US20060082372A1 - Nmr systems employing inverted variable capacitors - Google Patents
Nmr systems employing inverted variable capacitors Download PDFInfo
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- US20060082372A1 US20060082372A1 US10/965,481 US96548104A US2006082372A1 US 20060082372 A1 US20060082372 A1 US 20060082372A1 US 96548104 A US96548104 A US 96548104A US 2006082372 A1 US2006082372 A1 US 2006082372A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
- G01R33/3628—Tuning/matching of the transmit/receive coil
Definitions
- the invention in general relates to nuclear magnetic resonance (NMR) spectroscopy, and in particular to systems and methods using variable capacitors for adjusting the resonant frequencies of NMR measurement circuits.
- NMR nuclear magnetic resonance
- Nuclear magnetic resonance (NMR) spectrometers typically include a superconducting magnet for generating a static magnetic field B 0 , and an NMR probe including one or more special-purpose radio-frequency (RF) coils for generating a time-varying magnetic field B 1 perpendicular to the field B 0 , and for detecting the response of a sample to the applied magnetic fields.
- RF radio-frequency
- Each RF coil and associated circuitry can resonate at the Larmor frequency of a nucleus of interest present in the sample.
- the RF coils are typically provided as part of an NMR probe, and are used to analyze samples situated in sample tubes or flow cells.
- the direction of the static magnetic field B 0 is commonly denoted as the z-axis, while the plane perpendicular to the z-axis is commonly termed the x-y or ⁇ -plane.
- the frequency of interest is determined by the nucleus of interest and the strength of the applied static magnetic field B 0 .
- the resonant frequency of the excitation/detection circuitry is set to be equal to the frequency of interest.
- the impedance of each coil is matched to the impedance of the transmission line and associated components used to couple RF energy into the coil. If the coil is not impedance-matched, a sub-optimal fraction of the RF energy sent to the coil actually enters the coil. The rest of the energy is reflected out, and does not contribute to the NMR measurements.
- Variable capacitors may be used to adjust the circuit resonant frequency and to ensure optimal impedance matching.
- Typical variable capacitors used in NMR applications are non-magnetic capacitors capable of operating at voltages on the order of several kV. Such variable capacitors are often placed in a space-constrained region within the nuclear magnetic resonance probe, for example in a region immediately underneath the NMR sample coil. The tight spaces available within typical NMR probes and the high voltages applied to such variable capacitors may lead to undesirable arcing from the capacitors to surrounding probe components held at lower voltages. In addition, some NMR circuits may suffer from undesirable stray capacitance, which may degrade the circuits' performance.
- the present invention provides a nuclear magnetic resonance apparatus comprising a nuclear magnetic resonance sample coil and a variable capacitor electrically connected to the sample coil.
- the capacitor comprises an outer cylindrical conductor, an inner cylindrical conductor longitudinally movable in a space defined within the outer cylindrical conductor, and an outer capacitor contact electrically connected to the inner cylindrical conductor.
- the outer capacitor contact is positioned closer to the sample coil than the outer cylindrical conductor.
- a nuclear magnetic resonance probe comprises a nuclear magnetic resonance sample coil disposed within a nuclear magnetic resonance probe, a generally-transverse base plate disposed below the sample coil in the nuclear magnetic resonance probe, and a set of generally-longitudinal variable capacitors mounted on the base plate and extending upward from the base plate.
- Each variable capacitor comprises an outer cylindrical conductor, an inner cylindrical conductor longitudinally movable in a space defined within the outer cylindrical conductor, and an outer capacitor contact electrically connected to the inner cylindrical conductor and situated along a top region of each variable capacitor.
- FIG. 1 is a schematic diagram of an exemplary NMR spectrometer according to some embodiments of the present invention.
- FIG. 2 -A is a schematic diagram of a part of a tunable NMR probe circuit according to some embodiments of the present invention.
- FIG. 2 -B is a schematic diagram of a part of a tunable NMR probe circuit according to some embodiments of the present invention.
- FIG. 3 -A shows a side view of an exemplary arrangement of three prior-art capacitors in a nuclear magnetic resonance probe.
- FIG. 3 -B shows a side view of an exemplary arrangement of three variable capacitors in a nuclear magnetic resonance probe, according to some embodiments of the present invention.
- FIG. 3 -C shows a side view of a variable capacitor connected across a sample coil, according to some embodiments of the present invention.
- FIG. 4 -A shows a side view of a variable capacitor according to some embodiments of the present invention.
- FIG. 4 -B shows a side sectional view of the capacitor of FIG. 4 -A.
- FIG. 4 -C shows a central shaft design suitable for use in a capacitor such as the one illustrated in FIGS. 4 -A-B.
- a set of elements includes one or more elements.
- a set of rails may include one or more rails.
- Any reference to an element is understood to encompass one or more elements.
- Each recited element or structure can be formed by or be part of a monolithic structure, or be formed from multiple distinct structures.
