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US3862684A - Aseptic packing container and method of making and filling it - Google Patents

Aseptic packing container and method of making and filling it Download PDF

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Publication number
US3862684A
US3862684A US321255A US32125573A US3862684A US 3862684 A US3862684 A US 3862684A US 321255 A US321255 A US 321255A US 32125573 A US32125573 A US 32125573A US 3862684 A US3862684 A US 3862684A
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Prior art keywords
mouth
container
containers
foil
line
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US321255A
Inventor
Roland Schmitt
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KUKA AG
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Industrie Werke Karlsruhe Ausburg AG
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Priority claimed from DE19712120274 external-priority patent/DE2120274A1/en
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Priority to US321255A priority Critical patent/US3862684A/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003Filling medical containers such as ampoules, vials, syringes or the like
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00Closing containers or receptacles after filling
    • B65B7/16Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/161Sealing filled ampoules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/04Articles or materials wholly enclosed in single sheets or wrapper blanks
    • B65D75/20Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/40Packages formed by enclosing successive articles, or increments of material, in webs, e.g. folded or tubular webs, or by subdividing tubes filled with liquid, semi-liquid, or plastic materials
    • B65D75/42Chains of interconnected packages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00Methods of manufacture, assembly or production
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42Component parts, details or accessories; Auxiliary operations
    • B29C49/48Moulds
    • B29C49/48185Moulds with more than one separate mould cavity
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00Special receptacle or package
    • Y10S206/82Separable, striplike plural articles

Definitions

  • ABSTRACT A method for the production of aseptic packings, particularly a single use packing such as an ampoule, etc., comprises a plurality of oppositely directed substantially identical indentations on a foil on each side of a fold line. Thereafter, the foil material is folded along the fold line to align the indentations so that they form half portions of individual containers. The foil sections are welded or otherwise sealed together so that they close the container around the juncture line.
  • Each container indentation includes a neck portion terminating in an outwardly widening funnel opening adjacent the edge of the foil material.
  • the individual containers are then filled through the funnel and the neck portion is thereafter sealed directly below the bottom of the funnel by pressure welding.
  • the area adjacent the closed weld line is provided with tear lines to facilitate easy opening and removal of the contents from the containers.
  • An aseptic packing comprises a strip of two superposed foil sheets, each having aligned recessed portions forming container halves which to- .gether form a complete closed container which is closed around the periphery by the foil material.
  • the strip includes tear line portions for both separating individual containers from the strip and for opening the mouth of each container.
  • This invention relates in general to a construction of containers, and in particular, to a new and useful method for the production of aseptic packings, particularly packings designed for single use such as ampoules which are formed by superimposed and welded foil sheet portions which are folded in juxtaposition after they have been initially subjected to a pressure to form individual container half portions.
  • a burr is sometimes formed in the range of the breaking point which has been provided for easy opening. This burr can cause injuries to the eyes, ears, or nose when the contents of the ampoules are used for these sensitive body parts.
  • the present invention provides a container or ampoule construction which is such that it is substantially impossible to provide these undesirable burr formations.
  • a sheet of foil material is subjected to pressure in order to form the plurality of pairs of permanent container-form depressions arranged in a mirror fashion in respective rows.
  • the foil is then folded about a line midway between the foil depressions in order to superimpose the foils and align the congruent depressions to form a whole container from the depression half portions, with the complimentary depressions on each side of the fold line forming a respective container half part.
  • the folded foil is then welded together in the areas not overlying the depressions in order to seal the peripheries around the depressions and to form individual closed containers, each having a neck portion terminating in a widened filling funnel leading to the foil edge.
  • Each chamber is then filled through the funnel and the bottom end of the funnel is closed by welding after which a perforation or tear line is imparted to cross the neck, or an area adjacent the neck in order to permit easy opening thereof.
  • the tear line defines a preset breaking line to facilitate the opening of the ampoule directly below the filling funnel.
  • the folding of the foil material is preferably carried out along a longitudinal fold line or axis.
  • a plurality of pairs of permanent depressions are arranged in a mirror fashion during the deformation process on two independent foil bands extending substantially parallel to each other. These bands are then superimposed such as by completing the fold about the mid-point line separating the depressions.
  • the attached filling filter of the filling device is removed by means of a known cutting device.
  • the preferred form includes a tear strip arranged along a row of the formed containers which may be selectively torn to open-one or more containers.
  • the depressions are advantageously spaced apart sufficiently so that there is no large area of foil material between each depression forming the container so that they will be sealed tightly at all sides.
  • a packing such as an ampoule, vial, etc., produced with the method of the invention and destined particularly for one time use, is formed by mirror-like indenta' tions made in two foil sheets which are aligned to form substantially pear-shaped containers with a mouth portion having an outwardly tapered end defining a filling funnel.
  • the area surrounding thecontainers and surrounding the top of the filling funnel is sealed by the superimposed foil sheets which are secured together.
  • a strip of such containers is advantageously formed with a preset breaking point in the area of the juncture of the mouth portion, with the filling funnel and is constructed so that the strip may be removed to open the top of the mouth to permit discharge of the contents.
  • each container is formed directly below the preset breaking point of the foil material and extends below the top of the mouth portion so that the foil material may be easily broken across the mouth to open the same.
  • the upper edge surface of the foil material which surrounds the container which is formed by the foil sheets is provided with a large radius tear line which extends downwardly on each side of the mouth of the container.
  • the method of the invention is extremely simple in concept and economical to carry out.
  • the invention makes it possible to use as foils or foil materials, thermoplastic materials which may be heat sealed or welded together in order to provide a relatively inexpensive and disposable ampoule packing.
  • the foils may advantageously comprise polyvinyl chloride (PVC), a polypropylene (PP), or a polyethylene (PE).
  • Foil combinations of polyethylene and polypropylene are also suitable for the method of the invention, particularly in view of the fact that a blocking effect against the penetration of steam is insured under the influence of polyethylene and this is an indispensible prerequisite for certain packing media, for example, with regard to storage capacity.
