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US20090054458A1 - Use of a polymorph of flibanserin for treating disease - Google Patents

Use of a polymorph of flibanserin for treating disease Download PDF

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Publication number
US20090054458A1
US20090054458A1 US12/170,884 US17088408A US2009054458A1 US 20090054458 A1 US20090054458 A1 US 20090054458A1 US 17088408 A US17088408 A US 17088408A US 2009054458 A1 US2009054458 A1 US 2009054458A1
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patient
flibanserin
polymorph
treating
administering
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US12/170,884
Inventor
Carlo Bombarda
Enrica Dubini
Antoine Ezhaya
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Sprout Pharmaceuticals Inc
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Bidachem SpA
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Priority to US12/170,884 priority Critical patent/US20090054458A1/en
Publication of US20090054458A1 publication Critical patent/US20090054458A1/en
Assigned to SPROUT PHARMACEUTICALS, INC. reassignment SPROUT PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BIDACHEM S.P.A
Priority to US13/541,214 priority patent/US20120270883A1/en
Priority to US13/905,709 priority patent/US20140031365A1/en
Priority to US14/269,420 priority patent/US20150005316A1/en
Priority to US14/876,235 priority patent/US20160095855A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Definitions

  • the invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments.
  • Flibanserin shows affinity for the 5-HT 1A and 5-HT 2 -receptor. It is therefore a promising therapeutic agent for the treatment of a variety of diseases, for instance depression, schizophrenia, Parkinson, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment.
  • a certain pharmaceutical activity is of course the basic prerequisite to be fulfilled by a pharmaceutically active agent before same is approved as a medicament on the market.
  • a pharmaceutically active agent has to comply with. These requirements are based on various parameters which are connected with the nature of the active substance itself. Without being restrictive, examples of these parameters are the stability of the active agent under various environmental conditions, its stability during production of the pharmaceutical formulation and the stability of the active agent in the final medicament compositions.
  • the pharmaceutically active substance used for preparing the pharmaceutical compositions should be as pure as possible and its stability in long-term storage must be guaranteed under various environmental conditions. This is absolutely essential to prevent the use of pharmaceutical compositions which contain, in addition to the actual active substance, breakdown products thereof, for example. In such cases the content of active substance in the medicament might be less than that specified.
  • Uniform distribution of the medicament in the formulation is a critical factor, particularly when the medicament has to be given in low doses.
  • the particle size of the active substance can be reduced to a suitable level, e.g. by grinding. Since breakdown of the pharmaceutically active substance as a side effect of the grinding (or micronising) has to be avoided as far as possible, in spite of the hard conditions required during the process, it is absolutely essential that the active substance should be highly stable throughout the grinding process. Only if the active substance is sufficiently stable during the grinding process is it possible to produce a homogeneous pharmaceutical formulation which always contains the specified amount of active substance in reproducible manner.
  • Another problem which may arise in the grinding process for preparing the desired pharmaceutical formulation is the input of energy caused by this process and the stress on the surface of the crystals. This may in certain circumstances lead to polymorphous changes, to a change in the amorphous configuration or to a change in the crystal lattice. Since the pharmaceutical quality of a pharmaceutical formulation requires that the active substance should always have the same crystalline morphology, the stability and properties of the crystalline active substance are subject to stringent requirements from this point of view as well.
  • the stability of a pharmaceutically active substance is also important in pharmaceutical compositions for determining the shelf life of the particular medicament; the shelf life is the length of time during which the medicament can be administered without any risk. High stability of a medicament in the abovementioned pharmaceutical compositions under various storage conditions is therefore an additional advantage for both the patient and the manufacturer.
  • the aim of the invention is thus to provide a new, stable crystalline form of the compound flibanserin which meets the stringent requirements imposed on pharmaceutically active substances as mentioned above.
  • FIG. 1 shows the X-ray powder diffraction pattern of polymorph A of flibanserin.
  • polymorph A which can be obtained in crystalline form by choosing specific reaction conditions, meets the stringent requirements mentioned above and thus solves the problem on which the present invention is based. Accordingly the present invention relates to polymorph A of flibanserin.
  • Polymorph A of flibanserin is characterised by a melting point of about 161° C. (determined via DSC; heating rate 10 K/min). 161° C. as determined using DSC.
  • Polymorph B the less stable modification of flibanserin displays a melting point of about 120° C. (determined via DSC; heating rate 10 K/min). Whereas polymorph B shows little stability under the effects of for instance mechanical stress produced by grinding, polymorph A turned out to fulfil the aforementioned stability requirements.
  • the present invention relates to a process for the manufacture of polymorph A of flibanserin in technical scale.
  • the process according to the invention is illustrated in diagram 1.
  • the benzimidazolone 2 is reacted with the piperazine-derivative 3 under basic reaction conditions in a suitable solvent to lead to 1.
  • the group R denotes an amino protecting group.
  • the protecting group used may be any of the groups commonly used to protect the amino function. Examples include groups selected from alkyl, substituted alky, heterosubstituted alkyl, unsaturated alkyl, alkyl substituted heteroatoms, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, alkyloxycarbonyl groups and aryloxycarbonyl groups.
  • Preferred protecting groups are selected from butyl, 1,1-diphenylmethyl, methoxymethyl, benzyloxymethyl, trichloroethoxymethyl, pyrrolidinomethyl, cyanomethyl, pivaloyloxymethyl, allyl, 2-propenyl, t-butyidimethylsilyl, methoxy, thiomethyl, 4-methoxyphenyl, benzyl, 4-methoxybenzyl, 2,4-dimethoxybenzyl, 2-nitrobenzyl, t-butoxycarbonyl, benzyloxycarbonyl, phenoxy carbonyl, 4-chloro-phenoxycarbonyl, 4-nitro-phenoxycarbonyl, methoxycarbonyl and ethoxycarbonyl.
  • the preferred protecting groups are selected from t-butoxycarbonyl, ethoxycarbonyl, methoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl and 2-propenyl, the latter being most preferred.
  • X in 3 represents a leaving group selected from chlorine, bromine, iodine, methanesulphonate, trifluoromethanesulphonate or para-toluenesulphonate.
  • X denotes chlorine, bromine or iodine, chlorine being most preferred.
  • Suitable solvents are selected from water, alcohols and mixtures of water with alcohols, polar aprotic solvents and mixtures thereof with water.
  • Preferred solvents are selected from the group consisting of dimethylformamid, dimethylsulfoxid, acetonitrile, tetrahydrofurane, dioxane, methanol, ethanol isopropanaol and mixtures of one or several of the aforementioned solvents with water.
  • Preferred solvents are those being readily miscible with water.
  • a mixture of water with one of the alcohols methanol, ethanol or isopropanol is used as the solvent.
  • the base used may be an alkali metal- or alkaline earth metal carbonate of lithium, sodium, potassium, calcium such as sodium carbonate, lithium carbonate, potassium carbonate, calcium carbonate and preferably potassium carbonate. It is also possible to use the hydrogen carbonates of lithium, sodium and potassium.
  • Most preferred base is sodium hydroxide.
  • the base is preferably added in form of its aqueous solution, preferably in form of concentrated aqueous solutions, for example in concentrations between 30-50% weight/volume.
  • aqueous sodium hydroxide solution in a concentration of about 45% weight/volume is used.
  • the compounds 2 and 3 are introduced into the reaction in a molar ratio of between 1:1 to 1:2, preferably in a molar ratio of between 1:1.1 to 1:1.5.
  • a mixture of water and isopropanol is used as a preferred solvent mixture for the conduction of the process according to the invention.
  • the weight-ratio of water to isopropanol in the preferred solvent mixture is between 10:1 and 1:1, more preferred between 8:1 and 3:1, particular preferred between 7:1 and 5:1.
  • Per mol of compound 2 about 2-10 kg, preferably 3-8 kg, more preferred 4-7 kg of the aforementioned solvent mixture are used.
  • the reaction is conducted using aqueous sodium hydroxide solution in a concentration of about 45% weight/volume as the base. Per mol of 2 about 0.1-1.5 kg, preferably 0.2-1.0 kg, particularly preferred 0.3-0.6 kg of the aforementioned sodium hydroxide solution are used.
  • the reaction mixture containing 2,3 and the base in the aforementioned suitable solvent is preferably heated to at least 50° C. In a preferred embodiment the reaction temperature is in a range of between 60° C. to the boiling point of the solvent. Particularly preferred is a temperature between 70-90° C.
  • the reaction mixture is heated at the aforementioned temperature for about 10 minutes to about 12 hours, preferably for about 15 minutes to about 6 hours, more preferably for about 30 minutes to about 3 hours.
  • the reaction mixture is preferably heated at the aforementioned temperature for about 45 to 60 minutes.
  • the protective group R is cleaved.
  • the cleaving conditions depend on the choice of group R. If R denotes for instance benzyl, cleavage is conducted via hydrogenation in acetic acid in the presence of an appropriate catalyst (e.g. Pd on charcoal) or it can be cleaved in aqueous HBr.
  • R is methoxycarbonyl, ethoxycarbonyl, phenoxy carbonyl, 4-nitrophenoxycarbonyl it can be cleaved for example by using aqueous alkaline solutions such as NaOH (aq) or KOH (aq).
  • R is t-butoxycarbonyl it can be cleaved for instance in aqueous HCl or HBr.
  • R denotes 2-propenyl
  • the particularly preferred protective group according to the invention cleavage of R is effected via acidic reaction conditions.
  • the 2-propenyl group is cleaved by using a strong mineral acid, preferably an acid selected from the group consisting of hydrobromic acid, hydrochloric acid and sulfuric acid, more preferably hydrochloric acid.
  • Hydrochloric acid can be added in gaseous form or in form of its aqueous solutions, the addition of aqueous solutions being preferred.
  • hydrochloric acid in form of its concentrated solution (about 36% weight/volume).
  • at least one mol of hydrochloric acid is to be added.
  • the amount of added concentrated hydrochloric acid (36% weight/volume) per mol 2 is between 50-500g, more preferred between 80-250 g.
  • Particularly preferred about 120-160 g of concentrated (36% w/v) aqueous hydrochloric acid are added per mol 2 used.
  • Additional water can be optionally added.
  • a temperature of about 70-90° C. about 30-70%, preferably about 35-60% of the solvent is removed via distillation.
  • the pH of the remaining residue is adjusted to about 5-9, preferably to about 6-8 by addition of aqueous sodium hydroxide (45% w/v).
  • aqueous sodium hydroxide 45% w/v
  • the pH is adjusted to about 8-9 by addition of aqueous sodium hydroxide (45% w/v).
  • the mixture is cooled to about 20-40° C., preferably about 30-35° C. and centrifuged.
  • the residue thus obtained is washed with about 100 to 750 ml water per mol introduced 2, preferably with about 200 to 500, particularly preferred with about 300 to 400 ml water per mol introduced 2 and isopropanol (about 50 to 250 g per mol 2, preferably about 100 to 200 g per mol 2) and then with water until chlorides elimination.
  • the product thus obtained can be subjected to another purification step.
  • said purification is conducted via crystallization of 1 from for instance acetone.
  • One aspect of the present invention relates to flibanserin polymorph A obtainable via the method described above.
  • polymorph A was characterised by DSC (Differential Scanning Calorimetry).
  • the peak temperature (endothermic maximum) determined for polymorph A is about 161° C.
  • a Mettler TA 3000 System equipped with TC 10-A processor and DSC 20 cell was applied. The heating rate was 10 K/min.
  • the flibanserin polyrnorph A was additionally characterised by powder x-ray diffractometry.
  • the x-ray powder diffraction pattern for polymorph A was obtained according to the following conditions:
  • the x-ray powder diffraction pattern obtained for polymorph A is illustrated in FIG. 1 .
  • the appropriate values are shown below in Table 1.
  • the present invention furthermore relates to the use of flibanserin polymorph A as a medicament.
  • a further aspect of the present invention relates to the use of flibanserin polymorph A for preparing a pharmaceutical composition for treating diseases in which the use of compounds displaying affinity for the 5-HT 1A and 5-HT 2 -receptor may have a therapeutic benefit.
  • a further aspect of the present invention relates to the use of flibanserin polymorph A for preparing a pharmaceutical composition for treating a disease selected from depression, schizophrenia, Parkinson, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment.
  • the instant invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders of sexual desire.
  • the invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group consisting of Hypoactive Sexual Desire Disorder, loss of sexual desire, lack of sexual desire, decreased sexual desire, inhibited sexual desire, loss of libido, libido disturbance, and frigidity.
  • flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group consisting of Hypoactive Sexual Desire Disorder, loss of sexual desire, lack of sexual desire, decreased sexual desire, inhibited sexual desire.
  • the invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group of Hypoactive Sexual Desire Disorder and loss of sexual desire.
  • flibanserin polymorph A can be achieved in men and women.
  • the use of flibanserin polymorph A for the preparation of a medicament for the treatment of female sexual dysfunction is preferred.
  • flibanserin polymorph A The beneficial effects of flibanserin polymorph A can be observed regardless of whether the disturbance existed lifelong or was acquired, and independent of etiologic origin (organic—both, physically and drug induced—, psychogen, a combination of organic—both, physically and drug induced—, and psychogen, or unknown).
  • compositions comprising as an active ingredient flibanserin polymorph A in addition with one or more pharmaceutical carrier, diluents or excipients.
  • flibanserin polymorph A may be incorporated into the conventional pharmaceutical preparation in solid, liquid or spray form.
  • the composition may, for example, be presented in a form suitable for oral, rectal, parenteral administration or for nasal inhalation: preferred forms includes for example, capsules, tablets, coated tablets, ampoules, suppositories and nasal spray.
  • the active ingredient may be incorporated in excipients or carriers conventionally used in pharmaceutical compositions such as, for example, talc, arabic gum, lactose, gelatine, magnesium stearate, corn starch, acqueous or non acqueous vehicles, polyvynil pyrrolidone, semisynthetic glicerides of fatty acids, benzalconium chloride, sodium phosphate, EDTA, polysorbate 80.
  • the compositions are advantageously formulated in dosage units, each dosage unit being adapted to supply a single dose of the active ingredient.
  • Each dosage unit may conveniently contain from 0,01 mg to 100 mg, preferably from 0,1 to 50 mg.