- the statement that a coil is used to perform a nuclear magnetic measurement on a sample is understood to mean that the coil is used as transmitter, receiver, or both.
- Any recited electrical or mechanical connections can be direct connections or indirect connections through intermediary circuit elements or structures.
- the terms “high-voltage” and “low-voltage” are understood to be relative terms: a recited high voltage is understood to be higher than a recited low voltage.
- FIG. 1 is a schematic diagram illustrating an exemplary nuclear magnetic resonance (NMR) spectrometer 12 according to an embodiment of the present invention.
- Spectrometer 12 comprises a magnet 16 , an NMR probe 20 inserted in a cylindrical bore of magnet 16 , and a control/acquisition system 18 electrically connected to magnet 16 and probe 20 .
- Probe 20 includes one or more radio-frequency (RF) coils 24 and associated electrical circuit components.
- RF radio-frequency
- a sample container 22 is positioned within probe 20 , for holding an NMR sample of interest within coil 24 while measurements are performed on the sample.
- Sample container 22 may be a sample tube or a flow cell.
- a number of electrical circuit components such as capacitors, inductors, and other components are situated in a circuit region 26 of probe 20 , and are connected to coil 24 .
- Coil 24 and the various components connected to coil 24 form one or more NMR measurement circuits.
- Circuit region 26 is situated adjacent to coil 24 , immediately underneath coil 24 .
- a sample is inserted into a measurement space defined within coil 24 .
- Magnet 16 applies a static magnetic field B 0 to the sample held within sample container 22 .
- Control/acquisition system 18 comprises electronic components configured to apply desired radio-frequency pulses to probe 20 , and to acquire data indicative of the nuclear magnetic resonance properties of the samples within probe 20 .
- Coil 24 is used to apply radio-frequency magnetic fields B 1 to the sample, and/or to measure the response of the sample to the applied magnetic fields.
- the RF magnetic fields are perpendicular to the static magnetic field. The same coil may be used for both applying an RF magnetic field and for measuring the sample response to the applied magnetic field.
- one coil may be used for applying an RF magnetic field, and another coil for measuring the response of the sample to the applied magnetic field.
- a single coil may be used to perform measurements at multiple frequencies, by tuning the resonant frequency of the NMR measurement circuit that includes the coil. Tuning the circuit resonant frequency may be achieved by adjusting the capacitance values of one or more variable capacitors included in the circuit.
- FIG. 2 -A shows a schematic diagram of a tunable NMR measurement circuit 30 according to some embodiments of the present invention.
- Measurement circuit 30 includes NMR sample coil 24 and a set of variable capacitors 40 a - c connected to sample coil 24 .
- Measurement circuit 30 may also include other components such as capacitors and inductors.
- An input terminal 36 receives external excitation pulses.
- a continuously-variable impedance-matching capacitor 40 a is connected between input terminal 36 and the input (proximal) side of sample coil 24 . The capacitance of capacitor 40 a may be adjusted in order to optimize the impedance matching of circuit 30 .
- Two continuously-variable capacitors 40 b - c are connected between ground and the input and output sides of sample coil 24 , respectively.
- Suitable inductance and capacitance values for the various components shown in FIG. 2 -A may be chosen according to the desired NMR application.
- sample coil 24 has an inductance on the order of hundreds of mH, for example about 250 mH.
- Variable capacitors 40 a - c may take on continuously-adjustable values on the order of pF to tens of pF, for example 1-15 pF.
- the capacitance of capacitor 40 a may be adjusted to provide impedance matching to 50 ⁇ .
- capacitors 40 a - c have voltage ratings of 2500 V or higher.
- FIG. 2 -B is a schematic diagram of a tunable NMR probe circuit 130 according to other embodiments of the present invention.
- Circuit 130 includes sample coil 24 and a variable capacitor 40 connected across sample coil 24 .
- Circuit 130 may also include other components such as capacitors and inductors. Such components may be connected to coil 24 as illustrated in FIG. 2 -A, for example.
- FIG. 3 -A shows a side view of an exemplary arrangement of three prior-art capacitors 40 a ′- c ′ in a nuclear magnetic resonance probe.
- the illustrated arrangement corresponds to the circuit diagram of FIG. 2 -A.
- Capacitors such as the ones shown in FIG. 3 -A may be obtained commercially, for example from Voltronics Corporation, Denville, N.J.
- Sample coil 24 is illustrated schematically, as are the connections of capacitors 40 b ′- c ′ to ground.
- Capacitors 40 b ′- c ′ are connected between ground and the two sides of sample coil 24 , respectively.
- Capacitor 40 a ′ is connected between sample coil 24 and input terminal 36 . Electrically conductive lateral surfaces of capacitors 40 a ′- c ′ are hatched in FIG. 3 -A.
- Capacitors 40 a ′- c ′ are mounted through apertures defined in a horizontal base plate 60 .
