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US2776924A - Composition of matter containing polyvinylpyrrolidone and a fatty carrier - Google Patents

Composition of matter containing polyvinylpyrrolidone and a fatty carrier Download PDF

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Publication number
US2776924A
US2776924A US408600A US40860054A US2776924A US 2776924 A US2776924 A US 2776924A US 408600 A US408600 A US 408600A US 40860054 A US40860054 A US 40860054A US 2776924 A US2776924 A US 2776924A
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fatty
polyvinylpyrrolidone
composition
carrier
matter
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US408600A
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Jean R L Martin
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Coty Inc
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Coty Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Definitions

  • This invention relates to compositions of matter containing polyvinylpyrrolidone and more specifically, compositions including polyvinylpyrrolidone homogeneously dissolved in a carrier of a fatty or oily nature.
  • Polyvinylpyrrolidone (l-vinyl-2-pyrrolidone polymer) is a white powder which is readily soluble in water and certain organic solvents but is normally insoluble in fatty or oily carriers.
  • polyvinylpyr-rolidone has a number of important properties, particularly in the therapeutic field, it is im portant that the polyvinylpyrrolidone be made compatible with as many different types of solvents and carriers, as possible.
  • polyvinylpyrrolidone may detoxify therapeutic agents which are more or less toxic in charactor and also has the property of prolonging the eifective period of many drugs and anaesthetics.
  • one object of this invent-ion is to provide a composition of matter including a carrier of a fatty or oily nature and polyvinylpyrrolidone homogeneously dissolved in said carrier by means of a compound having a common solvent action with respect :0 the base and the polyvinylpyrrolidone.
  • Another object of this invention is to provide a composition of matter including a physiologically active agent which normally has an irritating effect when applied to the epidermis or mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of said agent, all homogeneously distributed in a fatty carrier by means of a common solvent.
  • Yet another object of this invention is to provide a composition of matter including a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
  • a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes
  • polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
  • Still another object of this invention is to provide a composition of matter in powder form applicable to the epidemis or mucous membranes and including an active agent which is normally irritating with respect to the epidermis or mucous membranes, wherein the active agent together with polyvinylpyrrolidone is dissolved in a fat or oil carrier by means of a common solvent, the solution being combined with an inert powdered carrier to form a powdered material free of the undesirable properties of the active agent.
  • polyvinylpyrrolidone may be dissolved in fatty or oil carriers and waxes of animal, vegetable or mineral origin, in their normal state or in hydrogenated form, such .as lanolin, lard, mineral oil, cottonseed oil, castor oil, cocoa butter, beeswax, carnauba wax, ozokerite and the like, through the use of fatty acids or fatty alcohols.
  • physiologically active agents Whose normally adverse physiological properties may be inhibited by the addition thereto of polyvinylpyrrolidone, such as iodine, salicylic acid or the like, may be uniformly dis- 2,776,924 Patented Jan. 8, 1957 i 2 tributed in a fatty carrier by the use 'of fatty acids or fatty alcohols, for application to the epidermis ormucous membranes and free of undesirable effects relative thereto.
  • polyvinylpyrrolidone such as iodine, salicylic acid or the like
  • Example 1 E xamp le 2 0.2 gram of iodine in methyl alcohol was combined with 2 grams of polyvinylpyrrol-idon'e and 8 grams of oleyl alcohol and dissolved in 19.8 grams of mineral oil to give a homogeneous solution.
  • the mineral .oil may be replaced by a lanolin carrier and the proportion of iodine used may be varied to give any desired concentration in the 'fatty carrier.
  • Example 3 2.0 grams :of polyvinylpyrrolidone .was added to 8.0 grams of palmitic acid to form a homogeneous mass. 30.0 grams of castor oil was added to the mass and produced a clear solution. The castor oil can be replaced by cottonseed oil or hydrogenated cottonseed oil.
  • Example 4 A solution of iodine and polyvinylpyrrolidone in a mineral oil carrier, as set forth in Example 1, was combined with an inert powdered material such as talc until the solid particles were well saturated with the solution yet provided a freely flowing powder.
  • the resultant powder can be readily applied to the human skin for therapeutic purposes without danger of irritation.
  • Other inert materials such as china clay, or the like may replace the talc as a carrier for the iatty solution of poly- 'vinylpym'olidone and iodine.
  • polyvinylpyrrolidone may also be readily dissolved in various fatty or oily carriers as well as waxes, of animal, vegetable or mineral origin, including cottonseed oil, olive oil, cocoa butter, beeswax, ozokerite or the like, as well as hydrogenated forms thereof, by means of fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
  • fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
  • oily and waxy materials which may be of animal, mineral :or vegetable origin shall be deemed the substantial equivalent of the water insoluble, fat soluble fatty alcohols and acids previously described, for use in the compositions of the instant invention.
  • composition of matter consistingessentia'lly of a homogeneous solution of .polyvinylpyrrolidone, a fatty carrier and a compound selected from the group consistingaof water insoluble," fat soluble'ifa'tty acids. and fatty alcoholsz.
  • composition of matterconsistings essentially of a homogeneous solution of polyvinylpyrrolidone, a fatty carrier and a water insoluble, fat solu'hle fatty alcohol.
  • composition of matter consisting essentially of a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, polyvinylp'y-r-roli-done for inhibiting saidirritant effects, a'fatty carrier for said agent andinhi bitor, and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols.
  • a composition of matter consisting essentially of a fatty carrier, polyvinylpyrrolidone, iodine, and a compound selected from the groupconsisting of water insoluble, 'fat soluble fatty acids and fatty alcohols.
  • a composition of matter in powder form comprising a solution including essentially a fatty ca-r-rier, polyvinylpyrrolidone and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols, and a powdered, inert inorganic vehicle for said solution.
  • composition as in cla'im6 said solution further including a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, the polyvinylpyrrolidone inhibiting said irritant efiects.
  • composition assin claim 7 said physiologically active agent being iodine.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