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Abstract

The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments.

Description

    RELATED APPLICATIONS
  • This application is a divisional of U.S. Ser. No. 10/210,474, filed Aug. 1, 2002, which claims, as does the present application, benefit of U.S. Provisional Application Serial No. 60/329,435, filed on Oct. 15, 2001, European Patent Application EP 01 118593, filed Aug. 2, 2001, and European Patent Application EP 01 130 180, filed Dec. 19, 2001, the disclosures of all of which are incorporated by reference in their entireties.
    • FIELD OF THE INVENTION
  • The invention relates to the polymorph A of flibanserin, to a technical process for the preparation thereof, as well as to the use thereof for preparing medicaments.
    • BACKGROUND OF THE INVENTION
  • The compound 1-[2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl)ethyl]-2,3-dihydro-1H-benzimidazol-2-one (flibanserin) is disclosed in form of its hydrochloride in European Patent Application EP-A-526434 and has the following chemical structure:
  • Figure US20090054458A1-20090226-C00001
  • Flibanserin shows affinity for the 5-HT1A and 5-HT2-receptor. It is therefore a promising therapeutic agent for the treatment of a variety of diseases, for instance depression, schizophrenia, Parkinson, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment.
  • A certain pharmaceutical activity is of course the basic prerequisite to be fulfilled by a pharmaceutically active agent before same is approved as a medicament on the market. However, there are a variety of additional requirements a pharmaceutically active agent has to comply with. These requirements are based on various parameters which are connected with the nature of the active substance itself. Without being restrictive, examples of these parameters are the stability of the active agent under various environmental conditions, its stability during production of the pharmaceutical formulation and the stability of the active agent in the final medicament compositions. The pharmaceutically active substance used for preparing the pharmaceutical compositions should be as pure as possible and its stability in long-term storage must be guaranteed under various environmental conditions. This is absolutely essential to prevent the use of pharmaceutical compositions which contain, in addition to the actual active substance, breakdown products thereof, for example. In such cases the content of active substance in the medicament might be less than that specified.
  • Uniform distribution of the medicament in the formulation is a critical factor, particularly when the medicament has to be given in low doses. To ensure uniform distribution, the particle size of the active substance can be reduced to a suitable level, e.g. by grinding. Since breakdown of the pharmaceutically active substance as a side effect of the grinding (or micronising) has to be avoided as far as possible, in spite of the hard conditions required during the process, it is absolutely essential that the active substance should be highly stable throughout the grinding process. Only if the active substance is sufficiently stable during the grinding process is it possible to produce a homogeneous pharmaceutical formulation which always contains the specified amount of active substance in reproducible manner.
  • Another problem which may arise in the grinding process for preparing the desired pharmaceutical formulation is the input of energy caused by this process and the stress on the surface of the crystals. This may in certain circumstances lead to polymorphous changes, to a change in the amorphous configuration or to a change in the crystal lattice. Since the pharmaceutical quality of a pharmaceutical formulation requires that the active substance should always have the same crystalline morphology, the stability and properties of the crystalline active substance are subject to stringent requirements from this point of view as well.
  • The stability of a pharmaceutically active substance is also important in pharmaceutical compositions for determining the shelf life of the particular medicament; the shelf life is the length of time during which the medicament can be administered without any risk. High stability of a medicament in the abovementioned pharmaceutical compositions under various storage conditions is therefore an additional advantage for both the patient and the manufacturer.
  • Apart from the requirements indicated above, it should be generally borne in mind that any change to the solid state of a pharmaceutical composition which is capable of improving its physical and chemical stability gives a significant advantage over less stable forms of the same medicament.
  • The aim of the invention is thus to provide a new, stable crystalline form of the compound flibanserin which meets the stringent requirements imposed on pharmaceutically active substances as mentioned above.
    • BRIEF DESCRIPTION OF THE DRAWING
  • FIG. 1 shows the X-ray powder diffraction pattern of polymorph A of flibanserin.
    •  DETAILED DESCRIPTION OF THE INVENTION
  • Surprisingly, it has been found that the free base of flibanserin in a specific polymorphic form fulfils the requirements mentioned hereinbefore.
  • Moreover it has been found that, depending on the choice of conditions which can be applied during the synthesis of flibanserin the free base occurs in different crystalline modifications, polymorphs A and B.
  • It has been found that these different modifications can be deliberately produced by a suitable choice of the process conditions used in the manufacturing process.
  • Surprisingly, it has been found that polymorph A, which can be obtained in crystalline form by choosing specific reaction conditions, meets the stringent requirements mentioned above and thus solves the problem on which the present invention is based. Accordingly the present invention relates to polymorph A of flibanserin.
  • Polymorph A of flibanserin is characterised by a melting point of about 161° C. (determined via DSC; heating rate 10 K/min). 161° C. as determined using DSC. Polymorph B, the less stable modification of flibanserin displays a melting point of about 120° C. (determined via DSC; heating rate 10 K/min). Whereas polymorph B shows little stability under the effects of for instance mechanical stress produced by grinding, polymorph A turned out to fulfil the aforementioned stability requirements.
  • According to another aspect, the present invention relates to a process for the manufacture of polymorph A of flibanserin in technical scale. The process according to the invention is illustrated in diagram 1.
  • Figure US20090054458A1-20090226-C00002
  • Diagram 1:
  • The benzimidazolone 2 is reacted with the piperazine-derivative 3 under basic reaction conditions in a suitable solvent to lead to 1. In 2 the group R denotes an amino protecting group. The protecting group used may be any of the groups commonly used to protect the amino function. Examples include groups selected from alkyl, substituted alky, heterosubstituted alkyl, unsaturated alkyl, alkyl substituted heteroatoms, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, alkyloxycarbonyl groups and aryloxycarbonyl groups. Preferred protecting groups are selected from butyl, 1,1-diphenylmethyl, methoxymethyl, benzyloxymethyl, trichloroethoxymethyl, pyrrolidinomethyl, cyanomethyl, pivaloyloxymethyl, allyl, 2-propenyl, t-butyidimethylsilyl, methoxy, thiomethyl, 4-methoxyphenyl, benzyl, 4-methoxybenzyl, 2,4-dimethoxybenzyl, 2-nitrobenzyl, t-butoxycarbonyl, benzyloxycarbonyl, phenoxy carbonyl, 4-chloro-phenoxycarbonyl, 4-nitro-phenoxycarbonyl, methoxycarbonyl and ethoxycarbonyl. Among them the preferred protecting groups are selected from t-butoxycarbonyl, ethoxycarbonyl, methoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl and 2-propenyl, the latter being most preferred. X in 3 represents a leaving group selected from chlorine, bromine, iodine, methanesulphonate, trifluoromethanesulphonate