- Capacitors 40 a ′- c ′ are structurally identical; the following description focuses on capacitor 40 c ′ for simplicity.
- Capacitor 40 c ′ includes a lower capacitor contact (electrode) 54 ′ and an upper capacitor contact (electrode) 50 ′. Contacts 50 ′, 54 ′ are separated by an insulative region 52 ′.
- a capacitance-adjustment member 58 ′ can be rotated to adjust the capacitance of capacitor 40 c ′. Adjustment member 58 ′ protrudes underneath base plate 60 .
- Lower contact 54 ′ may be connected to a longitudinally-movable internal cylindrical rotor, while upper contact 50 ′ may include a fixed external cylindrical stator. The longitudinal motion of the internal cylindrical rotor is controlled by the rotation of adjustment member 58 ′.
- Upper capacitor contact 50 ′ is situated along a top end region of capacitor 40 c ′, closer to sample coil 24 than lower capacitor contact 54 ′.
- Lower capacitor contact 54 ′ is situated closer to base plate 60 than upper capacitor contact 50 ′.
- Upper capacitor contact 50 ′ has a longer longitudinal extent than lower capacitor contact 54 ′. Generally, upper capacitor contact 50 ′ is subjected to higher voltages than lower capacitor contact 54 ′.
- FIG. 3 -B shows a side view of an exemplary arrangement of three variable capacitors 40 a - c in a nuclear magnetic resonance probe, according to some embodiments of the present invention.
- Capacitor 40 c includes an upper capacitor contact 50 and a lower capacitor contact 54 .
- Contacts 50 , 54 are separated by an insulative region 52 .
- Another insulative region 56 separates lower capacitor contact 54 from base plate 60 and/or a shorting external contact 76 described below.
- a capacitance-adjustment member 58 can be rotated to adjust the capacitance of capacitor 40 c. Adjustment member 58 protrudes underneath base plate 60 .
- upper contact 50 is connected to a longitudinally-movable internal cylindrical rotor, while lower contact 54 includes a fixed external cylindrical stator.
- Upper capacitor contact 50 is situated along a top end region of capacitor 40 c ′, closer to sample coil 24 than lower capacitor contact 54 ′.
- Lower capacitor contact 54 is situated closer to base plate 60 than upper capacitor contact 50 .
- Upper capacitor contact 50 has a shorter longitudinal extent than lower capacitor contact 54 .
- upper capacitor contact 50 is subjected to higher voltages than lower capacitor contact 54 .
- FIG. 3 -C shows a side view of a variable capacitor 40 connected across a sample coil, according to some embodiments of the present invention.
- Capacitor 40 may be structurally identical to the capacitors 40 a - c described above with reference to FIG. 3 -B.
- the minimum lead length used to connect capacitor 40 to sample coil 24 depends approximately on the longitudinal extents (lengths) of insulative region 52 and upper contact 50 .
- the corresponding lead length for a comparable capacitor in the configuration of FIG. 3 -A depends on the longitudinal extents of insulative region 52 ′ and upper contact 50 ′.
- the length of upper contact 50 ′ FIG.
- the total lead length for the capacitor of FIG. 3 -C is shorter by more than 0.5′′ than the lead length for a corresponding configuration using a capacitor such as the ones shown in FIG. 3 -A.
- FIG. 4 -A shows a side view of variable capacitor 40 , according to some embodiments of the present invention.
- FIG. 4 -B shows a side sectional view of the capacitor of FIG. 4 -A.
- Capacitor 4 includes two field-reduction bands 74 a - b situated at the interfaces between contacts 50 , 54 and region 52 , respectively.
- Bands 74 a - b may be formed by a material such as a room-temperature vulcanizing (RTV) silicone coating.
- Bands 74 a - b serve to reduce arcing by reducing the electrical field intensity generated by geometrical irregularities at the longitudinal ends of contacts 50 , 54 .
- a capacitor base 72 may rest on an NMR probe base plate, as shown in FIG. 3 -B. Capacitor base 72 is in a bottom region of capacitor 40 , longitudinally opposite upper contact 50 .
- Lower capacitor contact 54 forms an outer cylindrical conductor (capacitor plate) of capacitor 40 .
- the other capacitor plate is formed by an inner cylindrical conductor 64 , which is electrically connected to upper capacitor contact 50 .
- Cylindrical conductors 54 , 64 are disposed concentrically within capacitor 40 .
- Contacts 56 , 54 may be formed by corresponding metallization regions defined on a dielectric or insulative substrate forming part of the capacitor side wall.
- the insulative substrate may be a high-voltage polytetrafluoroethylene (PTFE, or Teflon®) dielectric. Insulative region 52 is defined by a bare region of the insulative substrate.
- Threaded shaft 68 is rigidly coupled to adjustment member 58 , which protrudes downward through base 72 .
- Threaded shaft 68 extends upward from base 72 , in the center of the cylindrical space defined in the interior of outer conductor 54 .
