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US3098483A - Two-compartment hypodermic syringe for separate storing of more components - Google Patents

Two-compartment hypodermic syringe for separate storing of more components Download PDF

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Publication number
US3098483A
US3098483A US163354A US16335461A US3098483A US 3098483 A US3098483 A US 3098483A US 163354 A US163354 A US 163354A US 16335461 A US16335461 A US 16335461A US 3098483 A US3098483 A US 3098483A
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Prior art keywords
piston
partition
needle
hypodermic
immovable
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US163354A
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Nielsen Helmuth
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Leo Pharma AS
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Leo Pharmaceutical Products Ltd AS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • the injection liquid is poured into a cylindrical container and sealed with a partially perforated stopple which forms a leak-tight piston inside the cylindrical container, and which is provided with a connecting hub for the mounting of a hypodermic needle.
  • the cylindrical container may be extended beyond the piston, e.g. by means of a sealed cap which encases the connecting hub and which must be removed prior to the mounting of the hypodermic needle.
  • the piston in the cylindrical container consists of a body provided with a central bore in which a tubular needle, pointed at both ends, is slidingly mounted, the bore at the end facing the injection liquid being sealed by a partition which can be pierced by the tubular needle being pushed in axial direction, and when the piston with the tubular needle in the above-mentioned position subsequently is pulled into the container, the injection liquid is forced out through the tubular needle.
  • hypodermic ampoules too, may be provided with a cap protecting the tubular needle and keeping it sterile until the hypodermic ampoule is to be employed, but they have the defect that the cap must be removed before it is possible to get the tubular needle into position for the piercing of the sealing partition of the piston.
  • injection preparations are instable when ready-made in the form of injectable solutions and are consequently treated in more, preferably two containers, the contents of which must be mixed shortly before use.
  • This is the case with a number of preparations which will only keep dry, e.g. crystalline or freeze-dried state and which immediately before use must be dissolved or suspended in a solvent or a suspension agent, possibly one which provides the preparation with a pH value by which it will only keep for a limited length of time.
  • a solvent or a suspension agent possibly one which provides the preparation with a pH value by which it will only keep for a limited length of time.
  • the medical profession is faced with the necessity of preparing their own injection preparation by mixing the two components of the injection preparation.
  • the drug is commonly sold in separate ampoules each containing one of the sterile components in question of the finished preparation, of which components at least one must be liquid; the ampoules are generally closed by means of a membrane which can be pierced by means of the hypodermic needle inserted in the hypodermic syringe.
  • the partition is in some cases given the shape of a stopple in which a special marked spot is sutficiently thin or soft to permit piercing, whereas the other part of the stopple is of a thicker or a more resistant material.
  • the medicament is used in the following way: First the hypodermic needle is inserted into the one ampoule, the contents of which are liquid, and of which a measured quantity is sucked into the syringe. The hypodermic needle is then pulled out and inserted into the other ampoule into which the contents of the syringe are ejected, whereupon the hypodermic needle, if necessary, is pulled out again to permit shaking of the ampoule so that an adequate mixing, dissolution or suspension can take place. Finally, the hypodermic needle is inserted into the latter ampoule again, and the desired quantity of the mixture is sucked into the syringe in order to be injected into the patient.
  • ampoules each having two compartments separated by a partition when stored, and the contents of which can be mixed either by removal of the partition so that the mixing can take place in the combined compartments; or by a hypodermic needle mounted on a hypodermic syringe being inserted into the ampoule through its cover and sucking up the contents of one of the compartments of the ampoule, whereupon the needle is inserted into the other compartment of the ampoule, which serves as a mixing compartment, and sucks up liquid there.
  • the ready-made preparation must, as in cases where separate ampoules are employed for each of the components, be sucked out of the mixing compartment and into the syringe from which it is injected into the patient.
  • the two-compartment ampoules in which the contents are mixed after the removal of the partition have the defect that it is difiicult to make the removable partition leaktight, and consequently the preparation will often prove to have been more or less damaged during the storing and must therefore be discarded.
  • the two-compartment ampoules, however, which in connection with the mixing of the components necessitate the sucking into the syringe from one of the compartments do not offer any substantial advantages over the use of individual ampoules for each of the components.
  • this invention relates to a hypodermic syringe with individual compartments for the storing of the components of the injection preparation, the mixing taking place through one operation, and the injection through another subsequent operation with the same, as a syringe constructed apparatus without another hypodermic syringe being employed at any time.
  • the syringe constructed as :a hypodermic ampoule can be discarded when the medicament contained in its ampoule compartment has been used.
  • FIGURE 1 is a longitudinal cross-section through one form of the invention.
  • FIGURES Q to 4 are longitudinal cross sections through modified forms of the invention.
  • the hypodermic syringe of the present invention is characterized in that the syringe has two cylindric compartments separated by :apartition which can be pierced, each of the said cylindric compartments being provided with a piston movable towards the partition, one of said pistons carrying a needle the free end of which points against the partition, whereas the other piston is provided with a hypodermic needle, the canal of which is connected with the other cylindric compartment through the piston accesss or with a connecting tube adapted to connect an injection needle to the cylindric compartment in question and to secure it to the syringe in injection position.
  • the needle intended for piercing the partition is preferably only very slightly shorter than the distance between the piston and the partition in the cylindric compartment in which it is housed.
