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WO1982003987A1 - Solution de dialyse contenant du glycerol - Google Patents

Solution de dialyse contenant du glycerol Download PDF

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Publication number
WO1982003987A1
WO1982003987A1 PCT/US1982/000488 US8200488W WO8203987A1 WO 1982003987 A1 WO1982003987 A1 WO 1982003987A1 US 8200488 W US8200488 W US 8200488W WO 8203987 A1 WO8203987 A1 WO 8203987A1
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WO
WIPO (PCT)
Prior art keywords
solution
glycerol
liter
previous
peritoneal dialysis
Prior art date
Application number
PCT/US1982/000488
Other languages
English (en)
Inventor
Travenol Lab Baxter
Ralph E Dolkart
Nicholas J Kartinos
Original Assignee
Travenol Lab Baxter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Travenol Lab Baxter filed Critical Travenol Lab Baxter
Priority to AU85216/82A priority Critical patent/AU8521682A/en
Priority to DE8282901684T priority patent/DE3273951D1/de
Publication of WO1982003987A1 publication Critical patent/WO1982003987A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Definitions

  • Peritoneal dialysis solution is inserted in the peritoneal cavity, whereby diffusion exchange takes place between the solution and the bloodstream across the natural body mem ⁇ branes, to remove by diffusion the waste products which are normally excreted through the kidneys, typically solutes such as sodium and chloride ions and other materials normally excreted as urine by the body such as urea and creatinine, and also water.
  • peritoneal dialysis The nature and rate of the materials removed from the body by peritoneal dialysis is a function of the solutes present in the peritoneal dialysis solution.
  • Physio ⁇ logical salts are present in the peritoneal dialysis solu- tion such as sodium chloride, calcium chloride, sodium lactate, and sodium acetate, generally at slightly hypo- tonic concentrations (but for calcium) so that excess con ⁇ centrations of the ions forming such salts in the blood ⁇ stream will di fuse into the peritoneal dialysis solution for removal.
  • solutes may be added to generate the necessary osmotic pressure.
  • this solute is a sugar such as glucose, which may normally be present in peritoneal dialysis solutions in a concentration of at 0.5 to 4.25 percent (wt/vol.).
  • V/IP the ultrafiltration of water from the patient, higher con ⁇ centrations of sugar in that range are used.
  • Glycerol which is a sugar alcohol, has been added on an experimental basis to glucose-containing hemodialysis solution in which the dialysis solution is directly dialyzed with an artificial membrane against blood. See the articles by Arieff et al.. Kidney International, Volume 14 (1978) pages 270-278, and Van Stone et al., Transactions of the American Society for Artificial
  • a dialysis solution which comprises a water solution of physio ⁇ logical pH, for example pH 5 to 7.4, and preferably pH 5.6 to 7.2.
  • the solution of this invention may have the typical physiological salts which are commonly found in conventional dialysis solutions, plus glycerol, present in concentrations sufficient to safely effect the removal of solutes and water from a patient by peritoneal dialysis.
  • the solution is used in peritoneal dialysis, although it may also be used in hemodialysis.
  • the glycerol (glycerine) is utilized in the dialysis solution as a partial or preferably complete substitute for a sugar such as dextrose, resulting in various significant advantages.
  • the substitution of a sugar by glycerol in a peritoneal dialysis solution reduces the body load of such sugar. This reduces the possibility of elevated trigly- cerides in the patients, who typically have a chronic and continued requirement for peritoneal dialysis, and thus by the prior art are receiving constant, high loads of sugar in the peritoneal dialysis solution in order to provide enough osmolality to permit a desired ultrafiltration of water to take place to remove water from a patient's system.
