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WO1996040087A3 - Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group - Google Patents

Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group Download PDF

Info

Publication number
WO1996040087A3
WO1996040087A3 PCT/US1996/008492 US9608492W WO9640087A3 WO 1996040087 A3 WO1996040087 A3 WO 1996040087A3 US 9608492 W US9608492 W US 9608492W WO 9640087 A3 WO9640087 A3 WO 9640087A3
Authority
WO
WIPO (PCT)
Prior art keywords
pressure sensitive
linked
hydroxyl group
drug
sensitive acrylate
Prior art date
Application number
PCT/US1996/008492
Other languages
French (fr)
Other versions
WO1996040087A2 (en
Inventor
Chunhua Li
Edward Schonfeld
Tara Chu
Chia-Ming Chiang
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Priority to AU60326/96A priority Critical patent/AU6032696A/en
Publication of WO1996040087A2 publication Critical patent/WO1996040087A2/en
Publication of WO1996040087A3 publication Critical patent/WO1996040087A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Non-yellowing organic solvent based pressure sensitive acrylate adhesives that have good cohesive strength and cold flow properties and are useful in fabricating transdermal drug delivery patches are made from an organic solvent based pressure sensitive acrylate adhesive cross-linked with aluminum acetylacetonate and combined with a drug, such as estradiol, that has a reactive aromatic hydroxyl group.
PCT/US1996/008492 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group WO1996040087A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60326/96A AU6032696A (en) 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48429495A 1995-06-07 1995-06-07
US08/484,294 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040087A2 WO1996040087A2 (en) 1996-12-19
WO1996040087A3 true WO1996040087A3 (en) 1997-01-30

Family

ID=23923554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008492 WO1996040087A2 (en) 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group

Country Status (2)

Country Link
AU (1) AU6032696A (en)
WO (1) WO1996040087A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7309497B2 (en) 2000-08-24 2007-12-18 Schwarz Pharma Ag Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
US7632859B2 (en) 2002-12-02 2009-12-15 Schwarz Pharma Ag Iontophoretic delivery of rotigotine for the treatment of Parkinson's disease
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228434B1 (en) * 1995-06-07 2013-03-28 Ortho Mcneil Pharm Inc Transdermal medicament for administering 17-deacetyl norgestimate alone or in combination with an estrogen
DE19706824C1 (en) * 1997-02-21 1998-03-26 Lohmann Therapie Syst Lts Plaster for transdermal drug delivery
DE19814084B4 (en) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's syndrome and process for its preparation
DE10000333A1 (en) * 2000-01-07 2001-07-19 Lohmann Therapie Syst Lts Pharmaceutical composition for the transdermal administration of hormones with a permeation-improving additive
EP1311559B1 (en) * 2000-06-01 2006-08-02 Kraton Polymers Research B.V. Compositions comprising a functionalized block copolymer crosslinked with aluminum acetylacetonate
DE10157745A1 (en) * 2001-11-24 2003-06-26 Hf Arzneimittelforsch Gmbh Transdermal therapeutic system for the administration of 17alpha-estradiol
US6653408B1 (en) 2002-11-21 2003-11-25 Kraton Polymers U.S. Llc Compositions comprising a functionalized block copolymer crosslinked with aluminum acetylacetonate
US7816546B2 (en) 2003-06-30 2010-10-19 Richter Gedeon Vegyeszeti Gyar Rt. Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
DE10333393A1 (en) * 2003-07-23 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with the active ingredient pramipexole
KR102416487B1 (en) 2014-07-04 2022-07-04 루예 파마 아게 Device for the manufacture of pharmaceutical patches
CA3010183A1 (en) 2015-12-30 2017-07-06 Corium International, Inc. Systems and methods for long term transdermal administration
AU2017281789B2 (en) 2016-06-23 2023-04-13 Corium, LLC. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
KR20230097203A (en) 2016-07-27 2023-06-30 코리움, 엘엘씨 Donepezil transdermal delivery system
EP3490559A1 (en) 2016-07-27 2019-06-05 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
RU2764764C2 (en) 2016-07-27 2022-01-21 Кориум Интернэшнл, Инк. Transdermal memantine delivery systems
CA3086163A1 (en) 2017-12-20 2019-06-27 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN113227291B (en) 2018-11-08 2023-03-21 艾利丹尼森公司 Yellowing-resistant PSA

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435200A2 (en) * 1989-12-28 1991-07-03 Nitto Denko Corporation Estrogen-containing gel preparation
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
US5306503A (en) * 1990-06-25 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch with a high content of softening ingredients

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
EP0435200A2 (en) * 1989-12-28 1991-07-03 Nitto Denko Corporation Estrogen-containing gel preparation
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
US5306503A (en) * 1990-06-25 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch with a high content of softening ingredients

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7309497B2 (en) 2000-08-24 2007-12-18 Schwarz Pharma Ag Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine
US7632859B2 (en) 2002-12-02 2009-12-15 Schwarz Pharma Ag Iontophoretic delivery of rotigotine for the treatment of Parkinson's disease

Also Published As

Publication number Publication date
AU6032696A (en) 1996-12-30
WO1996040087A2 (en) 1996-12-19

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