- threaded shaft 68 includes a conductive section 68 a longitudinally concatenated to an insulative section 68 b.
- Conductive section 68 a may be made of a metal, while insulative section 68 b may be made of a ceramic material. Insulative section 68 b breaks any electrical contact between inner conductor 64 and capacitor base 72 .
- Threaded shaft 68 may also be formed from a single monolithic piece of insulative material, such as a ceramic.
- threaded shaft 68 and adjustment member 58 may be formed from a single monolithic rigid piece. Threaded shaft 68 is also coupled to a longitudinally-movable internal cylindrical conductor (rotor) 64 , for example through a matching internal thread of internal conductor 64 .
- a set of rigid, fixed longitudinal rails 66 fit through matching longitudinal grooves or channels defined in internal conductor 64 .
- capacitor 40 may include two or more rails 66 spaced apart azimuthally. Rails 66 prevent the rotation of internal conductor 64 as adjustment member 58 and shaft 68 are rotated. Rotating shaft 68 thus causes internal conductor 64 to move longitudinally. Rails 66 also transport current from upper contact 50 to internal conductor 64 .
- the capacitance of capacitor 40 takes on its minimal value.
- inner conductor 64 is longitudinally aligned with (at the same height as) outer conductor 54 , the capacitance of capacitor 40 takes on its maximal value.
- the capacitance of capacitor 40 may be adjusted between its minimal and maximal values by longitudinally moving inner conductor 64 .
- Shorting capacitor 40 may be achieved by connecting inner conductor 64 to a conductor situated in the lower part of capacitor 40 .
- a conductor may be a transverse conductor connected to a shorting external contact 76 and/or capacitor base 72 .
- a transverse conductor may be provided as part of base 72 , or may be attached to base 72 .
- the transverse conductor may be a base plate 72 formed from a conductive material.
- Shorting capacitor 40 may be achieved by lowering inner conductor 64 until inner conductor 64 touches the transverse conductor, and connecting the transverse conductor and outer conductor 54 to the same potential (e.g. ground). The transverse conductor may be connected to a desired potential using shorting external contact 76 .
- FIG. 4 -C shows another central shaft 168 suitable for use in a capacitor such as the one illustrated in FIGS. 4 -A-B.
- Shaft 168 includes two conductive sections 168 a,c longitudinally separated by an insulative section 168 b. Section 168 c is connected to the capacitor base, while section 168 a is connected to the inner conductor. Insulative section 168 b electrically insulates sections 168 a, c from each other.
- the exemplary embodiments described above allow a reduced circuit stray capacitance, reduced arcing potential, a reduced lead length when a capacitor is positioned across the NMR sample coil, and convenient shorting of the capacitors if desired.
- Stray capacitance is of particular concerns for NMR systems using relatively high magnetic field strengths and higher frequencies (>600 MHz). The effect of stray capacitance is exacerbated at high frequencies. At higher frequencies, shorter pulse widths are required due to larger chemical shifts.
- One way to reduce pulse widths at high frequencies is to increase pulse power. At the same time, increasing pulse power may increase the incidence of arcing. Reducing the stray capacitance allows the NMR probe to be tuned to higher frequencies, and reduces the potential for arcing to other probe components.
- the higher-voltage, upper capacitor contact is shorter and has a lower external surface area than the lower-voltage, lower capacitor contact.
- the reduced external surface area reduces the potential for arcing.
- the higher-voltage inner cylinder is situated in an inner position, and is less susceptible to arcing than the outer capacitor cylinder. Internalizing the high-potential end of the capacitor also allows reducing the stray capacitance of the capacitor to the environment.
- variable capacitor across the leads of the NMR sample coil may allow increasing the frequency range the capacitor is able to tune over by factor of three or four.
- adding a variable capacitor across the sample coil leads requires additional lead length, which may negatively affect circuit performance. If both capacitor cylinders are electrically connected upward, toward the sample coil, the exemplary designs described above allow reduced lead lengths for the variable capacitor connections.
- the lead length to the lower conductor depends on the relatively short length of the upper conductor, rather than the longer outer conductor.
- the exemplary capacitor design shown in FIGS. 4 -A-B also allows convenient shorting of the capacitor as described above.
- the high-potential inner cylinder of the capacitor is normally connected to the top side of the capacitor, but the inner cylinder can be brought all the way down to the capacitor base to establish a connection to the same potential as the outer cylinder.
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Abstract
Description
- The invention in general relates to nuclear magnetic resonance (NMR) spectroscopy, and in particular to systems and methods using variable capacitors for adjusting the resonant frequencies of NMR measurement circuits.
