[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO1998054223A3 - Procede d'immunologie - Google Patents

Procede d'immunologie Download PDF

Info

Publication number
WO1998054223A3
WO1998054223A3 PCT/GB1998/001382 GB9801382W WO9854223A3 WO 1998054223 A3 WO1998054223 A3 WO 1998054223A3 GB 9801382 W GB9801382 W GB 9801382W WO 9854223 A3 WO9854223 A3 WO 9854223A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
cells
antigen
specific
responded
Prior art date
Application number
PCT/GB1998/001382
Other languages
English (en)
Other versions
WO1998054223A2 (fr
Inventor
Richard Andrew Kay
Original Assignee
Univ Dundee
Richard Andrew Kay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee, Richard Andrew Kay filed Critical Univ Dundee
Priority to JP50035099A priority Critical patent/JP2001517958A/ja
Priority to AU76631/98A priority patent/AU728909B2/en
Priority to EP98924427A priority patent/EP1017724A2/fr
Priority to CA002291004A priority patent/CA2291004A1/fr
Publication of WO1998054223A2 publication Critical patent/WO1998054223A2/fr
Publication of WO1998054223A3 publication Critical patent/WO1998054223A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

On décrit un procédé d'identification d'une cellule T sensibilisée par l'antigène parmi une population de cellules T. Le procédé consiste à: 1) se procurer un échantillon contenant des cellules T sensibles à l'antigène; 2) déterminer séparément, pour chaque récepteur d'un ensemble de récepteurs spécifiques de cellules T, ou séparément pour chaque sous-population d'un ensemble de sous-populations de récepteurs de cellules T, si l'expression d'un gène codant un récepteur spécifique de cellules T, ou si l'expression de gènes codant une sous-population de récepteurs de cellules T a augmenté par cellule T sensible au récepteur de cellules T spécifiques ou si elle a augmenté par sous-population de cellule T sensible au récepteur de cellules T spécifiques, par comparaison avec l'expression dudit gène ou desdits gènes dans un échantillon contenant des cellules T insensibles à l'antigène. Le procédé permet d'identifier efficacement des cellules T sensibilisées par l'antigène associées à un état pathologique tel que la polyarthrite rhumatoïde.
PCT/GB1998/001382 1997-05-27 1998-05-27 Procede d'immunologie WO1998054223A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50035099A JP2001517958A (ja) 1997-05-27 1998-05-27 免疫学的方法
AU76631/98A AU728909B2 (en) 1997-05-27 1998-05-27 Immunological method
EP98924427A EP1017724A2 (fr) 1997-05-27 1998-05-27 Procede d'immunologie
CA002291004A CA2291004A1 (fr) 1997-05-27 1998-05-27 Procede d'immunologie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9710820.3 1997-05-27
GBGB9710820.3A GB9710820D0 (en) 1997-05-27 1997-05-27 Immunological method

Publications (2)

Publication Number Publication Date
WO1998054223A2 WO1998054223A2 (fr) 1998-12-03
WO1998054223A3 true WO1998054223A3 (fr) 1999-03-04

Family

ID=10813057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001382 WO1998054223A2 (fr) 1997-05-27 1998-05-27 Procede d'immunologie

Country Status (6)

Country Link
EP (1) EP1017724A2 (fr)
JP (1) JP2001517958A (fr)
AU (1) AU728909B2 (fr)
CA (1) CA2291004A1 (fr)
GB (1) GB9710820D0 (fr)
WO (1) WO1998054223A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243327A1 (fr) * 2001-03-19 2002-09-25 BioChip Technologies GmbH Surface avec un motif de cellules et méthode pour sa production
GB0128153D0 (en) * 2001-11-23 2002-01-16 Bayer Ag Profiling of the immune gene repertoire
KR101431312B1 (ko) 2003-06-27 2014-08-20 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 Ｗｔ1 백신 적응 환자의 선택 방법
CN103374576A (zh) * 2007-03-05 2013-10-30 株式会社癌免疫研究所 癌抗原特异性t细胞受体基因、由该基因编码的肽及其使用
AU2012276908A1 (en) 2011-06-28 2014-02-20 International Institute Of Cancer Immunology, Inc. Receptor gene for peptide cancer antigen-specific T cell