or para-toluenesulphonate. Preferably X denotes chlorine, bromine or iodine, chlorine being most preferred. Suitable solvents are selected from water, alcohols and mixtures of water with alcohols, polar aprotic solvents and mixtures thereof with water. Preferred solvents are selected from the group consisting of dimethylformamid, dimethylsulfoxid, acetonitrile, tetrahydrofurane, dioxane, methanol, ethanol isopropanaol and mixtures of one or several of the aforementioned solvents with water. Preferred solvents are those being readily miscible with water. Preferably, a mixture of water with one of the alcohols methanol, ethanol or isopropanol is used as the solvent. In a preferred embodiment a mixture of water and isopropanol is used as the solvent The base used may be an alkali metal- or alkaline earth metal carbonate of lithium, sodium, potassium, calcium such as sodium carbonate, lithium carbonate, potassium carbonate, calcium carbonate and preferably potassium carbonate. It is also possible to use the hydrogen carbonates of lithium, sodium and potassium. Preferably, the alkali metal- or alkaline earth metal hydroxides of lithium, sodium, potassium, magnesium, calcium, but preferably sodium hydroxide, potassium hydroxide, lithium hydroxide and calcium hydroxide in alcohols or water may also be used. Most preferred base is sodium hydroxide. The base is preferably added in form of its aqueous solution, preferably in form of concentrated aqueous solutions, for example in concentrations between 30-50% weight/volume. In a preferred embodiment aqueous sodium hydroxide solution in a concentration of about 45% weight/volume is used.
  • The compounds 2 and 3 are introduced into the reaction in a molar ratio of between 1:1 to 1:2, preferably in a molar ratio of between 1:1.1 to 1:1.5. As mentioned hereinbefore a mixture of water and isopropanol is used as a preferred solvent mixture for the conduction of the process according to the invention. In this solvent mixture the weight-ratio of water to isopropanol in the preferred solvent mixture is between 10:1 and 1:1, more preferred between 8:1 and 3:1, particular preferred between 7:1 and 5:1. Per mol of compound 2 about 2-10 kg, preferably 3-8 kg, more preferred 4-7 kg of the aforementioned solvent mixture are used. In a 30 preferred embodiment the reaction is conducted using aqueous sodium hydroxide solution in a concentration of about 45% weight/volume as the base. Per mol of 2 about 0.1-1.5 kg, preferably 0.2-1.0 kg, particularly preferred 0.3-0.6 kg of the aforementioned sodium hydroxide solution are used. The reaction mixture containing 2,3 and the base in the aforementioned suitable solvent is preferably heated to at least 50° C. In a preferred embodiment the reaction temperature is in a range of between 60° C. to the boiling point of the solvent. Particularly preferred is a temperature between 70-90° C. The reaction mixture is heated at the aforementioned temperature for about 10 minutes to about 12 hours, preferably for about 15 minutes to about 6 hours, more preferably for about 30 minutes to about 3 hours. The reaction mixture is preferably heated at the aforementioned temperature for about 45 to 60 minutes.
  • Subsequently the protective group R is cleaved. The cleaving conditions depend on the choice of group R. If R denotes for instance benzyl, cleavage is conducted via hydrogenation in acetic acid in the presence of an appropriate catalyst (e.g. Pd on charcoal) or it can be cleaved in aqueous HBr. In case R is methoxycarbonyl, ethoxycarbonyl, phenoxy carbonyl, 4-nitrophenoxycarbonyl it can be cleaved for example by using aqueous alkaline solutions such as NaOH (aq) or KOH (aq). In case R is t-butoxycarbonyl it can be cleaved for instance in aqueous HCl or HBr. In case R denotes 2-propenyl, the particularly preferred protective group according to the invention, cleavage of R is effected via acidic reaction conditions. In a particularly preferred process according to the invention the 2-propenyl group is cleaved by using a strong mineral acid, preferably an acid selected from the group consisting of hydrobromic acid, hydrochloric acid and sulfuric acid, more preferably hydrochloric acid. Hydrochloric acid can be added in gaseous form or in form of its aqueous solutions, the addition of aqueous solutions being preferred. Particularly preferred is the addition of hydrochloric acid in form of its concentrated solution (about 36% weight/volume). Per mol 2 at least one mol of hydrochloric acid is to be added. Preferably the amount of added concentrated hydrochloric acid (36% weight/volume) per mol 2 is between 50-500g, more preferred between 80-250 g. Particularly preferred about 120-160 g of concentrated (36% w/v) aqueous hydrochloric acid are added per mol 2 used. Additional water can be optionally added. At a temperature of about 70-90° C. about 30-70%, preferably about 35-60% of the solvent is removed via distillation. At a temperature of about 60-80° C. the pH of the remaining residue is adjusted to about 5-9, preferably to about 6-8 by addition of aqueous sodium hydroxide (45% w/v). At a temperature of about 40-55° C. the pH is adjusted to about 8-9 by addition of aqueous sodium hydroxide (45% w/v). Subsequently the mixture is cooled to about 20-40° C., preferably about 30-35° C. and centrifuged. The residue thus obtained is washed with about 100 to 750 ml water per mol introduced 2, preferably with about 200 to 500, particularly preferred with about 300 to 400 ml water per mol introduced 2 and isopropanol (about 50 to 250 g per mol 2, preferably about 100 to 200 g per mol 2) and then with water until chlorides elimination. Optionally the product thus obtained can be subjected to another purification step. Preferably, said purification is conducted via crystallization of 1 from for instance acetone.
  • One aspect of the present invention relates to flibanserin polymorph A obtainable via the method described above.
  • The following example of synthesis serves to illustrate a method of preparing polymorph A of flibanserin. It is to be regarded only as a possible method described by way of example, without restricting the invention to its contents.
    • EXAMPLE
  • 375 kg of 1-[(3-trifluoromethyl)phenyl]-4-(2-cloroethyl)piperazin are charged in a reactor with 2500 kg of water and 200 kg of aqueous Sodium Hydroxide 45%. Under stirring 169.2 kg of 1-(2-propenyl)-1,3-dihydro-benzimidazol-2H-one, 780 kg of isopropanol, 2000 kg of water and 220 kg of aqueous Sodium Hydroxide 45% are added. The reaction mixture is heated to 75-85° C. and 160 kg of concentrated hydrochloric acid and 200 kg of water are added. The reaction mixture is stirred at constant temperature for about 45 minutes. After distillation of a mixture of water and Isopropanol (about 3000 kg) the remaining residue is cooled to about 65-75° C. and the pH is adjusted to 6.5-7.5 by addition of 125 kg of aqueous Sodium Hydroxide 45%. After cooling to a temperature of 45-50° C., the pH value is adjusted to 8-9 by addition of about 4 kg of aqueous Sodium Hydroxide 45%. Subsequently the mixture is cooled to 30-35° C. and centrifuged. The residue thus obtained is washed with 340 l of water and 126 l of isopropanol and then with water until chlorides elimination. The wet product is dried under vacuum at a temperature of about 45-55° C. which leads to 358 kg of crude flibanserin polymorph A. The crude product thus obtained is loaded in a reactor with 1750 kg of Acetone and the resulting mixture is heated under stirring until reflux. The obtained solution is filtered and the filtrate is concentrated by distillation. The temperature is maintained for about 1 hour 0-5° C., then the precipitate solid is isolated by filtration and dried at 55° C. for at least 12 hours. The final yield is 280 kg of pure flibanserin polymorph A.
  • As mentioned hereinbefore flibanserin polymorph A was characterised by DSC (Differential Scanning Calorimetry). The peak temperature (endothermic maximum) determined for polymorph A is about 161° C. For the characterization via DSC a Mettler TA 3000 System equipped with TC 10-A processor and DSC 20 cell was applied. The heating rate was 10 K/min.
