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US3619605A - Mass spectrometer method and apparatus employing high energy metastable ions to generate sample ions - Google Patents

Mass spectrometer method and apparatus employing high energy metastable ions to generate sample ions Download PDF

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US3619605A
US3619605A US836444A US3619605DA US3619605A US 3619605 A US3619605 A US 3619605A US 836444 A US836444 A US 836444A US 3619605D A US3619605D A US 3619605DA US 3619605 A US3619605 A US 3619605A
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ions
tube
rare gas
vessel
electrodes
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Charles F Cook
Thomas W Schmidt
Jack P Guillory
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Phillips Petroleum Co
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Phillips Petroleum Co
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    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/14Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers

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  • Metastable particles of high kinetic energy are produced by accelerating a stream of charged rare gas molecules. and contacting the accelerated stream of charged rare gas molecules, thereby producing metastable high kinetic energy particles which are directed perpendicularly into contact with a target beam of molecules moving at thermal velocities, the resulting ions being analyzed by a mass spectrometer.
  • metastable particles have been utilized in certain ionizing reactions referred to as Penning ionization. This involves the inelastic collision between a neutral electronically excited particle, i.e., a metastable particle, and another atom or polyatomic molecule. The result is production of a positively charged molecule or atom (hereinafter generically referred to as a particle) together with liberation of a free electron. Such reactions are useful in the analysis of gas streams, as by a mass spectrometer.
  • the resulting collisions produce ions which are directed into the analyzer of a mass spectrometer through suitable electronic focusing elements, the analyzer of course, being located within the vacuum vessel.
  • FIGURE is a schematic perspective diagram of an analyzer constructed in accordance with the invention.
  • a rare gas stream 10 is introduced from a source, not shown, into a tube 11 of insulating material, such as Pyrex.
  • the term, rare gas has its usual meaning and includes all the members of the inert gas series of the periodic table, i.e., helium, neon, argon, krypton, xenon and radon.
  • Other inert or rare gases which can be produced by nuclear reactions are within the scope of the invention.
  • the tube 11 is surrounded by a core 12 upon which two metal rings 13 and 14 are disposed.
  • An alternating electric field is applied to the rings 13, 14 by a radio frequency generator 15. This field accelerates the rare gas molecules, and they pass axially through the tube 11 and an aperture 16 to a chamber 17 containing neutral rare gas molecules at low pressure.
  • the aperture 16 is formed in a plate 18 constituting'a part of a vacuum chamber diagrammatically indicated by reference numeral 19.
  • a conduit 20 leads from this chamber to a vacuum pump, now shown, whereby a low pressure is main tained in the chamber 19, typically of the order of 50 to 5,000 microns of mercury, i.e., 5X10 to 5 millimeters of mercury.
  • the chamber 17 has a conduit 21 connected to a vacuum pump, not shown, whereby the inert rare gas molecules in the chamber are maintained at a low pressure, typically of the order of l0 to 10" millimeters of mercury.
  • the energetic particles produced in the chamber 19 which have considerable kinetic energy, for example, of the order of 10 to 50 electron volts, undergo charge exchange with the neutral molecules of gas contained within the chamber 17, and thus produce a beam of metastable particles of high kinetic energy.
  • the kinetic energy of these molecules can be varied by changing the direction of the electric field vector produced by the generator 15. Maximum kinetic energy is obtained when the vector is parallel to the efi'usion direction, i.e., coaxial with the tube 11, and the kinetic energy is a minimum when the vector is perpendicular to that axis.
  • the chamber 17 may contain a pair of spaced electrodes 22 and 23.
  • the electrodes When connected to a suitable current source, not shown, the electrodes constitute electrostatic deflectors which remove ions and electrons from the beam of hot metastable molecules passing axially of the chamber 17.
  • the beam of hot metastable rare gas molecules is collimated by the aperture 16 and by an aperture 24 in axial alignment therewith.
  • Suitable dimensions for securing proper collimation of the beam are a diameter of l millimeter for the aperture I6 and a diameter of 2 to 4 millimeters for the aperture 24.
  • the collimated beam passes into a vacuum chamber 25 supplied with a conduit 26 leading to a vacuum pump, not shown. There, it intersects a target beam of particles discharged from a source 27 in a path perpendicular to that of the collimated beam.
  • the source 27 may advantageously comprise a series of fused gas capillaries I00 microns in diameter and 2.5 millimeters long.
