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WO1988003804A3 - Method of treating viral infections in humans and compositions therefor - Google Patents

Method of treating viral infections in humans and compositions therefor Download PDF

Info

Publication number
WO1988003804A3
WO1988003804A3 PCT/EP1987/000719 EP8700719W WO8803804A3 WO 1988003804 A3 WO1988003804 A3 WO 1988003804A3 EP 8700719 W EP8700719 W EP 8700719W WO 8803804 A3 WO8803804 A3 WO 8803804A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating viral
humans
viral infections
compositions therefor
hypoxanthine
Prior art date
Application number
PCT/EP1987/000719
Other languages
French (fr)
Other versions
WO1988003804A2 (en
Inventor
Fritz Eckstein
Gerhard Hunsmann
Heinz Hartmann
Original Assignee
Max Planck Gesellschaft
Deutsches Primatenzentrum Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863639780 external-priority patent/DE3639780A1/en
Priority claimed from DE19873708849 external-priority patent/DE3708849A1/en
Priority claimed from US07/041,147 external-priority patent/US4880782A/en
Application filed by Max Planck Gesellschaft, Deutsches Primatenzentrum Gmbh filed Critical Max Planck Gesellschaft
Priority to DE1987907426 priority Critical patent/DE332626T1/en
Publication of WO1988003804A2 publication Critical patent/WO1988003804A2/en
Publication of WO1988003804A3 publication Critical patent/WO1988003804A3/en
Priority to FI892451A priority patent/FI892451A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method of treating viral diseases in a human subject. The method involves applying effective amounts of the compound (I), wherein X is an azido group, a methoxy radical or a fluorine atom and B is thymine, uracil, guanine, cytosine, purine or hypoxanthine if X is methoxy or fluorine, and B is guanine, purine or hypoxanthine if X is azido or a pharmaceutically acceptable salt thereof. Also disclosed are compositions and compounds useful in the method.
PCT/EP1987/000719 1986-11-21 1987-11-19 Method of treating viral infections in humans and compositions therefor WO1988003804A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1987907426 DE332626T1 (en) 1986-11-21 1987-11-19 METHOD FOR TREATING VIRAL INFECTIONS IN PEOPLE AND PREPARATIONS THEREFOR.
FI892451A FI892451A (en) 1986-11-21 1989-05-19 FOERFARANDE MED VILKET VIRUSINFEKTIONER I MAENNISKOR KAN SKOETAS OCH KOMPOSITIONER ANVAENDA DAERI.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19863639780 DE3639780A1 (en) 1986-11-21 1986-11-21 Pharmaceutical composition for the treatment of viral diseases
DEP3639780.6 1986-11-22
DE19873708849 DE3708849A1 (en) 1987-03-18 1987-03-18 Pharmaceutical composition for the treatment of viral diseases
DEP3708849.1 1987-03-18
US041,147 1987-04-22
US07/041,147 US4880782A (en) 1986-11-21 1987-04-22 Method of treating viral infections in humans and compositions therefor

Publications (2)

Publication Number Publication Date
WO1988003804A2 WO1988003804A2 (en) 1988-06-02
WO1988003804A3 true WO1988003804A3 (en) 1988-10-06

Family

ID=27195143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000719 WO1988003804A2 (en) 1986-11-21 1987-11-19 Method of treating viral infections in humans and compositions therefor

Country Status (6)

