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WO1991009630A1 - Method and solution for decontaminating a flexible contact lens, particularly of the hydrophilic type - Google Patents

Method and solution for decontaminating a flexible contact lens, particularly of the hydrophilic type Download PDF

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Publication number
WO1991009630A1
WO1991009630A1 PCT/FR1990/000938 FR9000938W WO9109630A1 WO 1991009630 A1 WO1991009630 A1 WO 1991009630A1 FR 9000938 W FR9000938 W FR 9000938W WO 9109630 A1 WO9109630 A1 WO 9109630A1
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WO
WIPO (PCT)
Prior art keywords
solution
agent
neutralizing agent
oxidizing
sodium
Prior art date
Application number
PCT/FR1990/000938
Other languages
French (fr)
Inventor
Lyliane Le Naour
Leang Ly
Original Assignee
Essilor International
Galenica Holding S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essilor International, Galenica Holding S.A. filed Critical Essilor International
Publication of WO1991009630A1 publication Critical patent/WO1991009630A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/10—Halogens or compounds thereof
    • A61L12/102—Chlorine dioxide (ClO2)

Definitions

  • the invention relates to the decontamination of a contac t flexible lens, in particular of hydrophilic type.
  • a known technique decontamination consists in putting the lens in the presence of a solution containing a power agent oxvdan t and optionally a suitable catalyst to promote the action of this agen t.
  • This technique requires eliminating or neutralizing the oxidizing agent, after decontamination, so that the lens can be put back into service without danger to the user.
  • An object of the invention is to significantly reduce the duration of the neutralization operation.
  • Another object of the invention is to reduce the risk of burning the eye in the event of forgetting the neutralization operation.
  • a sufficient amount of neutralizing agent is incorporated into the decontamination solution so that this agent is immediately active.
  • the proportion by mass of oxidizing agent in the initial decontamination solution is preferably included in the range Z .Z 5- .Z 25.
  • the neutralizing agent and the oxidizing agent are used so that the ratio of the percentages by weight of these agents in the decontamination solution is greater than 0.2, preferably included in the range O -0.8 .
  • a first fraction of the neutralizing agent solution is used for the decontamination operation and a second fraction of the same solution for the neutralizing operation, which avoids any dosage error.
  • the duration of the neutralization operation can be reduced to a few minutes, or even a minute.
  • the oxidizing agent is chosen from the agents known for this application and in particular in the range consisting of sodium chlo ⁇ te and potassium chlorite.
  • the optional catalyst is chosen from the catalysts known for this application, and in particular from the range consisting of an acid, citric acid, tartaric acid, hydrochloric acid and sulfuric acid, etc.
  • the neutralizing agent is chosen from the neutralizing agents known for this application, and in particular from the range consisting of sodium thiosulfate and potassium thiosulfate. Examples
  • a tertiary chlonte / acid / thiosulfate solution and, more particularly, sodium chlonte / citric acid / sodium thiosulfate is used as decontamination solution.
  • the decontaminating agent is sodium chlonte; citric acid is a catalyst for the action of chlonte. In the presence of the acid, sodium chlonte releases chlorine dioxide (oxidant and decontaminant).
  • Thiosulfate is a neutralizing agent that breaks down the chlorine dioxide formed by an oxidation-reduction reaction.
  • the user is provided with a cleaning and neutralization kit comprising chlorite, citric acid in the solid state and thiosulfate in the liquid state.
  • the solution is left to act for at least hours and preferably up to 12 hours.
  • the subsequent step of eliminating the excess of decontaminating agent remaining on / in the lens is preferably carried out with the thiosulfate solution which served to prepare the decontaminating and cleaning solution.
  • the thiosulfate solution which served to prepare the decontaminating and cleaning solution.
  • the 0.03% sodium thiosulfate solution is used, in which the lens is soaked.
  • the operation is carried out for 1 to 10 minutes. It is possible, after only one minute of treatment, to place the lenses directly on the eye without seeing any irritant effect, or any inconvenience during subsequent wear.
  • chlorite / acid / thiosulfate solutions allow protein deposits to be removed at room temperature. Repeated use of these solutions does not affect the lenses.
  • FIG. 1 the reduction kinetics as a function of time of the number of oxidizing functions in a solution containing 0.05 ° o by weight of sodium chlorite, 0.02.7 ° _ by weight of citric acid and one percent v ariable t age of sodium thiosulfate; - In Figure 2, the normality of the solution in oxidizing functions after 12 hours of treatment at room temperature.
  • the five curves in Figure 1 correspond respectively to Z ° _ (curve A), 0.005% (curve B), 0.01% (curve C), 0.03 ° ⁇ (curve D) and 0.05% by weight (curve E) of sodium thiosulfate in the solution of sodium chlorite and citric acid.