  • the target beam which can be composed of a hydrocarbon gas, for example, methane, accordingly effuses from the source 27 at thermal velocities.
  • the intersection of the target beam with the beam of metastable particles produces ions which, by virtue of their electric charge, can be guided to an analyzer 28 disposed in the vessel 25.
  • the analyzer 28 forms a part of a mass spectrometer, now shown, which is preferably of the quadrupole type, i.e., one that uses an electric field rather than a magnetic field to deflect the ions.
  • the ions produced by the collision of the two beams are guided to the analyzer 28 by an electric field existing between an electrode 29 and the analyzer 28.
  • a current source 30 is connected between the electrode 29 and analyzer 28 to produce a field vector mutually perpendicular to the hot metastable beam and the target beam.
  • Suitable guiding and focusing electrodes 31, 32 and 33 are provided to direct the ions into the analyzer.
  • the analyzer and mass spectrometer are operated, in well understood fashion, to analyze the proportions of ions of various mass numbers in the particles directed into the analyzer 28. By this means, mass spectra are obtained showing the cracking patterns resulting from contact of the hot metastable particles with the target stream.
  • helium, neon or argon is injected into the tube 11, and accelerated by the field produced by the generator 15 to an energy well above 0.2
  • the resulting particles contact the rare gas molecules in the chamber 17 which, preferably and advantageously, are of the same composition as the gas fed to the tube 11.
  • the particles undergo charge exchange with the neutral molecules in the chamber 17 and produce a beam of hot metastable particles which is collimated by the apertures 16, 24 an passes into the vessel 25.
  • the beam of hot metastable molecules contacts perpendicularly the target beam of particles to be analyzed which flow at thermal velocity from the source 27. lons are produced by the resulting collisions and these are directed into the analyzer 28 of the mass spectrometer, and the mass spectrum thereof is determined.
  • the method and apparatus of the invention are also useful for obtaining the mass spectra of various hydrocarbons, such as butene-l, isobutylene, n-heptane, isobutane and 2,2,4- trimethylpentane.
  • various hydrocarbons such as butene-l, isobutylene, n-heptane, isobutane and 2,2,4- trimethylpentane.
  • a method for detecting the mass of components in a gas sample which comprises impressing an alternating electric field upon a stream of rare gas ions to increase the kinetic energy thereof, contacting the resultant gas stream with neutral rare gas to produce a high energy beam of metastable rare gas ions directing said beam perpendicularly into contact with a target beam of said sample gas moving at thermal velocities, applying an electrical field to the zone of contact to deflect ions produced by such contact, and detecting the mass of the deflected ions.
  • the rare gas ions are selected from the group consisting of helium, neon, argon, krypton, xenon and radon, and the target beam is a hydrocarbon gas.
  • Apparatus for investigating the mass of components in a gas stream which comprises, in combination, a tube of insulating material, means for evacuating said tube, a source of rare gas ions connected to one end of said tube, a pair of electrodes disposed around said tube, a radio frequency generator connected to said electrodes, a chamber containing rare gas molecules at low pressure, a vacuum vessel, said chamber having an aperture therein communicating with the other end of said tube and a larger aperture communicating with said vessel, said apertures being coaxial with said tube, a capillary source in said vessel arranged to efl'use a gas sample thereinto perpendicular to the extended axis of said tube, a mass spectrometer having an analyzer disposed in said vessel, and means for directing ions produced in said vessel into said analyzer.
  • a pair of deflecting electrodes in said chamber and means for applying an electric potential to said electrodes to deflect ions and electrons away from said larger aperture.
  • capillary source is an array of fused glass capillaries coaxially arranged to discharge said gas sample into said vacuum vessel.

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Metastable particles of high kinetic energy are produced by accelerating a stream of charged rare gas molecules, and contacting the accelerated stream of charged rare gas molecules, thereby producing metastable high kinetic energy particles which are directed perpendicularly into contact with a target beam of molecules moving at thermal velocities, the resulting ions being analyzed by a mass spectrometer.

Description

United States Patent Charles F. Cook;
Thomas W. Schmidt; Jack P. Guillory, all of Bartlesville, Okla.
June 25, 1969 Nov. 9, 1971 Phillips Petroleum Company Inventors Appl. No. Filed Patented Assignee MASS SPECTROMETER METHOD AND APPARATUS EMPLOYING HIGH ENERGY METASTABLE IONS TO GENERATE SAMPLE IONS 8 Claims, 1 Drawing Fig.