  • The flibanserin polyrnorph A was additionally characterised by powder x-ray diffractometry. The x-ray powder diffraction pattern for polymorph A was obtained according to the following conditions:
  •
    Equipment: Philips PW 1800/10 diffractometer equipped with a
    digital microvax 2000.
    Setting parameters: X-ray
    Type tube: Cu (long fine focus)
    Wavelengths (λ): Kα1 = 1.54060 Å
    Kα2 = 1.54439 Å
    Intensity ratio (α2/α1): 0.500
    Start angle [°2θ]: 2.000
    End angle [°2θ]: 60.000
    Step size [°2θ]: 0.020
    Maximum intensity[s]: 7310.250
    Type of scan: continuous
    Minimum peak tip width: 0.00
    Maximum peak tip width: 1.00
    Peak base width: 2.00
    Minimum significance: 0.75
    Number of peaks: 69
    Generator: high voltage: 50 KV
    tube current: 30 mA
  • The x-ray powder diffraction pattern obtained for polymorph A is illustrated in FIG. 1. The appropriate values are shown below in Table 1.
  • TABLE 1
    Peak Rel.
    Angle d-value d-value width Peak int Back. int int
    [°2θ] α1 [Å] α2 [Å] [°2θ] [counts] [counts] [%] Signif.
    5.195 16.9967 17.0390 0.960 8 69 0.1 1.05
    9.045 9.7689 9.7931 0.100 92 96 1.3 0.97
    9.335 9.4660 9.4896 0.080 114 98 1.6 0.88
    10.025 8.8160 8.8379 0.140 400 100 5.5 7.18
    10.595 8.3430 8.3637 0.140 204 102 2.8 3.46
    11.290 7.8309 7.8503 0.140 467 104 6.4 6.91
    13.225 6.6891 6.7058 0.180 548 112 7.5 13.10
    14.595 6.0642 6.0793 0.180 404 121 5.5 19.17
    15.460 5.7268 5.7410 0.140 4186 125 57.3 23.20
    16.655 5.3185 5.3317 0.200 515 130 7.0 12.38
    17.085 5.1856 5.1985 0.100 1347 132 18.4 2.78
    17.285 5.1260 5.1388 0.060 1399 135 19.1 2.26
    17.420 5.0866 5.0992 0.100 1204 135 16.5 4.71
    18.140 4.8863 4.8984 0.180 1043 139 14.3 13.14
    18.650 4.7538 4.7656 0.120 1063 142 14.5 0.91
    19.140 4.6332 4.6447 0.140 7310 144 100.0 32.77
    19.820 4.4757 4.4869 0.160 3624 146 49.6 9.02
    20.080 4.4184 4.4294 0.140 5402 149 73.9 21.06
    20.385 4.3530 4.3638 0.160 2652 149 36.3 23.25
    21.215 4.1845 4.1949 0.160 369 154 5.0 5.78
    21.890 4.0570 4.0670 0.200 773 156 10.6 3.09
    22.630 3.9259 3.9357 0.280 4277 161 58.5 74.66
    23.210 3.8291 3.8386 0.120 484 164 6.6 3.33
    24.355 3.6516 3.6607 0.060 2725 169 37.3 1.16
    24.610 3.6144 3.6234 0.140 3540 172 48.4 17.08
    24.995 3.5596 3.5684 0.100 529 174 7.2 1.01
    25.260 3.5228 3.5316 0.120 557 174 7.6 3.02
    26.575 3.3514 3.3597 0.240 2421 182 33.1 42.58
    27.155 3.2811 3.2893 0.140 676 185 9.2 1.32
    27.310 3.2629 3.2710 0.100 767 185 10.5 2.75
    27.865 3.1991 3.2071 0.120 420 188 5.7 1.08
    28.210 3.1608 3.1686 0.100 1467 190 20.1 0.79
    28.325 3.1482 3.1560 0.140 1789 190 24.5 4.41
    28.650 3.1132 3.1210 0.180 1204 190 16.5 11.65
    29.520 3.0234 3.0309 0.220 1011 196 13.8 15.74
    30.250 2.9521 2.9594 0.120 159 199 2.2 1.22
    31.105 2.8729 2.8800 0.360 282 204 3.9 8.14
    31.905 2.8026 2.8096 0.100 339 207 4.6 0.96
    32.350 2.7651 2.7720 0.120 237 210 3.2 3.01
    33.300 2.6884 2.6950 0.180 1347 216 18.4 14.06
    33.640 2.6620 2.6686 0.100 404 216 5.5 1.45
    34.880 2.5701 2.5765 0.200 202 222 2.8 1.04
    35.275 2.5422 2.5486 0.240 299 225 4.1 4.84
    36.055 2.4890 2.4952 0.280 202 228 2.8 3.78
    36.910 2.4333 2.4393 0.320 169 234 2.3 0.90
    37.160 2.4175 2.4235 0.120 216 234 3.0 2.14
    37.680 2.3853 2.3912 0.240 240 237 3.3 1.58
    39.435 2.2831 2.2888 0.280 449 246 6.1 2.67
    39.675 2.2698 2.2755 0.080 396 246 5.4 0.82
    40.325 2.2347 2.2403 0.160 520 250 7.1 0.95
    40.930 2.2031 2.2086 0.120 480 253 6.6 2.66
    41.445 2.1769 2.1823 0.240 372 256 5.1 2.65
    41.990 2.1499 2.1552 0.120 538 259 7.4 1.31
    42.670 2.1172 2.1225 0.160 428 262 5.9 1.45
    43.145 2.0950 2.1002 0.120 433 266 5.9 1.50
    44.190 2.0478 2.0529 0.160 376 269 5.1 0.89
    46.095 1.9675 1.9724 0.160 279 279 3.8 0.86
    46.510 1.9509 1.9558 0.240 310 282 4.2 0.87
    48.305 1.8826 1.8872 0.200 506 292 6.9 2.06
    48.900 1.8610 1.8657 0.240 615 296 8.4 1.67
    50.330 1.8115 1.8160 0.160 437 303 6.0 1.73
    51.035 1.7881 1.7925 0.080 416 306 5.7 0.93
    53.550 1.7099 1.7141 0.480 177 317 2.4 2.84
    54.500 1.6823 1.6865 0.400 130 324 1.8 1.37
    55.420 1.6565 1.6606 0.320 130 328 1.8 1.72
    56.220 1.6348 1.6389 0.320 121 331 1.7 0.87
    56.770 1.6203 1.6243 0.240 142 335 1.9 1.59
    57.405 1.6039 1.6079 0.240 112 339 1.5 1.19
    58.500 1.5764 1.5804 0.240 67 342 0.9 1.57
  • In the light of the pharmaceutical efficacy of flibanserin, the present invention furthermore relates to the use of flibanserin polymorph A as a medicament.
  • A further aspect of the present invention relates to the use of flibanserin polymorph A for preparing a pharmaceutical composition for treating diseases in which the use of compounds displaying affinity for the 5-HT1A and 5-HT2-receptor may have a therapeutic benefit.
  • A further aspect of the present invention relates to the use of flibanserin polymorph A for preparing a pharmaceutical composition for treating a disease selected from depression, schizophrenia, Parkinson, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment.
  • In particular, the instant invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders of sexual desire.
  • In a preferred embodiment the invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group consisting of Hypoactive Sexual Desire Disorder, loss of sexual desire, lack of sexual desire, decreased sexual desire, inhibited sexual desire, loss of libido, libido disturbance, and frigidity.
  • Particular preferred according to the invention is the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group consisting of Hypoactive Sexual Desire Disorder, loss of sexual desire, lack of sexual desire, decreased sexual desire, inhibited sexual desire.
  • In a particularly preferred embodiment the invention relates to the use of flibanserin polymorph A for the preparation of a medicament for the treatment of disorders selected from the group of Hypoactive Sexual Desire Disorder and loss of sexual desire.
  • The aforementioned therapeutic effects of flibanserin polymorph A can be achieved in men and women. However, according to a further aspect of the invention the use of flibanserin polymorph A for the preparation of a medicament for the treatment of female sexual dysfunction is preferred.
  • The beneficial effects of flibanserin polymorph A can be observed regardless of whether the disturbance existed lifelong or was acquired, and independent of etiologic origin (organic—both, physically and drug induced—, psychogen, a combination of organic—both, physically and drug induced—, and psychogen, or unknown).
  • As a further feature of the present invention there are provided pharmaceutical compositions comprising as an active ingredient flibanserin polymorph A in addition with one or more pharmaceutical carrier, diluents or excipients. For pharmaceutical administration flibanserin polymorph A may be incorporated into the conventional pharmaceutical preparation in solid, liquid or spray form. The composition may, for example, be presented in a form suitable for oral, rectal, parenteral administration or for nasal inhalation: preferred forms includes for example, capsules, tablets, coated tablets, ampoules, suppositories and nasal spray. The active ingredient may be incorporated in excipients or carriers conventionally used in pharmaceutical compositions such as, for example, talc, arabic gum, lactose, gelatine, magnesium stearate, corn starch, acqueous or non acqueous vehicles, polyvynil pyrrolidone, semisynthetic glicerides of fatty acids, benzalconium chloride, sodium phosphate, EDTA, polysorbate 80. The compositions are advantageously formulated in dosage units, each dosage unit being adapted to supply a single dose of the active ingredient. Each dosage unit may conveniently contain from 0,01 mg to 100 mg, preferably from 0,1 to 50 mg.