  • the number of oxidizing functions present in the solution is assayed every hour, using a solution of sodium thiosulfate and measuring the amount of thiosulfate to be introduced to achieve neutralization. a) In the sodium chlorite / citric acid solution without sodium thiosulfate, the oxidizing power of the solution remains constant for at least four hours (curve A). In fact, it is the same after 12 hours.
  • FIG. 2 illustrates, after 12 hours of treatment, the normality of the solution in oxidizing functions, as a function of the% by mass of sodium thiosulfate in the initial solution.
  • the two phases of reduction of the oxidizing power are represented, namely a first phase (I) of rapid decrease in the oxidizing power and a second slower decay phase (II).
  • the decontamination operation is carried out in a case made of an inert material with respect to chlorinated derivatives of the chlorine dioxide type such as mineral glass, polystyrene and, preferably, a polyolefin such as polyethylene, polypropylene, polymethylpentene.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Detergent Compositions (AREA)

Abstract

The invention relates to the decontamination of a contact lens. An oxidizing agent is caused to react on the lens and, simultaneously, a neutralizing agent in sufficient quantity to obtain a immediate reduction of the oxidizing power. The figure shows the evolution of the total oxidizing fonction in relation to time for different concentrations of neutralizing agent. Application to flexible contact lenses, particularly of the hydrophilic type.

Description

PROCEDE ET SOLUTION POUR DECONTAMINER UNE LENTILLE SOUPLE , EN PARTICULIER DU TYPE HYDROPHILE METHOD AND SOLUTION FOR DECONTAMINATING A FLEXIBLE LENS, PARTICULARLY OF THE HYDROPHILIC TYPE
L'invention concerne la décontamination d'une lentille de contact souple, en particulier de type hydrophile.The invention relates to the decontamination of a contac t flexible lens, in particular of hydrophilic type.
Une technique connue de décontamination consiste à mettre la lentille en présence d'une solution contenant un agent à pouvoir oxvdant et, éventuellement, un catalyseur apte à favoriser l'action de cet agent.A known technique decontamination consists in putting the lens in the presence of a solution containing a power agent oxvdan t and optionally a suitable catalyst to promote the action of this agen t.
Cette technique nécessite d'éliminer ou de neutraliser l'agent oxydant, après décontamination, pour que la lentille puisse à nouv eau être mise en service sans danger pour l'utilisateur.This technique requires eliminating or neutralizing the oxidizing agent, after decontamination, so that the lens can be put back into service without danger to the user.
Il est connu, pour ce faire, de mettre la lentille, après décontamina- tion ou nettoyage, en présence d'un agent de neutralisation tel que le thiosulfate de sodium ou le bisulfite de sodium, comme décrit par exemple dans la publication de brevet français N° 2 256 767, dans la demande de brevet japonais publiée le 3 février 1983 sous le n° 58-18617, et dans le brevet EUA «. 568 5 17. Cette opération de neutralisation exige une attention de l'utilisateur qui doit veiller à ne pas l'oublier, à ne pas se tromper dans le dosage requis, et à respecter les délais d'intervention.It is known to do this, to put the lens, after decontamination or cleaning, in the presence of a neutralizing agent such as sodium thiosulfate or sodium bisulfite, as described for example in the publication of French patent No. 2,256,767, in the Japanese patent application published on February 3, 1983 under No. 58-18617, and in the EUA patent “. 568 5 17. This neutralization operation requires the attention of the user, who must take care not to forget it, not to make a mistake in the required dosage, and to respect the intervention deadlines.
Pour diminuer ces inconvénients, on a pensé à incorporer dans la même solution l'agent de décontamination ou de nettoyage et l'agent de neutralisation, mais ce dernier étant enrobé de façon à n'agir qu'après un certain temps.To reduce these drawbacks, it has been thought to incorporate in the same solution the decontamination or cleaning agent and the neutralizing agent, but the latter being coated so as to act only after a certain time.
Cet enrobage complique la préparation de l'agent de neutralisation. En outre, l'opération de neutralisation reste relativement longue. Un but de l'invention est de réduire de façon notable la durée de l'opération de neutralisation.This coating complicates the preparation of the neutralizing agent. In addition, the neutralization operation remains relatively long. An object of the invention is to significantly reduce the duration of the neutralization operation.
Un autre but de l'invention est de réduire les risques de brûlure de l'oeil en cas d'oubli de l'opération de neutralisation.Another object of the invention is to reduce the risk of burning the eye in the event of forgetting the neutralization operation.