  • the foil combination of polyethylene and polypropylene the latter component has a blocking effect against permeability to gas.
  • metal foils for example, aluminum or Dural may be used especially in conjunction with a coating of polyvinyl chloride, polyethylene, or polypropylene or other weldable or heat sealable plastic foil.
  • the materials used have no restoring properties after the deformation process and are weldable or heat sealable. Due to the natural elasticity inherent in such materials this further enhances the deformation process which is carried out in the course of the method to form the individual container outlines or ampoule configurations.
  • the removal of the material to form the necessary indentations in each of the sheets which are to be employed may be carried out merely by the manual pressure on the sheet to define a portion of the final container.
  • the method is such that the containers are formed so that a person removing the contents does not come into direct contact with the contents of the individual containers.
  • the pouring mouth orpipette of the container according to the invention is constructed so that it permits, for example, for use on the case of application to a personsnose, throat, ear or eye drugs without direct application to the respective body organ.
  • the container or ampoule is formed with a relatively elongated vertically extending mouth and the foil material directly above the mouth is formed with tear lines which extend downwardly in a large radius at a lo cation below the top of the mouth so that the mouth is opened when the tear strip at the upper marginal edge of the foil material is torn away.
  • the arrangement is such that when the tear strip is removed, the mouth is opened evenly, thereby preventing injuries in respect to the use of the contents of the ampoule.
  • a high portion of foil material with rounded corners on each side of the mouth of the container remains to form outwardly extending protective projections which prevent contact of a torn edge of the mouth with a body organ.
  • the projections are presented in the part of the body organ to be treated and a distance between the body organ, and the mouth of the containers is relatively small so that the distance can be bridged over by the pressure on the container to cause a variation in the dosing stream.
  • the distance between the mouth of the container and the body organ to be treated such as an car can be bridged over with a thin continuously reissuing jet of the material being dispensed or by drops which issue at intervals.
  • it is an object of the invention to provide an improved method of forming individual containers or ampoules from foil or similar material which comprises crimping the foil material at spaced locations along the length to form oppositely directed indentations of identical but oppositely facing configuration on each side of a centrally disposed fold line for the material, juxtaposing the material parts together so that the indentations are aligned and the foil material is secured together around the outline thereof to form the containers.
  • a further object of the invention is to provide a plurality of containers and a strip of material wherein container half portions are formed by indentations in respective foil strips which are superimposed and connected together, with thefoil strips forming the closure around the container elements and including a tear strip oriented around the one edge of the foil strips which overlies a mouth and which is provided with a weakened area in the vicinity of the mouth to permit the removal of a portion of the tear strip and the opening of the mouth.
  • a further object of the invention is to provide a small container construction which is simple in design, rugged in construction, and economical to manufacture.
  • FIG. 1 is a plan view of a portion of a foil material showing the outlines of container indentations for half portions of containers which are constructed in accordance with the method of the invention
  • FIG. la is a section taken along the line l-l of FIG.
  • FIG. 2 is a plan view of the foil material shown in FIG. I with the lower portion folded over the upper portion;
  • FIG. 2a is a section taken along the line lIll of FIG. 2;
  • FIG. 2b is a top plan view of the foil shown in FIG.
  • FIG. 3 is a schematic transverse sectional view showing the operation of a machine for effecting the welding and sealing of the foil material at the mouth after the ampoule or container is filled with liquid;
  • FIG. 4 is a view similar to FIG. 3 but showing a machine for cutting of portions of the foil material from the container directly below the filling funnel after it has been filled;
  • FIG. 5 is a medium sectional view of a filled ampoule having an outer contour with a perforation which joins it wih a remaining portion of its foil wall material;
  • FIG. 6 is a side elevational view of a strip of interconnected ampoules or containers.
  • FIG. 6a is an enlarged view of a single ampoule having the closure strip removed therefrom.
  • FIG.'5a is a section taken along the line VV of FIG. 5.
  • FIGS. 1 and 1a shows a continuous strip of foil or sheet material after it has been removed from a roll, band, etc., and which is generally designated 1.
  • the foil strip 1 has been first subjected to a pressure deformation to form a plurality of rows of container-like depressions la formed in sets with one row oriented to face in one direction and the other facing in a mirror-like manner in an opposite direction.
  • Each depression la includes an elongated mouth portion or pipette lb and a filling funnel portion which extends from the upper end of the mouth to the outer edge of the foil material 1.
  • the foil material I is folded along a media line 2 located between adjacent rows to align the indentations la so that they form half portions of finished containers or ampoules or similar vessels.
  • the indentations 1a are congruent so that when the flat portions of the funnel sheets are superimposed, the portions form the half portions of the whole finished container.
  • the superposed folded foil sheet is secured together such as by head welding to form it into the configuration indicated in FIGS. 2, 2a and 2b.
  • the foil 1 includes attached and filled ampoules 3 which have been filled by mechanism (not shown), and they are moved into association with means for sealing the mouth 1b which is accomplished by welding or hot-sealing jaws 4 and 4a which move together and define a welded closure line across the mouth of the container.
  • the jaws 4 and 4a are moved in the direction of the arrows and 22 during each operating cycle by means (not shown).
  • the ampoule 3 is advantageously closed tightly between its neck and the filling funnel It by high frequency, ultra sound impulse welding or by infra-red preheating.
  • cut-off means which include blades 5 and 5a movable in the directions of the arrows 24 and and carried by a tool 6 which cooperates with a counter tool 6a.
  • the juxtaposed foil sheet portions are provided with a perforation Id at a safety margin spaced outwardly from the surface of the ampoule 3 in order to permit easy removal of the ampoule from the foil when it is to be used.
  • the mouth lb is provided with a preset breaking point or tear line lle directly below a closure weld 26.
  • FIG. 6 there is shown a modified construction of a strip generally designated 32 made up of individual ampoules 3 which are formed on a foil strip 11a.
