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WO1995021919A3 - Proteine a activite de thrombopoietine (tpo) - Google Patents

Proteine a activite de thrombopoietine (tpo) Download PDF

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Publication number
WO1995021919A3
WO1995021919A3 PCT/JP1995/000208 JP9500208W WO9521919A3 WO 1995021919 A3 WO1995021919 A3 WO 1995021919A3 JP 9500208 W JP9500208 W JP 9500208W WO 9521919 A3 WO9521919 A3 WO 9521919A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
tpo
protein
production
tpo activity
Prior art date
Application number
PCT/JP1995/000208
Other languages
English (en)
Other versions
WO1995021919A2 (fr
Inventor
Hiroshi Miyazaki
Takashi Kato
Kinya Ohgami
Akihiro Iwamatsu
Hiromichi Akahori
Ryota Kuroki
Toshiyuki Shimizu
Takanori Muto
Original Assignee
Kirin Brewery
Hiroshi Miyazaki
Takashi Kato
Kinya Ohgami
Akihiro Iwamatsu
Hiromichi Akahori
Ryota Kuroki
Toshiyuki Shimizu
Takanori Muto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RO95-01791A priority Critical patent/RO118299B1/ro
Priority to KR1019970702400A priority patent/KR100272867B1/ko
Priority to AU16718/95A priority patent/AU702669B2/en
Priority to PL95311885A priority patent/PL179884B1/pl
Application filed by Kirin Brewery, Hiroshi Miyazaki, Takashi Kato, Kinya Ohgami, Akihiro Iwamatsu, Hiromichi Akahori, Ryota Kuroki, Toshiyuki Shimizu, Takanori Muto filed Critical Kirin Brewery
Priority to BR9505781A priority patent/BR9505781A/pt
Priority to NZ279555A priority patent/NZ279555A/en
Priority to MX9504057A priority patent/MX9504057A/es
Priority to EP95908381A priority patent/EP0695355A1/fr
Priority to KR1019970702401A priority patent/KR100260272B1/ko
Priority to KR1019950704474A priority patent/KR100237582B1/ko
Priority to JP7521122A priority patent/JP2996729B2/ja
Publication of WO1995021919A2 publication Critical patent/WO1995021919A2/fr
Priority to NO19954058A priority patent/NO323195B1/no
Priority to FI954889A priority patent/FI954889A/fi
Publication of WO1995021919A3 publication Critical patent/WO1995021919A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention porte sur des polypeptides de TPO ayant une activité biologique spécifique de stimulation ou d'accroissement de la production de plaquettes contenant la séquence d'aminoacides 1-332 de NO ID SEQ: 6 ou un dérivé, sur des molécules d'ADN codant des polypeptides de TPO, sur les procédés de production de ces polypeptides, sur des anticorps spécifiquement immunoréactifs vis-à-vis de ces polypeptides, sur des compositions pharmaceutiques contenant ces polypeptides, et sur les applications de ces polypeptides dans le traitement d'anomalies plaquettaires comme la thrombopénie.
PCT/JP1995/000208 1994-02-14 1995-02-14 Proteine a activite de thrombopoietine (tpo) WO1995021919A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
NZ279555A NZ279555A (en) 1994-02-14 1995-02-14 Thrombopoietin polypeptides their production and use
AU16718/95A AU702669B2 (en) 1994-02-14 1995-02-14 Protein having TPO activity
PL95311885A PL179884B1 (en) 1994-02-14 1995-02-14 Protein of tpo activity
EP95908381A EP0695355A1 (fr) 1994-02-14 1995-02-14 Proteine a activite de thrombopoietine (tpo)
BR9505781A BR9505781A (pt) 1994-02-14 1995-02-14 Proteina tendo atividade TPO
KR1019970702400A KR100272867B1 (ko) 1994-02-14 1995-02-14 Tpo활성을 갖는 단백질
MX9504057A MX9504057A (es) 1994-02-14 1995-02-14 Proteina que tiene actividad tpo.
RO95-01791A RO118299B1 (ro) 1994-02-14 1995-02-14 Polipeptida trombopoietina, secventa adn care o codifica, procedeu pentru prepararea polipeptidei trombopoietine si compozitie farmaceutica cu aceasta
KR1019970702401A KR100260272B1 (ko) 1994-02-14 1995-02-14 Tpo활성을 갖는 단백질의 아미노산을 코딩하는 염기 서열을 포함하는 dna
KR1019950704474A KR100237582B1 (ko) 1994-02-14 1995-02-14 Tpo 활성을 갖는 단백질의 제조방법
JP7521122A JP2996729B2 (ja) 1994-02-14 1995-02-14 Ｔｐｏ活性タンパク質に対する抗体
NO19954058A NO323195B1 (no) 1994-02-14 1995-10-12 Protein som har TPO aktivitet, DNA kodende for nevnte protein, fremstillingsmetoder, vertceller, farmasoytiske sammensetinger, anvendelser og antistoff
FI954889A FI954889A (fi) 1994-02-14 1995-10-13 Proteiini, jolla on TPO-aktiviteetti