US. Cl 250/41.9
Int. Cl ..Il0lj 37/08, BOld 59/44 Field of Search 250/41.9
[56] References Cited UNITED STATES PATENTS 2,653,620 9/1953 Morgan 250/419 2699505 1/1955 Usher et al.. 250/41.9 2,939,952 6/1960 Paul et a1. 250/4l.9 3,254,209 5/1966 Fite et a1 250/41.9
Primary Examiner-James W. Lawrence Assistant Examiner-C. E. Church Altorney- Young and Quigg ABSTRACT: Metastable particles of high kinetic energy are produced by accelerating a stream of charged rare gas molecules. and contacting the accelerated stream of charged rare gas molecules, thereby producing metastable high kinetic energy particles which are directed perpendicularly into contact with a target beam of molecules moving at thermal velocities, the resulting ions being analyzed by a mass spectrometer.
PATENTEUNUV 8 I97! 3,619.6 O5
INVENTORS c. F. COOK T. w. SCHMIDT BY J. P. GUILLORY ATTO VS MASS SPECTROMETER METHOD AND APPARATUS EMPLOYING HIGH ENERGY METASTABLE IONS TO GENERATE SAMPLE IONS BACKGROUND OF THE INVENTION l-leretofore, metastable particles have been utilized in certain ionizing reactions referred to as Penning ionization. This involves the inelastic collision between a neutral electronically excited particle, i.e., a metastable particle, and another atom or polyatomic molecule. The result is production of a positively charged molecule or atom (hereinafter generically referred to as a particle) together with liberation of a free electron. Such reactions are useful in the analysis of gas streams, as by a mass spectrometer.
The utilization of such reactions has been limited by the fact that the metastable particles have only thennal velocities (energies of less than 0.2 electron volt) and, hence, substantially no kinetic energy was transferred to the target particles in the ionizing collisions. It has been proposed to produce particles of higher energy by effusing alkali metal atoms, such as potassium atoms, from an oven. A charge transfer reaction between rare gas ions and the alkali metal atoms was utilized to produce beams of metastable particles of high kinetic energy. A rather complicated apparatus is required for this purpose, and it is difficult to maintain the alkali metal vapor at a constant pressure of the order of torr.
BRIEF STATEMENT OF THE INVENTION We have discovered that a high energy beam can be readily produced without the use of alkali metals requiring an oven for effusion of the particles. In accordance with our invention, molecules of a rare gas are accelerated by an alternating electric field and passed into a chamber containing neutral rare gas particles at low pressure. The resulting collisions produce a beam of highly energetic rare gas particles which is collimated and passed into a vacuum vessel. There, it intersects, at right angles, a target beam of particles moving at thermal velocities which is efi'used into the vacuum vessel.
The resulting collisions produce ions which are directed into the analyzer of a mass spectrometer through suitable electronic focusing elements, the analyzer of course, being located within the vacuum vessel.
The use of the high kinetic energy, i.e., hot," beam of metastable particles results in mass cracking patterns significantly different from those obtained with thermal metastable particles. For example, C and CI-I ions were produced where methane was utilized as the target beam whereas only CHJ CH and CH, were observed when the metastable particles had thennal velocities. Accordingly, Penning ionization investigations as a function of the transfer energy are no longer limited by the electronic energy levels of the metastable atoms and molecules. Also, translational and electronic energy transfer processes can be studied simultaneously. The method and apparatus of the invention can also be used advantageously for providing an ion source for mass spectrometers.
DETAILED DESCRIPTION OF THE INVENTION Various other objects and advantages and features of the invention will become apparent from the following detailed description taken in conjunction with the accompanying drawing, in which:
The FIGURE is a schematic perspective diagram of an analyzer constructed in accordance with the invention.
Referring now to the drawing in detail, a rare gas stream 10 is introduced from a source, not shown, into a tube 11 of insulating material, such as Pyrex. The term, rare gas, has its usual meaning and includes all the members of the inert gas series of the periodic table, i.e., helium, neon, argon, krypton, xenon and radon. Other inert or rare gases which can be produced by nuclear reactions are within the scope of the invention.
The tube 11 is surrounded by a core 12 upon which two metal rings 13 and 14 are disposed. An alternating electric field is applied to the rings 13, 14 by a radio frequency generator 15. This field accelerates the rare gas molecules, and they pass axially through the tube 11 and an aperture 16 to a chamber 17 containing neutral rare gas molecules at low pressure.