  • the ampoules 3 receive aseptic drugs and comprise the same material as the surrounding strip 11a.
  • For the continuous strip lla may be provided two superposed sheets of a material such as polyvinyl chloride, polypropylene or polyethylene.
  • materials may be employed such as aluminum or Duraluminum which can be combined with the polyvinyl chloride or polyethylene.
  • the strip 32 is provided with inwardly extending slots llb at the midpoint between each ampoule which extend inwardly from the edge 34.
  • the opposite edge 36 forms an outer edge of a tear strip 38.
  • the tear strip is defined at its inner end by perforation elements or tear lines 40 which terminate in ends llc which extend downwardly on each side of a mouth 11d of each ampoule 3.
  • the tear lines 40 define present breaking points which, when removed, leave a break line le extending across the mouth 11d of the container.
  • the tear line le can have burrs which may cause injury, for example, to sensitive body organs such as the eye, ear, nose, etc., when the ampoule is handled improperly.
  • the break lines define edges 42 which form smooth edges which provide protective projections which prevent damage to the body cavities by use of the ampoule.
  • the projections 44 and 46 provide safe engagement edges for orienting the mouth 1111 for the discharge of the fluid into the body cavity. This special design keeps the burr portion le away from the sensitive body organ when the ampoule is used so that injuries are avoided.
  • the corners of the perforation line 40 are rounded off with a relatively large radii on each side of the mouth tear line 1e. Tests have shown that danger of injuries increases if only one radius is provided, for example, on the side of the mouth 1d.
  • a one time use package comprising a container having a body portion, an elongated mouth extending outwardly from said body portion, said container comprising two superposed sheets, each sheet having a container half portion in the indentation forming a half of said body portion, said sheets extending on each side of said body portion and being welded together at their areas external to said body portion and being welded above said mouth to seal the top of said mouth and close it, in a break line defined on said sheets extending on each side of said mouth along substantially straight lines at a spaced location from the top of said mouth and terminating in downwardly extending portions extending in close proximity to each side of the mouth of said body portion at the level of the top of said mouth, said break lines being tearable to effect tearing along a smooth, straight line at a spaced location above the top of said mouth up to each side of said mouth and then downwardly to the plane of the top of said mouth so that any rough tearing across the top of said mouth is recessed from the smooth tear edge lines.
  • An aseptic packing including a protection perforation line defined around the periphery of said container on said sheet material to permit removal of the outline of said container from said sheet material.
  • An aseptic packing according to claim 1, wherein a row of containers are formed along said sheet, each container in said row being separated by a tear line, one end of said sheet having inwardly extending indentations extending into said tear line between said containers, said break line being defined across said sheets adjacent the top of the mouth of said containers and spaced from the opposite edge of said containers, said break line including downwardly curved ends terminating on each side of said mouth.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)

Abstract

A method for the production of aseptic packings, particularly a single use packing such as an ampoule, etc., comprises a plurality of oppositely directed substantially identical indentations on a foil on each side of a fold line. Thereafter, the foil material is folded along the fold line to align the indentations so that they form half portions of individual containers. The foil sections are welded or otherwise sealed together so that they close the container around the juncture line. Each container indentation includes a neck portion terminating in an outwardly widening funnel opening adjacent the edge of the foil material. The individual containers are then filled through the funnel and the neck portion is thereafter sealed directly below the bottom of the funnel by pressure welding. The area adjacent the closed weld line is provided with tear lines to facilitate easy opening and removal of the contents from the containers. An aseptic packing comprises a strip of two superposed foil sheets, each having aligned recessed portions forming container halves which together form a complete closed container which is closed around the periphery by the foil material. The strip includes tear line portions for both separating individual containers from the strip and for opening the mouth of each container.

Description

United States Patent [1 1 Schmitt 1 Jan. 28, 1975 I 1 ASEPTIC PACKING CONTAINER AND METHOD OF MAKING AND FILLING IT Roland Schmitt, Forchhcim. Germany [75] Inventor:
[73] Assignee: Industriewerke Karlsruhe-AugsburgAktiengesellschaft, Karlsruhe, Germany [22] Filed: Jan. 5, 1973 [21] Appl. No.: 321,255
Related U.S. Application Data [62] Division of Ser. No. 227,577, Feb. 18, 1972.
[52] U.S. Cl 206/277, 206/438, 206/484, 206/498, 206/820, 222/107 [51] Int. Cl 365d 75/40, 865d 83/00 [58] Field of Search 206/56 AB, 56 AA, 63.2 R; 222/107; 229/51 R [56] References Cited UNlTED STATES PATENTS 2,333,587 11/1943 Salfisberg 229/51 R 2,541,674 2/1951 Snyder v 206/56 AA 2,962,192 11/1960 Volckening.. 206/56 AA 3,162,306 12/1964 Zackhein 206/56 AB 3,278,085 10/1966 Brown 206/56 AA Primary Examiner-William T. Dixson, Jr. Attorney, Agent, or Firm-McGlew and Tuttle [5 7] ABSTRACT A method for the production of aseptic packings, particularly a single use packing such as an ampoule, etc., comprises a plurality of oppositely directed substantially identical indentations on a foil on each side of a fold line. Thereafter, the foil material is folded along the fold line to align the indentations so that they form half portions of individual containers. The foil sections are welded or otherwise sealed together so that they close the container around the juncture line. Each container indentation includes a neck portion terminating in an outwardly widening funnel opening adjacent the edge of the foil material. The individual containers are then filled through the funnel and the neck portion is thereafter sealed directly below the bottom of the funnel by pressure welding. The area adjacent the closed weld line is provided with tear lines to facilitate easy opening and removal of the contents from the containers. An aseptic packing comprises a strip of two superposed foil sheets, each having aligned recessed portions forming container halves which to- .gether form a complete closed container which is closed around the periphery by the foil material. The strip includes tear line portions for both separating individual containers from the strip and for opening the mouth of each container.
