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WO1997020933A3 - Mutational variants of mammalian ob gene proteins - Google Patents

Mutational variants of mammalian ob gene proteins Download PDF

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Publication number
WO1997020933A3
WO1997020933A3 PCT/US1996/018561 US9618561W WO9720933A3 WO 1997020933 A3 WO1997020933 A3 WO 1997020933A3 US 9618561 W US9618561 W US 9618561W WO 9720933 A3 WO9720933 A3 WO 9720933A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian
mutational variants
gene proteins
proteins
mutational
Prior art date
Application number
PCT/US1996/018561
Other languages
French (fr)
Other versions
WO1997020933A2 (en
Inventor
Scott W Altmann
Fernando Rock
J Fernando Bazan
Robert A Kastelein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU14064/97A priority Critical patent/AU1406497A/en
Publication of WO1997020933A2 publication Critical patent/WO1997020933A2/en
Publication of WO1997020933A3 publication Critical patent/WO1997020933A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Muteins, which are mutational variants of mammalian proteins. Particular positions of natural proteins are identified as critical in providing various different activities. Specific embodiments demonstrate properties of variations at these positions.
PCT/US1996/018561 1995-12-06 1996-12-03 MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS WO1997020933A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14064/97A AU1406497A (en) 1995-12-06 1996-12-03 Mutational variants of mammalian ob gene proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56807795A 1995-12-06 1995-12-06
US08/568,077 1995-12-06

Publications (2)

Publication Number Publication Date
WO1997020933A2 WO1997020933A2 (en) 1997-06-12
WO1997020933A3 true WO1997020933A3 (en) 1997-10-02

Family

ID=24269846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/018561 WO1997020933A2 (en) 1995-12-06 1996-12-03 MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS

Country Status (2)

Country Link
AU (1) AU1406497A (en)
WO (1) WO1997020933A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544492B1 (en) 1994-08-17 2009-06-09 The Rockefeller University OB polypeptides, modified forms and derivatives

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE741187T1 (en) * 1995-05-05 1997-04-30 Hoffmann La Roche Recombinant Obesity (OB) Proteins
AU2246097A (en) * 1996-01-25 1997-08-20 Eli Lilly And Company Obesity protein analog compounds and formulations thereof
US6025324A (en) * 1996-05-15 2000-02-15 Hoffmann-La Roche Inc. Pegylated obese (ob) protein compositions
US6590088B1 (en) 1996-07-19 2003-07-08 Human Genome Sciences, Inc. CD33-like protein
WO1999025824A1 (en) * 1997-11-14 1999-05-27 Centre National De La Recherche Scientifique (Cnrs) cDNA SEQUENCE CODING FOR A MUTATED LEPTIN AND APPLICATIONS
JP2002521496A (en) 1998-07-28 2002-07-16 フラームス・インテルウニフェルシタイル・インスティチュート・フォール・ビオテヒノロヒー Leptin-mediated gene induction
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
EP1151102B1 (en) * 1999-02-12 2006-04-19 Amgen Inc. Glycosylated leptin compositions and related methods
CA2365040A1 (en) * 1999-04-02 2000-10-12 Eli Lilly And Company Hob-bp2h compositions, methods and uses thereof
WO2001066593A1 (en) * 2000-03-07 2001-09-13 Biomolecular Engineering Research Institute Structural coordinate of protein complex and utilization of the structural coordinate
WO2001090188A2 (en) 2000-05-22 2001-11-29 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Receptor-based interaction trap
US7235629B2 (en) 2000-11-14 2007-06-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Functional fragment of the leptin receptor
CA2464277C (en) 2001-10-22 2013-02-05 Amgen, Inc. Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
ES2289235T3 (en) * 2003-08-21 2008-02-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. NEW LEPTINA ANTAGONIST.
US7423113B2 (en) 2004-08-25 2008-09-09 Vib Vzw Leptin antagonist
US7575878B2 (en) 2004-11-18 2009-08-18 Vib Vzw Methods of inhibiting leptin-induced signaling with fibronectin III domain antibodies
US7307142B2 (en) * 2004-11-26 2007-12-11 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Leptin antagonists
EP2416797A4 (en) 2009-04-10 2013-04-24 Amylin Pharmaceuticals Llc AMYLINE AGONIST COMPOUNDS FOR MAMMALS WITH STROGEN DEFICIENCY
PT2621515T (en) 2010-09-28 2017-07-12 Aegerion Pharmaceuticals Inc A chimeric seal-human leptin polypeptide with increased solubility
CN104829707B (en) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 The leptin activity peptide and its encoding gene and application of one CD ring and E spiral region mutations
CN104829708B (en) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 The leptin activity peptide of one D spiral region mutation and its encoding gene and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005309A2 (en) * 1994-08-17 1996-02-22 The Rockefeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
EP0725078A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
WO1996024670A1 (en) * 1995-02-06 1996-08-15 Eli Lilly And Company Human obesity gene
EP0743321A2 (en) * 1995-05-19 1996-11-20 Eli Lilly And Company Obesity gene product
EP0744408A2 (en) * 1995-05-26 1996-11-27 Eli Lilly And Company Rhesus ob protein and DNA

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005309A2 (en) * 1994-08-17 1996-02-22 The Rockefeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
EP0725078A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
EP0725079A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
WO1996024670A1 (en) * 1995-02-06 1996-08-15 Eli Lilly And Company Human obesity gene
EP0743321A2 (en) * 1995-05-19 1996-11-20 Eli Lilly And Company Obesity gene product
EP0744408A2 (en) * 1995-05-26 1996-11-27 Eli Lilly And Company Rhesus ob protein and DNA

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TAKASHI MURAKAMI ET AL: "CLONING OF RAT OBESE CDNA AND ITS EXPRESSION IN OBESE RATS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 209, no. 3, 26 April 1995 (1995-04-26), pages 944 - 952, XP000602094 *
YIYING ZHANG ET AL: "POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOGUE", NATURE, vol. 372, no. 6505, 1 December 1994 (1994-12-01), pages 425 - 432, XP000602062 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544492B1 (en) 1994-08-17 2009-06-09 The Rockefeller University OB polypeptides, modified forms and derivatives

Also Published As

Publication number Publication date
AU1406497A (en) 1997-06-27
WO1997020933A2 (en) 1997-06-12

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