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012260A1 (fr) * 1991-01-09 1992-07-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) PROCEDE DE DESCRIPTION DES REPERTOIRES D'ANTICORPS (Ab) ET DES RECEPTEURS DES CELLULES T (TcR) DU SYSTEME IMMUNITAIRE D'UN INDIVIDU ll
WO1993004695A1 (fr) * 1991-08-28 1993-03-18 The Wistar Institute Therapie de la polyarthrite rhumatoide basee sur le recepteur de lymphocytes t
WO1994014067A1 (fr) * 1992-12-14 1994-06-23 T Cell Sciences, Inc. Diagnostic et traitement de la sarcoïdose
WO1998001738A2 (fr) * 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification d'anomalies dans l'expression de recepteurs de reconnaissance de l'antigene des lymphocytes t et b en tant qu'indicateurs de diagnostic et de pronostic de maladies et predicteurs therapeutiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012260A1 (fr) * 1991-01-09 1992-07-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) PROCEDE DE DESCRIPTION DES REPERTOIRES D'ANTICORPS (Ab) ET DES RECEPTEURS DES CELLULES T (TcR) DU SYSTEME IMMUNITAIRE D'UN INDIVIDU ll
WO1993004695A1 (fr) * 1991-08-28 1993-03-18 The Wistar Institute Therapie de la polyarthrite rhumatoide basee sur le recepteur de lymphocytes t
WO1994014067A1 (fr) * 1992-12-14 1994-06-23 T Cell Sciences, Inc. Diagnostic et traitement de la sarcoïdose
WO1998001738A2 (fr) * 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification d'anomalies dans l'expression de recepteurs de reconnaissance de l'antigene des lymphocytes t et b en tant qu'indicateurs de diagnostic et de pronostic de maladies et predicteurs therapeutiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DADAGLIO G ET AL: "SELECTIVE ANERGY OF VBETA8+ T CELLS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 179, no. 2, February 1994 (1994-02-01), pages 413 - 424, XP000601471 *
DU BOIS R.M. ET AL.,: "T-Lymphocytes that accumulate in the lung in sarcoidosis have evidence of resent stimulation of the T-cell antigen receptor", RESPIRATORY DISEASES, vol. 145, no. 5, May 1992 (1992-05-01), pages 1205 - 1211, XP002086693 *
MAR P. ET AL.,: "Quantitative tracing of mRNAs for T- and B-Lymphocyte receptor genes in individual cells by in situ hybridization with fluorochrome-labeled gene probes. 1:Expression in malignancies carrying B-lineage associated antigens", BLOOD, vol. 74, no. 2, - 1 August 1989 (1989-08-01), pages 638 - 644, XP002086694 *
MARGUERIE C. ET AL.,: "PCR-based analysis of the TCR repertoire in human autoimmune diseases", IMMUNOLOGY TODAY, vol. 13, no. 9, - 1992, pages 336 - 338, XP002086695 *

Also Published As

Publication number Publication date
AU7663198A (en) 1998-12-30
WO1998054223A2 (fr) 1998-12-03
JP2001517958A (ja) 2001-10-09
GB9710820D0 (en) 1997-07-23
EP1017724A2 (fr) 2000-07-12
AU728909B2 (en) 2001-01-18
CA2291004A1 (fr) 1998-12-03

Similar Documents

Publication Publication Date Title
Gavazzi On the Phenomenology of Disk Galaxies
US8309317B2 (en) Method of screening single cells for the production of biologically active agents
CN102741430B (zh) 生化分析仪器、用于进行生化分析的第一模块以及相关方法
WO2001043869A3 (fr) Jeux de cellules et leurs utilisations
EP1965213A3 (fr) Microsystèmes et leurs mises en application
WO2001048145A3 (fr) Proteines des recepteurs de leucocytes t (tcr) a affinite elevee et procedes correspondants
EP1498497A3 (fr) Méthodes d'analyse d'acides nucléiques par spectrométrie de masse
AUPQ422399A0 (en) Method of screening transformed or transfected cells
AU4818599A (en) Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12),md-1, md2 and cyclin e2, related reagents and methods
WO1998027114A3 (fr) Antigenes de surface mammaliens et reactifs associes
EP1114864A3 (fr) Antigènes de surface de cellules de mammifères
BR9810844A (pt) Processo para detectar um microorganismo em uma amostra lìquida de teste, e, dispositivo de ensaio para conduzir o processo
WO1998054223A3 (fr) Procede d'immunologie
WO1999021976A3 (fr) Generation rapide de lignees cellulaires mammiferes stables produisant des niveaux eleves de proteines recombinantes
WO2000070342A3 (fr) Un systeme de criblage a base de cellules
EP2204447A3 (fr) Méthode de génération de diversité
WO2003093445A3 (fr) Procede de prevision de potentiel genique et de determination cellulaire
AU9356398A (en) Bioassay for thyroid stimulating antibodies
WO2001050130A3 (fr) Procedes de selection permettant d'identifier composes utiles dans le traitement de la maladie polykystique des reins
CA1231047A (fr) Epreuve de diagnostic des affections rhumatologiques
Lake et al. Mapping evolution with three dimensional ribosome structure
WO2001011082A3 (fr) Procedes de surveillance d'expression de genes
Fu et al. Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations
WO2002029107A3 (fr) Procede de detection et d'interpretation de mutations par l'intermediaire de tests d'expression ou de fonction de genes haploides
Prokisch et al. Protein import into mitochondria of Neurospora crassa

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998924427

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 76631/98

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2291004

Country of ref document: CA

Ref country code: CA

Ref document number: 2291004

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 1999 500350

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09424091

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1998924427

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 76631/98

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1998924427

Country of ref document: EP