On y parvient, selon l'invention, en faisant en sorte que le pouvoir oxydant de la solution de décontamination se trouve sensiblement réduit dès la fin de l'opération de décontamination et avant même l'opération de neutralisation, sans que cela nuise à l'efficacité de la décontamination. Selon l'invention, on incorpore à la solution de décontamination une quantité suffisante d'agent de neutralisation en sorte que cet agent soit immédiatement actif. La proportion massique d'agent oxydant dans la solution de décontamination initiale est de préférence compris dans la gamme Z .Z 5- .Z 25.This is achieved, according to the invention, by ensuring that the oxidizing power of the decontamination solution is significantly reduced from the end of the decontamination operation and even before the neutralization operation, without this harming the effectiveness of decontamination. According to the invention, a sufficient amount of neutralizing agent is incorporated into the decontamination solution so that this agent is immediately active. The proportion by mass of oxidizing agent in the initial decontamination solution is preferably included in the range Z .Z 5- .Z 25.
De préférence, l'agent de neutralisation et l'agent oxydant sont utilisés en sorte que le rapport des pourcentages en poids de ces agents dans la solution de décontamination soit supérieur à 0,2, de préférence compris dans la gamme O -0,8.Preferably, the neutralizing agent and the oxidizing agent are used so that the ratio of the percentages by weight of these agents in the decontamination solution is greater than 0.2, preferably included in the range O -0.8 .
On a constaté que, dans ces conditions, l'agent oxydant se décompose très rapidement pendant une phase initiale de l'opération de décontamina- tion, ce qui conduit, après quelques secondes à la formation d'une solution dont le pouvoir oxydant est réduit dans une large mesure, cette décroissance du pouvoir oxydant étant ensuite moins rapide pendant la phase subséquente de l'opération de décontamination.It has been found that, under these conditions, the oxidizing agent decomposes very rapidly during an initial phase of the decontamination operation, which leads, after a few seconds, to the formation of a solution whose oxidizing power is reduced to a large extent, this decrease in oxidizing power then being less rapid during the subsequent phase of the decontamination operation.
Dans une réalisation avantageuse, on utilise une première fraction de la solution d'agent neutralisant pour l'opération de décontamination et une deuxième fraction de la même solution pour l'opération de neutralisa¬ tion, ce qui évite toute erreur de dosage.In an advantageous embodiment, a first fraction of the neutralizing agent solution is used for the decontamination operation and a second fraction of the same solution for the neutralizing operation, which avoids any dosage error.
De façon typique, la durée de l'opération de neutralisation peut se réduire à quelques minutes, voire une minute seulement. L'agent oxydant est choisi parmi les agents connus pour cette application et notamment dans la gamme constituée par le chloπte de sodium et le chlorite de potassium.Typically, the duration of the neutralization operation can be reduced to a few minutes, or even a minute. The oxidizing agent is chosen from the agents known for this application and in particular in the range consisting of sodium chloπte and potassium chlorite.
Le catalyseur éventuel est choisi parmi les catalyseurs connus pour cette application, et notamment dans la gamme constituée par un acide, l'acide citrique, l'acide tartrique, l'acide chlorhydrique et l'acide sulfurique, etc.The optional catalyst is chosen from the catalysts known for this application, and in particular from the range consisting of an acid, citric acid, tartaric acid, hydrochloric acid and sulfuric acid, etc.
L'agent de neutralisation est choisi parmi les agents de neutralisa¬ tion connus pour cette application, et notamment dans la gamme constituée par le thiosulfate de sodium et le thiosuifate de potassium. ExemplesThe neutralizing agent is chosen from the neutralizing agents known for this application, and in particular from the range consisting of sodium thiosulfate and potassium thiosulfate. Examples
On utilise, comme solution de décontamination, une solution tertiaire chlonte / acide / thiosulfate et, plus particulièrement, chlonte de sodium / acide citrique / thiosulfate de sodium.A tertiary chlonte / acid / thiosulfate solution and, more particularly, sodium chlonte / citric acid / sodium thiosulfate is used as decontamination solution.
L'agent décontaminant est le chlonte de sodium ; l'acide citrique est un catalyseur de l'action du chlonte. En présence de l'acide, le chlonte de sodium libère du dioxyde de chlore (oxydant et décontaminant).The decontaminating agent is sodium chlonte; citric acid is a catalyst for the action of chlonte. In the presence of the acid, sodium chlonte releases chlorine dioxide (oxidant and decontaminant).
Le thiosulfate est un agent de neutralisation qui décompose le dioxyde de chlore formé par réaction d'oxydoréduction.Thiosulfate is a neutralizing agent that breaks down the chlorine dioxide formed by an oxidation-reduction reaction.