4 Claims, ll Drawing Figures 3L 3 "lie PATENTEDJAN28 I875 SHEET 2 BF 3 ASEPTIC PACKING CONTAINER AND METHOD OF MAKING AND FILLING IT This is a division of application Ser. No. 227,577 filed Feb. 18, l972.
BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates in general to a construction of containers, and in particular, to a new and useful method for the production of aseptic packings, particularly packings designed for single use such as ampoules which are formed by superimposed and welded foil sheet portions which are folded in juxtaposition after they have been initially subjected to a pressure to form individual container half portions.
2. Description of the Prior Art ln the pharmaceutical field, it is sometimes necessary to pack drugs aseptically, for example, those of a liquid or solid constituency. It has been known for a long time to use ampoules of glass or plastic, for example, for this purpose. For solid substances such as suppositories, it is known to use plastic coated light metal foils or thermoplastically deformable plastics. Although glass ampoules can meet all of the constructional requirements as far as the necessary asepis is concerned, their production is both expensive and it can only be used once. In addition, they are'difficult to open and they are subject to breakage in storage or in shipment. The sealed filling opening of such ampoules can only be opened by means of a saw or a file which must be enclosed with the ampoule packing in order to permitremoval of the contents.
With the presently known coated light metal foils used for packing solid substances, it is readily possible to pack the contents aseptically. There are difficulties, however, in keeping the contents sterile after it has been removed since the packing must be torn open and the contents removed by hand.
SUMMARY OF THE INVENTION In accordance with the present invention, there is provided a method of forming inexpensive packing ampoules or containers in a simple manner and which may be packed with contents which will remain aseptic until used. ln addition, the materials required are so inexpensive that their disposal loss after use is extremely minimal.
In the known construction, when an ampoule is opened by tearing the material away from the mouth,
a burr is sometimes formed in the range of the breaking point which has been provided for easy opening. This burr can cause injuries to the eyes, ears, or nose when the contents of the ampoules are used for these sensitive body parts. The present invention provides a container or ampoule construction which is such that it is substantially impossible to provide these undesirable burr formations.
in the preferred method of the invention, a sheet of foil material is subjected to pressure in order to form the plurality of pairs of permanent container-form depressions arranged in a mirror fashion in respective rows. The foil is then folded about a line midway between the foil depressions in order to superimpose the foils and align the congruent depressions to form a whole container from the depression half portions, with the complimentary depressions on each side of the fold line forming a respective container half part. The folded foil is then welded together in the areas not overlying the depressions in order to seal the peripheries around the depressions and to form individual closed containers, each having a neck portion terminating in a widened filling funnel leading to the foil edge. Each chamber is then filled through the funnel and the bottom end of the funnel is closed by welding after which a perforation or tear line is imparted to cross the neck, or an area adjacent the neck in order to permit easy opening thereof. The tear line defines a preset breaking line to facilitate the opening of the ampoule directly below the filling funnel. The folding of the foil material is preferably carried out along a longitudinal fold line or axis.
Preferably a plurality of pairs of permanent depressions are arranged in a mirror fashion during the deformation process on two independent foil bands extending substantially parallel to each other. These bands are then superimposed such as by completing the fold about the mid-point line separating the depressions. After the foil material is welded around the depression areas, which forms the vessel or container, the attached filling filter of the filling device is removed by means of a known cutting device. The preferred form includes a tear strip arranged along a row of the formed containers which may be selectively torn to open-one or more containers. The depressions are advantageously spaced apart sufficiently so that there is no large area of foil material between each depression forming the container so that they will be sealed tightly at all sides.
A packing such as an ampoule, vial, etc., produced with the method of the invention and destined particularly for one time use, is formed by mirror-like indenta' tions made in two foil sheets which are aligned to form substantially pear-shaped containers with a mouth portion having an outwardly tapered end defining a filling funnel. The area surrounding thecontainers and surrounding the top of the filling funnel is sealed by the superimposed foil sheets which are secured together. A strip of such containers is advantageously formed with a preset breaking point in the area of the juncture of the mouth portion, with the filling funnel and is constructed so that the strip may be removed to open the top of the mouth to permit discharge of the contents.
The tubular mouth or pipette construction of each container is formed directly below the preset breaking point of the foil material and extends below the top of the mouth portion so that the foil material may be easily broken across the mouth to open the same. The upper edge surface of the foil material which surrounds the container which is formed by the foil sheets is provided with a large radius tear line which extends downwardly on each side of the mouth of the container.
The method of the invention is extremely simple in concept and economical to carry out. The invention makes it possible to use as foils or foil materials, thermoplastic materials which may be heat sealed or welded together in order to provide a relatively inexpensive and disposable ampoule packing. The foils may advantageously comprise polyvinyl chloride (PVC), a polypropylene (PP), or a polyethylene (PE). Foil combinations of polyethylene and polypropylene are also suitable for the method of the invention, particularly in view of the fact that a blocking effect against the penetration of steam is insured under the influence of polyethylene and this is an indispensible prerequisite for certain packing media, for example, with regard to storage capacity. On the other hand, in the foil combination of polyethylene and polypropylene, the latter component has a blocking effect against permeability to gas.
Due to the fact that there is an incompatibility of polyethylene when packing certain oils or fats, it is readily possible according to the method of the invention to combine instead polyvinyl chloride and polyethylene with each other in such a way that any negative effect of the polyethylene is compensated by respective other coating, namely, the polyvinyl chloride.
In addition to plastic or thermoplastic foils, metal foils, for example, aluminum or Dural may be used especially in conjunction with a coating of polyvinyl chloride, polyethylene, or polypropylene or other weldable or heat sealable plastic foil. In the selection of the material for the ampoule packing, it is of importance that the materials used have no restoring properties after the deformation process and are weldable or heat sealable. Due to the natural elasticity inherent in such materials this further enhances the deformation process which is carried out in the course of the method to form the individual container outlines or ampoule configurations. The removal of the material to form the necessary indentations in each of the sheets which are to be employed may be carried out merely by the manual pressure on the sheet to define a portion of the final container. The method is such that the containers are formed so that a person removing the contents does not come into direct contact with the contents of the individual containers. The pouring mouth orpipette of the container according to the invention, is constructed so that it permits, for example, for use on the case of application to a personsnose, throat, ear or eye drugs without direct application to the respective body organ.