United States Patent COMPOSITION OF MATTER CONTAINING POLY- VINYLPYRROLIDONE AND A FATTY CARRIER Jean R. L. Martin, New York, N. Y., assignor to Coty, Inc., New York, N. Y., a corporation of Delaware No Drawing. Application February 5, 1954, Serial No. 408,600
8 Claims. (Cl. 167-82) This invention relates to compositions of matter containing polyvinylpyrrolidone and more specifically, compositions including polyvinylpyrrolidone homogeneously dissolved in a carrier of a fatty or oily nature.
Polyvinylpyrrolidone (l-vinyl-2-pyrrolidone polymer) is a white powder which is readily soluble in water and certain organic solvents but is normally insoluble in fatty or oily carriers.
Since polyvinylpyr-rolidone has a number of important properties, particularly in the therapeutic field, it is im portant that the polyvinylpyrrolidone be made compatible with as many different types of solvents and carriers, as possible. Thus, polyvinylpyrrolidone may detoxify therapeutic agents which are more or less toxic in charactor and also has the property of prolonging the eifective period of many drugs and anaesthetics.
Accordingly, one object of this invent-ion is to provide a composition of matter including a carrier of a fatty or oily nature and polyvinylpyrrolidone homogeneously dissolved in said carrier by means of a compound having a common solvent action with respect :0 the base and the polyvinylpyrrolidone.
Another object of this invention is to provide a composition of matter including a physiologically active agent which normally has an irritating effect when applied to the epidermis or mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of said agent, all homogeneously distributed in a fatty carrier by means of a common solvent.
Yet another object of this invention is to provide a composition of matter including a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
Still another object of this invention is to provide a composition of matter in powder form applicable to the epidemis or mucous membranes and including an active agent which is normally irritating with respect to the epidermis or mucous membranes, wherein the active agent together with polyvinylpyrrolidone is dissolved in a fat or oil carrier by means of a common solvent, the solution being combined with an inert powdered carrier to form a powdered material free of the undesirable properties of the active agent.
It has been found that substantial amounts of polyvinylpyrrolidone may be dissolved in fatty or oil carriers and waxes of animal, vegetable or mineral origin, in their normal state or in hydrogenated form, such .as lanolin, lard, mineral oil, cottonseed oil, castor oil, cocoa butter, beeswax, carnauba wax, ozokerite and the like, through the use of fatty acids or fatty alcohols.
Furthermore, physiologically active agents Whose normally adverse physiological properties may be inhibited by the addition thereto of polyvinylpyrrolidone, such as iodine, salicylic acid or the like, may be uniformly dis- 2,776,924 Patented Jan. 8, 1957 i 2 tributed in a fatty carrier by the use 'of fatty acids or fatty alcohols, for application to the epidermis ormucous membranes and free of undesirable effects relative thereto.
The following examples illustrate the present invention but it is understood that such examples do not limit the scope of said invention.
Example 1 E xamp le 2 0.2 gram of iodine in methyl alcohol was combined with 2 grams of polyvinylpyrrol-idon'e and 8 grams of oleyl alcohol and dissolved in 19.8 grams of mineral oil to give a homogeneous solution. The mineral .oil may be replaced by a lanolin carrier and the proportion of iodine used may be varied to give any desired concentration in the 'fatty carrier.
