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US20040083085A1 - Integrated virtual slide and live microscope system - Google Patents

Integrated virtual slide and live microscope system Download PDF

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Publication number
US20040083085A1
US20040083085A1 US10/620,016 US62001603A US2004083085A1 US 20040083085 A1 US20040083085 A1 US 20040083085A1 US 62001603 A US62001603 A US 62001603A US 2004083085 A1 US2004083085 A1 US 2004083085A1
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Prior art keywords
virtual
images
slide
image
virtual slide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/620,016
Inventor
Jack Zeineh
Usman Rashid
Rui-Tao Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss Microscopy GmbH
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Trestle Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/323,371 external-priority patent/US6606413B1/en
Priority to US10/620,016 priority Critical patent/US20040083085A1/en
Application filed by Trestle Corp filed Critical Trestle Corp
Assigned to TRESTLE CORPORATION reassignment TRESTLE CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DONG, RUI-TAO, RASHID, USMAN, ZEINEH, JACK A.
Publication of US20040083085A1 publication Critical patent/US20040083085A1/en
Priority to PCT/US2004/022356 priority patent/WO2005008297A2/en
Assigned to TRESTLE ACQUISITION CORP. reassignment TRESTLE ACQUISITION CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TRESTLE CORPORATION
Assigned to CLARIENT, INC., A DELAWARE CORPORATION reassignment CLARIENT, INC., A DELAWARE CORPORATION SECURITY AGREEMENT Assignors: TRESTLE ACQUISITION CORP., A DELAWARE CORPORATION
Assigned to CLARIENT, INC., A DELAWARE CORPORATION reassignment CLARIENT, INC., A DELAWARE CORPORATION SECURITY AGREEMENT Assignors: TRESTLE ACQUISITION CORP., A DELAWARE CORPORATION
Priority to US11/502,816 priority patent/US20060276974A1/en
Assigned to TRESTLE ACQUISITION CORP., A WHOLLY-OWNED SUBSIDIARY OF TRESTLE HOLDINGS, INC. reassignment TRESTLE ACQUISITION CORP., A WHOLLY-OWNED SUBSIDIARY OF TRESTLE HOLDINGS, INC. TERMINATION OF PATENT SECURITY AGREEMENT RECORDED AT REEL/FRAME NO. 017223/0757 Assignors: CLARIENT, INC.
Assigned to TRESTLE ACQUISITION CORP., A WHOLLY OWNED SUBSIDIARY OF TRESTLE HOLDINGS, INC. reassignment TRESTLE ACQUISITION CORP., A WHOLLY OWNED SUBSIDIARY OF TRESTLE HOLDINGS, INC. TERMINATION OF PATENT SECURITY AGREEMENT RECORDED AT REEL FRAME NO. 017811/0685 Assignors: CLARIENT, INC.
Assigned to CLRT ACQUISITION LLC reassignment CLRT ACQUISITION LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TRESTLE ACQUISITION CORP.
Assigned to CLARIENT, INC. reassignment CLARIENT, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLRT ACQUISITION LLC
Assigned to CARL ZEISS MICROIMAGING AIS, INC. reassignment CARL ZEISS MICROIMAGING AIS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLARIENT, INC.
Priority to US12/584,831 priority patent/US8036868B2/en
Priority to US12/958,985 priority patent/US20110187846A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T9/00—Image coding
    • G06T9/007—Transform coding, e.g. discrete cosine transform
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Definitions