In accordance with one embodiment of the invention, the container or ampoule is formed with a relatively elongated vertically extending mouth and the foil material directly above the mouth is formed with tear lines which extend downwardly in a large radius at a lo cation below the top of the mouth so that the mouth is opened when the tear strip at the upper marginal edge of the foil material is torn away. The arrangement is such that when the tear strip is removed, the mouth is opened evenly, thereby preventing injuries in respect to the use of the contents of the ampoule. When the tear strip is removed, a high portion of foil material with rounded corners on each side of the mouth of the container remains to form outwardly extending protective projections which prevent contact of a torn edge of the mouth with a body organ. Contact can only take place between the upper edge of the foil material which forms the projections but by no means between the part of the mouth which is torn away and which might possibly be formed with burrs. The projections are presented in the part of the body organ to be treated and a distance between the body organ, and the mouth of the containers is relatively small so that the distance can be bridged over by the pressure on the container to cause a variation in the dosing stream. For example, the distance between the mouth of the container and the body organ to be treated such as an car, can be bridged over with a thin continuously reissuing jet of the material being dispensed or by drops which issue at intervals.
Accordingly, it is an object of the invention to provide an improved method of forming individual containers or ampoules from foil or similar material which comprises crimping the foil material at spaced locations along the length to form oppositely directed indentations of identical but oppositely facing configuration on each side of a centrally disposed fold line for the material, juxtaposing the material parts together so that the indentations are aligned and the foil material is secured together around the outline thereof to form the containers.
A further object of the invention is to provide a plurality of containers and a strip of material wherein container half portions are formed by indentations in respective foil strips which are superimposed and connected together, with thefoil strips forming the closure around the container elements and including a tear strip oriented around the one edge of the foil strips which overlies a mouth and which is provided with a weakened area in the vicinity of the mouth to permit the removal of a portion of the tear strip and the opening of the mouth.
A further object of the invention is to provide a small container construction which is simple in design, rugged in construction, and economical to manufacture.
The various features of novelty which characterize the invention are pointed out with particularity in the claims annexed to and forming a part of this disclosure. For a better understanding of the invention, its operating advantages and specific objects attained by its uses, reference should be had to the accompanying drawing and descriptive matter in which there are illustrated preferred embodiments of the invention.
BRIEF DESCRIPTION OF THE DRAWING In the Drawings:
FIG. 1 is a plan view of a portion of a foil material showing the outlines of container indentations for half portions of containers which are constructed in accordance with the method of the invention;
FIG. la is a section taken along the line l-l of FIG.
FIG. 2 is a plan view of the foil material shown in FIG. I with the lower portion folded over the upper portion;
FIG. 2a is a section taken along the line lIll of FIG. 2;
FIG. 2b is a top plan view of the foil shown in FIG.
FIG. 3 is a schematic transverse sectional view showing the operation of a machine for effecting the welding and sealing of the foil material at the mouth after the ampoule or container is filled with liquid;
FIG. 4 is a view similar to FIG. 3 but showing a machine for cutting of portions of the foil material from the container directly below the filling funnel after it has been filled;
FIG. 5 is a medium sectional view of a filled ampoule having an outer contour with a perforation which joins it wih a remaining portion of its foil wall material;
FIG. 6 is a side elevational view ofa strip of interconnected ampoules or containers; and
FIG. 6a is an enlarged view of a single ampoule having the closure strip removed therefrom.
FIG.'5a is a section taken along the line VV of FIG. 5.
GENERAL DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings, in particular, the invention embodied therein in FIGS. 1 and 1a, shows a continuous strip of foil or sheet material after it has been removed from a roll, band, etc., and which is generally designated 1. The foil strip 1 has been first subjected to a pressure deformation to form a plurality of rows of container-like depressions la formed in sets with one row oriented to face in one direction and the other facing in a mirror-like manner in an opposite direction. Each depression la includes an elongated mouth portion or pipette lb and a filling funnel portion which extends from the upper end of the mouth to the outer edge of the foil material 1.
After the deformation process is completed, the foil material I is folded along a media line 2 located between adjacent rows to align the indentations la so that they form half portions of finished containers or ampoules or similar vessels. The indentations 1a are congruent so that when the flat portions of the funnel sheets are superimposed, the portions form the half portions of the whole finished container. The superposed folded foil sheet is secured together such as by head welding to form it into the configuration indicated in FIGS. 2, 2a and 2b.
In FIG. 3, the foil 1 includes attached and filled ampoules 3 which have been filled by mechanism (not shown), and they are moved into association with means for sealing the mouth 1b which is accomplished by welding or hot-sealing jaws 4 and 4a which move together and define a welded closure line across the mouth of the container. The jaws 4 and 4a are moved in the direction of the arrows and 22 during each operating cycle by means (not shown). The ampoule 3 is advantageously closed tightly between its neck and the filling funnel It by high frequency, ultra sound impulse welding or by infra-red preheating.
After the ampoule is filled, it is moved into association with cut-off means which include blades 5 and 5a movable in the directions of the arrows 24 and and carried by a tool 6 which cooperates with a counter tool 6a.
As indicated in FIG. 5, the juxtaposed foil sheet portions are provided with a perforation Id at a safety margin spaced outwardly from the surface of the ampoule 3 in order to permit easy removal of the ampoule from the foil when it is to be used. The mouth lb is provided with a preset breaking point or tear line lle directly below a closure weld 26.