Country Link
EP (1) EP0332626A1 (en)
JP (1) JPH02500364A (en)
CA (1) CA1296330C (en)
FI (1) FI892451A (en)
IL (1) IL84550A (en)
WO (1) WO1988003804A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
FR2640508B1 (en) * 1988-12-19 1994-07-01 Dietlin Francois NOVEL COMPOSITIONS AND NEW PHARMACEUTICAL PRODUCTS ENSURING THE REGENERATION OF LEUKOCYTES AND THEIR USE FOR THE TREATMENT OF IMMUNE DEFICIT SYNDROME
ES2617582T3 (en) 2005-09-26 2017-06-19 Gilead Pharmasset Llc 4'-Nucleosides modified as antiviral agents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD209197A1 (en) * 1981-07-21 1984-04-25 Akad Wissenschaften Ddr PROCESS FOR PREPARING 3'-FLUOR-2 ', 3'-DIDESOXYGUANOSINE
SU1053474A1 (en) * 1982-02-08 1985-08-07 Институт биоорганической химии АН БССР 3-fluorine-2,3-didesoxyguanosine showing cytostatic activity
EP0196185A2 (en) * 1985-03-16 1986-10-01 The Wellcome Foundation Limited Antiviral nucleosides
EP0199451A2 (en) * 1985-03-16 1986-10-29 The Wellcome Foundation Limited Therapeutic nucleosides
EP0217580A2 (en) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Therapeutic nucleosides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD279407A1 (en) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr METHOD FOR PRODUCING AN AGENT AGAINST AIDS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD209197A1 (en) * 1981-07-21 1984-04-25 Akad Wissenschaften Ddr PROCESS FOR PREPARING 3'-FLUOR-2 ', 3'-DIDESOXYGUANOSINE
SU1053474A1 (en) * 1982-02-08 1985-08-07 Институт биоорганической химии АН БССР 3-fluorine-2,3-didesoxyguanosine showing cytostatic activity
EP0196185A2 (en) * 1985-03-16 1986-10-01 The Wellcome Foundation Limited Antiviral nucleosides
EP0199451A2 (en) * 1985-03-16 1986-10-29 The Wellcome Foundation Limited Therapeutic nucleosides
EP0217580A2 (en) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Therapeutic nucleosides

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Biochem. Biophys. Res. Commun., Vol. 148, No. 1, October 14, 1987, pages 78-85; Acad. Press, Inc., US, E. MATTHES et al.: "Inhibition of HIV-associated reverse transcriptase by sugar-modified derivatives of thymidine 5'-triphosphate in comparison to cellular DNA polymerases alpha and beta", Abstract. *
Biochem. Pharm., Vol. 29, No. 12, 1980, pages 1849-1851, E. DE CLERCQ et al.: "Antiviral, antimetabolic and antineoplastic activities of 2'- of 3'-amino or -azido-substituted deoxyribonucleosides", whole document. *
Biomed. Biochim. Acta, Vol. 44, No. 10, 1985, pages K63-K73, E. MATTHES et al.: "3'-Deoxy-3'-fluorothymidinetriphosphate: Inhibitor and terminator of DNA synthesis catalysed by DNA polymerase beta, terminal deoxynucleotidyltransferase and DNA polymerase I", Abstract. *
CHEMICAL ABSTRACTS, Vol. 101, No. 19, November 5, 1984, page 740, Ref. No. 171660y; Columbus Ohio, US; & DD-A1-209197 (AKADEMIE DER WISSENSCHAFTEN DER DDR) 25-04-1984, Abstract. *
CHEMICAL ABSTRACTS, Vol. 105, No. 19, November 10, 1986, page 74, Ref. No. 165001a; Columbus, Ohio, US; & SU-A1-1053474 (INST. OF BIOORG. CHEM. AC. OF SCIENCES; BELORUSSIAN SSR), Abstract. *
Dialog Information Services, file 155: Medline 66-68; Accession No. 06296673, M. BABA et al.: "Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2',3'-dideoxyguanosine in vitro", & Biochem. Biophys. Res. Commun, June 30, 1987, 145(3), p. 1080-6, whole document. *
J. Biol. Chem., Vol. 262, No. 5, February 1987, pages 2187-2189, Am. Soc. of Biol. Chem. Inc., US, Y. CHENG et al.: "Human immunodeficiency virus reverse transcriptase", whole document. *
J. Med. Chem., Vol. 30, No. 8, August 1987, pages 1270-1278, Am. Chem. Soc., US, P. HERDEWIJN et al.: "3'-Substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents", whole document. *
The Lancet, Vol. I, No. 8523, January 3, 1987, pages 40-41, London, GB, H. HARTMANN et al.: "Inhibition of HIV-induced cytopathogenicity in vitro by 3'-azido-2',3'-dideoxyguanosine", whole document. *

Also Published As

Publication number Publication date
JPH02500364A (en) 1990-02-08
EP0332626A1 (en) 1989-09-20
WO1988003804A2 (en) 1988-06-02
CA1296330C (en) 1992-02-25
IL84550A (en) 1993-07-08
FI892451A0 (en) 1989-05-19
FI892451A (en) 1989-05-19

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