  • glycerol Being of a lower molecular weight than sugars, glycerol can express an osmotic effect at much lower con ⁇ centrations in terms of weight percent. Because of this, the patient is exposed to a significantly reduced caloric load, since less weight of glycerol present in the solu ⁇ tion can provide an equal osmotic effect to that of dex ⁇ trose, for example.
  • Anhydrous dextrose has a molecular weight of 180, while glycerol has a molecular weight of 92. Thus 180 mg. of dextrose are necessary to provide 1 milliosmol per liter of solution, while only 92 mg. of glycerol are required to provide a milliosmol per liter.
  • glycerol being a polyalcohol, does not contain a carbonyl group as do the usual sugars.
  • peritoneal dialysis solutions which are free of sugar, and containing glycerol as a substitute, can be steam sterilized at a higher pH than can solutions containing sugars.
  • Sugars must be typically maintained during sterilization in acid pH ranges of 5 to 5.5, to minimize degradation due to the presence of the carbonyl group in sugars.
  • Such pH ranges are slightly more acidic than is optimum for the ideal peritoneal dialysis solution to maximize the patient's comfort and well being. Irri- tation within the peritoneal cavity can take place due to the slightly acidic nature of such peritoneal dialysis solution, which, in turn, can increase the chances for peritonitis.
  • solutions free of sugars and containing glycerol nay be sterilized in more physiologic pH ranges, for example pH 5.6 - 7.4, for a better pH for use as a peritoneal dialysis solution.
  • Glycerol is rapidly and completely metabolized and has been clearly established to be safe. It is particularly advantageous, because a major metabolic route of the glycerol does not require insulin, although a portion of the glycerol is metabolized into glucose and thus requires insulin for further metabolization.
  • the advantage of this is that glycerol is clearly much more easily metab ⁇ olized by diabetics than an equal weight of glucose. This greatly facilitates the control and maintenance of the diabetic patient who must be maintained with peritoneal dialysis.
  • glycerol as a substitute for sugars provides practical opportunities for the creation of a peritoneal dialysis solution, or a parenteral solu ⁇ tion, which contains not only glycerol but also an amino acid source material such as free amino acids or protein hydrolyzates.
  • a solution not only can be utilized to provide normal or elevated osmolarity from both the amino acid source and the glycerol for stimulating ultra ⁇ filtration during peritoneal dialysis, but it can also serve as a nutrient solution, being capable of providing total parenteral nutrition by peritoneal dialysis or direct intravenous administration.
  • amino acids and (poly)- peptides cannot be effectively heat-sterilized in the presence of sugars containing carbonyl groups, because of a chemical reaction that can take place between the amino acids and the carbonyl group.
  • Glycerol is com ⁇ patible with amino acids and (poly)peptides at higher tem ⁇ peratures, so that the mixed solution can be effectively heat sterilized.
  • the peritoneal dialysis solution of this invention may comprise a water solution at a p ⁇ of 6.0 to 7.4 containing from 125 to 140 mEq/liter of sodium, 1 to 6 mEq/liter of calcium, 0.2 to 4 mEq/liter of magnesium, 90 to 140 mEq/liter of chloride, and, if desired, other ions, for example 30 to 50 mEq/liter of bicarbonate precursors such as lactate, acetate, malate, and/or succinate.
  • the above ions may be provided by the addition of conventional physiological salts such as sodium chloride, calcium
  • the glycerol may be added in a proportion sufficient to provide the desired osmolality or osmolarity, for the desired degree of ultrafiltration.
  • An amino acid source material may substitute for a portion of the glycerol to raise the osmolarity of the peritoneal dialysis solution, but due to its much higher cost it is usually only added in a concentration that provides a desired amount of nutrition to the patient. For example, many patients, particularly pediatric patients on chronic peritoneal dialysis, suffer serious protein loss due to the diffusion of amino acids and (poly)peptides from the blood into the peritoneal dialysis solution.