- Nuclear magnetic resonance (NMR) spectrometers typically include a superconducting magnet for generating a static magnetic field B0, and an NMR probe including one or more special-purpose radio-frequency (RF) coils for generating a time-varying magnetic field B1 perpendicular to the field B0, and for detecting the response of a sample to the applied magnetic fields. Each RF coil and associated circuitry can resonate at the Larmor frequency of a nucleus of interest present in the sample. The RF coils are typically provided as part of an NMR probe, and are used to analyze samples situated in sample tubes or flow cells. The direction of the static magnetic field B0 is commonly denoted as the z-axis, while the plane perpendicular to the z-axis is commonly termed the x-y or θ-plane.
- The frequency of interest is determined by the nucleus of interest and the strength of the applied static magnetic field B0. In order to maximize the accuracy of NMR measurements, the resonant frequency of the excitation/detection circuitry is set to be equal to the frequency of interest. The resonant frequency of the excitation/detection circuitry is generally
v=1/√{square root over (LC)} [1]
where L and C are the effective inductance and capacitance, respectively, of the excitation/detection circuitry. - Additionally, in order to maximize the transfer of RF energy into the RF coils, the impedance of each coil is matched to the impedance of the transmission line and associated components used to couple RF energy into the coil. If the coil is not impedance-matched, a sub-optimal fraction of the RF energy sent to the coil actually enters the coil. The rest of the energy is reflected out, and does not contribute to the NMR measurements.
- Variable capacitors may be used to adjust the circuit resonant frequency and to ensure optimal impedance matching. Typical variable capacitors used in NMR applications are non-magnetic capacitors capable of operating at voltages on the order of several kV. Such variable capacitors are often placed in a space-constrained region within the nuclear magnetic resonance probe, for example in a region immediately underneath the NMR sample coil. The tight spaces available within typical NMR probes and the high voltages applied to such variable capacitors may lead to undesirable arcing from the capacitors to surrounding probe components held at lower voltages. In addition, some NMR circuits may suffer from undesirable stray capacitance, which may degrade the circuits' performance.
- According to one aspect, the present invention provides a nuclear magnetic resonance apparatus comprising a nuclear magnetic resonance sample coil and a variable capacitor electrically connected to the sample coil. The capacitor comprises an outer cylindrical conductor, an inner cylindrical conductor longitudinally movable in a space defined within the outer cylindrical conductor, and an outer capacitor contact electrically connected to the inner cylindrical conductor. The outer capacitor contact is positioned closer to the sample coil than the outer cylindrical conductor.
- According to another aspect, a nuclear magnetic resonance probe comprises a nuclear magnetic resonance sample coil disposed within a nuclear magnetic resonance probe, a generally-transverse base plate disposed below the sample coil in the nuclear magnetic resonance probe, and a set of generally-longitudinal variable capacitors mounted on the base plate and extending upward from the base plate. Each variable capacitor comprises an outer cylindrical conductor, an inner cylindrical conductor longitudinally movable in a space defined within the outer cylindrical conductor, and an outer capacitor contact electrically connected to the inner cylindrical conductor and situated along a top region of each variable capacitor.
- The foregoing aspects and advantages of the present invention will become better understood upon reading the following detailed description and upon reference to the drawings where:
-
FIG. 1 is a schematic diagram of an exemplary NMR spectrometer according to some embodiments of the present invention. -
FIG. 2 -A is a schematic diagram of a part of a tunable NMR probe circuit according to some embodiments of the present invention. -
FIG. 2 -B is a schematic diagram of a part of a tunable NMR probe circuit according to some embodiments of the present invention. -
FIG. 3 -A shows a side view of an exemplary arrangement of three prior-art capacitors in a nuclear magnetic resonance probe. -
FIG. 3 -B shows a side view of an exemplary arrangement of three variable capacitors in a nuclear magnetic resonance probe, according to some embodiments of the present invention. -
FIG. 3 -C shows a side view of a variable capacitor connected across a sample coil, according to some embodiments of the present invention. -
FIG. 4 -A shows a side view of a variable capacitor according to some embodiments of the present invention. -
FIG. 4 -B shows a side sectional view of the capacitor ofFIG. 4 -A. -
FIG. 4 -C shows a central shaft design suitable for use in a capacitor such as the one illustrated in FIGS. 4-A-B. - In the following description, a set of elements includes one or more elements. For example, a set of rails may include one or more rails. Any reference to an element is understood to encompass one or more elements. Each recited element or structure can be formed by or be part of a monolithic structure, or be formed from multiple distinct structures. The statement that a coil is used to perform a nuclear magnetic measurement on a sample is understood to mean that the coil is used as transmitter, receiver, or both. Any recited electrical or mechanical connections can be direct connections or indirect connections through intermediary circuit elements or structures. Unless otherwise specified, the terms “high-voltage” and “low-voltage” are understood to be relative terms: a recited high voltage is understood to be higher than a recited low voltage.
- The following description illustrates embodiments of the invention by way of example and not necessarily by way of limitation.
