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WO1999028465A3 - Pias molecules that recognize and bind stat proteins and uses thereof - Google Patents

Pias molecules that recognize and bind stat proteins and uses thereof Download PDF

Info

Publication number
WO1999028465A3
WO1999028465A3 PCT/US1998/025316 US9825316W WO9928465A3 WO 1999028465 A3 WO1999028465 A3 WO 1999028465A3 US 9825316 W US9825316 W US 9825316W WO 9928465 A3 WO9928465 A3 WO 9928465A3
Authority
WO
WIPO (PCT)
Prior art keywords
pias
molecules
recognize
stat proteins
bind
Prior art date
Application number
PCT/US1998/025316
Other languages
French (fr)
Other versions
WO1999028465A2 (en
Inventor
Ke Shuai
Chan D Chung
Jiayu Liao
Bin Liu
Xiaoping Rao
Original Assignee
Univ California
Ke Shuai
Chan D Chung
Jiayu Liao
Bin Liu
Xiaoping Rao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Ke Shuai, Chan D Chung, Jiayu Liao, Bin Liu, Xiaoping Rao filed Critical Univ California
Priority to AU16106/99A priority Critical patent/AU1610699A/en
Priority to US09/573,651 priority patent/US7265202B1/en
Publication of WO1999028465A2 publication Critical patent/WO1999028465A2/en
Publication of WO1999028465A3 publication Critical patent/WO1999028465A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a family of proteins named PIAS which function as specific inhibitors of STAT proteins. Methods of using PIAS molecules are also provided to regulate STAT proteins.
PCT/US1998/025316 1997-11-28 1998-11-27 Pias molecules that recognize and bind stat proteins and uses thereof WO1999028465A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU16106/99A AU1610699A (en) 1997-11-28 1998-11-27 Pias molecules that recognize and bind stat proteins and uses thereof
US09/573,651 US7265202B1 (en) 1997-11-28 1998-11-27 PIAS molecules that recognize and bind STAT proteins and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6925197P 1997-11-28 1997-11-28
US60/069,251 1997-11-28
US9595098P 1998-08-10 1998-08-10
US60/095,950 1998-08-10

Publications (2)

Publication Number Publication Date
WO1999028465A2 WO1999028465A2 (en) 1999-06-10
WO1999028465A3 true WO1999028465A3 (en) 1999-10-07

Family

ID=26749861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025316 WO1999028465A2 (en) 1997-11-28 1998-11-27 Pias molecules that recognize and bind stat proteins and uses thereof

Country Status (1)

Country Link
WO (1) WO1999028465A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1146869A2 (en) 1999-01-27 2001-10-24 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US20030045680A1 (en) * 2001-03-12 2003-03-06 Praecis Pharmaceuticals Inc. Peptidic modulators of the androgen receptor
WO2003073105A2 (en) * 2002-02-28 2003-09-04 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of plag1 and plagl2 in cancer diagnosis and drug screening
US7638122B2 (en) 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
WO2011110359A1 (en) * 2010-03-10 2011-09-15 Georg-Speyer-Haus Chemotherapeutisches Forschungsinstitut Stat3 activation inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031544A1 (en) * 1994-05-11 1995-11-23 Yeda Research And Development Co., Ltd. Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors
WO1996020954A2 (en) * 1995-01-06 1996-07-11 The Rockefeller University Functionally active domains of signal transducer and activators of transcription (stat) proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031544A1 (en) * 1994-05-11 1995-11-23 Yeda Research And Development Co., Ltd. Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors
WO1996020954A2 (en) * 1995-01-06 1996-07-11 The Rockefeller University Functionally active domains of signal transducer and activators of transcription (stat) proteins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHUNG C D ET AL: "SPECIFIC INHIBITION OF STAT3 SIGNAL TRANSDUCTION BY PIAS3", SCIENCE, vol. 278, 5 December 1997 (1997-12-05), pages 1803 - 1805, XP002072146, ISSN: 0036-8075 *
IVASHKIV, L.B. ET AL.: "Inhibition of transcription factor STAT1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway.", JOURNAL OF IMMUNOLOGY, vol. 157, 1996, pages 1415 - 21, XP002109567 *
LIU, B. ET AL.: "Inhibition of Stat1-mediated gene activation by PIAS1.", PROC.NAT'L.ACAD.SCI.USA, vol. 95, September 1998 (1998-09-01), pages 10626 - 31, XP002109569 *
MINAMOTO, S. ET AL.: "Cloning and functional analysis of new members of STAT induced STAT inhibitors (SSI) family: SSI-2 and SSI-3.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 237, no. 1, July 1997 (1997-07-01), pages 79 - 83, XP002109568 *
VALDEZ, B.C. ET AL.: "Cloning and characterization of Gu/RH-II binding protein.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 234, no. 2, 19 May 1997 (1997-05-19), pages 335 - 40, XP002109565 *
WU, L. ET AL.: "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA", MECHANISMS OF DEVELOPMENT, vol. 65, no. 1-2, July 1997 (1997-07-01), pages 3 - 17, XP002109566 *

Also Published As

Publication number Publication date
WO1999028465A2 (en) 1999-06-10

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