  • the needle intended to pierce the partition is tubular and provided with an aperture which will permit transfer of the liquid component through the needle from one compartment to the other after the needle has pierced the partition.
  • the partition consists of, e.g. a rubber membrane or a membrane of a similar elastic material which when pierced fits close tothe piercing agent and prevents any substantial leaking out of the liquid through the perforation.
  • the needle intended for piercing the partition is movable in the axial direction of the cylindric compartment and is provided with an extension preferably having a sectional :area larger that of the needle, the extension being mounted in a tightfitting central bore in the piston and the operating rod connected with the piston, and provided with an operatnig plate extending beyond the operating rod.
  • the partition is of a nonelastic material, e.g. aluminium foil, which after piercing by the needle will permit the liquid to move Without hindrance along the needle.
  • a pressure on the operating plate will push the needle towards the partition, and through it, whereupon the operating plate will be forced against the operating rod which will then push the piston towards the partition and force the liquid into the adjacent compartment.
  • the sectional area of the needle is smaller than that of the extension, it is furthermore possible to mount the piston in the liquid-containing compartment of the ampoule close to the surface of the liquid, i.e. without any substantial air space between piston and liquid, as the needle, having a smaller sectional area than the bore, can be inserted in the operating rod without a pressure above the atmosphere in the liquid-containing compartment, the thickened extension of the needle acting as an adequate seal when inserted.
  • a case for the protection of the hypodermic needle or device for the mounting of a hypodermic needle is attached to the inner wall of the latter cylindric compartment or supported by the said wall or connected with the edge of the piston end of the said wall.
  • the hypodermic needle or the device for the mounting of such a needle being sterile when leaving the factory, will remain sterile.
  • the said protecting case remains untouched in its position during the transfer of the injection component from the first compartment to the other as well as during the process of mixing. Only when the mixing is completed and the injection is to be made into the patient, it will be necessary to remove the protecting case.
  • the walls of both cylindric compartments may furthermore be mutually connected or integrally moulded with the wall of the protecting case so that they form a tube in which the piston, carrying the hypodermic needle or the device for the mounting of such a needle, is inserted to such a depth that the said hypodermic needle or device is completely encased in the space formed by the tube.
  • the stationary partition is mounted in the same barrel, and at a suitable distance from the partition the other piston is mounted. Consequently, the hypodermic syringe with ampoule compartments and protecting case will form a whole, inside which sterile conditions prevail.
  • the tube may be sealed by a wall moulded integrally with the wall of the tube or by a cover which can be sterilized.
  • a wall moulded integrally with the wall of the tube or by a cover which can be sterilized.
  • the drawings show in sections (the various embodiments of the hypodermic syringe according to the present invention.
  • a tube 1 one end of which is sealed by means of a barrel plate 2, two pistons 3 and 4 tightly fitting against the barrel wall, and a partition 5, also tightly fitting against the barrel wall and fixed on it, are mounted.
  • the piston 3 has in the construction shown a connecting piece 6 with a through-canal 7, (the piston end of which has an enlarged section 8.
  • the free end g of the connecting piece 6 is cone-shaped, thus making it suitable for the mounting of a hypodermic needle holder not shown in the illustration, and, if desired, is provided with a flange or handle for the impression of the piston during the injection.
  • the piston 3 is mounted at a distance from the partition 5 which will allow for a suitable ampoule compartment 10 which may contain one of the injection components, if desired a powder component.
  • the partition 5 is provided with a central part which can be pierced by means of a tubular needle.
  • an ampoule compartment 12 which in essentials may be filled with a liquid injection component, eg. a solvent for the solid powdered drug in ampoule compartment 10.
  • the piston 4 is firmly and closely connected with a holder 13 which is provided with a pointed tubular'needle 14, the point of the needle facing and being close to that part of the partition 5 which can be pierced 11; besides,
  • the holder is provided with a suitable operating rod 16.
  • the syringe is used and operates as follows: Immediately or shortly before use the piston 4 is pressed to the right towards that part of the partition 5 which can be pierced Ill. The point of the tubular needle 14 will consequently pierce the partition, and a connection between the ampoule compartments l0 and 12 is established. By pressing the piston 4 further to the right, as shown in the figure, the contents of the ampoule compartment 12 is ejected into the ampoule compartment 10. The two components can now be mixed by shaking.
  • the said operation may be carried out by an assistant before the syringes prepared in this way are handed to the physician or the person who is going to perform the injection.
  • the part of the tube 1 which extends beyond the piston 3 is removed, which part forms a case protecting the throughcanal 7.
  • the tube may be provided with a groove making it possible to break or cut off the protecting case.
  • a hypodermic needle is then mount-ed on the cone 9, and the injection is performed by pressing the piston 3 back into the ampoule compartment 10. In this way the tubular needle 14 will fit into the enlarged section 8. After the injection the hypodermic needle is removed and sterilized, whereas the syringe is discarded.
  • the tube 1, the pistons, the partition, the connecting piece and the piston rod may be made of many different materials.
  • the tube may be made of glass in which case a glass file will be the adequate means for cutting off the part of the tube extending beyond the piston 3 before the syringe is used.
  • the pistons may be made of caoutchouc or a suitable plastic, erg. a polyvinyl material, and this also applies to the partition 5.
  • the connecting piece 6 may be of erg. polyethylene, and the piston rod of Plexiglas etc.
  • the tube 1 may also be of some plastic material. The choice of material, however, should be made with due regard to the possibilities of sterilization.
  • the essential advantage of using the syringe according to the present invention is that no outside air is sucked in through the canals of the hypodermic needle or the connecting piece at any time.