The aperture 16 is formed in a plate 18 constituting'a part of a vacuum chamber diagrammatically indicated by reference numeral 19. A conduit 20 leads from this chamber to a vacuum pump, now shown, whereby a low pressure is main tained in the chamber 19, typically of the order of 50 to 5,000 microns of mercury, i.e., 5X10 to 5 millimeters of mercury. The chamber 17 has a conduit 21 connected to a vacuum pump, not shown, whereby the inert rare gas molecules in the chamber are maintained at a low pressure, typically of the order of l0 to 10" millimeters of mercury.
In the chamber 17, the energetic particles produced in the chamber 19, which have considerable kinetic energy, for example, of the order of 10 to 50 electron volts, undergo charge exchange with the neutral molecules of gas contained within the chamber 17, and thus produce a beam of metastable particles of high kinetic energy.
The kinetic energy of these molecules can be varied by changing the direction of the electric field vector produced by the generator 15. Maximum kinetic energy is obtained when the vector is parallel to the efi'usion direction, i.e., coaxial with the tube 11, and the kinetic energy is a minimum when the vector is perpendicular to that axis.
It is a feature of the invention that the chamber 17 may contain a pair of spaced electrodes 22 and 23. When connected to a suitable current source, not shown, the electrodes constitute electrostatic deflectors which remove ions and electrons from the beam of hot metastable molecules passing axially of the chamber 17.
The beam of hot metastable rare gas molecules is collimated by the aperture 16 and by an aperture 24 in axial alignment therewith. Suitable dimensions for securing proper collimation of the beam are a diameter of l millimeter for the aperture I6 and a diameter of 2 to 4 millimeters for the aperture 24.
From the aperture 24, the collimated beam passes into a vacuum chamber 25 supplied with a conduit 26 leading to a vacuum pump, not shown. There, it intersects a target beam of particles discharged from a source 27 in a path perpendicular to that of the collimated beam. The source 27 may advantageously comprise a series of fused gas capillaries I00 microns in diameter and 2.5 millimeters long. The target beam, which can be composed of a hydrocarbon gas, for example, methane, accordingly effuses from the source 27 at thermal velocities.
The intersection of the target beam with the beam of metastable particles produces ions which, by virtue of their electric charge, can be guided to an analyzer 28 disposed in the vessel 25. The analyzer 28 forms a part of a mass spectrometer, now shown, which is preferably of the quadrupole type, i.e., one that uses an electric field rather than a magnetic field to deflect the ions.
The ions produced by the collision of the two beams are guided to the analyzer 28 by an electric field existing between an electrode 29 and the analyzer 28. To this end, a current source 30 is connected between the electrode 29 and analyzer 28 to produce a field vector mutually perpendicular to the hot metastable beam and the target beam. Suitable guiding and focusing electrodes 31, 32 and 33 are provided to direct the ions into the analyzer.
The analyzer and mass spectrometer are operated, in well understood fashion, to analyze the proportions of ions of various mass numbers in the particles directed into the analyzer 28. By this means, mass spectra are obtained showing the cracking patterns resulting from contact of the hot metastable particles with the target stream.
In a preferred form of operation, helium, neon or argon is injected into the tube 11, and accelerated by the field produced by the generator 15 to an energy well above 0.2
electron volt, for example, 39 electron volts. The resulting particles contact the rare gas molecules in the chamber 17 which, preferably and advantageously, are of the same composition as the gas fed to the tube 11. The particles undergo charge exchange with the neutral molecules in the chamber 17 and produce a beam of hot metastable particles which is collimated by the apertures 16, 24 an passes into the vessel 25. Here, the beam of hot metastable molecules contacts perpendicularly the target beam of particles to be analyzed which flow at thermal velocity from the source 27. lons are produced by the resulting collisions and these are directed into the analyzer 28 of the mass spectrometer, and the mass spectrum thereof is determined.
Metastable Ion Abundance.
Atom Helium Neon Argon Helium 0.2l 2.3 97.5 Neon l .5 3.7 94.8 Argon 1.] 5.0 93.9
The method and apparatus of the invention are also useful for obtaining the mass spectra of various hydrocarbons, such as butene-l, isobutylene, n-heptane, isobutane and 2,2,4- trimethylpentane. When bombarded with hot mestable particles of helium, neon, argon and krypton, different cracking patterns containing ions of lower mass numbers are produced than where the target material is contacted with metastable particles having thermal velocities. Accordingly, by the method and apparatus of the invention, we are able to substantially extend the study of Penning ionization phenomena. It is an additional feature of the invention that the same apparatus can be utilized for the study of beams of thermal metastable particles simply by adjusting the field direction of the generator or by changing the concentration of rare gas in the chamber 17. Finally, in many cases, our invention is useful in providing ion sources for mass spectroscopic analyses.