  • This invention relates to a method and apparatus for viewing remote microscope images.
  • live remote control microscopy a user receives images that are taken from a slide on a microscope.
  • virtual slide imaging a user receives images previously captured.
  • Virtual slide systems take one or more images of an area of interest and assemble them together (if there is more than one image) to form a virtual slide.
  • Live remote imaging provides users with the closest approximation to manual manipulation. Virtual slides allow faster image viewing, since images are already captured.
  • Virtual slide systems take one or more images and assemble them to form a “virtual slide.”
  • a method and apparatus are provided for the analysis of remote slides in a hybrid live and virtual medium. Users obtain benefits of each technique in a unified environment.
  • a virtual slide is a digital representation of an area of interest of a microscopic slide.
  • a virtual slide can be created multiple ways.
  • One method is to use a motorized microscope that can move a specimen with respect to a microscope objective (e.g., a microscope with a motorized stage).
  • a microscope objective e.g., a microscope with a motorized stage.
  • Each image is then joined together to form a composite or “virtual image.”
  • Multiple methods of joining images together are known in the art.
  • One example is when images are simply abutted one next to another.
  • this method does not generally produce virtual slides without seams, because errors such as camera rotation relative to the axis of motion are difficult to correct. Even with submicron accuracy stages it is, in practice, difficult to obtain consistent positioning.
  • Another method is to utilize overlap between adjacent images to edge align images for maximum seamlessness. This can be done by sequentially shifting overlapping regions in the x and/or y axis, for example, by a stepping motor, and calculating a correlation value (or measure of goodness of overlap). The shift which results in the best correlation value is then used to join the images together (FIG. 1). While this method can be computationally expensive, it reduces reliance on difficult-to-attain mechanical positioning,requirements and ultimately produces the best images in the sense of seamlessness.
  • the virtual slide is made simply by utilizing an imaging device with optics suitable to take a an image of the area of interest on the slide in one snapshot.
  • This method is embodied in the form of a conventional digital or analog camera with a macro lens.
  • This virtual slide can then be used to create a thumbnail view of the slide.
  • the virtual slide is shrunk in resolution from its original, base resolution to a target resolution. If the target resolution is the same as the base resolution, then the image is unchanged. However, typically the resolution of the thumbnail desired is several times smaller than the base resolution.
  • Optical objectives are images that are created by a camera digitizing an image through a microscope objective (e.g., 10 ⁇ , 20 ⁇ , or 40 ⁇ ) in real time (i.e., an image is captured at the time the user requests the image).
  • Virtual objectives are digitally created magnifications created not by digitizing in real time, but rather by utilizing the existing virtual slide data to digitally create a field of view.
  • a “change objective” command is sent to the microscope.
  • This change objective command can also, specify additional qualifying information, such as microscope x, y, z positions, exposure setting, compression type and level, and image dimensions. If additional qualifying information is not sent, then the implicit qualifying information is the current state of the microscope or the last specified state.
  • actions are taken to change the objective lens and to change the state of the microscope commensurate with the command (e.g., change the relative position of the objective lens relative to the microscopic slide, change exposure, etc.).
  • An image is then digitized, compressed if so specified, and then transmitted to the user for display.
  • a virtual objective command is sent to the microscope. Similar to an optical objective command, this virtual objective command can also specify additional qualifying information, such as microscope x, y, and/or z position. If additional qualifying information is not sent, then the implicit qualifying information is current microscope state or the last specified state.
  • a region of interest is defined by the virtual request—it is the area on the microscope slide included in the field specified by the coordinates of the stage x, y and magnification of the command. This region of interest may optionally be trimmed such that image information already residing at the requesting user's, view is not retransmitted to the user.
  • An image of the region of interest can be created from the virtual slide in multiple ways. If the virtual slide is not compressed, the retrieval of image information corresponding to the region of interest can be done by simply copying data from the virtual slide. If the virtual slide is compressed, a region corresponding to at least the region of interest can be decompressed to a raw bitmap from the main compressed image. If the virtual slide was stored as multiple compressed images rather than one large image, additional efficiencies are possible. For example, only those images that contain the desired region of interest need be accessed for decompression, rather than the entire area of the virtual slide. This enhances performance.
  • the decompression itself can also be performed in various ways. Strategies such as scaled decoding, as in the case of jpeg type compression, can be employed to improve the speed of the decompression by coupling a resolution reduction process with the decompression to speed up decompression when resolution reduction is required. Once the region of interest is decompressed, it can then be recompressed using a variety of strategies known to those skilled in the imaging field, which need not be the same as the method by which the virtual slide was compressed.
  • Partial decompression such as decoding of Huffman-encoded data, as in the case of jpeg
  • Partial decompression can be performed to produce raw coefficients, rather than full decompression, which produces a raw bitmap.
  • the raw coefficients corresponding to the area of the region of interest can then be selected.
  • These coefficients which correspond to the region of interest are then re-encoded.
  • the result is a compressed region of interest.
  • the compressed region of interest is then transmitted to the user for viewing.
  • the described method is more advantageous than sending the entire virtual slide, as one efficiently sends only that information required by the user.
  • FIG. 1 is a drawing showing the overlap between adjacent images during optimization of overlap.
  • FIG. 2 is a photograph of a user's view of the remote microscope, showing a thumbnail view, microscope imaging window, and a set of microscope controls.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • General Physics & Mathematics (AREA)
  • Discrete Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and :virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