On prépare les solutions suivantes, 1, 2 et 3 dont on teste l'action décontaminante à température ambiante pendant 4 heures, conformément à la méthode décrite dans la norme AFNOR NF T72190 et pour les bactéries suivantes : escherichia coli, citrobacter freundii, pseudomonas aeruginosa, staphylococcus aureus et pour le champignon candida albicans.The following solutions are prepared, 1, 2 and 3, the decontaminating action of which is tested at room temperature for 4 hours, in accordance with the method described in standard AFNOR NF T72190 and for the following bacteria: escherichia coli, citrobacter freundii, pseudomonas aeruginosa , staphylococcus aureus and for the fungus candida albicans.
Composés Chlorite Acide Thiosulfate PouvoirCompounds Chlorite Acid Thiosulfate Power
Solution de sodium citrique de sodium décontaminantCitric sodium solution decontaminating sodium
(Afnor T72/190)(Afnor T72 / 190)
0,05 % 0,087 % 0,0 . %0.05% 0.087% 0.0. %
0,05 % 0,087 % 0,03 %0.05% 0.087% 0.03%
0,05 % 0,087 % 0,02 %0.05% 0.087% 0.02%
(Tous les % indiqués sont des % massiques en produit actif présent dans la solution initiale)(All the% indicated are% by mass of active product present in the initial solution)
+ décontaminant au bout de <+ heures dans les conditions de la norme AFNOR pour les microorganismes cités.+ decontaminant after <+ hours under the conditions of the AFNOR standard for the microorganisms mentioned.
.+ d' 1 heure. L'excès d'agent décontaminant en fin de traitement est élimine par une solution de thiosulfate de sodium.. + 1 hour. The excess decontaminating agent at the end of the treatment is removed with a sodium thiosulfate solution.
Dans une mise en oeuvre préférentielle de cette technique, on fournit à l'utilisateur un kit de nettoyage et de neutralisation comprenant le chlorite, l'acide citrique à l'état solide et le thiosulfate à l'état liquide.In a preferred implementation of this technique, the user is provided with a cleaning and neutralization kit comprising chlorite, citric acid in the solid state and thiosulfate in the liquid state.
Dans le cas de l'exemple 2, on utilise une solution de thiosul fate aIn the case of Example 2, a solution of thiosul fate a is used
0,03 % dont on verse une quantité déterminée dans un étui prévu à cet effet et muni d'un repère de niveau.0.03% of which a determined quantity is poured into a case provided for this purpose and provided with a level mark.
On ajoute une quantité prédéterminée de chlonte - acide citrique permettant d'obtenir les concentrations recherchées dans la solution décontaminante et nettoyante, puis on introduit la lentille dans la solution.Add a predetermined amount of chlonte - citric acid to obtain the desired concentrations in the decontaminating and cleaning solution, then introduce the lens into the solution.
On laisse agir la solution au minimum heures et, de préférence, jusqu'à 12 heures.The solution is left to act for at least hours and preferably up to 12 hours.
L'étape subséquente d'élimination de l'excès d'agent décontaminant restant sur/dans la lentille s'effectue de préférence avec la solution de thiosulfate ayant servi à préparer la solution décontaminante et nettoyan¬ te. Dans le cas de l'exemple 2, on utilise la solution à 0,03 % de thiosulfate de sodium, dans laquelle on vient tremper la lentille.The subsequent step of eliminating the excess of decontaminating agent remaining on / in the lens is preferably carried out with the thiosulfate solution which served to prepare the decontaminating and cleaning solution. In the case of Example 2, the 0.03% sodium thiosulfate solution is used, in which the lens is soaked.
Dans ce cas, l'opération est effectuée pendant 1 à 10 minutes. Il est possible, après seulement une minute de traitement, de placer directement les lentilles sur l'oeil sans constater d'effet irritant, ni d'inconvénient lors du port ultérieur.In this case, the operation is carried out for 1 to 10 minutes. It is possible, after only one minute of treatment, to place the lenses directly on the eye without seeing any irritant effect, or any inconvenience during subsequent wear.
Les solutions peuvent être utilisées comme solutions nettoyantesSolutions can be used as cleaning solutions
(élimination des protéines et des dépôts) en traitement à chaud (jusqu'à 85°C). Elles présentent alors, en outre, l'intérêt d'éviter l'odeur de chlore, fort déplaisante pour l'utilisateur, que présentent les solutions de chlorite de l'art antérieur.(elimination of proteins and deposits) in hot treatment (up to 85 ° C). They then present, in addition, the advantage of avoiding the odor of chlorine, which is very unpleasant for the user, presented by the chlorite solutions of the prior art.