-
FIG. 1 is a schematic diagram illustrating an exemplary nuclear magnetic resonance (NMR)spectrometer 12 according to an embodiment of the present invention.Spectrometer 12 comprises amagnet 16, anNMR probe 20 inserted in a cylindrical bore ofmagnet 16, and a control/acquisition system 18 electrically connected tomagnet 16 andprobe 20.Probe 20 includes one or more radio-frequency (RF)coils 24 and associated electrical circuit components. For simplicity, the following discussion will focus on asingle coil 24, although it is understood that a system may include other similar coils. Asample container 22 is positioned withinprobe 20, for holding an NMR sample of interest withincoil 24 while measurements are performed on the sample.Sample container 22 may be a sample tube or a flow cell. A number of electrical circuit components such as capacitors, inductors, and other components are situated in acircuit region 26 ofprobe 20, and are connected tocoil 24.Coil 24 and the various components connected to coil 24 form one or more NMR measurement circuits.Circuit region 26 is situated adjacent tocoil 24, immediately underneathcoil 24. - To perform a measurement, a sample is inserted into a measurement space defined within
coil 24.Magnet 16 applies a static magnetic field B0 to the sample held withinsample container 22. Control/acquisition system 18 comprises electronic components configured to apply desired radio-frequency pulses toprobe 20, and to acquire data indicative of the nuclear magnetic resonance properties of the samples withinprobe 20.Coil 24 is used to apply radio-frequency magnetic fields B1 to the sample, and/or to measure the response of the sample to the applied magnetic fields. The RF magnetic fields are perpendicular to the static magnetic field. The same coil may be used for both applying an RF magnetic field and for measuring the sample response to the applied magnetic field. Alternatively, one coil may be used for applying an RF magnetic field, and another coil for measuring the response of the sample to the applied magnetic field. A single coil may be used to perform measurements at multiple frequencies, by tuning the resonant frequency of the NMR measurement circuit that includes the coil. Tuning the circuit resonant frequency may be achieved by adjusting the capacitance values of one or more variable capacitors included in the circuit. -
FIG. 2 -A shows a schematic diagram of a tunableNMR measurement circuit 30 according to some embodiments of the present invention.Measurement circuit 30 includesNMR sample coil 24 and a set ofvariable capacitors 40 a-c connected tosample coil 24.Measurement circuit 30 may also include other components such as capacitors and inductors. Aninput terminal 36 receives external excitation pulses. A continuously-variable impedance-matchingcapacitor 40 a is connected betweeninput terminal 36 and the input (proximal) side ofsample coil 24. The capacitance ofcapacitor 40 a may be adjusted in order to optimize the impedance matching ofcircuit 30. Two continuously-variable capacitors 40 b-c are connected between ground and the input and output sides ofsample coil 24, respectively. - Suitable inductance and capacitance values for the various components shown in
FIG. 2 -A may be chosen according to the desired NMR application. In an exemplary implementation,sample coil 24 has an inductance on the order of hundreds of mH, for example about 250 mH.Variable capacitors 40 a-c may take on continuously-adjustable values on the order of pF to tens of pF, for example 1-15 pF. The capacitance ofcapacitor 40 a may be adjusted to provide impedance matching to 50 Ω. In an exemplary implementation,capacitors 40 a-c have voltage ratings of 2500 V or higher. -
FIG. 2 -B is a schematic diagram of a tunableNMR probe circuit 130 according to other embodiments of the present invention.Circuit 130 includessample coil 24 and avariable capacitor 40 connected acrosssample coil 24.Circuit 130 may also include other components such as capacitors and inductors. Such components may be connected tocoil 24 as illustrated inFIG. 2 -A, for example. -
FIG. 3 -A shows a side view of an exemplary arrangement of three prior-art capacitors 40 a′-c′ in a nuclear magnetic resonance probe. The illustrated arrangement corresponds to the circuit diagram ofFIG. 2 -A. Capacitors such as the ones shown inFIG. 3 -A may be obtained commercially, for example from Voltronics Corporation, Denville, N.J.Sample coil 24 is illustrated schematically, as are the connections ofcapacitors 40 b′-c′ to ground.Capacitors 40 b′-c′ are connected between ground and the two sides ofsample coil 24, respectively.Capacitor 40 a′ is connected betweensample coil 24 andinput terminal 36. Electrically conductive lateral surfaces ofcapacitors 40 a′-c′ are hatched inFIG. 3 -A. -