Description

    BACKGROUND OF THE INVENTION
  • This invention relates to a method and apparatus for viewing remote microscope images. [0001]
  • Currently there is increasing demand for pathologist review of samples at remote locations. There exist multiple systems to address this need. They typically fall within one of two categories: live remote microscopy and virtual slide imaging. [0002]
  • In live remote control microscopy, a user receives images that are taken from a slide on a microscope. In virtual slide imaging, a user receives images previously captured. Virtual slide systems take one or more images of an area of interest and assemble them together (if there is more than one image) to form a virtual slide. Each of these techniques has its advantages. Live remote imaging provides users with the closest approximation to manual manipulation. Virtual slides allow faster image viewing, since images are already captured. [0003]
  • Virtual slide systems take one or more images and assemble them to form a “virtual slide.”[0004]
  • However, users in the past were limited in their ability to integrate these technologies. One could only view and manipulate live and virtual images independently of one another. A user would have to clumsily go back and forth between these two modes of operation to separately look at the virtual slides and live microscope slides. We present a new method that integrates these ideas into one seamless operating environment. [0005]
    • SUMMARY OF THE INVENTION
  • In accordance with the present invention, a method and apparatus are provided for the analysis of remote slides in a hybrid live and virtual medium. Users obtain benefits of each technique in a unified environment. [0006]
    • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
  • A virtual slide is a digital representation of an area of interest of a microscopic slide. A virtual slide can be created multiple ways. [0007]
  • One method is to use a motorized microscope that can move a specimen with respect to a microscope objective (e.g., a microscope with a motorized stage). With such system, one can capture one or more images through a microscope objective, such that a region of interest (all or part of the microscopic slide) is imaged. Each image is then joined together to form a composite or “virtual image.” Multiple methods of joining images together are known in the art. One example is when images are simply abutted one next to another. However, this method does not generally produce virtual slides without seams, because errors such as camera rotation relative to the axis of motion are difficult to correct. Even with submicron accuracy stages it is, in practice, difficult to obtain consistent positioning. Another method is to utilize overlap between adjacent images to edge align images for maximum seamlessness. This can be done by sequentially shifting overlapping regions in the x and/or y axis, for example, by a stepping motor, and calculating a correlation value (or measure of goodness of overlap). The shift which results in the best correlation value is then used to join the images together (FIG. 1). While this method can be computationally expensive, it reduces reliance on difficult-to-attain mechanical positioning,requirements and ultimately produces the best images in the sense of seamlessness. [0008]
  • In another method, the virtual slide is made simply by utilizing an imaging device with optics suitable to take a an image of the area of interest on the slide in one snapshot. This method is embodied in the form of a conventional digital or analog camera with a macro lens. [0009]
  • This virtual slide can then be used to create a thumbnail view of the slide. To create the thumbnail view, the virtual slide is shrunk in resolution from its original, base resolution to a target resolution. If the target resolution is the same as the base resolution, then the image is unchanged. However, typically the resolution of the thumbnail desired is several times smaller than the base resolution. [0010]
  • With the virtual slide created, the user may fully utilize the full capabilities of the remote microscope. The user is presented with an image window and a set of control features (FIG. 2). Among these control features is a set of “optical objectives” and “virtual objectives.”[0011]
  • Optical objectives are images that are created by a camera digitizing an image through a microscope objective (e.g., 10×, 20×, or 40×) in real time (i.e., an image is captured at the time the user requests the image). Virtual objectives are digitally created magnifications created not by digitizing in real time, but rather by utilizing the existing virtual slide data to digitally create a field of view. [0012]
  • When a user selects one of the optical objectives, a “change objective” command is sent to the microscope. This change objective command can also, specify additional qualifying information, such as microscope x, y, z positions, exposure setting, compression type and level, and image dimensions. If additional qualifying information is not sent, then the implicit qualifying information is the current state of the microscope or the last specified state. When the microscope receives the command, actions are taken to change the objective lens and to change the state of the microscope commensurate with the command (e.g., change the relative position of the objective lens relative to the microscopic slide, change exposure, etc.). An image is then digitized, compressed if so specified, and then transmitted to the user for display. [0013]
  • When a user selects a virtual objective, a virtual objective command is sent to the microscope. Similar to an optical objective command, this virtual objective command can also specify additional qualifying information, such as microscope x, y, and/or z position. If additional qualifying information is not sent, then the implicit qualifying information is current microscope state or the last specified state. A region of interest is defined by the virtual request—it is the area on the microscope slide included in the field specified by the coordinates of the stage x, y and magnification of the command. This region of interest may optionally be trimmed such that image information already residing at the requesting user's, view is not retransmitted to the user. [0014]
  • An image of the region of interest can be created from the virtual slide in multiple ways. If the virtual slide is not compressed, the retrieval of image information corresponding to the region of interest can be done by simply copying data from the virtual slide. If the virtual slide is compressed, a region corresponding to at least the region of interest can be decompressed to a raw bitmap from the main compressed image. If the virtual slide was stored as multiple compressed images rather than one large image, additional efficiencies are possible. For example, only those images that contain the desired region of interest need be accessed for decompression, rather than the entire area of the virtual slide. This enhances performance. [0015]
  • The decompression itself can also be performed in various ways. Strategies such as scaled decoding, as in the case of jpeg type compression, can be employed to improve the speed of the decompression by coupling a resolution reduction process with the decompression to speed up decompression when resolution reduction is required. Once the region of interest is decompressed, it can then be recompressed using a variety of strategies known to those skilled in the imaging field, which need not be the same as the method by which the virtual slide was compressed. [0016]
  • An alternative type of decompression/recompression step can also be used involving partial decompression. Partial decompression, such as decoding of Huffman-encoded data, as in the case of jpeg, can be performed to produce raw coefficients, rather than full decompression, which produces a raw bitmap. The raw coefficients corresponding to the area of the region of interest can then be selected. These coefficients which correspond to the region of interest are then re-encoded. In the case of jpeg compression, this would involve re Huffman encoding of the coefficients, rather than in normal full compression, where a dct must be performed followed by quantization and then Huffman coding. [0017]
  • Whichever the technique, the result is a compressed region of interest. The compressed region of interest is then transmitted to the user for viewing. The described method is more advantageous than sending the entire virtual slide, as one efficiently sends only that information required by the user. [0018]
  • However, direct transfer of the compressed image without decompression is feasible when the virtual slide is stored as multiple compressed images. The compressed images that include the area specified by the region of interest can be directly transferred to the user, rather than going through a decompression/recompression step. The disadvantage is that one may transfer more information than is needed if, for example, the compressed images are at a higher resolution that the requested resolution. This can be partially solved by creation of multiple resolution versions of the virtual slide. There are also compression strategies available that allow only portions of the compressed images to be sent, such that a given resolution can be attained depending on which portions of the compressed image one chooses to send (e.g., progressive encoding). However, there is still the issue that the region of interest only partially covers the area of the compressed image. In this case, direct transfer of the image results in inefficiently sending data including both the region of interest and data outside the region of interest to the user. [0019]
  • With this invention, users are afforded a streamlined method of utilizing the features of virtual and live microscopy techniques.[0020]
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a drawing showing the overlap between adjacent images during optimization of overlap. [0021]
  • FIG. 2 is a photograph of a user's view of the remote microscope, showing a thumbnail view, microscope imaging window, and a set of microscope controls.[0022]
  • While the apparatus and methods of the present invention have been illustrated in terms of certain embodiments, the invention claimed herein is not limited to embodiments disclosed in this application. Rather, the scope of the invention is defined by the claims attached hereto. [0023]
  • While the invention has been illustrated and explained herein in terms of certain embodiments the invention is not limited to the specific embodiments disclosed. Rather, the invention is defined by the scope of the claims appended hereto.[0024]