Outre la décontamination, les solutions de chlorite / acide / thiosulfate permettent d'éliminer, à température ambiante, les dépôts de protéines. L'utilisation répétée de ces solutions n'altère pas les lentilles.In addition to decontamination, the chlorite / acid / thiosulfate solutions allow protein deposits to be removed at room temperature. Repeated use of these solutions does not affect the lenses.
Les figures du dessin joint illustrent : - en figure 1, la cinétique de réduction en fonction du temps du nombre de fonctions oxydantes dans une solution contenant 0,05 °o en poids de chlorite de sodium, 0,02,7 °_ en poids d'acide citrique et un pourcentage v ariable de thiosulfate de sodium ; - en figure 2, la normalité de la solution en fonctions oxydantes après 12 heures de traitement à température ambiante.The figures in the attached drawing illustrate: - in FIG. 1, the reduction kinetics as a function of time of the number of oxidizing functions in a solution containing 0.05 ° o by weight of sodium chlorite, 0.02.7 ° _ by weight of citric acid and one percent v ariable t age of sodium thiosulfate; - In Figure 2, the normality of the solution in oxidizing functions after 12 hours of treatment at room temperature.
Les cinq courbes de la figure 1 correspondent respectivement à Z °_ (courbe A), 0,005 % (courbe B), 0,01 % (courbe C), 0,03 °Ό (courbe D) et 0,05 % en poids (courbe E) de thiosulfate de sodium dans la solution de chlorite de sodium et d'acide citrique.The five curves in Figure 1 correspond respectively to Z ° _ (curve A), 0.005% (curve B), 0.01% (curve C), 0.03 ° Ό (curve D) and 0.05% by weight (curve E) of sodium thiosulfate in the solution of sodium chlorite and citric acid.
On dose toutes les heures le nombre de fonctions oxydantes présentes dans la solution, en utilisant une solution de thiosulfate de sodium et mesurant la quantité de thiosulfate à introduire pour arriver à la neutralisation. a) Dans la solution chlorite de sodium / acide citrique sans thiosulfate de sodium, le pouvoir oxydant de la solution reste constant pendant au moins quatre heures (courbe A). De fait, il en est de même au bout de 12 heures.The number of oxidizing functions present in the solution is assayed every hour, using a solution of sodium thiosulfate and measuring the amount of thiosulfate to be introduced to achieve neutralization. a) In the sodium chlorite / citric acid solution without sodium thiosulfate, the oxidizing power of the solution remains constant for at least four hours (curve A). In fact, it is the same after 12 hours.
Il est par ailleurs particulièrement étonnant de constater que, dans les mêmes conditions, le couple chlorite / thiosulfate seul ne libère aucune fonction oxydante dans la solution à température ambiante, contrairement à l'enseignement de la demande de brevet japonais 58-18617. L'acide citrique et le thiosulfate jouent un rôle différent vis-à-vis du chlorite. b) Dès lors qu'on utilise le couple chlorite / acide citrique en combinaison avec du thiosulfate (courbes B et C) à 0,005 % et 0,01 %, on observe une décroissance immédiate du pouvoir oxydant, cette décroissance se poursuivant pendant au moins 4 heures. c) Dans la solution à 0,03 % de thiosulfate de sodium (courbe D), on constate deux phases : - une réaction immédiate (t = 0) du chlorite de sodium avec le thiosulfate de sodium, avec consommation du thiosulfate, la solution devenant très rapidement 0,006 N, - une décroissance progressive du pouvoir oxydant de la solution. Au bout de 4 heures : la solution est 0,0028 N Λu bout de 12 heures : la solution est 0,0010 \ (voir figure 2) On constate par ailleurs qu'une solution correspondant à la courbe D est déconτaminante suivant AFNOR NF T 72.190 alors qu'une solution chlorite de sodium / acide citrique correspondant au pouvoir oxydant de 0,0064 N ne l'est pas. d) La courbe E présente toujours une phase de décroissance progressive.It is also particularly surprising to note that, under the same conditions, the chlorite / thiosulfate couple alone does not release any oxidizing function in the solution at room temperature, contrary to the teaching of Japanese patent application 58-18617. Citric acid and thiosulfate play a different role vis-à-vis chlorite. b) As soon as the chlorite / citric acid couple is used in combination with thiosulfate (curves B and C) at 0.005% and 0.01%, an immediate decrease in the oxidizing power is observed, this decrease continuing for at least 4 hours. c) In the 0.03% solution of sodium thiosulfate (curve D), there are two phases: - an immediate reaction (t = 0) of sodium chlorite with sodium thiosulfate, with consumption of thiosulfate, the solution very quickly becoming 0.006 N, - a progressive decrease in oxidizing power of the solu t ion. After 4 hours: the solution is 0.0028 N Λ after 12 hours: the solution is 0.0010 \ (see Figure 2) We also note that a solution corresponding to curve D is deconτaminant according to AFNOR NF T 72.190 while a sodium chlorite / citric acid solution corresponding to the oxidizing power of 0.0064 N is not. d ) The curve E always exhibits a phase of progressive decrease.