Capacitors 40 a′-c′ are mounted through apertures defined in ahorizontal base plate 60.Capacitors 40 a′-c′ are structurally identical; the following description focuses oncapacitor 40 c′ for simplicity.Capacitor 40 c′ includes a lower capacitor contact (electrode) 54′ and an upper capacitor contact (electrode) 50′.Contacts 50′, 54′ are separated by aninsulative region 52′. A capacitance-adjustment member 58′ can be rotated to adjust the capacitance ofcapacitor 40 c′.Adjustment member 58′ protrudes underneathbase plate 60.Lower contact 54′ may be connected to a longitudinally-movable internal cylindrical rotor, whileupper contact 50′ may include a fixed external cylindrical stator. The longitudinal motion of the internal cylindrical rotor is controlled by the rotation ofadjustment member 58′.Upper capacitor contact 50′ is situated along a top end region ofcapacitor 40 c′, closer to samplecoil 24 thanlower capacitor contact 54′.Lower capacitor contact 54′ is situated closer tobase plate 60 thanupper capacitor contact 50′.Upper capacitor contact 50′ has a longer longitudinal extent thanlower capacitor contact 54′. Generally,upper capacitor contact 50′ is subjected to higher voltages thanlower capacitor contact 54′. -
FIG. 3 -B shows a side view of an exemplary arrangement of threevariable capacitors 40 a-c in a nuclear magnetic resonance probe, according to some embodiments of the present invention. The illustrated arrangement corresponds to the circuit diagram ofFIG. 2 -A. Capacitor 40 c includes anupper capacitor contact 50 and alower capacitor contact 54.Contacts insulative region 52. Anotherinsulative region 56 separateslower capacitor contact 54 frombase plate 60 and/or a shortingexternal contact 76 described below. A capacitance-adjustment member 58 can be rotated to adjust the capacitance ofcapacitor 40 c.Adjustment member 58 protrudes underneathbase plate 60. As described in detail below,upper contact 50 is connected to a longitudinally-movable internal cylindrical rotor, whilelower contact 54 includes a fixed external cylindrical stator.Upper capacitor contact 50 is situated along a top end region ofcapacitor 40 c′, closer to samplecoil 24 thanlower capacitor contact 54′.Lower capacitor contact 54 is situated closer tobase plate 60 thanupper capacitor contact 50.Upper capacitor contact 50 has a shorter longitudinal extent thanlower capacitor contact 54. Generally,upper capacitor contact 50 is subjected to higher voltages thanlower capacitor contact 54. -
FIG. 3 -C shows a side view of avariable capacitor 40 connected across a sample coil, according to some embodiments of the present invention. The illustrated arrangement corresponds to the circuit diagram ofFIG. 2 -B. Capacitor 40 may be structurally identical to thecapacitors 40 a-c described above with reference toFIG. 3 -B. Forcapacitor 40, the minimum lead length used to connectcapacitor 40 to samplecoil 24 depends approximately on the longitudinal extents (lengths) ofinsulative region 52 andupper contact 50. The corresponding lead length for a comparable capacitor in the configuration ofFIG. 3 -A depends on the longitudinal extents ofinsulative region 52′ andupper contact 50′. In an exemplary implementation, the length ofupper contact 50′ (FIG. 3 -A) is about 0.8″, while the length of upper contact 50 (FIG. 3 -C) is about 0.25″. In such an implementation, the total lead length for the capacitor ofFIG. 3 -C is shorter by more than 0.5″ than the lead length for a corresponding configuration using a capacitor such as the ones shown inFIG. 3 -A. -
FIG. 4 -A shows a side view ofvariable capacitor 40, according to some embodiments of the present invention.FIG. 4 -B shows a side sectional view of the capacitor ofFIG. 4 -A. Capacitor 4 includes two field-reduction bands 74 a-b situated at the interfaces betweencontacts region 52, respectively. Bands 74 a-b may be formed by a material such as a room-temperature vulcanizing (RTV) silicone coating. Bands 74 a-b serve to reduce arcing by reducing the electrical field intensity generated by geometrical irregularities at the longitudinal ends ofcontacts capacitor base 72 may rest on an NMR probe base plate, as shown inFIG. 3 -B. Capacitor base 72 is in a bottom region ofcapacitor 40, longitudinally oppositeupper contact 50. -
Lower capacitor contact 54 forms an outer cylindrical conductor (capacitor plate) ofcapacitor 40. The other capacitor plate is formed by an innercylindrical conductor 64, which is electrically connected toupper capacitor contact 50.Cylindrical conductors capacitor 40.Contacts Insulative region 52 is defined by a bare region of the insulative substrate. - An internal threaded
shaft 68 is rigidly coupled toadjustment member 58, which protrudes downward throughbase 72. Threadedshaft 68 extends upward frombase 72, in the center of the cylindrical space defined in the interior ofouter conductor 54. As illustrated, threadedshaft 68 includes aconductive section 68 a longitudinally concatenated to aninsulative section 68 b.Conductive section 68 a may be made of a metal, whileinsulative section 68 b may be made of a ceramic material.Insulative section 68 b breaks any electrical contact betweeninner conductor 64 andcapacitor base 72. Threadedshaft 68 may also be formed from a single monolithic piece of insulative material, such as a ceramic. Also, threadedshaft 68 andadjustment member 58, or part of threadedshaft 68 andadjustment member 58 may be formed from a single monolithic rigid piece. Threadedshaft 68 is also coupled to a longitudinally-movable internal cylindrical conductor (rotor) 64, for example through a matching internal thread ofinternal conductor 64. A set of rigid, fixedlongitudinal rails 66 fit through matching longitudinal grooves or channels defined ininternal conductor 64. In some embodiments,capacitor 40 may include two ormore rails 66 spaced apart azimuthally.Rails 66 prevent the rotation ofinternal conductor 64 asadjustment member 58 andshaft 68 are rotated. Rotatingshaft 68 thus causesinternal conductor 64 to move longitudinally.Rails 66 also transport current fromupper contact 50 tointernal conductor 64. - When