We claim:
1. A method for detecting the mass of components in a gas sample which comprises impressing an alternating electric field upon a stream of rare gas ions to increase the kinetic energy thereof, contacting the resultant gas stream with neutral rare gas to produce a high energy beam of metastable rare gas ions directing said beam perpendicularly into contact with a target beam of said sample gas moving at thermal velocities, applying an electrical field to the zone of contact to deflect ions produced by such contact, and detecting the mass of the deflected ions.
2. The method of claim 1 wherein the pressure of the rare gas subjected to the alternating electric field is SXlO to 5 millimeters of mercury and the pressure of the neutral rare gas is l0 to 10 millimeters of mercury.
3. The method of claim 1 wherein the rare gas ions are selected from the group consisting of helium, neon, argon, krypton, xenon and radon, and the target beam is a hydrocarbon gas.
4. Apparatus for investigating the mass of components in a gas stream which comprises, in combination, a tube of insulating material, means for evacuating said tube, a source of rare gas ions connected to one end of said tube, a pair of electrodes disposed around said tube, a radio frequency generator connected to said electrodes, a chamber containing rare gas molecules at low pressure, a vacuum vessel, said chamber having an aperture therein communicating with the other end of said tube and a larger aperture communicating with said vessel, said apertures being coaxial with said tube, a capillary source in said vessel arranged to efl'use a gas sample thereinto perpendicular to the extended axis of said tube, a mass spectrometer having an analyzer disposed in said vessel, and means for directing ions produced in said vessel into said analyzer.
5. In the apparatus of claim 4, a pair of deflecting electrodes in said chamber, and means for applying an electric potential to said electrodes to deflect ions and electrons away from said larger aperture.
6. The apparatus of claim 5 wherein the capillary source is an array of fused glass capillaries coaxially arranged to discharge said gas sample into said vacuum vessel.
7. In the apparatus of claim 6, means for varying the direction of the electric field vector produced by said electrodes.
8. The apparatus of claim 7 wherein the mass spectrometer is of the quadrupole type.
UNITED 'STATES m'rm'r OFFICE CERTIFICATE OF coamacnon itent Noe 3,619,605 Da November 9, 1971 Charles F. Cook et a1.
It is certified that errer appears in the above-identified patent and that said atters Patent are hereby corrected as shown below:
age 1, ABSTRACT, line 3, delete "of charged" and insert with neutral iolumn 1, line 26, Delete 10 and insert 10- olumn 2, line 9, delete "now and insert not line 11, delete 10 and insert 10" line 15, delete "10 to 10 and insert 10- to 10' T1.
line 55, delete now" and insert not olumn 3, line 7, delete "a.n and insert and olumn 1+, line 9, after ions" insert a comma and insert 1O" line 15, delete lO line 17, delete 10 to 10 and insert 10' to 10' Signed and sealed this 6th day of June 1972.
(SEAL) Attest:
EDWARD M.FLETCHER,JR. ROBERT GOTISCHALK Attesting Officer Commissioner of Patents

Claims (7)

  1. 2. The method of claim 1 wherein the pressure of the rare gas subjected to the alternating electric field is 5 X 10 2 to 5 millimeters of mercury and the pressure of the neutral rare gas is 10 1 to 10 3 millimeters of mercury.
  2. 3. The method of claim 1 wherein the rare gas ions are selected from the group consisting of helium, neon, argon, krypton, xenon and radon, and the target beam is a hydrocarbon gas.
  3. 4. Apparatus for investigating the mass of components in a gas stream which comprises, in combination, a tube of insulating material, means for evacuating said tube, a source of rare gas ions connected to one end of said tube, a pair of electrodes disposed around said tube, a radio frequency generator connected to said electrodes, a chamber containing rare gas molecules at low pressure, a vacuum vessel, said chamber having an aperture therein communicating with the other end of said tube and a larger aperture communicating with said vessel, said apertures being coaxial with said tube, a capillary source in said vessel arranged to effuse a gas sample thereinto perpendicular to the extended axis of said tube, a mass spectrometer having an analyzer disposed in said vessel, and means for directing ions produced in said vessel into said analyzer.
