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WO1998006411A2 - Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale - Google Patents

Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale Download PDF

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Publication number
WO1998006411A2
WO1998006411A2 PCT/IT1997/000201 IT9700201W WO9806411A2 WO 1998006411 A2 WO1998006411 A2 WO 1998006411A2 IT 9700201 W IT9700201 W IT 9700201W WO 9806411 A2 WO9806411 A2 WO 9806411A2
Authority
WO
WIPO (PCT)
Prior art keywords
diarrhoea
lactobacillus
treatment
acute
preparation
Prior art date
Application number
PCT/IT1997/000201
Other languages
English (en)
Other versions
WO1998006411A3 (fr
Inventor
Stefano Guandalini
Original Assignee
Dicofarm S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dicofarm S.P.A. filed Critical Dicofarm S.P.A.
Priority to EP97935765A priority Critical patent/EP0918531A2/fr
Priority to AU38639/97A priority patent/AU3863997A/en
Publication of WO1998006411A2 publication Critical patent/WO1998006411A2/fr
Publication of WO1998006411A3 publication Critical patent/WO1998006411A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis

Definitions

  • the present invention seeks to provide a formulation responsive to such requirements.
  • Lactobacillus casei subspecies rhamnosius (so-called also Lactobacillus GG initially isolated from the intestinal bacterial flora of a man) , administered both in the form of powder and yoghurt produced by the fermentation of the milk with said enzyme, is capable of shortening by about 2 days the duration of the diarrhoea in little patients with gastroenteritis by rotavirus which is considered as the most common etiologic agent of acute infant's diarrhoea in the world.
  • enteric pathogens Rotavirus and Adenoviru ⁇ of the enteric type (40-41) , Giardia and Cryptosporidium, Salmonella, Shigella, Campylobacter, Yersinia, Aeromonas, E. Coli pathogens (ETEC, EPEC, EHEC, EIEC, EAggEC, searched by specific DNA probes) .
  • enteric pathogens Rotavirus and Adenoviru ⁇ of the enteric type (40-41) , Giardia and Cryptosporidium, Salmonella, Shigella, Campylobacter, Yersinia, Aeromonas, E. Coli pathogens (ETEC, EPEC, EHEC, EIEC, EAggEC, searched by specific DNA probes) .

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'administration précoce de Lactobacillus GG pendant la phase de réhydratation permet de raccourcir la durée de la diarrhée, de prévenir le syndrome d'allergie alimentaire s'ensuivant chez le patient, et de stimuler une augmentation rapide du poids. Pour ce faire, on a produit une préparation à administrer par voie buccale et constituée d'une solution de réhydration orale de type commercial, tel que Dicodral 60, dans laquelle est contenue une dose efficace de ferments Lactobacillus GG à la fois vivants et inactivés.
PCT/IT1997/000201 1996-08-09 1997-08-04 Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale WO1998006411A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97935765A EP0918531A2 (fr) 1996-08-09 1997-08-04 Utilisation de lactobacillus gg dans la solution de rehydratation
AU38639/97A AU3863997A (en) 1996-08-09 1997-08-04 Treatment of the acute infant's diarrhoea and prevention of allergic reactions to foods swallowed in the following phase by administering lactobacillus gg in the oral rehydrating solution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96RM000571A IT1284877B1 (it) 1996-08-09 1996-08-09 Trattamento delle diarree acute del bambino e prevenzione della sensibilizzazione allergica verso alimenti introdotti nella fase
ITRM96A000571 1996-08-09

Publications (2)

Publication Number Publication Date
WO1998006411A2 true WO1998006411A2 (fr) 1998-02-19
WO1998006411A3 WO1998006411A3 (fr) 1998-05-07

Family

ID=11404390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1997/000201 WO1998006411A2 (fr) 1996-08-09 1997-08-04 Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale

Country Status (4)

Country Link
EP (1) EP0918531A2 (fr)
AU (1) AU3863997A (fr)
IT (1) IT1284877B1 (fr)
WO (1) WO1998006411A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1034787A1 (fr) * 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Souches de lactobacillus capables de prévenir la diarrhée causée des bactéries pathogènes
EP1034788A1 (fr) * 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Souches de bacteries lactiques capables de prevenir la diarrhée
WO2000053202A1 (fr) * 1999-03-11 2000-09-14 Societe Des Produits Nestle S.A. Souches de lactobacille pouvant prevenir la diarrhee provoquee par des bacteries pathogenes et des rotavirus
WO2001095741A1 (fr) * 2000-06-13 2001-12-20 Unilever N.V. Produit alimentaire contenant du lactobacille non-viable
US7183108B1 (en) 1998-11-18 2007-02-27 Compagnie Gervais Danone Selection and uses of lactic acid bacteria strains modulating non-specific immunity
ES2277550A1 (es) * 2005-12-21 2007-07-01 Laboratorios Casen-Fleet, S.L. Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes.
WO2012062781A1 (fr) * 2010-11-11 2012-05-18 Nestec S.A. Micro-organismes probiotiques ne se répliquant pas et protégeant les enfants des infections gastro-intestinales