Claims (1)

We claim:
1. A method for simultaneously viewing remote microscope images comprising virtual and live images and producing a seamless view of live and virtual images comprising:
providing a virtual slide
providing a live microscope slide
automatically and sequentially shifting regions overlapping regions of images from the slides to obtain the optimal image
US10/620,016 1998-06-01 2003-07-14 Integrated virtual slide and live microscope system Abandoned US20040083085A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/620,016 US20040083085A1 (en) 1998-06-01 2003-07-14 Integrated virtual slide and live microscope system
PCT/US2004/022356 WO2005008297A2 (en) 2003-07-14 2004-07-14 Integrated virtual slide and live microscope system
US11/502,816 US20060276974A1 (en) 2003-07-14 2006-08-11 System for remote viewing and display of a slide
US12/584,831 US8036868B2 (en) 1998-06-01 2009-09-11 Intergrated systems and methods of virtual or live microscope slide presentation
US12/958,985 US20110187846A1 (en) 2003-07-14 2010-12-02 System for remote viewing and display of a slide

Applications Claiming Priority (4)

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US8752398P 1998-06-01 1998-06-01
US09/323,371 US6606413B1 (en) 1998-06-01 1999-06-01 Compression packaged image transmission for telemicroscopy
US10/448,913 US7224839B2 (en) 1998-06-01 2003-05-30 Compression packaged image transmission for telemicroscopy
US10/620,016 US20040083085A1 (en) 1998-06-01 2003-07-14 Integrated virtual slide and live microscope system

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US10/448,913 Continuation-In-Part US7224839B2 (en) 1998-06-01 2003-05-30 Compression packaged image transmission for telemicroscopy