Example 3 2.0 grams :of polyvinylpyrrolidone .was added to 8.0 grams of palmitic acid to form a homogeneous mass. 30.0 grams of castor oil was added to the mass and produced a clear solution. The castor oil can be replaced by cottonseed oil or hydrogenated cottonseed oil.
Example 4 A solution of iodine and polyvinylpyrrolidone in a mineral oil carrier, as set forth in Example 1, was combined with an inert powdered material such as talc until the solid particles were well saturated with the solution yet provided a freely flowing powder. The resultant powder can be readily applied to the human skin for therapeutic purposes without danger of irritation. Other inert materials such as china clay, or the like may replace the talc as a carrier for the iatty solution of poly- 'vinylpym'olidone and iodine.
"It has been found that substantial amounts of polyvinylpyrrolidone may also be readily dissolved in various fatty or oily carriers as well as waxes, of animal, vegetable or mineral origin, including cottonseed oil, olive oil, cocoa butter, beeswax, ozokerite or the like, as well as hydrogenated forms thereof, by means of fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
It is also understood that various physiologically active agents, therapeutic agents and the like, which may normally have adverse effects when applied to the skin or mucous membranes, may be readily combined with polyvinylpyrrolidone to inhibit such ad-verse eifects, the combination being homogeneously dissolved in a fatty or oily carrier, in accordance with the present invention, thereby facilitating the application of such agents to the skin or other portions of the human body.
It is to be understood that oily and waxy materials, which may be of animal, mineral :or vegetable origin shall be deemed the substantial equivalent of the water insoluble, fat soluble fatty alcohols and acids previously described, for use in the compositions of the instant invention.
The foregoing examples are to be deemed illustrative tion on the scope of the claims following.
Whatis claimedis:
1. A composition of matter consistingessentia'lly of a homogeneous solution of .polyvinylpyrrolidone, a fatty carrier and a compound selected from the group consistingaof water insoluble," fat soluble'ifa'tty acids. and fatty alcoholsz.
ZUA composition of matterzzconsisting essentially of a homogeneous solution of polyvinylpynrolidone, a fatty carrier'andia water insoluble, fat soluble fatty acid.
3. A composition of matterconsistingsessentially of a homogeneous solution of polyvinylpyrrolidone, a fatty carrier and a water insoluble, fat solu'hle fatty alcohol.
4. A composition of matter consisting essentially of a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, polyvinylp'y-r-roli-done for inhibiting saidirritant effects, a'fatty carrier for said agent andinhi bitor, and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols.
'5. A composition of matter consisting essentially of a fatty carrier, polyvinylpyrrolidone, iodine, and a compound selected from the groupconsisting of water insoluble, 'fat soluble fatty acids and fatty alcohols.
6. A composition of matter in powder form comprising a solution including essentially a fatty ca-r-rier, polyvinylpyrrolidone and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols, and a powdered, inert inorganic vehicle for said solution.
7. A composition as in cla'im6, said solution further including a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, the polyvinylpyrrolidone inhibiting said irritant efiects.
S. A composition assin claim 7, said physiologically active agent being iodine.
References Cited in the file of this patent UNITED STATES PATENTS Esselen Dec. 3, 1935 OTHER REFERENCES