Des tests ont montré qu'une telle solution n'était plus décontaminante suivant la norme AFNOR NF T 72.190, en raison d'une décomposition trop rapide du chlorite de sodium dans la première phase. Il est clair que le pouvoir décontaminant est lié à la concentration initiale en chlorite de sodium dans la solution et que, pour une concentration donnée initiale de chlorite, l'homme de métier choisira avantageusement la concentration en thio sulf ate avec le rappo rt thiosulfate/chlorite dépassant 0,2, de sorte que la puissance décontami¬ nante soit obtenue. La figure 2 illustre, après 12 heures de traitement, la normalité de la solution en fonctions oxydantes, en fonction du % massique de thiosulfate de sodium dans la solution initiale.Tests have shown that such a solution was no longer decontaminating according to the AFNOR NF T 72.190 standard, due to too rapid decomposition of sodium chlorite in the first phase. It is clear that the decontaminating power is linked to the initial concentration of sodium chlorite in the solution and that, for a given initial concentration of chlorite, the skilled person will advantageously choose the concentration of thio sulf ate with the ratio thiosulfate / chlorite exceeding 0.2, so that the decontaminating power is obtained. FIG. 2 illustrates, after 12 hours of treatment, the normality of the solution in oxidizing functions, as a function of the% by mass of sodium thiosulfate in the initial solution.
Ce calcul des fonctions oxydantes encore présentes est effectué, comme dans le cas de la figure précédente, par dosage avec une solution de thiosulfate.This calculation of the oxidizing functions still present is carried out, as in the case of the previous figure, by assay with a thiosulfate solution.
On constate qu'on obtient une décroissance plus rapide du pouvoir oxydant de la solution finale dès lors que le rapport [thiosulfate]It is found that a faster decrease in the oxidizing power of the final solution is obtained when the ratio [thiosulfate]
[chlorite] dépasse 0,2. Préférentieilement, on opère dans la gamme [0,4-0,8].[chlorite] exceeds 0.2. Preferably, one operates in the range [0.4-0.8].
Pour les concentrations en thiosulfate de 0,03 % et 0,05 % dans la solution de base, on a représenté les deux phases de réduction du pouvoir oxydant, à savoir une première phase (I) de décroissance rapide du pouvoir oxydant et une deuxième phase (II) de décroissance plus lente. De préférence, on effectue l'opération de décontamination dans un étui en matériau inerte vis-à-vis des dérivés chlorés du type du dioxyde de chlore tel que le verre minéral, le polystyrène et, préférentiellement, une polyoléfine telle que le polyéthylène, le polypropylène, le polyméthyl- pentène. On a trouvé en effet que le matériau de l'étui joue un rôle dans l'efficacité de cette décontamination, certains matériaux polymères présentant une affinité particulière à l'égard des dérivés chlorés décontaminants libérés lors de la décontamination, tel que le dioxyde de chlore, une partie non négligeable de ces dérivés chlorés étant alors absorbée par ledit matériau. For the thiosulfate concentrations of 0.03% and 0.05% in the basic solution, the two phases of reduction of the oxidizing power are represented, namely a first phase (I) of rapid decrease in the oxidizing power and a second slower decay phase (II). Preferably, the decontamination operation is carried out in a case made of an inert material with respect to chlorinated derivatives of the chlorine dioxide type such as mineral glass, polystyrene and, preferably, a polyolefin such as polyethylene, polypropylene, polymethylpentene. It has indeed been found that the material of the case plays a role in the effectiveness of this decontamination, certain polymeric materials having a particular affinity with respect to the chlorinated decontaminating derivatives released during the decontamination, such as chlorine dioxide. , a non-negligible part of these chlorinated derivatives then being absorbed by said material.

Claims

REVENDICATIONS j_. Procédé pour décontaminer et nettoyer une lentille de contact dans lequel on fait agir sur la lentille un agent à pouvoir oxydant, éventuellement en présence d'un catalyseur apte à favoriser cette action, caractérisé en ce qu'on fait simultanément agir un agent de neutralisation en quantité suffisante pour obtenir une réduction immédiate du pouvoir oxydant.CLAIMS j_. Method for decontaminating and cleaning a contact lens in which an agent with oxidizing power is made to act on the lens, optionally in the presence of a catalyst capable of promoting this action, characterized in that a neutralizing agent is acted on simultaneously sufficient quantity to obtain an immediate reduction in oxidizing power.