  • such protein loss can be counterbalanced, and a net gain of protein may be provided to the patient during the peritoneal dialysis procedure by the use of an amino acid source material in the peritoneal dialysis solution in accordance with this invention.
  • an amino acid source material in the peritoneal dialysis solution in accordance with this invention.
  • Such a solution when glucose-free, may be readily sterilized because of the compatability between glycerol and amino acids at sterilizing temperatures.
  • the osmolarity, rela ⁇ tive to water, of the peritoneal dialysis solutions of this invention it is generally preferable for the osmolarity, rela ⁇ tive to water, of the peritoneal dialysis solutions of this invention to be from 272 to 700 milliosmols per liter, preferably 279 to 500 milliosmols per liter.
  • the bicarbonate precursor acid ions, as well as other acid ions of the Krebs cycle, may be added to also offer advantages in pH control of the peritoneal dialysis solu ⁇ tion of this invention.
  • the sodium or potassium salts of such ions for example, may be used for this purpose, or the free acids.
  • Sulfhydryl-type antioxidants for example N-acyl cysteine, may be also added to stabilize the amino acids in the peritoneal dialysis solution of this invention.
  • glycerol may be present per liter of peritoneal dialysis solution, and preferably 5 to 30 grams per liter, glycerol being a well established, safe and effective food in man.
  • Sources of amino acid are well known, with protein hydrolyzates and the like being currently available as parenteral solutions. From such a source, the amino acids, if desired, may be added to the peritoneal dialysis solution of this invention.
  • the amount and types of amino acids used herein may vary, for example 1 to 40 grams per liter and preferably 5 to 30 grams/liter. Amino acid mixtures containing both essential and nonessential amino acids may be used, but differ in their osmolarities. However, assuming no elec ⁇ trolytes are present, a 1 percent amino acid mixture (10 grams/liter) will generate approximately 84 illi- osmols/liter of osmotic force. As mixed amino acids are introduced and increased, glycerol levels may be reduced so as to maintain the overall desired osmotic properties of the peritoneal dialysis solution.
  • glycerol at a concen- tration of 92 mg./liter will exert 1 milliosmol of osmotic force.
  • amino acids are generally assumed to have an average molecular weight of 120.
  • 120 mg. of amino acids per liter will exert 1 milliosmol of os ⁇ motic force.
  • from 0 to 51.6 gram/liter of amino acids may be employed to provide a range of osmotic force from 0 to 430 milliosmols per liter.
  • glycerol Since glycerol has a smaller molecule than dextrose, it diffuses more rapidly through the body membranes of the peritoneal cavity. However, since only slightly over one-half the weight of glycerol in solution can provide equal osmolarity to a given amount of glucose, the net weight of glycerol which is received into the blood stream of the patient by diffusion is less than the weight of dextrose diffusing into the patient in a peritoneal dialysis procedure, when comparing glycerol peritoneal dialysis solution with a corresponding dextrose peritoneal dialysis solution of equal osmolarity. Thus the amount of calories diffused into the patient with a glycerol solu- tion is substantially reduced.
  • the net ultrafiltration of a glycerol peritoneal dialysis solution is calculated to be about 10 percent less when both solutions have concentrations providing 358.7 milliosmols per kilogram of solution.
  • concentration of glycerol can be increased, and the patient will still receive considerably less weight of glycerol into his bloodstream during the four hour peri- toneal dialysis procedure than he would with the corres ⁇ ponding dextrose solution.