Claims (8)

1) A method for treating a disease that is treatable with a compound having an affinity for the 5-HT1A or 5-HT2-receptors in a patient, comprising administering to said patient a therapeutically effective amount of a crystalline polymorph, designated form A, of flibanserin 1,
Figure US20090054458A1-20090226-C00003
having an endothermic maximum at about 161° C. which occurs during thermal analysis using DSC.
2) A method for treating a disease that is treatable with a compound having an affinity for the 5-HTIA or 5-HT2-receptors in a patient, comprising administering to said patient a therapeutically effective amount of flibanserin 1 comprising form A according to claim 1.
3) A method for treating a disease that is treatable with a compound having an affinity for the 5-HT,A or 5-HT2-receptors in a patient, comprising administering to said patient a therapeutically effective amount of a polymorph of flibanserin 1 characterized by the following X-ray powder diffraction pattern:
Peak Rel. Angle d-value d-value width Peak int Back. int int [°2θ] α1 [Å] α2 [Å] [°2θ] [counts] [counts] [%] Signif. 5.195 16.9967 17.0390 0.960 8 69 0.1 1.05 9.045 9.7689 9.7931 0.100 92 96 1.3 0.97 9.335 9.4660 9.4896 0.080 114 98 1.6 0.88 10.025 8.8160 8.8379 0.140 400 100 5.5 7.18 10.595 8.3430 8.3637 0.140 204 102 2.8 3.46 11.290 7.8309 7.8503 0.140 467 104 6.4 6.91 13.225 6.6891 6.7058 0.180 548 112 7.5 13.10 14.595 6.0642 6.0793 0.180 404 121 5.5 9.17 15.460 5.7268 5.7410 0.140 4186 125 57.3 23.20 16.655 5.3185 5.3317 0.200 515 130 7.0 12.38 17.085 5.1856 5.1985 0.100 1347 132 18.4 2.78 17.285 5.1260 5.1388 0.060 1399 135 19.1 2.26 17.420 5.0866 5.0992 0.100 1204 135 16.5 4.71 18.140 4.8863 4.8984 0.180 1043 139 14.3 13.14 18.650 4.7538 4.7656 0.120 1063 142 14.5 0.91 19.140 4.6332 4.6447 0.140 7310 144 100.0 32.77 19.820 4.4757 4.4869 0.160 3624 146 49.6 9.02 20.080 4.4184 4.4294 0.140 5402 149 73.9 21.06 20.385 4.3530 4.3638 0.160 2652 149 36.3 23.25 21.215 4.1845 4.1949 0.160 369 154 5.0 5.78 21.890 4.0570 4.0670 0.200 773 156 10.6 3.09 22.630 3.9259 3.9357 0.280 4277 161 58.5 74.66 23.210 3.8291 3.8386 0.120 484 164 6.6 3.33 24.355 3.6516 3.6607 0.060 2725 169 37.3 1.16 24.610 3.6144 3.6234 0.140 3540 172 48.4 17.08 24.995 3.5596 3.5684 0.100 529 174 7.2 1.01 25.260 3.5228 3.5316 0.120 557 174 7.6 3.02 26.575 3.3514 3.3597 0.240 2421 182 33.1 42.58 27.155 3.2811 3.2893 0.140 676 185 9.2 1.32 27.310 3.2629 3.2710 0.100 767 185 10.5 2.75 27.865 3.1991 3.2071 0.120 420 188 5.7 1.08 28.210 3.1608 3.1686 0.100 1467 190 20.1 0.79 28.325 3.1482 3.1560 0.140 1789 190 24.5 4.41 28.650 3.1132 3.1210 0.180 1204 190 16.5 11.65 29.520 3.0234 3.0309 0.220 1011 196 13.8 15.74 30.250 2.9521 2.9594 0.120 159 199 2.2 1.22 31.105 2.8729 2.8800 0.360 282 204 3.9 8.14 31.905 2.8026 2.8096 0.100 339 207 4.6 0.96 32.350 2.7651 2.7720 0.120 237 210 3.2 3.01 33.300 2.6884 2.6950 0.180 1347 216 18.4 14.06 33.640 2.6620 2.6686 0.100 404 216 5.5 1.45 34.880 2.5701 2.5765 0.200 202 222 2.8 1.04 35.275 2.5422 2.5486 0.240 299 225 4.1 4.84 36.055 2.4890 2.4952 0.280 202 228 2.8 3.78 36.910 2.4333 2.4393 0.320 169 234 2.3 0.90 37.160 2.4175 2.4235 0.120 216 234 3.0 2.14 37.680 2.3853 2.3912 0.240 240 237 3.3 1.58 39.435 2.2831 2.2888 0.280 449 246 6.1 2.67 39.675 2.2698 2.2755 0.080 396 246 5.4 0.82 40.325 2.2347 2.2403 0.160 520 250 7.1 0.95 40.930 2.2031 2.2086 0.120 480 253 6.6 2.66 41.445 2.1769 2.1823 0.240 372 256 5.1 2.65 41.990 2.1499 2.1552 0.120 538 259 7.4 1.31 42.670 2.1172 2.1225 0.160 428 262 5.9 1.45 43.145 2.0950 2.1002 0.120 433 266 5.9 1.50 44.190 2.0478 2.0529 0.160 376 269 5.1 0.89 46.095 1.9675 1.9724 0.160 279 279 3.8 0.86 46.510 1.9509 1.9558 0.240 310 282 4.2 0.87 48.305 1.8826 1.8872 0.200 506 292 6.9 2.06 48.900 1.8610 1.8657 0.240 615 296 8.4 1.67 50.330 1.8115 1.8160 0.160 437 303 6.0 1.73 51.035 1.7881 1.7925 0.080 416 306 5.7 0.93 53.550 1.7099 1.7141 0.480 177 317 2.4 2.84 54.500 1.6823 1.6865 0.400 130 324 1.8 1.37 55.420 1.6565 1.6606 0.320 130 328 1.8 1.72 56.220 1.6348 1.6389 0.320 121 331 1.7 0.87 56.770 1.6203 1.6243 0.240 142 335 1.9 1.59 57.405 1.6039 1.6079 0.240 112 339 1.5 1.19 58.500 1.5764 1.5804 0.240 67 342 0.9 1.57
4) A method for treating a disease that is treatable with a compound having an affinity for the 5-HT1A or 5-HT2-receptors in a patient, comprising administering to said patient a therapeutically effective amount of a polymorph of flibanserin 1 characterized by having an X-ray powder diffraction pattern as shown in FIG. 1.
5) A method for treating a disease selected from depression, schizophrenia, Parkinson's, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment in a patient, comprising administering to said patient a therapeutically effective amount of form A according to claim 1.
6) A method for treating a disease selected from depression, schizophrenia, Parkinson's, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment in a patient, comprising administering to said patient a therapeutically effective amount of flibanserin 1 comprising form A according to claim 1.
7) A method for treating a disease selected from depression, schizophrenia, Parkinson's, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment in a patient, comprising administering to said patient a therapeutically effective amount of a polymorph of flibanserin 1 characterized by the X-ray powder diffraction pattern according to claim 3.
8) A method for treating a disease selected from depression, schizophrenia, Parkinson's, anxiety, sleep disturbances, sexual and mental disorders and age associated memory impairment in a patient, comprising administering to said patient a therapeutically effective amount of a polymorph of flibanserin 1 characterized by having an X-ray powder diffraction pattern as shown in FIG. 1.
US12/170,884 2001-08-02 2008-07-10 Use of a polymorph of flibanserin for treating disease Abandoned US20090054458A1 (en)