2. Procédé selon la revendication 1, caractérisé en ce qu'on choisit le pourcentage d'agent de neutralisation de façon à obtenir une décroissance rapide du pouvoir oxydant suivi d'une décroissance plus lente.2. Method according to claim 1, characterized in that the percentage of neutralizing agent is chosen so as to obtain a rapid decrease in the oxidizing power followed by a slower decrease.
3. Procédé selon l'une des revendications l et 2, caractérisé en ce qu'on prépare une solution d'agent de neutralisation et en ce qu'on utilise une partie de cette solution pour l'opération de décontamination et nettoyage et une autre partie de la même solution pour une opération ultérieure de neutralisation.3. Method according to one of claims l and 2, characterized in that a solution of neutralizing agent is prepared and in that part of this solution is used for the decontamination and cleaning operation and another part of the same solution for a subsequent neutralization operation.
4. Procédé selon l'une des revendications 1 à 3, caractérisé en ce que l'on utilise le chlorite de sodium ou de potassium comme agent oxydant.4. Method according to one of claims 1 to 3, characterized in that one uses sodium or potassium chlorite as oxidizing agent.
5. Procédé selon l'une des revendications 1 à 4, caractérisé en ce qu'on utilise le thiosulfate de sodium ou de potassium comme agent de neutralisation.5. Method according to one of claims 1 to 4, characterized in that sodium or potassium thiosulfate is used as neutralizing agent.
6. Procédé selon les revendications 4 et 5, caractérisé en ce que l'agent à pouvoir oxydant et l'agent de neutralisation sont utilisés en sorte que le rapport massique6. Method according to claims 4 and 5, characterized in that the oxidizing agent and the neutralizing agent are used so that the mass ratio
% agent de neutralisation % agent à pouvoir oxydant soit supérieur à 0,2 et, de préférence, dans la gamme 0,4-0,8.% neutralizing agent% agent with oxidizing power is greater than 0.2 and, preferably, in the range 0.4-0.8.
7. Procédé selon l'une des revendications 1 à 6, caractérisé en ce αjû'on met en oeuvre le procédé de décontamination dans un étui en un matériau inerte vis-à-vis des dérivés chlorés tel que le dioxyde de chlore.7. Method according to one of claims 1 to 6, characterized in that αjû'on implements the decontamination process in a case made of an inert material vis-à-vis chlorinated derivatives such as chlorine dioxide.
8. Procédé selon la revendication 7, caractérisé en ce qu'on choisit le matériau principal de l'étui dans la gamme constituée par le verre minéral, le polystyrène, les polyoléfines. 9. Solution de décontamination pour lentille de contact qui comprend un agent à pouvoir oxydant choisi dans la gamme constituée par le chlorite de sodium et le chlorite de potassium, éventuellement un catalyseur, et un agent de neutralisation choisi dans la gamme constituée par le thiosulfate de sodium et le thiosulfate de potassium, cet agent de neutralisation étant apte à provoquer une réduction du pouvoir oxydant et le rapport massique % agent de neutralisation / % agent à pouvoir oxydant étant supérieur à 0,2.8. Method according to claim 7, characterized in that the main material of the case is chosen from the range consisting of mineral glass, polystyrene, polyolefins. 9. Decontamination solution for contact lens which comprises an agent with oxidizing power chosen from the range consisting of sodium chlorite and potassium chlorite, optionally a catalyst, and a neutralizing agent chosen from the range consisting of thiosulphate. sodium and potassium thiosulfate, this neutralizing agent being capable of causing a reduction in the oxidizing power and the mass ratio% neutralizing agent /% agent with oxidizing power being greater than 0.2.
J_0 . Solution selon la revendication 9, caractérisée en ce que ledit rapport est compris dans la gamme 0,4-0,8.D_0. Solution according to claim 9, characterized in that said ratio is in the range 0.4-0.8.
_1_1 Solution selon l'une des revendications 9 et 1 0, caractérisée en ce que le catalyseur éventuel est choisi parmi les catalyseurs connus pour cette application, et notamment dans la gamme constituée par un acide, l'acide citrique, l'acide tartrique, l'acide chlorhydrique et l'acide sulfuπque. 1 2 Solution selon l'une des revendications 9 à1 1, caractérisée en ce qu'elle comprend le chlorite de sodium comme agent à pouvoir oxydant, l'acide citrique comme catalyseur et le thiosulfate de sodium ou "de potassium comme agent de neutralisation._1_1 Solution according to one of claims 9 and 1 0, characterized in that the optional catalyst is chosen from the catalysts known for this application, and in particular in the range consisting of an acid, citric acid, tartaric acid, hydrochloric acid and sulfuπque acid. 1 2 Solution according to one of claims 9 to 1 1, characterized in that it comprises sodium chlorite as an agent with oxidizing power, citric acid as a catalyst and sodium thiosulfate or " potassium" as a neutralizing agent.