  • Glycerol is rapidly metabolized in the body, with a greatly reduced need for insulin when compared with dex ⁇ trose, so that the peritoneal dialysis solution of this invention is particularly advantageous for use with diabetics.
  • the ultrafiltration rates of the glycerol-containing peritoneal dialysis solutions of this invention are increased when the solutions contain the desired amino acid source material, which functions both to increase ultrafiltration and to prevent protein loss on the part of the patient, and even to provide a protein nutrient to the patient during the peritoneal dialysis process by diffusion of the amino acids or (poly)peptides into the bloodstream.
  • a peritoneal dialysis solution may be utilized with advantage having the ingredients in the pro ⁇ portions stated, as indicated in the Examples below.
  • the examples and the specification are offered for il- lustrative purposes only, and are not intended to limit the scope of the invention of the application, which is defined in the claims below.
  • a solution for peritoneal dialysis having a relatively low osmolarity of about 279 milliosmols may be prepared by adding, per liter of water, 5.67 grams of sodium chloride, 3.92 grams of sodium lactate, 0.257 gram of calcium chloride dihydrate, 0.152 gram of magnesium chloride hexa- hydrate, and 0.69 gram of glycerol.
  • the glycerol serves as a substitute for the conventional glucose, having the advantages specified above.
  • the solution must, of course, be sterilized in conventional manner, as of course all parenteral solutions must be.
  • a peritoneal dialysis solution having an intermediate level osmolarity of about 330 milliosmols may be prepared by adding, per liter of water, 5.55 grams of sodium chloride, 1.96 grams of sodium lactate, 0.257 gram of calcium chloride dihydrate, 0.152 gram of magnesium chloride hexahydrate, 1.42 grams of sodium succinate, and 5.38 grams of glycerol.
  • This sugar-free solution provides a measure of carbohydrate nutrition to the patient, as well as providing ultrafiltration capability.
  • EXAMPLE 3 This solution may be used as a peritoneal dialysis solution having a high osmolarity of about 600 milliosmols per liter, offering high ultrafiltration. It may also be used for parenteral nutrition, either by intravenous in ⁇ jection or peritoneal dialysis.
  • OMPI OMPI To each liter of water there is added 5.67 grams of sodium chloride, 3.92 grams of sodium lactate, 0.15 gram of potassium chloride, 0.257 gram of calcium chloride dihydrate, 0.152 gram of magnesium chloride hexahydrate, 20.25 grams of glycerol, and 13.2 grams of a mixture of essential and nonessential amino acids including either lysine hydrochloride or lysine acetate.
  • the specific mix ⁇ ture of amino acids may be similar to the blend of amino acids found in Travasol* parenteral solution sold by Tra- venol Laboratories, Inc. of Deerfield, Illinois, or any other conventional blend of amino acids, particularly a balanced blend which is suitable as a nutrient.
  • the resulting solution (when lysine hydrochloride is used) may contain about 112 mEq of chloride ion.
  • the os- motic effect of the amount of glycerol present is approxi ⁇ mately double the osmotic effect of the amino acid mix ⁇ ture, and they both contribute, along with the salts pres ⁇ ent, to provide a high osmolarity as specified above.
  • solutions may be used as dialysis solutions, or they may be intravenously administered to the patient for parenteral nutrition.
  • Peritoneal dialysis solutions may be formulated containing, per 100 ml., 538 milligrams of sodium chloride, 448 milligrams of sodium lactate. 25.7 milligrams of calcium chloride dihydrate, and 5.08 milligrams of magnesium chloride hexahydrate.
  • the peritoneal dialysis solutions may also contain, respectively, 8.5 grams per liter of glycerol to provide a solution having an osmolarity of 346 milliosmols per liter or, alternatively, 25 grams per liter of glycerol to provide a solution having an osmolarity of 485 milliosmols per liter.
  • the pH of both of these solutions is 6.0.