  4. 5. In the apparatus of claim 4, a pair of deflecting electrodes in said chamber, and means for applying an electric potential to said electrodes to deflect ions and electrons away from said larger aperture.
  5. 6. The apparatus of claim 5 wherein the capillary source is an array of fused glass capillaries coaxially arranged to discharge said gas sample into said vacuum vessel.
  6. 7. In the apparatus of claim 6, means for varying the direction of the electric field vector produced by said electrodes.
  7. 8. The apparatus of claim 7 wherein the mass spectrometer is of the quadrupole type.
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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620095A (en) * 1984-01-18 1986-10-28 Miziolek Andrzej W Ion neutralization resonance emission elemental detector
US5192865A (en) * 1992-01-14 1993-03-09 Cetac Technologies Inc. Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems
US6124675A (en) * 1998-06-01 2000-09-26 University Of Montreal Metastable atom bombardment source
WO2002044683A2 (en) * 2000-11-28 2002-06-06 Universite De Montreal Time-of-flight bacteria analyser using metastable source ionization
US6495823B1 (en) 1999-07-21 2002-12-17 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US20030052263A1 (en) * 2001-06-30 2003-03-20 Sionex Corporation System for collection of data and identification of unknown ion species in an electric field
US20030070913A1 (en) * 2001-08-08 2003-04-17 Sionex Corporation Capacitive discharge plasma ion source
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US20040182702A1 (en) * 2003-03-21 2004-09-23 Roman Chistyakov Plasma generation using multi-step ionization
US6806652B1 (en) 2003-04-22 2004-10-19 Zond, Inc. High-density plasma source using excited atoms
US6806463B2 (en) 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6815669B1 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US6815668B2 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US20040222745A1 (en) * 2003-05-06 2004-11-11 Zond, Inc. Generation of Uniformly-Distributed Plasma
US20050092914A1 (en) * 2002-10-12 2005-05-05 Sionex Corporation NOx monitor using differential mobility spectrometry
US20050156107A1 (en) * 2002-04-12 2005-07-21 Miller Raanan A. Method and apparatus for control of mobility-based ion species identification
US20050173629A1 (en) * 2001-06-30 2005-08-11 Miller Raanan A. Methods and apparatus for enhanced sample identification based on combined analytical techniques
US7091481B2 (en) 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US20060222562A1 (en) * 2004-12-03 2006-10-05 Sionex Corporation Method and apparatus for enhanced ion based sample filtering and detection
US7122794B1 (en) 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
US7579589B2 (en) 2005-07-26 2009-08-25 Sionex Corporation Ultra compact ion mobility based analyzer apparatus, method, and system
US7619214B2 (en) 1999-07-21 2009-11-17 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US8217344B2 (en) 2007-02-01 2012-07-10 Dh Technologies Development Pte. Ltd. Differential mobility spectrometer pre-filter assembly for a mass spectrometer

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US2939952A (en) * 1953-12-24 1960-06-07 Paul Apparatus for separating charged particles of different specific charges
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US2653620A (en) * 1949-01-04 1953-09-29 Phillips Petroleum Co Process and means for regulating the gas pressure in containers
US2699505A (en) * 1952-09-24 1955-01-11 Gen Electric Mass spectrometry
US2939952A (en) * 1953-12-24 1960-06-07 Paul Apparatus for separating charged particles of different specific charges
US3254209A (en) * 1962-11-29 1966-05-31 Gen Dynamics Corp Method and apparatus for increasing the ionization of impurity ions in a mass spectrometer

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620095A (en) * 1984-01-18 1986-10-28 Miziolek Andrzej W Ion neutralization resonance emission elemental detector
US5192865A (en) * 1992-01-14 1993-03-09 Cetac Technologies Inc. Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems
US6661178B1 (en) 1998-06-01 2003-12-09 Universite De Montreal Metastable atom bombardment source
US6124675A (en) * 1998-06-01 2000-09-26 University Of Montreal Metastable atom bombardment source
US7547879B2 (en) 1999-07-21 2009-06-16 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US6815669B1 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US7211791B2 (en) 1999-07-21 2007-05-01 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US20070084999A1 (en) * 1999-07-21 2007-04-19 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US7365316B2 (en) 1999-07-21 2008-04-29 The Charles Stark Draper Laboratory Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US7176453B2 (en) 1999-07-21 2007-02-13 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US7619214B2 (en) 1999-07-21 2009-11-17 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
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