  • the filling of an ordinary hypodermic syringe with the liquid drom an ampoule will cause suction of a considerable quantity of outside air the moment the hypodermic needle is removed from the ampoule after the contents of the latter have been sucked into the hypodermic syringe, as a vacuum prevails during the suction operation, which vacuum is neutralized when the hypodermic needle is removed from the cover membrane of the ampoule.
  • the tube 1 ends close in front of (the ampotule compartment 10, and the foremost closed part of the tube 1 has been replaced by a cap 17 which preferably may be of a plastic which can easily be cut.
  • the cap 17 fits closely to the foremost part of the tube 1 and may be connected with the latter by welding or by means of an adhesive.
  • the material of the cap 17 must be strong enough to stand sterilizaiton by heating.
  • the tube 1 which preferably may also be of a plastic, is provided with a partition 19 integrally cast with the wall of the tube, the central part of the partition consisting of a thin membrane 20, which can be easily pierced by the tubular needle 14.
  • the foremost part of the tube 1 is shaped as a separate cap 17.
  • the tube 1 is limited to form the part which surrounds the ampoule compartment id, as the ampoule compartment 12 forms a separate, hindmost part 18 of the tube.
  • the tube 1 has at its backward-facing opening an inwardturning flange 22, and the pant 18 in its foremost section a similar flange 21.
  • the tube '1 and the part 18 are assembled in such a way that the two flanges abut on each other with an intermediary membrane 20 of e.g. caoutchouc, the flanges and the membrane (forming together a closely fitting partition of which the central part of the membrane is free and can be pierced by the tubular needle 14.
  • the partition 20 consists of a thin non-elastic membrane soldered to the wall of the barrel and provided with a hollow in which the point of the needle 27 rests.
  • the extension of the needle which has a larger sectional area than the needle proper is mounted in a tight-fitting central bore through the piston 25 and the operating rod 24 and extends beyond the operating rod in an operating plate 23.
  • the operating plate is mounted at such a distance from the top of the operating rod that a pressure on the tormer will push the needle so much forward that the partition 24) is pierced afite-r which a continued pressure will push the operating rod and the piston 25 against the partition and force the liquid contents into the adjacent container.
  • the device for the mounting of a hypodermic needle is in glge present embodiment provided with a protecting cap I claim:
  • Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition, and a piston inserted in each of said cylindric compartments so as to be tightly movable towards the immovable partition along the cylindric wall thereof, the piston inserted in one of the cylinders carrying a piercing needle extending into the space enclosed by the walls of the cylinder, the piston and the immovable partition and pointing towards the latter, and the one inserted in the other of said cylinders carrying a hypodermic needle the rear end of which is directed against the immovable partition and, the point of which is directed away from the immovable partition and the interior cavity of which is in connection with the space confined by the wall of the cylinder, the piston and the immovable partition.
  • Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition and a piston inserted in each of said cylindric compartments so as to be tightly movable along the cylindric wall thereof, the piston inserted in one of the cylinders carrying a piercing needle extending into the space enclosed by the walls of the cylinder, the piston and the immovable partition and pointing towards the latter, and the one inserted into the other of said cylinders carrying a connecting pipe adapted for connecting a hypodermic needle with said compartment and securing said needle to the syringe.
  • Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition and a piston inserted in each of said cylinders so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid piercing needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder carrying a hypodermic needle the rearward end of which is directed against the immovable partition and the point of which is directed away from the piston and the interior cavity of which is inconnection with the space confined by the walls of the cylinder, the piston and the partition,
  • hypodermic syringe as claimed in claim 7, in which the piercing needle pointing towards the partition and extending through one of the compartments is tubular and its interior cavity adjacent to the piston is connected to the interior space defined by the walls of the cylinder, the piston and the-immovable partition.
  • Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition, and a piston-inserted into each of the cylinders so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in'whioh a solid piercing'needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder carrying a connecting tubeadapted to connect the cavity of an injection needle with the interior of the compartment confined by the walls of the cylinder, the piston and the immovable partition and to fix the said injection needle in injection position to the syringe.
  • hypodermic syringe as claimed in claim 10, in which the extension of the piercing needle into the space enclosed has substantially the same length as the length of the cylinder between the piston and the immovable partition.
  • Syringe comprising a cylindric tubular body the interior cavity of which is divided into two parts by a fluid-tight immovable pierceable partition, a piston being inserted into each part so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid'piercing .needle is tightly fitttd so as to permit longitudinal shifting thereof, the part of the needle extending into the spacebetween the piston and the immovable partition pointing againstthe latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder'carrying a hypodermic needle the rear endof which is directed against the immovable partition and the point of which is directed away from the piston and the interior cavity of which is in connection with the space confined by the walls of the cylinder, the piston and the partition, the length of the tubular body being so .chosen that the hypodermic needle is protected in its entire'length by the part of the
  • Syringe comprising a cylindric tubular body the interior cavity of which is divided into two parts by a fluid-tight immovable pierceable partition, a piston being inserted into each part so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid piercing needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided wtih an operating plate, and the piston inserted into the other cylinder carrying aconnecting tube adapted to connect the cavity of an injection needle with the interior of the compartment confined by the walls of the cylinder, the piston and the immovable partition and to fix the said injection needle in injection position to the syringe, the length of the tubular body being so chosen that the connecting tube is protected in its entire length by the part of the wall of the body extending beyond the piston carrying said connecting tube when the piston is