In FIG. 6, there is shown a modified construction of a strip generally designated 32 made up of individual ampoules 3 which are formed on a foil strip 11a. The ampoules 3 receive aseptic drugs and comprise the same material as the surrounding strip 11a. For the continuous strip lla may be provided two superposed sheets ofa material such as polyvinyl chloride, polypropylene or polyethylene. As an alternative to the plastic, materials may be employed such as aluminum or Duraluminum which can be combined with the polyvinyl chloride or polyethylene.
The strip 32 is provided with inwardly extending slots llb at the midpoint between each ampoule which extend inwardly from the edge 34. The opposite edge 36 forms an outer edge of a tear strip 38. The tear strip is defined at its inner end by perforation elements or tear lines 40 which terminate in ends llc which extend downwardly on each side of a mouth 11d of each ampoule 3. The tear lines 40 define present breaking points which, when removed, leave a break line le extending across the mouth 11d of the container. The tear line le can have burrs which may cause injury, for example, to sensitive body organs such as the eye, ear, nose, etc., when the ampoule is handled improperly. In order to avoid this, the break lines define edges 42 which form smooth edges which provide protective projections which prevent damage to the body cavities by use of the ampoule. The projections 44 and 46 provide safe engagement edges for orienting the mouth 1111 for the discharge of the fluid into the body cavity. This special design keeps the burr portion le away from the sensitive body organ when the ampoule is used so that injuries are avoided. The corners of the perforation line 40 are rounded off with a relatively large radii on each side of the mouth tear line 1e. Tests have shown that danger of injuries increases if only one radius is provided, for example, on the side of the mouth 1d.
While specific embodiments of the invention have been shown and described in detail to illustrate the application of the principles of the invention, it will be understood that the invention may be embodied otherwise without departing from such principles.
What is claimed is:
1. A one time use package comprising a container having a body portion, an elongated mouth extending outwardly from said body portion, said container comprising two superposed sheets, each sheet having a container half portion in the indentation forming a half of said body portion, said sheets extending on each side of said body portion and being welded together at their areas external to said body portion and being welded above said mouth to seal the top of said mouth and close it, in a break line defined on said sheets extending on each side of said mouth along substantially straight lines at a spaced location from the top of said mouth and terminating in downwardly extending portions extending in close proximity to each side of the mouth of said body portion at the level of the top of said mouth, said break lines being tearable to effect tearing along a smooth, straight line at a spaced location above the top of said mouth up to each side of said mouth and then downwardly to the plane of the top of said mouth so that any rough tearing across the top of said mouth is recessed from the smooth tear edge lines.
2. An aseptic packing, according to claim 1, including a protection perforation line defined around the periphery of said container on said sheet material to permit removal of the outline of said container from said sheet material.
3. As aseptic packing, according to claim I, wherein said sheet material is provided with severance lines between adjacent containers.
4. An aseptic packing, according to claim 1, wherein a row of containers are formed along said sheet, each container in said row being separated by a tear line, one end of said sheet having inwardly extending indentations extending into said tear line between said containers, said break line being defined across said sheets adjacent the top of the mouth of said containers and spaced from the opposite edge of said containers, said break line including downwardly curved ends terminating on each side of said mouth.

Claims (4)

1. A one time use package comprising a container having a body portion, an elongated mouth extending outwardly from said body portion, said container comprising two superposed sheets, each sheet having a container half portion in the indentation forming a half of said body portion, said sheets extending on each side of said body portion and being welded together at their areas external to said body portion and being welded above said mouth to seal the top of said mouth and close it, in a break line defined on said sheets extending on each side of said mouth along substantially straight lines at a spaced location from the top of said mouth and terminating in downwardly extending portions extending in close proximity to each side of the mouth of said body portion at the level of the top of said mouth, said break lines being tearable to effect tearing along a smooth, straight line at a spaced location above the top of said mouth up to each side of said mouth and then downwardly to the plane of the top of said mouth so that any rough tearing across the top of said mouth is recessed from the smooth tear edge lines.
2. An aseptic packing, according to claim 1, including a protection perforation line defined around the periphery of said container on said sheet material to permit removal of the outline of said container from said sheet material.
3. As aseptic packing, according to claim 1, wherein said sheet material is provided with severance lines between adjacent containers.
4. An aseptic packing, according to claim 1, wherein a row of containers are formed along said sheet, each container in said row being separated by a tear line, one end of said sheet having inwardly extending indentations extending into said tear line between said containers, said break line being defined across said sheets adjacent the top of the mouth of said containers and spaced from the opposite edge of said containers, said break line including downwardly curved ends terminating on each side of said mouth.
