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WO1998032534A1 - Procede de manipulation de substances et recipients pour de telles substances - Google Patents

Procede de manipulation de substances et recipients pour de telles substances Download PDF

Info

Publication number
WO1998032534A1
WO1998032534A1 PCT/IB1998/000096 IB9800096W WO9832534A1 WO 1998032534 A1 WO1998032534 A1 WO 1998032534A1 IB 9800096 W IB9800096 W IB 9800096W WO 9832534 A1 WO9832534 A1 WO 9832534A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
zone
substances
wall portions
opposite wall
Prior art date
Application number
PCT/IB1998/000096
Other languages
English (en)
Inventor
Nils Peter Adler
Original Assignee
Unifill (International) Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unifill (International) Ag filed Critical Unifill (International) Ag
Priority to AU53376/98A priority Critical patent/AU5337698A/en
Publication of WO1998032534A1 publication Critical patent/WO1998032534A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples

Definitions

  • This invention relates to a method of handling substances and to a container for such substances.
  • a container consisting of two loose pieces assembled together after manufacture of the pieces by injection moulding of thermoplastics.
  • One of the pieces is a vial closed at its bottom and open at its top.
  • the other of the pieces is a closure device consisting of a ring, a cap, and a tether interconnecting the ring and the cap.
  • the ring is a friction fit around the vial and is prevented from leaving the upper end of the vial by an external bead round the mouth of the vial.
  • the cap includes a substantially cylindrical part which is a friction fit in the mouth of the vial.
  • the closure device is mounted on the vial, the vial is partly filled with a blood-diluting liquid, and the vial is closed by the cap.
  • the partly filled containers are supplied to hospitals. At the hospitals, nurses take blood samples out of patients' fingertips into glass capillary tubes. The nurse holds the container, opens the cap, drops into the vial the capillary tube containing the blood sample, and then closes the vial with the cap. Thereafter, she shakes the container for about 10 seconds and then re-opens the cap to enable a nozzle of a small handpump to be inserted into the vial to draw out the mixture of blood and blood-diluting liquid.
  • the nurse has to use protective gloves, such as of silicone rubber, to avoid risk of skin contact with the mixture when the cap is opened and the mixture drawn out, especially since the shaking causes the mixture to coat the inside of the cap.
  • BE-A-849898 discloses apparatus for the dilution and filtration of a sample in the form of a very small volume of liquid, of the order of lcc, particularly for analysis.
  • the apparatus is comprised of a container containing liquid, a cylindrical tube and a nozzle.
  • the container is of flexible plastics and comprises a main body zone of generally tubular form which shrinks at its upper extremity in a hollow cylindrical neck closed at its upper extremity by a top detachable according to a peripheral line of weakness.
  • the lower extremity of the main body region is flattened and closed by heat-or ultrasonic-welding.
  • the tube is of flexible plastics and is engaged by friction in the nozzle which terminates in a cannula.
  • the latter has a constriction zone constituted by an annular thickening of its wall.
  • the nozzle is moulded of plastics which may be somewhat harder than that of the container and contains a filtering device consisting of a pile of disc filters crimped by the tube in the nozzle.
  • a method of use for blood sampling is as follows.
  • the top is twisted off the container to provide an open mouth, albeit very narrow, and a capillary tube containing a blood sample is introduced into the container through the open mouth, and then the open end of the plastics tube is frictionally engaged on the neck of the container.
  • the plastics tube is then folded upon itself and the apparatus shaken in such manner as to homogenise the dispersion of the sample in the diluent without wetting the filtering device, so that, after almost inverting the apparatus and squeezing the container body, correct filtration takes place.
  • a method of handling substances comprising providing a closed container containing a first substance, opening said closed container to provide an open mouth thereof, inserting the second substance through said open mouth into said first substance, bringing together manually in a substantially liquid-tight manner opposite wall portions above the first and second substances in said container, and subsequently manually releasing the substantially liquid- tight seal between said opposite wall portions, characterized in that said bringing together comprises bringing together opposite wall portions of said container above the first and second substances in said container, and in that said releasing comprises releasing the substantially liquid-tight seal between said opposite wall portions to allow access to the first and second substances in the container.
  • a container comprising an upper zone, a lower zone and an intermediate zone, said intermediate zone being of flexible material, whereby opposite wall portions of said intermediate zone may be manually brought together, characterised in that said container consists of one piece. Owing to the present invention, risk of leakage between an opened container and a fitment thereon can be avoided.
  • the invention is applicable to a wide variety of fields, but particularly to analytical fields, for example biological or chemical analysis.
