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WO1997012036A3 - Bone stimulating factor - Google Patents

Bone stimulating factor Download PDF

Info

Publication number
WO1997012036A3
WO1997012036A3 PCT/CA1996/000653 CA9600653W WO9712036A3 WO 1997012036 A3 WO1997012036 A3 WO 1997012036A3 CA 9600653 W CA9600653 W CA 9600653W WO 9712036 A3 WO9712036 A3 WO 9712036A3
Authority
WO
WIPO (PCT)
Prior art keywords
ile
lys
asp
ser
thr
Prior art date
Application number
PCT/CA1996/000653
Other languages
French (fr)
Other versions
WO1997012036A2 (en
Inventor
Cherk Shing Tam
Original Assignee
Osteopharm Ltd
Cherk Shing Tam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteopharm Ltd, Cherk Shing Tam filed Critical Osteopharm Ltd
Priority to AU70811/96A priority Critical patent/AU7081196A/en
Priority to JP9513029A priority patent/JPH11514858A/en
Priority to EP96931700A priority patent/EP0853667A2/en
Publication of WO1997012036A2 publication Critical patent/WO1997012036A2/en
Publication of WO1997012036A3 publication Critical patent/WO1997012036A3/en
Priority to US09/229,304 priority patent/US6693081B2/en
Priority to US10/718,526 priority patent/US20040147450A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Polypeptides which increase or promote mammalian bone growth, related nucleotide sequences, antibodies, diagnostic kits and treatments. Subsequences of the polypeptide Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp have been shown to promote growth. Subsequences include Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser; Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Glu Ser; and Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln.
PCT/CA1996/000653 1995-09-26 1996-09-26 Bone stimulating factor WO1997012036A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU70811/96A AU7081196A (en) 1995-09-26 1996-09-26 Bone stimulating factor
JP9513029A JPH11514858A (en) 1995-09-26 1996-09-26 Bone stimulating factor
EP96931700A EP0853667A2 (en) 1995-09-26 1996-09-26 Bone stimulating factor
US09/229,304 US6693081B2 (en) 1995-09-26 1999-01-13 Bone stimulating factor
US10/718,526 US20040147450A1 (en) 1995-09-26 2003-11-24 Bone stimulating factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US431495P 1995-09-26 1995-09-26
US60/004,314 1995-09-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US4805898A Continuation 1995-09-26 1998-03-26

Publications (2)

Publication Number Publication Date
WO1997012036A2 WO1997012036A2 (en) 1997-04-03
WO1997012036A3 true WO1997012036A3 (en) 1997-06-05

Family

ID=21710157

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1996/000653 WO1997012036A2 (en) 1995-09-26 1996-09-26 Bone stimulating factor

Country Status (5)

Country Link
EP (1) EP0853667A2 (en)
JP (1) JPH11514858A (en)
AU (1) AU7081196A (en)
WO (1) WO1997012036A2 (en)
ZA (1) ZA968062B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693081B2 (en) * 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
WO2000075185A1 (en) * 1999-06-02 2000-12-14 Osteopharm Inc. Bone stimulating factor
FR2811991B1 (en) * 2000-07-19 2003-01-17 Univ Bordeaux 1 PF-4 MUTE, ITS FRAGMENTS AND MUTED FUSION PEPTIDES, THEIR ANALOGS, THE CORRESPONDING DNA, DNA AND CDNA SEQUENCES, AND THEIR USE IN THE INHIBITION OF ANGIOGENESIS
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
DE102019207859A1 (en) * 2018-12-21 2020-06-25 Gelita Ag Synthetic and recombinantly produced collagen peptides with biological effectiveness

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005309A1 (en) * 1992-08-28 1994-03-17 University Of Louisville Research Foundation, Inc. Use of platelet factor 4 to inhibit osteoblast proliferation
WO1995028172A1 (en) * 1994-04-18 1995-10-26 Osteopharm Limited Human bone stimulating factor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005309A1 (en) * 1992-08-28 1994-03-17 University Of Louisville Research Foundation, Inc. Use of platelet factor 4 to inhibit osteoblast proliferation
US5304542A (en) * 1992-08-28 1994-04-19 University Of Louisville Research Foundation, Inc. Use of platelet factor 4 to inhibit osteoblast proliferation
WO1995028172A1 (en) * 1994-04-18 1995-10-26 Osteopharm Limited Human bone stimulating factor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAN E. EHLERT ET AL.: "Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2)", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 11, 17 March 1995 (1995-03-17), MD US, pages 6338 - 6344, XP002022825 *

Also Published As

Publication number Publication date
WO1997012036A2 (en) 1997-04-03
JPH11514858A (en) 1999-12-21
EP0853667A2 (en) 1998-07-22
AU7081196A (en) 1997-04-17
ZA968062B (en) 1997-06-18

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