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

July 23, 1963 H. NIELSEN 3,093,433
TWO-COMPARTMENT HYPODERMIC SYRINGE FOR SEPARATE STORING OF MORE COMPONENTS Filed Dec. 29, 1961 Fig. I
fist-nun! was United States Patent 3,698,483 TWO-COMPARTMENT HYPODERl HC SYRTNGE FGR SEPARATE STORING OF MQRE CGM- PONENTS Helmuth Nielsen, Herlev, Denmark, assignor to Lovens Kemiske Fahrik yet! A. Kongsted, a Danish firm Filed Dec. 29, 1961, Ser. No. 163,354 Claims priority, application Denmark .lan. 3, M61 16 (Jlaims. (Cl. 128-220) This invention relates to hypodermic syringes of the kind which are provided with compartments for the storing of the injection preparation. Such hypodermic syringes, also known as hypodermic ampoules are, in fact, well-known. In comparison with the ordinary ampoules they olfer considerable advantages; for instance, it is not necessary first to suck the injection liquid from an ampoule into the barrel of the hypodermic syringe prior to the injection, which transfer is complicated and time-Wasting and involves the danger of contamination or infection of the contents. This disadvantage may be considerably reduced by the use of a hypodermic ampoule which has been charged with the injection liquid under sterile conditions at the factory where the injection liquid was manufactured, and which may be discarded when the contents have been injected.
In certain well-known hypodermic ampoules the injection liquid is poured into a cylindrical container and sealed with a partially perforated stopple which forms a leak-tight piston inside the cylindrical container, and which is provided with a connecting hub for the mounting of a hypodermic needle. The cylindrical container may be extended beyond the piston, e.g. by means of a sealed cap which encases the connecting hub and which must be removed prior to the mounting of the hypodermic needle.
In other well-known hypodermic syringes the piston in the cylindrical container consists of a body provided with a central bore in which a tubular needle, pointed at both ends, is slidingly mounted, the bore at the end facing the injection liquid being sealed by a partition which can be pierced by the tubular needle being pushed in axial direction, and when the piston with the tubular needle in the above-mentioned position subsequently is pulled into the container, the injection liquid is forced out through the tubular needle. Such hypodermic ampoules, too, may be provided with a cap protecting the tubular needle and keeping it sterile until the hypodermic ampoule is to be employed, but they have the defect that the cap must be removed before it is possible to get the tubular needle into position for the piercing of the sealing partition of the piston.
Many injection preparations, however, are instable when ready-made in the form of injectable solutions and are consequently treated in more, preferably two containers, the contents of which must be mixed shortly before use. This, for instance, is the case with a number of preparations which will only keep dry, e.g. crystalline or freeze-dried state and which immediately before use must be dissolved or suspended in a solvent or a suspension agent, possibly one which provides the preparation with a pH value by which it will only keep for a limited length of time. In case of such pharmaceuticals being marketed in ampoules, the medical profession is faced with the necessity of preparing their own injection preparation by mixing the two components of the injection preparation. For this purpose the drug is commonly sold in separate ampoules each containing one of the sterile components in question of the finished preparation, of which components at least one must be liquid; the ampoules are generally closed by means of a membrane which can be pierced by means of the hypodermic needle inserted in the hypodermic syringe. In order to make it sufliciently strong without so much force being required for the piercing that the hypodermic needle is damaged, the partition is in some cases given the shape of a stopple in which a special marked spot is sutficiently thin or soft to permit piercing, whereas the other part of the stopple is of a thicker or a more resistant material. The medicament is used in the following way: First the hypodermic needle is inserted into the one ampoule, the contents of which are liquid, and of which a measured quantity is sucked into the syringe. The hypodermic needle is then pulled out and inserted into the other ampoule into which the contents of the syringe are ejected, whereupon the hypodermic needle, if necessary, is pulled out again to permit shaking of the ampoule so that an adequate mixing, dissolution or suspension can take place. Finally, the hypodermic needle is inserted into the latter ampoule again, and the desired quantity of the mixture is sucked into the syringe in order to be injected into the patient.
This method is even more complicated and offers an even greater risk of contamination or infection of the preparation than the method aforesaid which employs only one ampoule.
Consequently, a great number of ampoules have been suggested, each having two compartments separated by a partition when stored, and the contents of which can be mixed either by removal of the partition so that the mixing can take place in the combined compartments; or by a hypodermic needle mounted on a hypodermic syringe being inserted into the ampoule through its cover and sucking up the contents of one of the compartments of the ampoule, whereupon the needle is inserted into the other compartment of the ampoule, which serves as a mixing compartment, and sucks up liquid there. Finally, the ready-made preparation must, as in cases where separate ampoules are employed for each of the components, be sucked out of the mixing compartment and into the syringe from which it is injected into the patient.
The two-compartment ampoules in which the contents are mixed after the removal of the partition have the defect that it is difiicult to make the removable partition leaktight, and consequently the preparation will often prove to have been more or less damaged during the storing and must therefore be discarded. The two-compartment ampoules, however, which in connection with the mixing of the components necessitate the sucking into the syringe from one of the compartments do not offer any substantial advantages over the use of individual ampoules for each of the components. Consequently, this invention relates to a hypodermic syringe with individual compartments for the storing of the components of the injection preparation, the mixing taking place through one operation, and the injection through another subsequent operation with the same, as a syringe constructed apparatus without another hypodermic syringe being employed at any time. The syringe constructed as :a hypodermic ampoule can be discarded when the medicament contained in its ampoule compartment has been used.
In connection with the description of the invention given below, the drawing shows the following:
FIGURE 1 is a longitudinal cross-section through one form of the invention. FIGURES Q to 4 are longitudinal cross sections through modified forms of the invention.
The hypodermic syringe of the present invention is characterized in that the syringe has two cylindric compartments separated by :apartition which can be pierced, each of the said cylindric compartments being provided with a piston movable towards the partition, one of said pistons carrying a needle the free end of which points against the partition, whereas the other piston is provided with a hypodermic needle, the canal of which is connected with the other cylindric compartment through the piston accesss or with a connecting tube adapted to connect an injection needle to the cylindric compartment in question and to secure it to the syringe in injection position. By this it is possible to transfer the solid drug contained in the first barrel compartment to the other barrel compartment only by forcing the piston of the former towards the partition between the two compartments which is then pierced by the needle, establishing contact between the two compartments, whereupon the liquid, while the piston is forced further towards the pierced partition, is pressed into the other ampoule compartment without the hypodermic needle having been used or even touched. When mixed, the ready preparation is injected into the patient just by pressing down the other piston. In this way the handling of the hypodermic syringe is simple and quick, and the danger of infection which may arise if a hypodermic needle is inserted into one or the other of the ampoule compartments, has been eliminated.
The needle intended for piercing the partition is preferably only very slightly shorter than the distance between the piston and the partition in the cylindric compartment in which it is housed.
In one embodiment of the invention the needle intended to pierce the partition is tubular and provided with an aperture which will permit transfer of the liquid component through the needle from one compartment to the other after the needle has pierced the partition. This embodiment is particularly suitable if the partition consists of, e.g. a rubber membrane or a membrane of a similar elastic material which when pierced fits close tothe piercing agent and prevents any substantial leaking out of the liquid through the perforation.
In another embodiment of the invention the needle intended for piercing the partition is movable in the axial direction of the cylindric compartment and is provided with an extension preferably having a sectional :area larger that of the needle, the extension being mounted in a tightfitting central bore in the piston and the operating rod connected with the piston, and provided with an operatnig plate extending beyond the operating rod. This embodiment is particularly suitable if the partition is of a nonelastic material, e.g. aluminium foil, which after piercing by the needle will permit the liquid to move Without hindrance along the needle. In this embodiment a pressure on the operating plate will push the needle towards the partition, and through it, whereupon the operating plate will be forced against the operating rod which will then push the piston towards the partition and force the liquid into the adjacent compartment.
If the sectional area of the needle is smaller than that of the extension, it is furthermore possible to mount the piston in the liquid-containing compartment of the ampoule close to the surface of the liquid, i.e. without any substantial air space between piston and liquid, as the needle, having a smaller sectional area than the bore, can be inserted in the operating rod without a pressure above the atmosphere in the liquid-containing compartment, the thickened extension of the needle acting as an adequate seal when inserted.
According to a particularly appropriate embodiment of the invention, a case (for the protection of the hypodermic needle or device for the mounting of a hypodermic needle is attached to the inner wall of the latter cylindric compartment or supported by the said wall or connected with the edge of the piston end of the said wall. In this way it is possible to secure that the hypodermic needle or the device for the mounting of such a needle, being sterile when leaving the factory, will remain sterile. It is a special advantage that the said protecting case remains untouched in its position during the transfer of the injection component from the first compartment to the other as well as during the process of mixing. Only when the mixing is completed and the injection is to be made into the patient, it will be necessary to remove the protecting case.
According to the present invention the walls of both cylindric compartments may furthermore be mutually connected or integrally moulded with the wall of the protecting case so that they form a tube in which the piston, carrying the hypodermic needle or the device for the mounting of such a needle, is inserted to such a depth that the said hypodermic needle or device is completely encased in the space formed by the tube. At a suitable distance from the said piston the stationary partition is mounted in the same barrel, and at a suitable distance from the partition the other piston is mounted. Consequently, the hypodermic syringe with ampoule compartments and protecting case will form a whole, inside which sterile conditions prevail.
Beyond the point of [the hypodermic needle the tube may be sealed by a wall moulded integrally with the wall of the tube or by a cover which can be sterilized. In this way the hypodermic needle or the device for the mounting of such a needle is protected from damage and infection:
The drawings show in sections (the various embodiments of the hypodermic syringe according to the present invention. In a tube 1, one end of which is sealed by means of a barrel plate 2, two pistons 3 and 4 tightly fitting against the barrel wall, and a partition 5, also tightly fitting against the barrel wall and fixed on it, are mounted. The piston 3 has in the construction shown a connecting piece 6 with a through-canal 7, (the piston end of which has an enlarged section 8. The free end g of the connecting piece 6 is cone-shaped, thus making it suitable for the mounting of a hypodermic needle holder not shown in the illustration, and, if desired, is provided with a flange or handle for the impression of the piston during the injection. The piston 3 is mounted at a distance from the partition 5 which will allow for a suitable ampoule compartment 10 which may contain one of the injection components, if desired a powder component. The partition 5 is provided with a central part which can be pierced by means of a tubular needle. Between the partition 5 and the piston 4 is an ampoule compartment 12 which in essentials may be filled with a liquid injection component, eg. a solvent for the solid powdered drug in ampoule compartment 10. The piston 4 is firmly and closely connected with a holder 13 which is provided with a pointed tubular'needle 14, the point of the needle facing and being close to that part of the partition 5 which can be pierced 11; besides,