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Abstract

Une solution de dialyse, typiquement une solution de dialyse peritoneale, comprend une solution aqueuse presentant un pH physiologique, et possedant des concentrations de sels physiologiques et de glycerine suffisantes pour effectuer surement l'extraction des solutes et de l'eau d'un patient au moyen d'une dialyse peritoneale.
PCT/US1982/000488 1981-05-15 1982-04-16 Solution de dialyse contenant du glycerol WO1982003987A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU85216/82A AU8521682A (en) 1981-05-15 1982-04-16 Dialysis solution containing glycerol
DE8282901684T DE3273951D1 (en) 1981-05-15 1982-04-16 Dialysis solution containing glycerol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US263818810515 1981-05-15
US06/263,818 US4574085A (en) 1981-05-15 1981-05-15 Method for using dialysis solution containing glycerol

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WO1982003987A1 true WO1982003987A1 (fr) 1982-11-25

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US (1) US4574085A (fr)
EP (1) EP0078832B1 (fr)
JP (1) JPS57188512A (fr)
CA (1) CA1187801A (fr)
DE (1) DE3273951D1 (fr)
IE (1) IE53392B1 (fr)
IL (1) IL65574A (fr)
IT (1) IT1157936B (fr)
WO (1) WO1982003987A1 (fr)
ZA (1) ZA822818B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548897A1 (fr) * 1983-07-15 1985-01-18 Univ Southern California Solution pour irrigation chirurgicale
EP0199357A2 (fr) * 1985-04-25 1986-10-29 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Solution pour la dialyse péritonéale
WO1987001286A1 (fr) * 1985-08-31 1987-03-12 Research Corporation Limited Composition medicinale
US5112865A (en) * 1987-11-19 1992-05-12 Solvay & Cie (Societe Anonyme) Pharmaceutical compositions containing a derivative of 3-hydroxybutanoic acid chosen from oligomers of this acid and esters of this acid or of these oligomers with 1,3-butanediol
EP0612528A1 (fr) * 1993-02-24 1994-08-31 B. BRAUN CAREX S.p.A. Solutions pour dialyse péritonéale
EP0827748A2 (fr) † 1992-12-22 1998-03-11 Baxter International Inc. Solution pour dialyse péritonéale
WO1999001144A1 (fr) 1997-07-04 1999-01-14 Allied Therapeutics Limited Fluide pour dialyse peritoneale
US5869444A (en) * 1985-09-10 1999-02-09 Research Corporation Technologies, Inc. Osmotic agents for peritoneal dialysis

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3812525C1 (fr) * 1988-04-15 1989-06-22 Fresenius Ag, 6380 Bad Homburg, De
ES2121941T3 (es) * 1992-02-04 1998-12-16 Baxter Int Soluciones de dialisis peritoneal y metodos utiles para reducir las lesiones y los efectos psicologicos negativos producidos por la peritonitis.
WO1993014796A1 (fr) * 1992-02-04 1993-08-05 Baxter International, Inc. Composition de dialyse peritoneale et procede pouvant etre utilise pendant ou apres la peritonite
US5811600A (en) * 1993-04-30 1998-09-22 University Of New Mexico Glycerol enhanced rehydration formulation
JP3636468B2 (ja) * 1994-07-01 2005-04-06 バクスター、インターナショナル、インコーポレイテッド 生化学的にバランスさせた腹膜透析溶液
ATE405277T1 (de) 1999-04-26 2008-09-15 Edwards Lifesciences Ag Substitutions-infusionflüssigkeit und zitratanticoagulation
US8105258B2 (en) * 1999-04-26 2012-01-31 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
US7186420B2 (en) * 1999-04-26 2007-03-06 Edwards Lifesciences Corporation Multi-part substitution infusion fluids and matching anticoagulants
US6375992B1 (en) 2000-02-23 2002-04-23 The Procter & Gamble Co. Methods of hydrating mammalian skin comprising oral administration of a defined composition
US20050148647A1 (en) * 2003-10-31 2005-07-07 Landry Donald W. Hemodialysis solutions and uses thereof
PL2156188T3 (pl) 2007-03-28 2021-11-15 University Of Southern California Indukcja zróżnicowanej odporności na stres i jej zastosowania
CA3045883C (fr) * 2008-04-24 2022-06-28 University Of Southern California Compositions alimentaires et procedes pour la protection contre la chimiotherapie, la radiotherapie, le stress oxydatif et le vieillissement
EP3912656A1 (fr) * 2020-05-19 2021-11-24 CoreQuest Sagl Solution de dialyse péritonéale

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US3234089A (en) * 1962-04-17 1966-02-08 Cutter Lab Non-toxic intravenous, high-calorie solution containing glycerol
US3793450A (en) * 1968-08-16 1974-02-19 Braun Melsungen Ag Stable,non-pyrogenetic,intravenously administrable aqueous fat emulsions containing amino acids
US3897550A (en) * 1971-06-01 1975-07-29 Cybersol Method for administering water soluble drugs, nutrients and other solutes to a mammal
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same
US3968205A (en) * 1974-01-31 1976-07-06 J. Pfrimmer And Co. Infusion solution for the treatment of tachycardiac disturbances of heart rhythm and use thereof
US4005190A (en) * 1974-07-10 1977-01-25 J. Pfrimmer & Co. Infusion solution for parenteral feeding
US4164568A (en) * 1976-03-27 1979-08-14 Beechamgroup Limited Oral scour formulations with citrate