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US3920122A (en) * 1973-12-26 1975-11-18 Jones & Co Inc R A Label web and die making methods
US3993223A (en) * 1974-07-25 1976-11-23 American Home Products Corporation Dispensing container
US4155454A (en) * 1977-01-12 1979-05-22 Schering Corporation Safety packaging for ampoules
US4218155A (en) * 1978-02-10 1980-08-19 Etablissements Armor, S.A. Stick for applying a liquid
US4301796A (en) * 1979-07-26 1981-11-24 Child Laboratories Inc. Method and apparatus for dispensing fluid
US4491245A (en) * 1982-03-24 1985-01-01 Jamison Mark D Liquid dispensing container
US4502616A (en) * 1982-01-04 1985-03-05 Health Care Concepts, Inc. Single use vial
WO1985003275A1 (en) * 1984-01-23 1985-08-01 Laipply Thomas C Alcohol wipe and methods
US4588090A (en) * 1981-07-07 1986-05-13 Cito-Pac Verpackungsgesellschaft Mbh Blister pack strip
US4696393A (en) * 1981-10-19 1987-09-29 Laipply Thomas C Applicator wipe for inviscid fluids
US4786534A (en) * 1987-02-02 1988-11-22 Business Systems Enterprises, Inc. Disposable package for liquid material and method of making same
US4787536A (en) * 1985-03-29 1988-11-29 Aktiebolaget Draco Dosage package
US4871091A (en) * 1988-09-29 1989-10-03 Mason-Keller Corporation Disposable package for liquids
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
US5018646A (en) * 1988-11-23 1991-05-28 S. C. Johnson & Son, Inc. Squeezable fluid container
WO1991008951A1 (en) * 1989-12-18 1991-06-27 Ukrainsky Nauchno-Issledovatelsky Institut Po Plemennomu Delu V Zhivotnovodstve 'ukrniiplem' Hermetic package for packing and storing liquid products
US5046608A (en) * 1981-10-19 1991-09-10 Laipply Thomas C Combined fluid storage container and applicator device and method
AU633218B2 (en) * 1990-08-02 1993-01-21 Miles Inc. Reagent containment and delivery tray
US5272093A (en) * 1990-08-02 1993-12-21 Miles Inc. Reagent containment and delivery tray and method of use
WO1996004185A1 (en) * 1994-08-03 1996-02-15 Danfoss A/S Container device for storage of media
US5839609A (en) * 1997-08-27 1998-11-24 Colgate-Palmolive Company Thermoformed pack with ridge valve
EP0955244A3 (en) * 1998-05-04 2001-11-28 Otto Volz Multi-compartment container for liquids
US6346109B1 (en) * 1998-08-26 2002-02-12 Linvatec Corporation Cannulated tissue anchor system
US6557731B1 (en) * 2000-08-14 2003-05-06 Robert Lyon Single use glue dispensing package
US6586060B2 (en) * 1997-10-30 2003-07-01 Yoshino Kogyosho Co., Ltd. Thin-walled synthetic resin laminated body for liquid container and method for manufacturing the same
US6605064B2 (en) 2000-09-15 2003-08-12 Thomas Hatch Single-use syringe
AU2003255202B2 (en) * 1997-09-23 2006-07-06 Pharmacia Aktiebolag Prefilled ampoules and manufacture thereof
US20070034647A1 (en) * 2005-06-29 2007-02-15 Patrick Michael K Dispensing pouch and a method of making the same
US7241066B1 (en) 2003-04-15 2007-07-10 American Grease Stick Company Container for flowable products
US20090205993A1 (en) * 2008-02-19 2009-08-20 Klocke Verpackungs-Service Gmbh Packaging unit with protective section
US20100107560A1 (en) * 2007-02-19 2010-05-06 Alain Ehrsam Packaging tube for a predetermined volume of a biological substance to be stored at a low temperature and system including same
US20100257681A1 (en) * 2009-04-14 2010-10-14 Chia-Ching Lin Fluid receiving device with a wiping layer and a manufacturing method thereof
US20110233232A1 (en) * 2010-03-26 2011-09-29 Juergen Greiner-Perth Discharging device for liquids
US8061563B1 (en) 2007-05-29 2011-11-22 Ags I-Prop, Llc Flexible pouch with expulsion aid
US20110284582A1 (en) * 2008-01-23 2011-11-24 Andreas Johannes Boehm Dental package, and method of making the package
US8376183B1 (en) 2008-06-10 2013-02-19 Ags I-Prop, Llc Fluid dispenser having multiple chambers
US20130264238A1 (en) * 2009-09-03 2013-10-10 Croma-Pharma Gmbh Method for producing a container welded in a protective cover
US20130292414A1 (en) * 2012-05-02 2013-11-07 Spencer D. Sutherland Dispensing Device
US20140221917A1 (en) * 2012-04-20 2014-08-07 Pedia Solutions Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US8945182B2 (en) 2012-04-20 2015-02-03 Pedia Solutions, Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US20150122840A1 (en) * 2013-11-06 2015-05-07 The Procter & Gamble Company Flexible containers having flexible valves
USD740430S1 (en) 2013-04-19 2015-10-06 Pedia Solutions, Llc Fluid dispensing pacifier
US20160122103A1 (en) * 2009-05-20 2016-05-05 Virbac Sa Non-resealable thermoformed packaging for liquid or pasty substances
US20160152359A1 (en) * 2013-07-09 2016-06-02 Lameplast S.P.A. Procedure for the manufacture of vials for fluid products, particularly for medical, pharmaceutical, cosmetic, food products or the like
US9850046B2 (en) 2013-11-06 2017-12-26 The Procter & Gamble Company Flexible containers with vent systems
US9988190B2 (en) 2015-04-10 2018-06-05 The Procter & Gamble Company Flexible containers with biased dispensing
US10017300B2 (en) 2015-04-10 2018-07-10 The Procter & Gamble Company Flexible containers with product dispensing visibility
US10532836B2 (en) * 2016-02-29 2020-01-14 Klocke Verpackungs-Service Gmbh Method for the productions and filling of an application package for a liquid pharmaceutical product

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Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920122A (en) * 1973-12-26 1975-11-18 Jones & Co Inc R A Label web and die making methods
US3993223A (en) * 1974-07-25 1976-11-23 American Home Products Corporation Dispensing container
US4155454A (en) * 1977-01-12 1979-05-22 Schering Corporation Safety packaging for ampoules
US4218155A (en) * 1978-02-10 1980-08-19 Etablissements Armor, S.A. Stick for applying a liquid
US4301796A (en) * 1979-07-26 1981-11-24 Child Laboratories Inc. Method and apparatus for dispensing fluid