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199535A2 (fr) * 1985-04-17 1986-10-29 Sherwood L. Gorbach Souches bactériennes de Lactobacillus acidophilus et compositions les contenant
EP0271364A2 (fr) * 1986-12-12 1988-06-15 Biorem C.C. Composition appropriée au traitement de désordres entériques
WO1991015199A1 (fr) * 1990-04-09 1991-10-17 Medicis Corporation Composition et procede antidiarrheique
WO1994018997A1 (fr) * 1993-02-24 1994-09-01 Valio Ltd. Procede d'amelioration de la reponse immunitaire aux vaccins oraux
US5413785A (en) * 1993-01-27 1995-05-09 New England Deaconess Hospital Corp. Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199535A2 (fr) * 1985-04-17 1986-10-29 Sherwood L. Gorbach Souches bactériennes de Lactobacillus acidophilus et compositions les contenant
EP0271364A2 (fr) * 1986-12-12 1988-06-15 Biorem C.C. Composition appropriée au traitement de désordres entériques
WO1991015199A1 (fr) * 1990-04-09 1991-10-17 Medicis Corporation Composition et procede antidiarrheique
US5413785A (en) * 1993-01-27 1995-05-09 New England Deaconess Hospital Corp. Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo
WO1994018997A1 (fr) * 1993-02-24 1994-09-01 Valio Ltd. Procede d'amelioration de la reponse immunitaire aux vaccins oraux

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. R. PANT ET AL.: "LACTOBACILLUS GG AND ACUTE DIARRHOEA IN YOUNG CHILDREN IN THE TROPICS." JOURNAL OF TROPICAL PEDIATRICS, vol. 42, no. 3, June 1996, pages 162-165, XP002058046 *
HELI MAJAMAA ET AL.: "LACTIC ACID BACTERIA IN THE TREATMENT OF ACUTE ROTAVIRUS GASTROENTERITIS." JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 20, no. 3, April 1995, pages 333-338, XP002058047 *
MINNA KAILA ET AL: "NUTRITIONAL MANAGEMENT OF ACUTE DIARRHEA" NUTRITION TODAY, vol. 31, no. 6, November 1996 - December 1996, pages 16S-18S, XP002058044 *
MINNA KAILA ETAL.: "VIABLE VERSUS INACTIVATED LACTOBACILLUS STRAIN GG IN ACUTE ROTAVIRUS DIARRHOEA." ARCHIVES OF DISEASE IN CHILDHOOD, vol. 72, no. 1, January 1995, pages 51-53, XP002058045 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183108B1 (en) 1998-11-18 2007-02-27 Compagnie Gervais Danone Selection and uses of lactic acid bacteria strains modulating non-specific immunity
US6835376B1 (en) 1999-03-11 2004-12-28 Nestec S.A. Lactobacillus paracasei strain for preventing diarrhea caused by pathogenic bacteria
US7029669B1 (en) 1999-03-11 2006-04-18 Nestec S. A. Lactic acid bacteria strains capable of preventing diarrhoea
AU779789B2 (en) * 1999-03-11 2005-02-10 Societe Des Produits Nestle S.A. Lactobacillus strains capable of preventing diarrhoea caused by pathogenic bacteria and rotaviruses
WO2000053202A1 (fr) * 1999-03-11 2000-09-14 Societe Des Produits Nestle S.A. Souches de lactobacille pouvant prevenir la diarrhee provoquee par des bacteries pathogenes et des rotavirus
AU779804B2 (en) * 1999-03-11 2005-02-10 Societe Des Produits Nestle S.A. Lactic acid bacteria strains capable of preventing diarrhoea
EP1415656A1 (fr) * 1999-03-11 2004-05-06 Société des Produits Nestlé S.A. Souches de Lactobacillus pouvant prévenir la diarrhée causée par les rotavirus
EP1034788A1 (fr) * 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Souches de bacteries lactiques capables de prevenir la diarrhée
US6887465B1 (en) 1999-03-11 2005-05-03 Nestec S.A. Lactobacillus strains capable of preventing diarrhoea caused by pathogenic bacteria and rotaviruses
WO2000053201A1 (fr) * 1999-03-11 2000-09-14 Societe Des Produits Nestle S.A. Souches de bacteries d'acide lactique a capacite antidiarrheique
WO2000053200A1 (fr) * 1999-03-11 2000-09-14 Societe Des Produits Nestle S.A. Souches de lactobacille empechant la diarrhee causee par des bacteries pathogenes
EP1034787A1 (fr) * 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Souches de lactobacillus capables de prévenir la diarrhée causée des bactéries pathogènes
WO2001095741A1 (fr) * 2000-06-13 2001-12-20 Unilever N.V. Produit alimentaire contenant du lactobacille non-viable
AU2001269015B2 (en) * 2000-06-13 2004-10-14 Unilever Plc Non-viable lactobacillus containing food product
ES2277550A1 (es) * 2005-12-21 2007-07-01 Laboratorios Casen-Fleet, S.L. Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes.
WO2012062781A1 (fr) * 2010-11-11 2012-05-18 Nestec S.A. Micro-organismes probiotiques ne se répliquant pas et protégeant les enfants des infections gastro-intestinales
EP2455094A1 (fr) * 2010-11-11 2012-05-23 Nestec S.A. Micro-organismes probiotiques sans réplication pour protéger les enfants contre les infections gastro-intestinales
US9345728B2 (en) 2010-11-11 2016-05-24 Nestec S.A. Non-replicating probiotic micro-organisms protect children against gastrointestinal infections

Also Published As

Publication number Publication date
ITRM960571A1 (it) 1998-02-09
EP0918531A2 (fr) 1999-06-02
IT1284877B1 (it) 1998-05-22
AU3863997A (en) 1998-03-06
ITRM960571A0 (fr) 1996-08-09
WO1998006411A3 (fr) 1998-05-07

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