Claims (1)

1. A COMPOSITION OF MATTER CONSISTING ESSENTIALLY OF A HOMOGENEOUS SOLUTION OF POLYVINYLPYRROLIDONE, A FATTY CARRIER AND A COMPOUND SELECTED FROM THE GROUP CONSISTING OF WATER INSOLUBLE, FAT SOLUBLE FATLTY ACIDS AND FATTY ALCOHOLS,
US408600A 1954-02-05 1954-02-05 Composition of matter containing polyvinylpyrrolidone and a fatty carrier Expired - Lifetime US2776924A (en)

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918411A (en) * 1957-11-01 1959-12-22 Olin Mathieson Pharmaceutical preparations
US3102845A (en) * 1960-11-18 1963-09-03 Mcneilab Inc Pharmaceutical tablet
US3152951A (en) * 1960-11-18 1964-10-13 Perlman Samuel Donald Germicidal composition of iodine and liquid lanolin
US3544679A (en) * 1968-06-24 1970-12-01 Frederic C Mccoy Paraffinic base oil carrier compositions for use in metal working and pesticides
US3671545A (en) * 1969-05-05 1972-06-20 Synergistics Inc Polyvinylpyrrolidone-iodine compounds
US4130640A (en) * 1974-09-10 1978-12-19 Chazan Reuwen R Germicidal cleaning compositions
WO1981000207A1 (en) * 1979-07-11 1981-02-05 P Harrigan Pharmaceutical preparation
US4289749A (en) * 1979-08-14 1981-09-15 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing phenylpropanolamine
US4291014A (en) * 1979-01-11 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estradiol diacetate
US4482534A (en) * 1980-12-16 1984-11-13 Forest Laboratories, Inc. Nitroglycerin preparations
US4604283A (en) * 1984-04-24 1986-08-05 Gresham Anne L Hoof conditioner and dressing and methods of use
US4847078A (en) * 1987-01-14 1989-07-11 Arseco, Inc. Storage stable topical composition having moisture control agent
US5128138A (en) * 1989-07-21 1992-07-07 Izhak Blank Estradiol compositions and methods for topical application
US5209922A (en) * 1992-03-19 1993-05-11 Isp Investments Inc. Water soluble polymers having antifungal properties
US5232703A (en) * 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
US6479076B2 (en) 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2022710A (en) * 1933-12-29 1935-12-03 Specialty Guild Inc Process of coloring synthetic resin articles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2022710A (en) * 1933-12-29 1935-12-03 Specialty Guild Inc Process of coloring synthetic resin articles

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918411A (en) * 1957-11-01 1959-12-22 Olin Mathieson Pharmaceutical preparations
US3102845A (en) * 1960-11-18 1963-09-03 Mcneilab Inc Pharmaceutical tablet
US3152951A (en) * 1960-11-18 1964-10-13 Perlman Samuel Donald Germicidal composition of iodine and liquid lanolin
US3544679A (en) * 1968-06-24 1970-12-01 Frederic C Mccoy Paraffinic base oil carrier compositions for use in metal working and pesticides
US3671545A (en) * 1969-05-05 1972-06-20 Synergistics Inc Polyvinylpyrrolidone-iodine compounds
US4130640A (en) * 1974-09-10 1978-12-19 Chazan Reuwen R Germicidal cleaning compositions
US4291014A (en) * 1979-01-11 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estradiol diacetate
WO1981000207A1 (en) * 1979-07-11 1981-02-05 P Harrigan Pharmaceutical preparation
US4292301A (en) * 1979-08-14 1981-09-29 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing ephedrine
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4289749A (en) * 1979-08-14 1981-09-15 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing phenylpropanolamine
US4292303A (en) * 1979-08-14 1981-09-29 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing clonidine
US4292302A (en) * 1979-08-14 1981-09-29 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing terbutaline
US4294820A (en) * 1979-08-14 1981-10-13 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing phenylephrine
US4482534A (en) * 1980-12-16 1984-11-13 Forest Laboratories, Inc. Nitroglycerin preparations
US4604283A (en) * 1984-04-24 1986-08-05 Gresham Anne L Hoof conditioner and dressing and methods of use
US4847078A (en) * 1987-01-14 1989-07-11 Arseco, Inc. Storage stable topical composition having moisture control agent
US5128138A (en) * 1989-07-21 1992-07-07 Izhak Blank Estradiol compositions and methods for topical application
US5232703A (en) * 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
US5209922A (en) * 1992-03-19 1993-05-11 Isp Investments Inc. Water soluble polymers having antifungal properties
US6479076B2 (en) 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions

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