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US11/502,816 Division US20060276974A1 (en) 2003-07-14 2006-08-11 System for remote viewing and display of a slide
US12/584,831 Continuation US8036868B2 (en) 1998-06-01 2009-09-11 Intergrated systems and methods of virtual or live microscope slide presentation

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US11/502,816 Abandoned US20060276974A1 (en) 2003-07-14 2006-08-11 System for remote viewing and display of a slide
US12/584,831 Expired - Fee Related US8036868B2 (en) 1998-06-01 2009-09-11 Intergrated systems and methods of virtual or live microscope slide presentation
US12/958,985 Abandoned US20110187846A1 (en) 2003-07-14 2010-12-02 System for remote viewing and display of a slide

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US12/958,985 Abandoned US20110187846A1 (en) 2003-07-14 2010-12-02 System for remote viewing and display of a slide

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7027628B1 (en) * 2000-11-14 2006-04-11 The United States Of America As Represented By The Department Of Health And Human Services Automated microscopic image acquisition, compositing, and display
US20060251309A1 (en) * 1998-06-01 2006-11-09 Trestle Acquisition Corp. System and method for remote navigation of a specimen
US20060276974A1 (en) * 2003-07-14 2006-12-07 Trestle Acquisition Corp. System for remote viewing and display of a slide

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2406679T3 (en) 2009-03-11 2017-04-18 Sakura Finetek Usa Inc AUTO FOCUS PROCEDURE AND AUTO FOCUS DEVICE
EP2460139A4 (en) 2009-07-27 2015-05-27 Corista LLC System for networked digital pathology exchange
US8504726B2 (en) 2009-07-27 2013-08-06 Corista LLC User targeted medical imaging and information packaging, compression and distribution system
US8555406B2 (en) 2009-10-06 2013-10-08 At&T Intellectual Property I, L.P. Remote viewing of multimedia content
US10139613B2 (en) 2010-08-20 2018-11-27 Sakura Finetek U.S.A., Inc. Digital microscope and method of sensing an image of a tissue sample
US8970618B2 (en) * 2011-06-16 2015-03-03 University Of Leeds Virtual microscopy
JP2013153429A (en) * 2011-12-27 2013-08-08 Canon Inc Image processing apparatus, image display system, image processing method and image processing program
TWI499309B (en) * 2012-03-28 2015-09-01 Albert Chang Image control system and method thereof
DE102013103971A1 (en) 2013-04-19 2014-11-06 Sensovation Ag Method for generating an overall picture of an object composed of several partial images
US10007102B2 (en) 2013-12-23 2018-06-26 Sakura Finetek U.S.A., Inc. Microscope with slide clamping assembly
EP3236486A1 (en) * 2016-04-22 2017-10-25 Carl Zeiss Microscopy GmbH Method for generating a composite image of an object and particle beam device for carrying out the method
US11280803B2 (en) 2016-11-22 2022-03-22 Sakura Finetek U.S.A., Inc. Slide management system
CN109281071B (en) * 2018-09-19 2020-11-27 睿派控股(山东)集团有限公司 Intelligent sewing workstation and processing method thereof
US12023817B1 (en) * 2023-11-14 2024-07-02 Pramana, Inc. System and method for a slide marking technique for target tissue extraction and downstream application