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
JP6/39090 1994-02-14
JP3909094 1994-02-14
US21216494A 1994-03-14 1994-03-14
JP7984294 1994-03-25
JP6/79842 1994-03-25
US22102094A 1994-04-01 1994-04-01
JP6/155126 1994-06-01
JP15512694 1994-06-01
JP16732894 1994-06-15
JP6/167328 1994-06-15
US27808394A 1994-07-20 1994-07-20
JP22715994 1994-08-17
JP19316994 1994-08-17
JP6/193169 1994-08-17
JP6/227159 1994-08-17
JP6/193916 1994-08-18
JP19391694 1994-08-18
US32030094A 1994-10-11 1994-10-11
JP6/304167 1994-11-01
JP30416794 1994-11-01
JP29866994 1994-12-01
JP6/298669 1994-12-01
US36181194A 1994-12-22 1994-12-22
JP34120094 1994-12-28
JP6/341200 1994-12-28

Publications (2)

Publication Number Publication Date
WO1995021919A2 WO1995021919A2 (fr) 1995-08-17
WO1995021919A3 true WO1995021919A3 (fr) 1995-12-07

Family

ID=27585306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/000208 WO1995021919A2 (fr) 1994-02-14 1995-02-14 Proteine a activite de thrombopoietine (tpo)

Country Status (1)

Country Link
WO (1) WO1995021919A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules
US9145450B2 (en) 1998-10-23 2015-09-29 Amgen Inc. Thrombopoietic compounds

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192955B1 (en) 1994-01-03 2012-06-05 Genentech, Inc. Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US8357513B1 (en) 1994-01-03 2013-01-22 Genentech, Inc. Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US8147844B1 (en) 1994-01-03 2012-04-03 Genentech, Inc. Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
US8241900B1 (en) 1994-01-03 2012-08-14 Genentech, Inc. mpl ligand
US8278099B1 (en) 1994-02-15 2012-10-02 Genentech, Inc. Monoclonal antibody to human thrombopoietin
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
KR100203824B1 (ko) * 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EP0885242B1 (fr) 1995-06-07 2008-03-26 Glaxo Group Limited Peptides et composes se fixant a un recepteur de thrombopoietine
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
PT1542714E (pt) 2002-09-18 2014-06-23 Janssen Pharmaceuticals Inc Métodos para aumentar a produção de células estaminais plaquetárias e hematopoiéticas
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
KR20120078742A (ko) 2003-08-28 2012-07-10 오르토-맥네일 파마슈티칼, 인코퍼레이티드 수용체에 결합하는 펩티드 및 화합물
JP2007528195A (ja) 2003-10-09 2007-10-11 デウン カンパニー，リミテッド 高シアル酸含量のヒトトロンボポエチンを精製する方法
CA2550301A1 (fr) 2003-12-30 2005-07-14 Bionethos Holding Gmbh Procede de regeneration de tissus
MX2007000216A (es) 2004-07-08 2007-03-15 Amgen Inc Peptidos terapeuticos.
EP2540309B1 (fr) * 2005-08-05 2017-11-22 Araim Pharmaceuticals, Inc. Peptides protecteurs de tissus et utilisations associées
WO2007102946A2 (fr) 2006-01-23 2007-09-13 Amgen Inc. Polypeptides cristallins
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
CA2687141C (fr) 2007-05-22 2014-04-01 Amgen Inc. Compositions et procedes pour produire des proteines de fusion bioactives
CN102066413B (zh) 2008-01-22 2015-01-21 阿拉伊姆药品公司 用于预防和治疗组织损伤相关疾病和病症的组织保护肽和肽类似物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARTLEY ET AL: "IDENTIFICATION AND CLONING OF A MEGAKARYOCYTE GROWTH AND DEVLOPMENT FACTOR THAT IS A LIGAND FOR THE CYTOKINE RECEPTOR MPL", CELL, vol. 77, 1 July 1994 (1994-07-01), pages 1117 - 1124 *
DE SAUVAGE ET AL: "STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND", NATURE, vol. 369, 16 June 1994 (1994-06-16), pages 533 - 538 *
MCDONALD: "THROMBOPOIETIN:ITS BIOLOGY,PURIFICATION,AND CHARACTERIZATION", EXPERIMENTAL HEMATOLOGY, vol. 16, no. 3, pages 201 - 205 *
SOHMA ET AL: "MOLECULAR CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN THROMBOPOIETIN GENE", FEBS LETTERS, vol. 353, no. 1, 10 October 1994 (1994-10-10), pages 57 - 61 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145450B2 (en) 1998-10-23 2015-09-29 Amgen Inc. Thrombopoietic compounds
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

Also Published As

Publication number Publication date
WO1995021919A2 (fr) 1995-08-17

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