internal conductor 64 is at its highest position, the capacitance ofcapacitor 40 takes on its minimal value. Wheninner conductor 64 is longitudinally aligned with (at the same height as)outer conductor 54, the capacitance ofcapacitor 40 takes on its maximal value. The capacitance ofcapacitor 40 may be adjusted between its minimal and maximal values by longitudinally movinginner conductor 64. - Shorting
capacitor 40 may be achieved by connectinginner conductor 64 to a conductor situated in the lower part ofcapacitor 40. Such a conductor may be a transverse conductor connected to a shortingexternal contact 76 and/orcapacitor base 72. A transverse conductor may be provided as part ofbase 72, or may be attached tobase 72. For example, the transverse conductor may be abase plate 72 formed from a conductive material. Shortingcapacitor 40 may be achieved by loweringinner conductor 64 untilinner conductor 64 touches the transverse conductor, and connecting the transverse conductor andouter conductor 54 to the same potential (e.g. ground). The transverse conductor may be connected to a desired potential using shortingexternal contact 76. -
FIG. 4 -C shows anothercentral shaft 168 suitable for use in a capacitor such as the one illustrated in FIGS. 4-A-B.Shaft 168 includes twoconductive sections 168 a,c longitudinally separated by aninsulative section 168 b.Section 168 c is connected to the capacitor base, whilesection 168 a is connected to the inner conductor.Insulative section 168 b electrically insulatessections 168 a, c from each other. - The exemplary embodiments described above allow a reduced circuit stray capacitance, reduced arcing potential, a reduced lead length when a capacitor is positioned across the NMR sample coil, and convenient shorting of the capacitors if desired. Stray capacitance is of particular concerns for NMR systems using relatively high magnetic field strengths and higher frequencies (>600 MHz). The effect of stray capacitance is exacerbated at high frequencies. At higher frequencies, shorter pulse widths are required due to larger chemical shifts. One way to reduce pulse widths at high frequencies is to increase pulse power. At the same time, increasing pulse power may increase the incidence of arcing. Reducing the stray capacitance allows the NMR probe to be tuned to higher frequencies, and reduces the potential for arcing to other probe components.
- In the embodiments described with reference to FIGS. 4-A-B, the higher-voltage, upper capacitor contact is shorter and has a lower external surface area than the lower-voltage, lower capacitor contact. The reduced external surface area reduces the potential for arcing. The higher-voltage inner cylinder is situated in an inner position, and is less susceptible to arcing than the outer capacitor cylinder. Internalizing the high-potential end of the capacitor also allows reducing the stray capacitance of the capacitor to the environment.
- Placing a variable capacitor across the leads of the NMR sample coil may allow increasing the frequency range the capacitor is able to tune over by factor of three or four. At the same time, adding a variable capacitor across the sample coil leads requires additional lead length, which may negatively affect circuit performance. If both capacitor cylinders are electrically connected upward, toward the sample coil, the exemplary designs described above allow reduced lead lengths for the variable capacitor connections. The lead length to the lower conductor depends on the relatively short length of the upper conductor, rather than the longer outer conductor.
- The exemplary capacitor design shown in FIGS. 4-A-B also allows convenient shorting of the capacitor as described above. The high-potential inner cylinder of the capacitor is normally connected to the top side of the capacitor, but the inner cylinder can be brought all the way down to the capacitor base to establish a connection to the same potential as the outer cylinder.
- The above embodiments may be altered in many ways without departing from the scope of the invention. For example, various known mechanisms other than a helical thread/rail mechanism may be used to move two capacitor conductors longitudinally relative to each other. Accordingly, the scope of the invention should be determined by the following claims and their legal equivalents.
Claims (20)
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US8164336B1 (en) * | 2007-11-10 | 2012-04-24 | Murphree Jr Dennis Haaga | Transmission line probe for NMR |
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US7446530B2 (en) * | 2006-12-08 | 2008-11-04 | Varian, Inc. | NMR coil having integrated capacitive structures |
US9110132B2 (en) * | 2011-08-05 | 2015-08-18 | Chris Chiodo | Electrical and fluid connection system for magnetic imaging |
CN110850478B (en) * | 2019-11-26 | 2022-05-31 | 出门问问创新科技有限公司 | Touch detection method, equipment and device and computer readable storage medium |
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