Citations (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922909A (en) * 1987-07-17 1990-05-08 Little James H Video monitoring and reapposition monitoring apparatus and methods
US5329616A (en) * 1990-08-16 1994-07-12 Canon Kabushiki Kaisha Compressed image stores for high resolution computer graphics
US5499097A (en) * 1994-09-19 1996-03-12 Neopath, Inc. Method and apparatus for checking automated optical system performance repeatability
US5602674A (en) * 1993-07-09 1997-02-11 Compucyte Corp. Computerized specimen encoder
US5619032A (en) * 1995-01-18 1997-04-08 International Remote Imaging Systems, Inc. Method and apparatus for automatically selecting the best focal position from a plurality of focal positions for a focusing apparatus
US5626144A (en) * 1994-05-23 1997-05-06 Enact Health Management Systems System for monitoring and reporting medical measurements
US5655029A (en) * 1990-11-07 1997-08-05 Neuromedical Systems, Inc. Device and method for facilitating inspection of a specimen
US5790710A (en) * 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
US5793969A (en) * 1993-07-09 1998-08-11 Neopath, Inc. Network review and analysis of computer encoded slides
US5836877A (en) * 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US5883982A (en) * 1995-10-24 1999-03-16 Neopath, Inc. Astigmatism measurement apparatus and method based on a focal plane separation measurement
US5920657A (en) * 1991-11-01 1999-07-06 Massachusetts Institute Of Technology Method of creating a high resolution still image using a plurality of images and apparatus for practice of the method
US5991729A (en) * 1997-06-28 1999-11-23 Barry; James T. Methods for generating patient-specific medical reports
US6031930A (en) * 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US6043475A (en) * 1996-04-16 2000-03-28 Olympus Optical Co., Ltd. Focal point adjustment apparatus and method applied to microscopes
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US6259080B1 (en) * 1998-03-18 2001-07-10 Olympus Optical Co. Ltd. Autofocus device for microscope
US6272235B1 (en) * 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6404906B2 (en) * 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6466690B2 (en) * 2000-12-19 2002-10-15 Bacus Research Laboratories, Inc. Method and apparatus for processing an image of a tissue sample microarray
US20020149628A1 (en) * 2000-12-22 2002-10-17 Smith Jeffrey C. Positioning an item in three dimensions via a graphical representation
US20030012420A1 (en) * 2001-06-12 2003-01-16 Applied Imaging Corporation Automated scanning method for pathology samples
US20030090127A1 (en) * 2001-11-13 2003-05-15 Nissan Motor Co., Ltd. Front body structure for vehicle
US20030112330A1 (en) * 2001-12-19 2003-06-19 Olympus Optical Co., Ltd. Microscopic image capture apparatus
US20030138139A1 (en) * 2001-12-28 2003-07-24 Strom John T. Dual-axis scanning system and method
US6606413B1 (en) * 1998-06-01 2003-08-12 Trestle Acquisition Corp. Compression packaged image transmission for telemicroscopy
US20030184730A1 (en) * 2002-01-23 2003-10-02 The Regents Of The University Of California Fast 3D cytometry for information in tissue engineering
US20030210262A1 (en) * 2002-05-10 2003-11-13 Tripath Imaging, Inc. Video microscopy system and multi-view virtual slide viewer capable of simultaneously acquiring and displaying various digital views of an area of interest located on a microscopic slide
US20030228053A1 (en) * 2002-05-03 2003-12-11 Creatv Microtech, Inc. Apparatus and method for three-dimensional image reconstruction
US20030228038A1 (en) * 1995-11-30 2003-12-11 Chroma Vision Medical Systems, Inc., A California Corporation Method and apparatus for automated image analysis of biological specimens
US20030231791A1 (en) * 2002-06-12 2003-12-18 Torre-Bueno Jose De La Automated system for combining bright field and fluorescent microscopy
US20040004614A1 (en) * 2002-02-22 2004-01-08 Bacus Laboratories, Inc. Focusable virtual microscopy apparatus and method
US20040047033A1 (en) * 2002-09-10 2004-03-11 Olympus Optical Co., Ltd. Microscopic image capture apparatus and microscopic image capturing method
US6711283B1 (en) * 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551937A (en) * 1984-02-06 1985-11-12 Seehase Jack C Recoil pad utilizing struts disposed at a compound angle and having adjustable energy-absorbing characteristics
US4742558A (en) * 1984-02-14 1988-05-03 Nippon Telegraph & Telephone Public Corporation Image information retrieval/display apparatus
US4760385A (en) * 1985-04-22 1988-07-26 E. I. Du Pont De Nemours And Company Electronic mosaic imaging process
US5216596A (en) * 1987-04-30 1993-06-01 Corabi International Telemetrics, Inc. Telepathology diagnostic network
JP2793244B2 (en) 1989-04-13 1998-09-03 オリンパス光学工業株式会社 Microscope equipment
US5252487A (en) * 1989-05-19 1993-10-12 Cell Analysis Systems, Inc. Method and apparatus for determining the amount of oncogene protein product in a cell sample