the holder is provided with a suitable operating rod 16.
The syringe is used and operates as follows: Immediately or shortly before use the piston 4 is pressed to the right towards that part of the partition 5 which can be pierced Ill. The point of the tubular needle 14 will consequently pierce the partition, and a connection between the ampoule compartments l0 and 12 is established. By pressing the piston 4 further to the right, as shown in the figure, the contents of the ampoule compartment 12 is ejected into the ampoule compartment 10. The two components can now be mixed by shaking.
If the syringe is used, e.g. in hospitals, the said operation may be carried out by an assistant before the syringes prepared in this way are handed to the physician or the person who is going to perform the injection.
When the injection is going to talce place, the part of the tube 1 which extends beyond the piston 3 is removed, which part forms a case protecting the throughcanal 7. In order to facilitate the removal the tube may be provided with a groove making it possible to break or cut off the protecting case. A hypodermic needle is then mount-ed on the cone 9, and the injection is performed by pressing the piston 3 back into the ampoule compartment 10. In this way the tubular needle 14 will fit into the enlarged section 8. After the injection the hypodermic needle is removed and sterilized, whereas the syringe is discarded.
The tube 1, the pistons, the partition, the connecting piece and the piston rod may be made of many different materials. The tube may be made of glass in which case a glass file will be the adequate means for cutting off the part of the tube extending beyond the piston 3 before the syringe is used. The pistons may be made of caoutchouc or a suitable plastic, erg. a polyvinyl material, and this also applies to the partition 5. The connecting piece 6 may be of erg. polyethylene, and the piston rod of Plexiglas etc. The tube 1 may also be of some plastic material. The choice of material, however, should be made with due regard to the possibilities of sterilization.
When filling the ampoule compartment 12 with a liquid injection component it must be taken into account that the piston 4 must be capable of being pressed so much forward that the tubular needle will pierce the partition 11 without any liquid leaking out. In most cases it is therefore necessary, when filling, to allow for a suitable air space. When the piston 4 is pressed towards the partition, an excess pressure will arise in the amponle compartment which excess pressure will be transmitted to the compartment between the piston 3 and the partition. Therefore, it is necessary during this operation to keep the syringe in a vertical position with the piston 3, pointing upwards to prevent any liquid leaking out through the canal 7. By cutting off the foremost part of the tube 1, the excess pressure arising from the movement of the piston 4 is neutralized, and will also cause air to escape through the canal 7. The essential advantage of using the syringe according to the present invention is that no outside air is sucked in through the canals of the hypodermic needle or the connecting piece at any time. Conversely, the filling of an ordinary hypodermic syringe with the liquid drom an ampoule will cause suction of a considerable quantity of outside air the moment the hypodermic needle is removed from the ampoule after the contents of the latter have been sucked into the hypodermic syringe, as a vacuum prevails during the suction operation, which vacuum is neutralized when the hypodermic needle is removed from the cover membrane of the ampoule.
In the embodiment of the present invention shown in FIG. 2, the tube 1 ends close in front of (the ampotule compartment 10, and the foremost closed part of the tube 1 has been replaced by a cap 17 which preferably may be of a plastic which can easily be cut. The cap 17 fits closely to the foremost part of the tube 1 and may be connected with the latter by welding or by means of an adhesive. The material of the cap 17 must be strong enough to stand sterilizaiton by heating. Furthermore, the tube 1 which preferably may also be of a plastic, is provided with a partition 19 integrally cast with the wall of the tube, the central part of the partition consisting of a thin membrane 20, which can be easily pierced by the tubular needle 14.
Also in the embodiment of the present invention shown in FIG. 3 the foremost part of the tube 1 is shaped as a separate cap 17. In this embodiment, however, the tube 1 is limited to form the part which surrounds the ampoule compartment id, as the ampoule compartment 12 forms a separate, hindmost part 18 of the tube. The tube 1 has at its backward-facing opening an inwardturning flange 22, and the pant 18 in its foremost section a similar flange 21. The tube '1 and the part 18 are assembled in such a way that the two flanges abut on each other with an intermediary membrane 20 of e.g. caoutchouc, the flanges and the membrane (forming together a closely fitting partition of which the central part of the membrane is free and can be pierced by the tubular needle 14.
In the embodiment shown in FIG. 4 the partition 20 consists of a thin non-elastic membrane soldered to the wall of the barrel and provided with a hollow in which the point of the needle 27 rests. The extension of the needle which has a larger sectional area than the needle proper is mounted in a tight-fitting central bore through the piston 25 and the operating rod 24 and extends beyond the operating rod in an operating plate 23. The operating plate is mounted at such a distance from the top of the operating rod that a pressure on the tormer will push the needle so much forward that the partition 24) is pierced afite-r which a continued pressure will push the operating rod and the piston 25 against the partition and force the liquid contents into the adjacent container. The device for the mounting of a hypodermic needle is in glge present embodiment provided with a protecting cap I claim:
=1. Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition, and a piston inserted in each of said cylindric compartments so as to be tightly movable towards the immovable partition along the cylindric wall thereof, the piston inserted in one of the cylinders carrying a piercing needle extending into the space enclosed by the walls of the cylinder, the piston and the immovable partition and pointing towards the latter, and the one inserted in the other of said cylinders carrying a hypodermic needle the rear end of which is directed against the immovable partition and, the point of which is directed away from the immovable partition and the interior cavity of which is in connection with the space confined by the wall of the cylinder, the piston and the immovable partition.