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US13/905,709 US20140031365A1 (en) 2001-08-02 2013-05-30 Use of a polymorph of flibanserin for treating disease
US14/269,420 US20150005316A1 (en) 2001-08-02 2014-05-05 Use of a polymorph of flibanserin for treating disease
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US10/210,474 US7183410B2 (en) 2001-08-02 2002-08-01 Stable polymorph of flibanserin
US11/079,070 US20050159430A1 (en) 2001-08-02 2005-03-14 Use of a polymorph of flibanserin for treating disease
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US13/541,214 Abandoned US20120270883A1 (en) 2001-08-02 2012-07-03 Use of a polymorph of flibanserin for treating disease
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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20060160822A1 (en) * 2001-08-10 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method of Using Flibanserin for Neuroprotection
US20070072872A1 (en) * 2001-10-20 2007-03-29 Boehringer Ingelheim Pharma Kg Treating sexual desire disorders with flibanserin
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
US20070196473A1 (en) * 2002-05-22 2007-08-23 Thomas Friedl Pharmaceutical compositions containing flibanserin
US20070265276A1 (en) * 2006-05-09 2007-11-15 Stephane Pollentier Use of flibanserin for the treatment of post-menopausal Sexual Desire Disorders
US20080069873A1 (en) * 2006-08-25 2008-03-20 Nantharat Pearnchob Controlled release system and method for manufacturing the same
US20080242678A1 (en) * 2005-08-03 2008-10-02 Angelo Ceci Use of Flibanserin in the Treatment of Obesity
US20090312242A1 (en) * 2006-06-30 2009-12-17 Ramiro Castro Flibanserin for the treatment of urinary incontinence and related diseases
US20090318469A1 (en) * 2006-07-14 2009-12-24 Boehringer Ingelheim International Gmbh Use of Flibanserin for the Treatment of Sexual Disorders in Females
US20100031379A1 (en) * 2007-01-23 2010-02-04 Keiko Fujikawa Non-human animal for eye disease model
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20110136825A1 (en) * 2007-09-12 2011-06-09 Boehringer Ingelheim International Gmbh Treatment of Vasomotor Symptoms
US8545886B2 (en) 2006-08-14 2013-10-01 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8658207B2 (en) 2006-08-14 2014-02-25 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US9546141B2 (en) 2008-12-15 2017-01-17 Sprout Pharmaceuticals, Inc. Salts
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
WO2005102342A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for the treatment of sexual disorders ii
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
JP2008511569A (en) * 2004-09-03 2008-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング How to treat attention-deficit hyperactivity disorder
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
WO2006096439A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
CA2599721A1 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of depression
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JP2008540672A (en) * 2005-05-19 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Method for treating sexual dysfunction caused by medical condition
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
CA2672957C (en) * 2006-12-20 2015-04-14 Boehringer Ingelheim International Gmbh Sulfated benzimidazolone derivatives having mixed serotonine receptor affinity
EP2129400A2 (en) * 2007-03-28 2009-12-09 Boehringer Ingelheim International GmbH Pharmaceutical compositions comprising flibanserin and a further agent in the treatment of sexual disorders
WO2017128932A1 (en) * 2016-01-31 2017-08-03 孟晓明 Novel polymorph of flibanserin and preparation method thereof and use of same
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CN109232434A (en) * 2018-10-29 2019-01-18 湖北大学 A kind of new method synthesizing flibanserin

Citations (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096248A (en) * 1959-04-06 1963-07-02 Rexall Drug & Chemical Company Method of making an encapsulated tablet
US3406178A (en) * 1964-02-04 1968-10-15 Monsanto Chem Australia Ltd Preparation of 2-substituted benzimidazoles
US3472854A (en) * 1965-08-19 1969-10-14 Sterling Drug Inc 1-((benzimidazolyl)-lower-alkyl)-4-substituted-piperazines
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
US4367217A (en) * 1980-01-12 1983-01-04 Boehringer Ingelheim Gmbh Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
US4737500A (en) * 1985-06-22 1988-04-12 Sandoz Pharm. Corp. 1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents
US4792452A (en) * 1987-07-28 1988-12-20 E. R. Squibb & Sons, Inc. Controlled release formulation
US4797399A (en) * 1986-01-17 1989-01-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds and antithrombotic pharmaceutical composition comprising the same
US4859692A (en) * 1985-04-17 1989-08-22 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
US4886803A (en) * 1986-07-25 1989-12-12 Nisshin Flour Milling Co., Ltd. Benzimidazole derivatives
US4940793A (en) * 1984-08-14 1990-07-10 Ravizza S.P.A. Pharmacologically active piperazino derivatives
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US5002948A (en) * 1988-12-28 1991-03-26 H. Lundbeck A/S 3-[4-[4-substituted-1-piperazinyl]-1-butyl]-1H-2,3-dihydroindoles
US5036088A (en) * 1986-06-09 1991-07-30 Pfizer Inc. Antiallergy and antiinflammatory agents, compositions and use
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5405642A (en) * 1991-02-27 1995-04-11 Janssen Pharmaceutica N.V. Method of highlighting intagliations in tablets
US5407686A (en) * 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5434156A (en) * 1991-03-22 1995-07-18 Pharmacia Ab Use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders
US5492907A (en) * 1992-12-09 1996-02-20 The United States Of America As Represented By The Department Of Health & Human Services Antipsychotic composition and method of treatment
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5576318A (en) * 1991-07-30 1996-11-19 Boehringer Ingelheim Italia S.P.A. Benzimidazolone derivatives
US5591743A (en) * 1993-07-06 1997-01-07 Pierre Fabre Medicament 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives as 5HT1A ligands
US5854290A (en) * 1995-09-21 1998-12-29 Amy F. T. Arnsten Use of guanfacine in the treatment of behavioral disorders
US5883094A (en) * 1995-04-24 1999-03-16 Pfizer Inc. Benzimidazolone derivatives with central dopaminergic activity
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
US5929054A (en) * 1996-12-02 1999-07-27 Merck Sharp Use of NK-1 receptor antagonists for treating sexual dysfunctions
US5977106A (en) * 1994-12-02 1999-11-02 Pierre Fabre Medicament 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives
US6068846A (en) * 1998-08-05 2000-05-30 Melaleuca, Incorporated Methods and materials for treating depression and mood disorder
US6083947A (en) * 1996-01-29 2000-07-04 The Regents Of The University Of California Method for treating sexual dysfunctions
US6165513A (en) * 1997-06-11 2000-12-26 The Procter & Gamble Co. Film-coated tablet for improved upper gastrointestinal tract safety
US6187340B1 (en) * 1997-09-10 2001-02-13 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical preparation
US6281218B1 (en) * 1999-09-22 2001-08-28 Ingelheim Italia S.P.A. Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity
US6284757B1 (en) * 1998-08-17 2001-09-04 Pfizer Inc. Pyrrolo[1,2-a]pyrazine derivatives as 5HT1A ligands
US20020001397A1 (en) * 1997-10-30 2002-01-03 Takatoshi Ishikawa Screen image observing device and method
US20020010216A1 (en) * 2000-02-24 2002-01-24 Karen Rogosky New drug combinations
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6426087B1 (en) * 1998-02-23 2002-07-30 Merck Patent Gesellschaft Mit Orally administrable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent
US20020103208A1 (en) * 2000-09-19 2002-08-01 Enzo Cereda Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
US20020104980A1 (en) * 1999-07-23 2002-08-08 Herbert Jainek Quick-connect coupling for opening a valve
US20020151543A1 (en) * 1998-05-28 2002-10-17 Sepracor Inc. Compositions and methods employing R (-) fluoxetine and other active ingredients
US6482841B1 (en) * 1997-10-09 2002-11-19 Cermol S.A. Pyridyl compounds and pharmaceutical compositions containing them
US20030027823A1 (en) * 2000-09-19 2003-02-06 Enzo Cereda N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
US20030083228A1 (en) * 2001-08-21 2003-05-01 Carpino Philip A. Treatments for female sexual dysfunction and methods for identifying compounds useful for treating female sexual dysfunction
US20030104980A1 (en) * 2001-10-20 2003-06-05 Boehringer Ingelheim Pharma Kg Treating sexual desire disorders with flibanserin
US20030119850A1 (en) * 2001-08-02 2003-06-26 Boehringer Ingelheim International Gmbh Stable polymorph of flibanserin
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
US6680071B1 (en) * 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
US20040023948A1 (en) * 1997-03-24 2004-02-05 Green Richard David Fast-dispersing dosage form containing 5-HT1 agonists
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
US20040132697A1 (en) * 2002-11-06 2004-07-08 Pfizer Inc. Treatment of female sexual dysfunction
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040180904A1 (en) * 2001-05-11 2004-09-16 Beck Jurgen K. Novel use of 2h-benzimidazol-2-one, 1,3-Dihydro-1-(2{4-[3-(trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-and its physiologically acceptable addition salts
US20040193452A1 (en) * 2003-01-06 2004-09-30 Laura Berman Method and system for computerized sexual function assessment of female users
US20040258749A1 (en) * 2001-10-09 2004-12-23 Peter Guldner Oral dosage form for propiverine or its pharmaceutically acceptable salts with an extended release of the active ingredient
US20050004105A1 (en) * 2003-01-29 2005-01-06 Emer Leahy Treatment for a attention-deficit hyperactivity disorder
US20050037983A1 (en) * 2003-03-11 2005-02-17 Timothy Dinan Compositions and methods for the treatment of depression and other affective disorders
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US20050095293A1 (en) * 2002-03-07 2005-05-05 Boehringer Ingelheim Pharma Gmbh Co. Kg Administration form for the oral application of poorly soluble drugs
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20050245539A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment of sexual disorders II
US20060014757A1 (en) * 2004-07-14 2006-01-19 Boehringer Ingelheim Pharmaceuticals Method for the treatment of anorexia nervosa
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
US20060052391A1 (en) * 2004-09-03 2006-03-09 Boehringer Ingelheim International Gmbh Method for the treatment of attention deficit hyperactivity disorder
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
US20060204486A1 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
US20060211685A1 (en) * 2005-03-04 2006-09-21 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of depression
US20060252773A1 (en) * 2005-05-06 2006-11-09 Boehringer Ingelheim International Gmbh Method for the treatment of drug abuse
US20060258640A1 (en) * 2005-05-13 2006-11-16 Boehringer Ingelheim International Gmbh Use of Flibanserin in the treatment of chronic pain
US20060264511A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of drug-induced sexual dysfunction
US20060264512A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of sexual dysfunction due to medical conditions
US20070043654A1 (en) * 2000-02-22 2007-02-22 Libman Brian L Automated loan evaluation system
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070265276A1 (en) * 2006-05-09 2007-11-15 Stephane Pollentier Use of flibanserin for the treatment of post-menopausal Sexual Desire Disorders
US20080038346A1 (en) * 2006-08-14 2008-02-14 Wolfram Eisenreich Extended release tablet formulations of flibanserin and method for manufacturing the same
US20080038347A1 (en) * 2006-08-14 2008-02-14 Wolfram Eisenreich Extended release tablet formulations of flibanserin and method for manufacturing the same
US20080069873A1 (en) * 2006-08-25 2008-03-20 Nantharat Pearnchob Controlled release system and method for manufacturing the same
US20080242679A1 (en) * 2005-10-29 2008-10-02 Angelo Ceci Benzimidazolone Derivatives For the Treatment of Premenstrual and Other Female Sexual Disorders
US20080242678A1 (en) * 2005-08-03 2008-10-02 Angelo Ceci Use of Flibanserin in the Treatment of Obesity
US20090023712A1 (en) * 2006-02-18 2009-01-22 Boehringer Ingelheim International Gmbh Pharmaceutical Compositions for the Treatment of Attention Deficit Hyperactivity Disorder Comprising Flibanserin
US20090176698A1 (en) * 2006-02-20 2009-07-09 Boehringer Ingelheim International Gmbh Benzimidazolone Derivatives for the Treatment of Urinary Incontinence
US20090239881A1 (en) * 2006-07-14 2009-09-24 Boehringer Ingelheim International Gmbh Combinations of Flibanserin with Caffeine, Process for Their Preparation and Use Thereof as Medicaments
US20090247546A1 (en) * 2006-02-28 2009-10-01 Boehringer Ingelheim International Gmbh Treatment of Prevention of Valvular Heart Disease with Flibanserin

