir un traitement medical sur la base du calcul de la demande
JP2006503596A (ja) * 2002-01-03 2006-02-02 バクスター・インターナショナル・インコーポレイテッド 計算された要求に基づいて医療処置セラピーを提供する方法および装置
EP1386626A1 (fr) * 2002-07-31 2004-02-04 Novo Nordisk A/S Dispositif d'administration pour le traitement de diabète mellitus
US8040509B2 (en) 2004-02-17 2011-10-18 The Curators Of The University Of Missouri Light scattering detector
WO2007015954A2 (fr) * 2005-07-27 2007-02-08 The Curators Of The University Of Missouri Nebuliseur focalisant pour detecteur de diffusion de lumiere a l'evaporation
WO2007015954A3 (fr) * 2005-07-27 2008-10-30 Univ Missouri Nebuliseur focalisant pour detecteur de diffusion de lumiere a l'evaporation
US7760355B2 (en) * 2005-07-27 2010-07-20 The Curators Of The University Of Missouri Focused droplet nebulizer for evaporative light scattering detector
US20070023037A1 (en) * 2005-07-27 2007-02-01 The Curators Of The University Of Missouri Focused droplet nebulizer for evaporative light scattering detector
US8397553B2 (en) 2006-12-06 2013-03-19 The Curators Of The University Of Missouri Liquid chromatography detector and flow controller therefor
RU2643346C2 (ru) * 2007-06-19 2018-02-01 Годо Кайся АйПи Бридж 1 Устройство беспроводной связи и способ расширения ответных сигналов
JP2020110667A (ja) * 2012-07-10 2020-07-27 ベクトン ディキンソン フランス 統合された注射システムおよび通信装置
JP2022058970A (ja) * 2012-07-10 2022-04-12 ベクトン ディキンソン フランス 統合された注射システムおよび通信装置
WO2023114413A1 (fr) * 2021-12-17 2023-06-22 Becton, Dickinson And Company Générateur thermoélectrique pour alimenter un auto-injecteur

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