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EP0076841A4 (fr) * 1981-04-17 1984-01-16 American Hospital Supply Corp Solution amelioree pour nutrition par voie parenterale.
WO1982003773A1 (fr) * 1981-04-27 1982-11-11 Baxter Travenol Lab Solution de dialyse contenant du glucose, des acides amines et de l'insuline

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US3234089A (en) * 1962-04-17 1966-02-08 Cutter Lab Non-toxic intravenous, high-calorie solution containing glycerol
US3793450A (en) * 1968-08-16 1974-02-19 Braun Melsungen Ag Stable,non-pyrogenetic,intravenously administrable aqueous fat emulsions containing amino acids
US3897550A (en) * 1971-06-01 1975-07-29 Cybersol Method for administering water soluble drugs, nutrients and other solutes to a mammal
US3968205A (en) * 1974-01-31 1976-07-06 J. Pfrimmer And Co. Infusion solution for the treatment of tachycardiac disturbances of heart rhythm and use thereof
US4005190A (en) * 1974-07-10 1977-01-25 J. Pfrimmer & Co. Infusion solution for parenteral feeding
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same
US4164568A (en) * 1976-03-27 1979-08-14 Beechamgroup Limited Oral scour formulations with citrate

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Title
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FINCKH, Journal of Pathological Bacteriology, Volume 78, pp. 197-202 (1959) *
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548897A1 (fr) * 1983-07-15 1985-01-18 Univ Southern California Solution pour irrigation chirurgicale
EP0199357A2 (fr) * 1985-04-25 1986-10-29 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Solution pour la dialyse péritonéale
EP0199357A3 (en) * 1985-04-25 1988-08-10 Terumo Kabushiki Kaisha Trading As Terumo Corporation Dialytic solution for peritoneal dialysis
US4880629A (en) * 1985-04-25 1989-11-14 Terumo Kabushiki Kaisha Dialytic solution for peritoneal dialysis
WO1987001286A1 (fr) * 1985-08-31 1987-03-12 Research Corporation Limited Composition medicinale
US4906616A (en) * 1985-08-31 1990-03-06 Thomas Gilchrist Hydrolyzed sodium casein compositions for dialysis procedures
US5869444A (en) * 1985-09-10 1999-02-09 Research Corporation Technologies, Inc. Osmotic agents for peritoneal dialysis
US5112865A (en) * 1987-11-19 1992-05-12 Solvay & Cie (Societe Anonyme) Pharmaceutical compositions containing a derivative of 3-hydroxybutanoic acid chosen from oligomers of this acid and esters of this acid or of these oligomers with 1,3-butanediol
EP0827748A2 (fr) † 1992-12-22 1998-03-11 Baxter International Inc. Solution pour dialyse péritonéale
EP0827749A2 (fr) † 1992-12-22 1998-03-11 Baxter International Inc. Solution pour dialyse péritonéale
EP0827748B2 (fr) † 1992-12-22 2006-08-02 Baxter International Inc. Solution pour dialyse péritonéale
EP0827749B2 (fr) † 1992-12-22 2006-09-27 Baxter International Inc. Solution pour dialyse péritonéale
EP0612528A1 (fr) * 1993-02-24 1994-08-31 B. BRAUN CAREX S.p.A. Solutions pour dialyse péritonéale
WO1999001144A1 (fr) 1997-07-04 1999-01-14 Allied Therapeutics Limited Fluide pour dialyse peritoneale

Also Published As

Publication number Publication date
EP0078832B1 (fr) 1986-10-29
IL65574A0 (en) 1982-07-30
IT1157936B (it) 1987-02-18
US4574085A (en) 1986-03-04
DE3273951D1 (en) 1986-12-04
CA1187801A (fr) 1985-05-28
EP0078832A4 (fr) 1984-01-10
IE53392B1 (en) 1988-11-09
JPS57188512A (en) 1982-11-19
IE821162L (en) 1982-11-15
ZA822818B (en) 1983-02-23
EP0078832A1 (fr) 1983-05-18
IL65574A (en) 1985-11-29
IT8221177A0 (it) 1982-05-10

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