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US210474A (en) * 1878-12-03 Improvement in leather-finishing machines
US546303A (en) * 1895-09-17 Half to james stewart
US546304A (en) * 1895-09-17 Shutter-hook
US658611A (en) * 1898-10-12 1900-09-25 Bausch & Lomb Microscope.
US658551A (en) * 1899-10-21 1900-09-25 Edward S Lord Bracket or fixture.
US658566A (en) * 1900-06-18 1900-09-25 John F Deems Feed-water heater.
US734405A (en) * 1902-08-05 1903-07-21 Samuel J H Howell Fertilizer-distributer and seed-dropper.
AU521110B2 (en) 1978-06-20 1982-03-18 Synthelabo Phenylpiperazine derivatives
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
DE3620643A1 (en) 1985-06-22 1987-01-22 Sandoz Ag Thiazoles, their preparation and use
EP0497985B1 (en) 1990-08-24 1998-07-22 Shin-Etsu Chemical Co., Ltd. Coating base for pharmaceutical film and production thereof
FR2675800A1 (en) 1991-04-26 1992-10-30 Rhone Poulenc Rorer Sa HETEROCYCLIC ANTISEROTONINE DERIVATIVES AND PREPARATION AND MEDICAMENTS CONTAINING SAME.
ES2163506T3 (en) 1994-06-14 2002-02-01 Pfizer DERIVATIVES OF BENCIMIDAZOLONA WITH CENTRAL DOPAMINERGIC ACTIVITY.
CN1083265C (en) 1994-08-23 2002-04-24 史密斯克莱·比奇曼公司 Improved pharmaceutical formulations containing ibuprofen and codeine
ES2204932T3 (en) 1994-09-12 2004-05-01 Eli Lilly And Company Limited SEROTONERGIC MODULATORS
JPH08143476A (en) 1994-11-18 1996-06-04 Japan Tobacco Inc Medicinal agent release-controlling membrane and solid preparation
GB9613423D0 (en) 1996-06-26 1996-08-28 Lilly Industries Ltd Pharmaceutical compounds
US5859246A (en) 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
GB9706089D0 (en) 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
WO2000028993A1 (en) 1998-11-19 2000-05-25 Nortran Pharmaceuticals, Inc. Serotonin ligands as pro-erectile compounds
JP2002542287A (en) 1999-04-28 2002-12-10 レスピラトリウス アクチボラゲット Medicine
AU2001293804A1 (en) 2000-09-19 2002-04-02 Boehringer Ingelheim Pharma Kg New benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
GEP20063783B (en) 2001-03-28 2006-04-10 Pfizer N-Phenpropylcyclopentyl-Substituted Glutaramide Derivatives as Inhibitors of Neutral Endopeptidase Enzyme (NEP) for Treating Female Sexual Dysfunction (FSAD)
DE60223031T2 (en) 2001-07-30 2008-07-24 Spectrum Pharmaceuticals, Inc., Irvine ARYLPIPERAZINE-BOUND TETRAHYDROINDOLON DERIVATIVES
EP1518858A1 (en) 2001-08-02 2005-03-30 BIDACHEM S.p.A. Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments
DE10138273A1 (en) 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Medicines with neuroprotective effects
US6856211B2 (en) * 2002-05-21 2005-02-15 Nagano Japan Radio Co., Ltd. Coaxial type impedance matching device
EP1510133A1 (en) * 2003-09-01 2005-03-02 Belovo S.A., Egg Science & Technology Balanced oil composition