  • the opposite wall portions may be manually brought together by squeezing them between the thumb and a finger of a hand, or by bending over downwards the upper zone of the container.
  • the container may be made by blow-moulding or vacuum- moulding, but is preferably made by welding together two sheets at container outlines and then blow-thermoforming of the two sheets.
  • the first substance may be a liquid, for example a blood-diluting liquid, whilst the second substance may comprise a substance to be mixed therewith, for example blood in a sampling tube.
  • thermoplastics which may be a single web centrally folded
  • Those wall portions of the two strips bounded by the outlines are then pneumatically thermoformed in moulds which define the shapes of the containers.
  • the individual hollow interiors so formed between the two strips are then partly filled with blood-diluting liquid 2 and the liquid inlets then heat- welded to seal the liquid 2 into the hollow interiors. Then the individual, one-piece containers 1 are cut out and supplied to hospitals.
  • each container has a peripheral weld fin 3 encircling and joining two symmetrical shells 4 defining between them the hollow interior 5 a lower zone 5b of which is partly filled with the liquid 2.
  • the interior 5 has an upper zone 5a, with a narrowed intermediate zone 5c between the upper and lower zones 5a and 5b.
  • the zone 5c is of a minimum internal cross- sectional area significantly less than the maximum internal cross-sectional areas of the respective zones 5a and 5b.
  • the weld fin 3 also has a narrowed intermediate zone 3c between its upper and lower zones 3a and 3b; thus, the intermediate zone lc of the container 1 is weaker than each of the upper zone la and the lower zone lb of the container, so that the upper zone la of the container may be manually folded down about the intermediate zone lc.
  • Across the upper zone la of the container at about the level of the maximum internal cross-sectional area of the upper zone 5a may be formed a severing indication constituted by a line of weakness 6, to facilitate severing of the top of the container 1 from the remainder of the container 1 to expose the top of the hollow interior 5.
  • a nurse having taken blood out of a patient's fingertip into a glass capillary tube 7, twists off the top of the container along the line 6 to expose a relatively wide, open mouth 8 (see Figure 2) and then drops the tube 7 down through the mouth 8 into the liquid 2, as shown in Figure 3. She then bends the upper zone la of the container downwards about the intermediate zone lc, while holding the lower zone lb upright, to bring the container into the condition shown in Figure 4, thereby to cause the opposite wall portions of the shells 4 at the intermediate zone lc to be pressed together in a liquid- tight manner. The nurse then shakes the container as illustrated in Figure 5, for about ten seconds. Then the nurse returns the upper zone la back into its upright condition and inserts a nozzle 9 of a handpump 10 down through the mouth 8 into the bottom of the hollow interior 5 and draws out the blood-containing mixture 2 ' .
  • the container and method described with reference to the drawing have the advantage that there is no risk of the nurse's hand coming into contact with an internal surface of the container 1 which has come into contact with the blood- containing mixture 2', so that the nurse does not need to wear gloves. Moreover, since the container 1 is manufactured as one piece, no assembly of container pieces is required, while risk of leakage between such container pieces is avoided. Moreover, a lower weight of thermoplastics can be used to manufacture each container 1 compared with the known container assembled from two pieces manufactured by injection-moulding. Furthermore, the feature that the mouth 8 is relatively wide makes it easier to drop the tube 7 into the container without the tube coming into contact with any external surface of the container.
  • the bottom of the lower zone 5b may be of downwardly narrowing, conical shape externally, to facilitate standing the container in a storage, transport, or treatment device or even in an automatic shaker in which the upper zone la is mechanically retained bent-over during shaking.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Cette invention se rapporte à un récipient (1) fabriqué par thermoformage-soufflage, qui comprend une ailette soudée périphérique (3) encerclant et joignant deux coques symétriques (4), lesquelles définissent entre elles un espaace intérieur creux (5) dont une zone inférieure (5b) et partiellement remplie d'un liquide (2). Cet espace intérieur (5) possède une zone supérieure (5a) et une zone intermédiaire rétrécie (5c). L'ailette soudée (3) comporte également une zone intermédiaire rétrécie (3c) entre ses zones supérieures et inférieure (3a, 3b). La zone intermédiaire (1c) est plus faible que la zone supérieure (1a) et que la zone inférieure (1b), pour que la zone supérieure (1a) puisse être abaissée manuellement par pliage autour de la zone intermédiaire (1c). On peut former une ligne de faiblesse en travers de la zone supérieure (1a), pour qu'il soit plus facile de séparer le dessus du récipient (1) du reste du récipient (1), afin de découvrir le dessus de l'espace intérieur creux (5).
PCT/IB1998/000096 1997-01-25 1998-01-23 Procede de manipulation de substances et recipients pour de telles substances WO1998032534A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53376/98A AU5337698A (en) 1997-01-25 1998-01-23 A method of handling substances and a container for such substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9701548.1A GB9701548D0 (en) 1997-01-25 1997-01-25 A method of handling substances and a container for such substances
GB9701548.1 1997-01-25