US4588090A (en) * 1981-07-07 1986-05-13 Cito-Pac Verpackungsgesellschaft Mbh Blister pack strip
US4696393A (en) * 1981-10-19 1987-09-29 Laipply Thomas C Applicator wipe for inviscid fluids
US5046608A (en) * 1981-10-19 1991-09-10 Laipply Thomas C Combined fluid storage container and applicator device and method
US4502616A (en) * 1982-01-04 1985-03-05 Health Care Concepts, Inc. Single use vial
US4491245A (en) * 1982-03-24 1985-01-01 Jamison Mark D Liquid dispensing container
WO1985003275A1 (en) * 1984-01-23 1985-08-01 Laipply Thomas C Alcohol wipe and methods
US4787536A (en) * 1985-03-29 1988-11-29 Aktiebolaget Draco Dosage package
US4786534A (en) * 1987-02-02 1988-11-22 Business Systems Enterprises, Inc. Disposable package for liquid material and method of making same
US4871091A (en) * 1988-09-29 1989-10-03 Mason-Keller Corporation Disposable package for liquids
US5018646A (en) * 1988-11-23 1991-05-28 S. C. Johnson & Son, Inc. Squeezable fluid container
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
WO1991008951A1 (en) * 1989-12-18 1991-06-27 Ukrainsky Nauchno-Issledovatelsky Institut Po Plemennomu Delu V Zhivotnovodstve 'ukrniiplem' Hermetic package for packing and storing liquid products
AU633218B2 (en) * 1990-08-02 1993-01-21 Miles Inc. Reagent containment and delivery tray
US5272093A (en) * 1990-08-02 1993-12-21 Miles Inc. Reagent containment and delivery tray and method of use
WO1996004185A1 (en) * 1994-08-03 1996-02-15 Danfoss A/S Container device for storage of media
US5839609A (en) * 1997-08-27 1998-11-24 Colgate-Palmolive Company Thermoformed pack with ridge valve
AU2003255202B2 (en) * 1997-09-23 2006-07-06 Pharmacia Aktiebolag Prefilled ampoules and manufacture thereof
US6586060B2 (en) * 1997-10-30 2003-07-01 Yoshino Kogyosho Co., Ltd. Thin-walled synthetic resin laminated body for liquid container and method for manufacturing the same
EP0955244A3 (en) * 1998-05-04 2001-11-28 Otto Volz Multi-compartment container for liquids
US6346109B1 (en) * 1998-08-26 2002-02-12 Linvatec Corporation Cannulated tissue anchor system
US6557731B1 (en) * 2000-08-14 2003-05-06 Robert Lyon Single use glue dispensing package
US6605064B2 (en) 2000-09-15 2003-08-12 Thomas Hatch Single-use syringe
US6645180B1 (en) 2000-09-15 2003-11-11 Thomas Hatch Single-use syringe
US7241066B1 (en) 2003-04-15 2007-07-10 American Grease Stick Company Container for flowable products
US20070034647A1 (en) * 2005-06-29 2007-02-15 Patrick Michael K Dispensing pouch and a method of making the same
US20100107560A1 (en) * 2007-02-19 2010-05-06 Alain Ehrsam Packaging tube for a predetermined volume of a biological substance to be stored at a low temperature and system including same
US8266872B2 (en) * 2007-02-19 2012-09-18 Cryo Bio System Packaging tube for a predetermined volume of a biological substance to be stored at a low temperature and system including same
US8061563B1 (en) 2007-05-29 2011-11-22 Ags I-Prop, Llc Flexible pouch with expulsion aid
US9095399B2 (en) * 2008-01-23 2015-08-04 3M Innovative Properties Company Dental package, and method of making the package
US20110284582A1 (en) * 2008-01-23 2011-11-24 Andreas Johannes Boehm Dental package, and method of making the package
US8141709B2 (en) * 2008-02-19 2012-03-27 Klocke Verpackungs-Service Gmbh Packaging unit with protective section
US20090205993A1 (en) * 2008-02-19 2009-08-20 Klocke Verpackungs-Service Gmbh Packaging unit with protective section
US8376183B1 (en) 2008-06-10 2013-02-19 Ags I-Prop, Llc Fluid dispenser having multiple chambers
US20100257681A1 (en) * 2009-04-14 2010-10-14 Chia-Ching Lin Fluid receiving device with a wiping layer and a manufacturing method thereof
US20160122103A1 (en) * 2009-05-20 2016-05-05 Virbac Sa Non-resealable thermoformed packaging for liquid or pasty substances
US20130264238A1 (en) * 2009-09-03 2013-10-10 Croma-Pharma Gmbh Method for producing a container welded in a protective cover
US20110233232A1 (en) * 2010-03-26 2011-09-29 Juergen Greiner-Perth Discharging device for liquids
US20140221917A1 (en) * 2012-04-20 2014-08-07 Pedia Solutions Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US8945182B2 (en) 2012-04-20 2015-02-03 Pedia Solutions, Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US10780025B2 (en) 2012-04-20 2020-09-22 Fridababy, Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US9463143B2 (en) * 2012-04-20 2016-10-11 Pedia Solutions, Llc Apparatus and methods for oral administration of fluids and medical instrumentation
US20130292414A1 (en) * 2012-05-02 2013-11-07 Spencer D. Sutherland Dispensing Device
USD740430S1 (en) 2013-04-19 2015-10-06 Pedia Solutions, Llc Fluid dispensing pacifier
US20160152359A1 (en) * 2013-07-09 2016-06-02 Lameplast S.P.A. Procedure for the manufacture of vials for fluid products, particularly for medical, pharmaceutical, cosmetic, food products or the like
US20150122840A1 (en) * 2013-11-06 2015-05-07 The Procter & Gamble Company Flexible containers having flexible valves
US20170259984A1 (en) * 2013-11-06 2017-09-14 The Procter & Gamble Company Flexible containers having flexible valves
US9850046B2 (en) 2013-11-06 2017-12-26 The Procter & Gamble Company Flexible containers with vent systems
US10138049B2 (en) * 2013-11-06 2018-11-27 The Procter & Gamble Company Flexible containers having flexible valves
US9694965B2 (en) * 2013-11-06 2017-07-04 The Procter & Gamble Company Flexible containers having flexible valves
US9988190B2 (en) 2015-04-10 2018-06-05 The Procter & Gamble Company Flexible containers with biased dispensing
US10017300B2 (en) 2015-04-10 2018-07-10 The Procter & Gamble Company Flexible containers with product dispensing visibility
US10532836B2 (en) * 2016-02-29 2020-01-14 Klocke Verpackungs-Service Gmbh Method for the productions and filling of an application package for a liquid pharmaceutical product

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