US5123056A (en) * 1990-02-02 1992-06-16 Siemens Medical Systems, Inc. Whole-leg x-ray image processing and display techniques
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
US5655028A (en) * 1991-12-30 1997-08-05 University Of Iowa Research Foundation Dynamic image analysis system
US5451643A (en) * 1993-03-05 1995-09-19 Baylor University Poly(alkylene dicarboxylates) and synthesis thereof
US5625765A (en) * 1993-09-03 1997-04-29 Criticom Corp. Vision systems including devices and methods for combining images for extended magnification schemes
US5797130A (en) * 1993-11-16 1998-08-18 Neopath, Inc. Method for testing proficiency in screening images of biological slides
US5440343A (en) * 1994-02-28 1995-08-08 Eastman Kodak Company Motion/still electronic image sensing apparatus
JP3537205B2 (en) * 1995-02-02 2004-06-14 オリンパス株式会社 Microscope equipment
JPH08287218A (en) * 1995-04-10 1996-11-01 Sharp Corp Image composing device
JPH0937232A (en) 1995-07-17 1997-02-07 Mitsubishi Denki Eng Kk Remote image monitor
JPH0951498A (en) 1995-08-08 1997-02-18 Canon Inc Image recording and reproducing system
JPH09117417A (en) 1995-10-27 1997-05-06 Gemetsukusu:Kk Phthologic image telediagnosis system
US5818637A (en) * 1996-02-26 1998-10-06 Hoover; Rex A. Computerized video microscopy system
US6078681A (en) * 1996-03-18 2000-06-20 Marine Biological Laboratory Analytical imaging system and process
US6006191A (en) * 1996-05-13 1999-12-21 Dirienzo; Andrew L. Remote access medical image exchange system and methods of operation therefor
DE19625862A1 (en) 1996-06-27 1998-01-02 Siemens Ag Medical system architecture with component navigation using HTML
GB9614434D0 (en) * 1996-07-10 1996-09-04 Fairfield Telepathology Limite Video display systems
DE19633997C1 (en) 1996-08-23 1998-03-26 Univ Stuttgart Remote image inspection facility for image transmission
US5987519A (en) 1996-09-20 1999-11-16 Georgia Tech Research Corporation Telemedicine system using voice video and data encapsulation and de-encapsulation for communicating medical information between central monitoring stations and remote patient monitoring stations
US5968731A (en) * 1996-12-10 1999-10-19 The Regents Of The University Of California Apparatus for automated testing of biological specimens
US5991461A (en) * 1996-12-20 1999-11-23 Veeco Corporation Selection process for sequentially combining multiple sets of overlapping surface-profile interferometric data to produce a continuous composite map
JPH10186238A (en) 1996-12-26 1998-07-14 Nippon Telegr & Teleph Corp <Ntt> Remote control microscope system
US6252989B1 (en) * 1997-01-07 2001-06-26 Board Of The Regents, The University Of Texas System Foveated image coding system and method for image bandwidth reduction
JPH10224794A (en) * 1997-02-10 1998-08-21 Kokusai Denshin Denwa Co Ltd <Kdd> Hierarchy processing method for moving image coding data and its device
JPH10224783A (en) 1997-02-12 1998-08-21 Nippon Colin Co Ltd Image transmitter with resolution selecting function and image display device
DE19707026B4 (en) 1997-02-21 2004-10-28 Siemens Ag Medical therapy and / or diagnostic system
US6038257A (en) 1997-03-12 2000-03-14 Telefonaktiebolaget L M Ericsson Motion and still video picture transmission and display
US5940834A (en) * 1997-03-13 1999-08-17 Mitel Corporation Automatic web page generator
JPH10274741A (en) 1997-03-31 1998-10-13 Tsushin Hoso Kiko Specimen remote observation system
FR2763190B1 (en) * 1997-05-07 1999-08-06 Sgs Thomson Microelectronics METHOD AND DEVICE FOR TRANSFERRING INFORMATION BETWEEN DATA-EXCHANGING CIRCUITS THROUGH CONVERTERS
JP3608346B2 (en) 1997-06-26 2005-01-12 株式会社日立製作所 Telemedicine support system and telemedicine support method used therefor
AU9476798A (en) 1997-09-10 1999-03-29 Bellsouth Corporation Digital telepathology imaging system with bandwidth optimization and virtual focus control functions
CA2301606C (en) 1997-09-12 2005-11-01 Boston Scientific Limited Method and system for synchronized acquisition, processing and sharing of instrumentation data and for synchronized control in a client-server network
US6014451A (en) * 1997-10-17 2000-01-11 Pioneer Hi-Bred International, Inc. Remote imaging system for plant diagnosis
US20040083085A1 (en) * 1998-06-01 2004-04-29 Zeineh Jack A. Integrated virtual slide and live microscope system
US6305115B1 (en) * 1998-07-29 2001-10-23 Ra Brands, L.L.C. Gel recoil pad
US6137915A (en) * 1998-08-20 2000-10-24 Sarnoff Corporation Apparatus and method for error concealment for hierarchical subband coding and decoding
US6317915B1 (en) * 1998-10-30 2001-11-20 Multuloc International Systems Energy efficient deck framing system and method
IT1314643B1 (en) * 2000-02-03 2002-12-31 Beretta Armi Spa COMPOSITE MATERIAL RECOIL FOR GUNS
US6406906B1 (en) * 2000-05-10 2002-06-18 Sartorius Ag Gelatin membrane filters and method for producing the same
US7155049B2 (en) * 2001-01-11 2006-12-26 Trestle Acquisition Corp. System for creating microscopic digital montage images