1 Solution selon la revendication 1 2 , caractérisée en ce que le pourcentage massique de chlorite est compris dans la gamme 0,05 à 0,025.1 Solution according to claim 1 2, characterized in that the mass percentage of chlorite is in the range 0.05 to 0.025.
1 4 Solution selon l'une des revendications 9 à 1 3, caractérisée en ce qu'elle est fournie à l'utilisateur sous forme d'un kit comprenant l'agent à pouvoir oxydant et le catalyseur éventuel à l'état solide, et l'agent de neutralisation à l'état liquide, éventuellement d'autres adjuvants de formulation.1 4 Solution according to one of claims 9 to 1 3, characterized in that it is supplied to the user in the form of a kit comprising the oxidizing agent and the optional catalyst in the solid state, and the neutralizing agent in the liquid state, possibly other formulation adjuvants.
15. Solution selon la revendication 14, caractérisée en ce que le kit comprend un étui pour effectuer l'opération de décontamination dont le matériau principal est choisi dans la gamme constituée par le verre minéral, le polystyrène et une polyoléfine. 15. Solution according to claim 14, characterized in that the kit comprises a case for carrying out the decontamination operation, the main material of which is chosen from the range consisting of mineral glass, polystyrene and a polyolefin.
PCT/FR1990/000938 1989-12-22 1990-12-21 Method and solution for decontaminating a flexible contact lens, particularly of the hydrophilic type WO1991009630A1 (en)

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FR8917099A FR2656431B1 (en) 1989-12-22 1989-12-22 METHOD AND SOLUTION FOR DECONTAMINATING A FLEXIBLE LENS, ESPECIALLY OF THE HYDROPHILIC TYPE.
FR89/17099 1989-12-22

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US9371374B2 (en) 2013-03-14 2016-06-21 Abbott Laboratories HCV core lipid binding domain monoclonal antibodies
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
US9841427B2 (en) 2013-03-14 2017-12-12 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
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US5324447A (en) * 1989-10-02 1994-06-28 Allergan, Inc. Method and activator compositions to disinfect lenses
US5338480A (en) * 1989-10-02 1994-08-16 Allegan, Inc. Compositions and methods to clean contact lenses
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US8680239B2 (en) 2000-12-22 2014-03-25 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Use of RGM and its modulators
US8906864B2 (en) 2005-09-30 2014-12-09 AbbVie Deutschland GmbH & Co. KG Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
US9605069B2 (en) 2008-02-29 2017-03-28 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM a protein and uses thereof
US8030026B2 (en) 2009-02-24 2011-10-04 Abbott Laboratories Antibodies to troponin I and methods of use thereof
USRE45763E1 (en) 2009-02-24 2015-10-20 Abbott Laboratories Antibodies to troponin I and methods of use thereof
US9175075B2 (en) 2009-12-08 2015-11-03 AbbVie Deutschland GmbH & Co. KG Methods of treating retinal nerve fiber layer degeneration with monoclonal antibodies against a retinal guidance molecule (RGM) protein
US9365643B2 (en) 2012-01-27 2016-06-14 AbbVie Deutschland GmbH & Co. KG Antibodies that bind to repulsive guidance molecule A (RGMA)
US9102722B2 (en) 2012-01-27 2015-08-11 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration
US10106602B2 (en) 2012-01-27 2018-10-23 AbbVie Deutschland GmbH & Co. KG Isolated monoclonal anti-repulsive guidance molecule A antibodies and uses thereof
US9371374B2 (en) 2013-03-14 2016-06-21 Abbott Laboratories HCV core lipid binding domain monoclonal antibodies
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
US9841427B2 (en) 2013-03-14 2017-12-12 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
US10197573B2 (en) 2013-03-14 2019-02-05 Abbott Laboratories HCV core lipid binding domain monoclonal antibodies
US10345311B2 (en) 2013-03-14 2019-07-09 Abbott Laboratories Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies
US10444242B2 (en) 2013-03-14 2019-10-15 Abbott Laboratories Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies
US11428694B2 (en) 2013-03-14 2022-08-30 Abbott Laboratories Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies
WO2018064436A1 (en) 2016-09-30 2018-04-05 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-il23 specific antibody

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