2. Syringe as claimed in claim 1, in which the extension of the piercing needle into the space enclosed has substantially the same length as the length of the cylinder between the piston and the immovable partition.
3. Syringe as claimed in claim 1, in which the piercing needle pointing towards the partition and extending through one of the compartments is tubular and its interior cavity adjacent to the piston is connected to the interior space defined by the walls of the cylinder, the piston and the immovable partition.
4. Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition and a piston inserted in each of said cylindric compartments so as to be tightly movable along the cylindric wall thereof, the piston inserted in one of the cylinders carrying a piercing needle extending into the space enclosed by the walls of the cylinder, the piston and the immovable partition and pointing towards the latter, and the one inserted into the other of said cylinders carrying a connecting pipe adapted for connecting a hypodermic needle with said compartment and securing said needle to the syringe.
5. Syringe as claimed in claim 4, in which the extension of'the piercing needle into the space enclosed has substantially the same length as the length of the cylinder between the piston and the immovable partition.
6. Syringe as claimed in claim 4, in which the piercing needle pointing towards the partition and extending through one of the compartments is tubular and its interior cavity adjacent to the piston is connected to the interior space defined by the walls of the cylinder, the piston and the immovable partition.
7. Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition and a piston inserted in each of said cylinders so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid piercing needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder carrying a hypodermic needle the rearward end of which is directed against the immovable partition and the point of which is directed away from the piston and the interior cavity of which is inconnection with the space confined by the walls of the cylinder, the piston and the partition,
8. Hypodermic syringe according toclaim 7, in which the extension of the piercing needle into the space enclosed has substantially the same length as the length of the cylinder between the piston and the immovable partition. I
9. Hypodermic syringe as claimed in claim 7, in which the piercing needle pointing towards the partition and extending through one of the compartments is tubular and its interior cavity adjacent to the piston is connected to the interior space defined by the walls of the cylinder, the piston and the-immovable partition.
10. Hypodermic syringe comprising two cylindric compartments placed in aligned coaxial relation to each other and separated by an immovable pierceable partition, and a piston-inserted into each of the cylinders so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in'whioh a solid piercing'needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder carrying a connecting tubeadapted to connect the cavity of an injection needle with the interior of the compartment confined by the walls of the cylinder, the piston and the immovable partition and to fix the said injection needle in injection position to the syringe.
ll. Hypodermic syringe as claimed in claim 10, in which the extension of the piercing needle into the space enclosed has substantially the same length as the length of the cylinder between the piston and the immovable partition.
12. Hypodermic syrings as claimed in claim 10, [in which the piercing needle pointing towards the partition and-extending through one of the compartments is tubular and its interior cavity adjacent to the piston is connected to the interior space defined by the walls of the cylinder, the piston and the immovable partition.
'13. Syringe comprising a cylindric tubular body the interior cavity of which is divided into two parts by a fluid-tight immovable pierceable partition, a piston being inserted into each part so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid'piercing .needle is tightly fitttd so as to permit longitudinal shifting thereof, the part of the needle extending into the spacebetween the piston and the immovable partition pointing againstthe latter and the other end being provided with an operating plate, and the piston inserted into the other cylinder'carrying a hypodermic needle the rear endof which is directed against the immovable partition and the point of which is directed away from the piston and the interior cavity of which is in connection with the space confined by the walls of the cylinder, the piston and the partition, the length of the tubular body being so .chosen that the hypodermic needle is protected in its entire'length by the part of the wall of the body extending beyond the piston carrying said hypodermic needle when the piston is inserted to a distance from the partition, leaving adequate space .for mixing the contents of the two compartments.
14. Hypodermic syringe as claimed in claim 13, in which the part of the tubular body extending beyond the piston carrying the hypodermic needle is closed at its free end.
15. Hypodermic syringe as claimed in claim 13, in which the part of the tubular body extending beyond the piston carrying the hypodermic needle is provided with a lid of a material capable of being sterilized.
16. Syringe comprising a cylindric tubular body the interior cavity of which is divided into two parts by a fluid-tight immovable pierceable partition, a piston being inserted into each part so as to be tightly movable along the cylindric wall thereof, the piston inserted into one of said cylinders having an axial bore in which a solid piercing needle is tightly fitted so as to permit longitudinal shifting thereof, the part of the needle extending into the space between the piston and the immovable partition pointing against the latter and the other end being provided wtih an operating plate, and the piston inserted into the other cylinder carrying aconnecting tube adapted to connect the cavity of an injection needle with the interior of the compartment confined by the walls of the cylinder, the piston and the immovable partition and to fix the said injection needle in injection position to the syringe, the length of the tubular body being so chosen that the connecting tube is protected in its entire length by the part of the wall of the body extending beyond the piston carrying said connecting tube when the piston is inserted to a distance from the immovable partition leaving adequate space for the mixing of the contents of the two compartments.
References Cited in the file of this patent UNITED STATES PATENTS 2,159,217 Lozier et a1 May 23, 1939 2,266,998 Smith Dec. 23, 194-1 2,408,323 Lockhart Sept. 24, 1946 2,567,001 Watson Sept. 4, 1951 2,590,900 Sommerstein Apr. 1, 1952 2,604,095 Brody July 22, 1952 FOREIGN PATENTS 1,224,324 France Feb. 8, 1960