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096248A (en) * 1959-04-06 1963-07-02 Rexall Drug & Chemical Company Method of making an encapsulated tablet
US3406178A (en) * 1964-02-04 1968-10-15 Monsanto Chem Australia Ltd Preparation of 2-substituted benzimidazoles
US3472854A (en) * 1965-08-19 1969-10-14 Sterling Drug Inc 1-((benzimidazolyl)-lower-alkyl)-4-substituted-piperazines
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
US4367217A (en) * 1980-01-12 1983-01-04 Boehringer Ingelheim Gmbh Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
US4940793A (en) * 1984-08-14 1990-07-10 Ravizza S.P.A. Pharmacologically active piperazino derivatives
US4859692A (en) * 1985-04-17 1989-08-22 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
US4737500A (en) * 1985-06-22 1988-04-12 Sandoz Pharm. Corp. 1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents
US4797399A (en) * 1986-01-17 1989-01-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds and antithrombotic pharmaceutical composition comprising the same
US5036088A (en) * 1986-06-09 1991-07-30 Pfizer Inc. Antiallergy and antiinflammatory agents, compositions and use
US4886803A (en) * 1986-07-25 1989-12-12 Nisshin Flour Milling Co., Ltd. Benzimidazole derivatives
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US4792452A (en) * 1987-07-28 1988-12-20 E. R. Squibb & Sons, Inc. Controlled release formulation
US5002948A (en) * 1988-12-28 1991-03-26 H. Lundbeck A/S 3-[4-[4-substituted-1-piperazinyl]-1-butyl]-1H-2,3-dihydroindoles
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5405642A (en) * 1991-02-27 1995-04-11 Janssen Pharmaceutica N.V. Method of highlighting intagliations in tablets
US5434156A (en) * 1991-03-22 1995-07-18 Pharmacia Ab Use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders
US5576318A (en) * 1991-07-30 1996-11-19 Boehringer Ingelheim Italia S.P.A. Benzimidazolone derivatives
US5407686A (en) * 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5492907A (en) * 1992-12-09 1996-02-20 The United States Of America As Represented By The Department Of Health & Human Services Antipsychotic composition and method of treatment
US5591743A (en) * 1993-07-06 1997-01-07 Pierre Fabre Medicament 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives as 5HT1A ligands
US5977106A (en) * 1994-12-02 1999-11-02 Pierre Fabre Medicament 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5883094A (en) * 1995-04-24 1999-03-16 Pfizer Inc. Benzimidazolone derivatives with central dopaminergic activity
US5854290A (en) * 1995-09-21 1998-12-29 Amy F. T. Arnsten Use of guanfacine in the treatment of behavioral disorders
US6083947A (en) * 1996-01-29 2000-07-04 The Regents Of The University Of California Method for treating sexual dysfunctions
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
US5929054A (en) * 1996-12-02 1999-07-27 Merck Sharp Use of NK-1 receptor antagonists for treating sexual dysfunctions
US20040023948A1 (en) * 1997-03-24 2004-02-05 Green Richard David Fast-dispersing dosage form containing 5-HT1 agonists
US6165513A (en) * 1997-06-11 2000-12-26 The Procter & Gamble Co. Film-coated tablet for improved upper gastrointestinal tract safety
US6187340B1 (en) * 1997-09-10 2001-02-13 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical preparation
US6482841B1 (en) * 1997-10-09 2002-11-19 Cermol S.A. Pyridyl compounds and pharmaceutical compositions containing them
US20020001397A1 (en) * 1997-10-30 2002-01-03 Takatoshi Ishikawa Screen image observing device and method
US6426087B1 (en) * 1998-02-23 2002-07-30 Merck Patent Gesellschaft Mit Orally administrable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent
US20020151543A1 (en) * 1998-05-28 2002-10-17 Sepracor Inc. Compositions and methods employing R (-) fluoxetine and other active ingredients
US6068846A (en) * 1998-08-05 2000-05-30 Melaleuca, Incorporated Methods and materials for treating depression and mood disorder
US6284757B1 (en) * 1998-08-17 2001-09-04 Pfizer Inc. Pyrrolo[1,2-a]pyrazine derivatives as 5HT1A ligands
US6680071B1 (en) * 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
US20020104980A1 (en) * 1999-07-23 2002-08-08 Herbert Jainek Quick-connect coupling for opening a valve
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6281218B1 (en) * 1999-09-22 2001-08-28 Ingelheim Italia S.P.A. Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity
US20070043654A1 (en) * 2000-02-22 2007-02-22 Libman Brian L Automated loan evaluation system
US20020010216A1 (en) * 2000-02-24 2002-01-24 Karen Rogosky New drug combinations
US6521623B1 (en) * 2000-09-19 2003-02-18 Boehringer Ingelheim Pharma Kg N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors
US20030027823A1 (en) * 2000-09-19 2003-02-06 Enzo Cereda N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors
US20020103208A1 (en) * 2000-09-19 2002-08-01 Enzo Cereda Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
US6586435B2 (en) * 2000-09-19 2003-07-01 Boehringer Ingelheim Pharma Kg Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
US20040180904A1 (en) * 2001-05-11 2004-09-16 Beck Jurgen K. Novel use of 2h-benzimidazol-2-one, 1,3-Dihydro-1-(2{4-[3-(trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-and its physiologically acceptable addition salts
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
US20050159430A1 (en) * 2001-08-02 2005-07-21 Bidachem Spa Use of a polymorph of flibanserin for treating disease
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20070032655A1 (en) * 2001-08-02 2007-02-08 Bidachem Spa Stable polymorph of flibanserin
US7420057B2 (en) * 2001-08-02 2008-09-02 Boehringer Ingelheim Pharma Kg Stable polymorph of flibanserin
US20030119850A1 (en) * 2001-08-02 2003-06-26 Boehringer Ingelheim International Gmbh Stable polymorph of flibanserin
US20040235861A1 (en) * 2001-08-10 2004-11-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method of using flibanserin for neuroprotection
US20060160822A1 (en) * 2001-08-10 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method of Using Flibanserin for Neuroprotection
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
US20030083228A1 (en) * 2001-08-21 2003-05-01 Carpino Philip A. Treatments for female sexual dysfunction and methods for identifying compounds useful for treating female sexual dysfunction
US20040258749A1 (en) * 2001-10-09 2004-12-23 Peter Guldner Oral dosage form for propiverine or its pharmaceutically acceptable salts with an extended release of the active ingredient
US7151103B2 (en) * 2001-10-20 2006-12-19 Boehringer Ingelheim Pharma Kg Method of treating female hypoactive sexual desire disorder with flibanserin
US20070072872A1 (en) * 2001-10-20 2007-03-29 Boehringer Ingelheim Pharma Kg Treating sexual desire disorders with flibanserin
US20030104980A1 (en) * 2001-10-20 2003-06-05 Boehringer Ingelheim Pharma Kg Treating sexual desire disorders with flibanserin
US20050095293A1 (en) * 2002-03-07 2005-05-05 Boehringer Ingelheim Pharma Gmbh Co. Kg Administration form for the oral application of poorly soluble drugs
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
US20070196473A1 (en) * 2002-05-22 2007-08-23 Thomas Friedl Pharmaceutical compositions containing flibanserin
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
US20040132697A1 (en) * 2002-11-06 2004-07-08 Pfizer Inc. Treatment of female sexual dysfunction
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040193452A1 (en) * 2003-01-06 2004-09-30 Laura Berman Method and system for computerized sexual function assessment of female users
US20050004105A1 (en) * 2003-01-29 2005-01-06 Emer Leahy Treatment for a attention-deficit hyperactivity disorder
US20050037983A1 (en) * 2003-03-11 2005-02-17 Timothy Dinan Compositions and methods for the treatment of depression and other affective disorders
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US20080103155A1 (en) * 2004-04-22 2008-05-01 Klaus Mendla Pharmaceutical compositions for the treatment of sexual disorders II
US20050245539A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment of sexual disorders II
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20060014757A1 (en) * 2004-07-14 2006-01-19 Boehringer Ingelheim Pharmaceuticals Method for the treatment of anorexia nervosa
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
US20080119482A1 (en) * 2004-09-03 2008-05-22 Mikael Goeran Dolsten Method for the treatment of attention deficit hyperactivity disorder
US20060052391A1 (en) * 2004-09-03 2006-03-09 Boehringer Ingelheim International Gmbh Method for the treatment of attention deficit hyperactivity disorder
US20060211685A1 (en) * 2005-03-04 2006-09-21 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of depression
US20060204486A1 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
US20060252773A1 (en) * 2005-05-06 2006-11-09 Boehringer Ingelheim International Gmbh Method for the treatment of drug abuse
US20060258640A1 (en) * 2005-05-13 2006-11-16 Boehringer Ingelheim International Gmbh Use of Flibanserin in the treatment of chronic pain
US20060264512A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of sexual dysfunction due to medical conditions
US20060264511A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of drug-induced sexual dysfunction
US20080242678A1 (en) * 2005-08-03 2008-10-02 Angelo Ceci Use of Flibanserin in the Treatment of Obesity
US20080242679A1 (en) * 2005-10-29 2008-10-02 Angelo Ceci Benzimidazolone Derivatives For the Treatment of Premenstrual and Other Female Sexual Disorders
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
US20090023712A1 (en) * 2006-02-18 2009-01-22 Boehringer Ingelheim International Gmbh Pharmaceutical Compositions for the Treatment of Attention Deficit Hyperactivity Disorder Comprising Flibanserin
US20090176698A1 (en) * 2006-02-20 2009-07-09 Boehringer Ingelheim International Gmbh Benzimidazolone Derivatives for the Treatment of Urinary Incontinence
US20090247546A1 (en) * 2006-02-28 2009-10-01 Boehringer Ingelheim International Gmbh Treatment of Prevention of Valvular Heart Disease with Flibanserin
US20070265276A1 (en) * 2006-05-09 2007-11-15 Stephane Pollentier Use of flibanserin for the treatment of post-menopausal Sexual Desire Disorders
US20090239881A1 (en) * 2006-07-14 2009-09-24 Boehringer Ingelheim International Gmbh Combinations of Flibanserin with Caffeine, Process for Their Preparation and Use Thereof as Medicaments
US20080038347A1 (en) * 2006-08-14 2008-02-14 Wolfram Eisenreich Extended release tablet formulations of flibanserin and method for manufacturing the same
US20080038346A1 (en) * 2006-08-14 2008-02-14 Wolfram Eisenreich Extended release tablet formulations of flibanserin and method for manufacturing the same
US20080069873A1 (en) * 2006-08-25 2008-03-20 Nantharat Pearnchob Controlled release system and method for manufacturing the same

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060160822A1 (en) * 2001-08-10 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method of Using Flibanserin for Neuroprotection
US9782403B2 (en) 2001-10-20 2017-10-10 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US11058683B2 (en) 2001-10-20 2021-07-13 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US8227471B2 (en) 2001-10-20 2012-07-24 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US20070072872A1 (en) * 2001-10-20 2007-03-29 Boehringer Ingelheim Pharma Kg Treating sexual desire disorders with flibanserin
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US20070196473A1 (en) * 2002-05-22 2007-08-23 Thomas Friedl Pharmaceutical compositions containing flibanserin
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US20080242678A1 (en) * 2005-08-03 2008-10-02 Angelo Ceci Use of Flibanserin in the Treatment of Obesity
US10874668B2 (en) 2005-08-03 2020-12-29 Sprout Pharmaceuticals, Inc. Use of Flibanserin in the treatment of obesity
US9730927B2 (en) 2005-08-03 2017-08-15 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US10335407B2 (en) 2005-08-03 2019-07-02 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
US20070265276A1 (en) * 2006-05-09 2007-11-15 Stephane Pollentier Use of flibanserin for the treatment of post-menopausal Sexual Desire Disorders
US20090312242A1 (en) * 2006-06-30 2009-12-17 Ramiro Castro Flibanserin for the treatment of urinary incontinence and related diseases
US9763936B2 (en) 2006-06-30 2017-09-19 Sprout Pharmaceuticals, Inc. Flibanserin for the treatment of urinary incontinence and related diseases
US10004731B2 (en) 2006-06-30 2018-06-26 Sprout Pharmaceuticals, Inc. Flibanserin for the treatment of urinary incontinence and related diseases
US20090318469A1 (en) * 2006-07-14 2009-12-24 Boehringer Ingelheim International Gmbh Use of Flibanserin for the Treatment of Sexual Disorders in Females
US8658207B2 (en) 2006-08-14 2014-02-25 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8545886B2 (en) 2006-08-14 2013-10-01 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8512748B2 (en) 2006-08-25 2013-08-20 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
US20080069873A1 (en) * 2006-08-25 2008-03-20 Nantharat Pearnchob Controlled release system and method for manufacturing the same
US20100031379A1 (en) * 2007-01-23 2010-02-04 Keiko Fujikawa Non-human animal for eye disease model
US10166230B2 (en) 2007-09-12 2019-01-01 Sprout Pharmaceuticals Inc. Treatment of vasomotor symptoms
US20110136825A1 (en) * 2007-09-12 2011-06-09 Boehringer Ingelheim International Gmbh Treatment of Vasomotor Symptoms
US9546141B2 (en) 2008-12-15 2017-01-17 Sprout Pharmaceuticals, Inc. Salts

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