Publications (1)

Publication Number Publication Date
WO1998032534A1 true WO1998032534A1 (fr) 1998-07-30

Family

ID=10806579

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/000096 WO1998032534A1 (fr) 1997-01-25 1998-01-23 Procede de manipulation de substances et recipients pour de telles substances

Country Status (4)

Country Link
AU (1) AU5337698A (fr)
GB (1) GB9701548D0 (fr)
WO (1) WO1998032534A1 (fr)
ZA (1) ZA98620B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067503A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Préparation d'échantillons pour l'échantillonnage de l'environnement
WO2009067518A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Récipient et procédé de préparation d'échantillons
WO2009067513A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Récipient et procédé de préparation d'échantillons
WO2009067498A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Contenant pour la préparation d'échantillons et procédé
US8272255B2 (en) 2006-05-22 2012-09-25 3M Innovative Properties Company System and method for preparing samples

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647386A (en) * 1969-09-26 1972-03-07 Gilford Instr Labor Inc Sample processing container
BE849898A (fr) * 1976-12-28 1977-06-28 Dispositif de dilution et de filtration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647386A (en) * 1969-09-26 1972-03-07 Gilford Instr Labor Inc Sample processing container
BE849898A (fr) * 1976-12-28 1977-06-28 Dispositif de dilution et de filtration

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8272255B2 (en) 2006-05-22 2012-09-25 3M Innovative Properties Company System and method for preparing samples
US8991239B2 (en) 2006-05-22 2015-03-31 3M Innovative Properties Company System and method for preparing samples
WO2009067503A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Préparation d'échantillons pour l'échantillonnage de l'environnement
WO2009067518A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Récipient et procédé de préparation d'échantillons
WO2009067513A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Récipient et procédé de préparation d'échantillons
WO2009067498A1 (fr) * 2007-11-20 2009-05-28 3M Innovative Properties Company Contenant pour la préparation d'échantillons et procédé
CN101909757A (zh) * 2007-11-20 2010-12-08 3M创新有限公司 环境取样的样品制备

Also Published As

Publication number Publication date
GB9701548D0 (en) 1997-03-12
ZA98620B (en) 1998-07-27
AU5337698A (en) 1998-08-18

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