Claims (1)

1. HYPODERMIC SYRINGE COMPRISING TWO CYLINDRIC COMPARTMENTS PLACED IN ALIGNED COAXIAL RELATION TO EACH OTHER AND SEPARATED BY AN IMMOVABLE PIERCEABLE PARTITION, AND A PISTON INSERTED IN EACH OF SAID CYLINDRIC COMPARTMENTS SO AS TO BE TIGHTLY MOVABLE TOWARDS THE IMMOVABLE PARTITION ALONG THE CYLINDRICAL WALL THEREOF, THE PISTON INSERTED IN ONE OF THE CYLINDERS CARRYING A PIERCING NEEDLE EXTENDING INTO THE SPACE ENCLOSED BY THE WALLS OF THE CYLINDER, THE PISTON AND THE IMMOVABLE PARTITION AND POINTING TOWARDS THE LATTER, AND THE ONE INSERTED IN THE OTHER OF SAID CYLINDERS CARRYING A HYPODERMIC NEEDLE THE REAR END OF WHICH IS DIRECTED AGAINST THE IMMOVABLE PARTITION AND, THE POINT OF WHICH IS DIRECTED AWAY FROM THE IMMOVABLE PARTITION AND THE INTERIOR CAVITY OF WHICH IS IN CONNECTION WITH THE SPACE CONFINED BY THE WALL OF THE CYLINDER, THE PISTON, AND THE IMMOVABLE PARTITION.
US163354A 1961-01-03 1961-12-29 Two-compartment hypodermic syringe for separate storing of more components Expired - Lifetime US3098483A (en)

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DK1061AA DK97661C (en) 1961-01-03 1961-01-03 Syringe with two cylindrical chambers.

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US3237815A (en) * 1964-06-05 1966-03-01 V P P Inc Universal plunger
US3828775A (en) * 1969-02-06 1974-08-13 Iso Nuclear Corp Self-packaged hypodermic syringe
WO1991003224A1 (en) * 1989-08-30 1991-03-21 Polak Robert B Medicament container/dispenser assembly
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
WO2005084819A2 (en) * 2004-02-27 2005-09-15 3M Espe Ag Dose delivery system

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US3494352A (en) * 1969-03-26 1970-02-10 Becton Dickinson Co Apparatus for taking multiple samples
FR2315954A1 (en) * 1975-07-04 1977-01-28 Chibret Laboratoires Syringe for storing and mixing two medicaments - administrating the reconstituted mixt.
US4340056A (en) * 1981-02-02 1982-07-20 The Franklin Institute Non-air-entraining mixer/dispenser
CN110934745B (en) * 2019-12-23 2022-04-22 重庆市潼南区中医院 Safe and rapid medicine preparation injector

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US2266998A (en) * 1939-05-22 1941-12-23 Arthur E Smith Side loading syringe
US2408323A (en) * 1943-06-10 1946-09-24 Margaret L Lockhart Hypodermic syringe
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FR1224324A (en) * 1959-02-25 1960-06-23 Rota App & Maschb Dr Hennig Injection ampoules

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US2591046A (en) * 1948-10-18 1952-04-01 Frederick M Turnbull Hypodermic syringe assembly
US2907329A (en) * 1955-01-26 1959-10-06 Milton J Cohen Hypodermic syringe
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US2896602A (en) * 1957-03-12 1959-07-28 Borg Warner Fuel injection system

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US2159217A (en) * 1937-11-05 1939-05-23 Cook Lab Inc Controllable transfer element for multiple ampules
US2266998A (en) * 1939-05-22 1941-12-23 Arthur E Smith Side loading syringe
US2408323A (en) * 1943-06-10 1946-09-24 Margaret L Lockhart Hypodermic syringe
US2604095A (en) * 1948-12-18 1952-07-22 Brody Nathan Disposable syringe
US2590900A (en) * 1949-03-23 1952-04-01 Sommerstein Cwi Ampoule
US2567001A (en) * 1950-02-06 1951-09-04 Thomas E Watson Hypodermic syringe
FR1224324A (en) * 1959-02-25 1960-06-23 Rota App & Maschb Dr Hennig Injection ampoules

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US3237815A (en) * 1964-06-05 1966-03-01 V P P Inc Universal plunger
US3828775A (en) * 1969-02-06 1974-08-13 Iso Nuclear Corp Self-packaged hypodermic syringe
WO1991003224A1 (en) * 1989-08-30 1991-03-21 Polak Robert B Medicament container/dispenser assembly
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
WO2005084819A2 (en) * 2004-02-27 2005-09-15 3M Espe Ag Dose delivery system
WO2005084819A3 (en) * 2004-02-27 2006-01-12 3M Espe Ag Dose delivery system
US20080227052A1 (en) * 2004-02-27 2008-09-18 Marc Peuker Dose Delivery System
US8292619B2 (en) 2004-02-27 2012-10-23 3M Deutschland Gmbh Dose delivery system

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DK97661C (en) 1964-01-06
GB920604A (en) 1963-03-13
DE1254825B (en) 1967-11-23
FR1309044A (en) 1962-11-09

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