Patent Citations (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922909A (en) * 1987-07-17 1990-05-08 Little James H Video monitoring and reapposition monitoring apparatus and methods
US5329616A (en) * 1990-08-16 1994-07-12 Canon Kabushiki Kaisha Compressed image stores for high resolution computer graphics
US5655029A (en) * 1990-11-07 1997-08-05 Neuromedical Systems, Inc. Device and method for facilitating inspection of a specimen
US5790710A (en) * 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
US5920657A (en) * 1991-11-01 1999-07-06 Massachusetts Institute Of Technology Method of creating a high resolution still image using a plurality of images and apparatus for practice of the method
US5602674A (en) * 1993-07-09 1997-02-11 Compucyte Corp. Computerized specimen encoder
US5793969A (en) * 1993-07-09 1998-08-11 Neopath, Inc. Network review and analysis of computer encoded slides
US5626144A (en) * 1994-05-23 1997-05-06 Enact Health Management Systems System for monitoring and reporting medical measurements
US5499097A (en) * 1994-09-19 1996-03-12 Neopath, Inc. Method and apparatus for checking automated optical system performance repeatability
US5619032A (en) * 1995-01-18 1997-04-08 International Remote Imaging Systems, Inc. Method and apparatus for automatically selecting the best focal position from a plurality of focal positions for a focusing apparatus
US5883982A (en) * 1995-10-24 1999-03-16 Neopath, Inc. Astigmatism measurement apparatus and method based on a focal plane separation measurement
US20030228038A1 (en) * 1995-11-30 2003-12-11 Chroma Vision Medical Systems, Inc., A California Corporation Method and apparatus for automated image analysis of biological specimens
US6043475A (en) * 1996-04-16 2000-03-28 Olympus Optical Co., Ltd. Focal point adjustment apparatus and method applied to microscopes
US6674884B2 (en) * 1996-08-23 2004-01-06 Bacus Laboratories, Inc. Apparatus for remote control of a microscope
US6674881B2 (en) * 1996-08-23 2004-01-06 Bacus Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6031930A (en) * 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US6101265A (en) * 1996-08-23 2000-08-08 Bacus Research Laboratories, Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6226392B1 (en) * 1996-08-23 2001-05-01 Bacus Research Laboratories, Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US20040136582A1 (en) * 1996-08-23 2004-07-15 Bacus Laboratories, Inc. Apparatus for remote control of a microscope
US20040141637A1 (en) * 1996-08-23 2004-07-22 Bacus Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5836877A (en) * 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US6404906B2 (en) * 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US20040236773A1 (en) * 1997-03-03 2004-11-25 Bacus Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6775402B2 (en) * 1997-03-03 2004-08-10 Bacus Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6522774B1 (en) * 1997-03-03 2003-02-18 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6272235B1 (en) * 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US20030123717A1 (en) * 1997-03-03 2003-07-03 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US5991729A (en) * 1997-06-28 1999-11-23 Barry; James T. Methods for generating patient-specific medical reports
US6259080B1 (en) * 1998-03-18 2001-07-10 Olympus Optical Co. Ltd. Autofocus device for microscope
US6606413B1 (en) * 1998-06-01 2003-08-12 Trestle Acquisition Corp. Compression packaged image transmission for telemicroscopy
US6711283B1 (en) * 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner
US6466690B2 (en) * 2000-12-19 2002-10-15 Bacus Research Laboratories, Inc. Method and apparatus for processing an image of a tissue sample microarray
US6466690C1 (en) * 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US20030039384A1 (en) * 2000-12-19 2003-02-27 Bacus Research Laboratories, Inc. Method and apparatus for processing an image of a tissue sample microarray
US20020149628A1 (en) * 2000-12-22 2002-10-17 Smith Jeffrey C. Positioning an item in three dimensions via a graphical representation
US20030012420A1 (en) * 2001-06-12 2003-01-16 Applied Imaging Corporation Automated scanning method for pathology samples
US20030090127A1 (en) * 2001-11-13 2003-05-15 Nissan Motor Co., Ltd. Front body structure for vehicle
US20030112330A1 (en) * 2001-12-19 2003-06-19 Olympus Optical Co., Ltd. Microscopic image capture apparatus
US20030138139A1 (en) * 2001-12-28 2003-07-24 Strom John T. Dual-axis scanning system and method
US20030184730A1 (en) * 2002-01-23 2003-10-02 The Regents Of The University Of California Fast 3D cytometry for information in tissue engineering
US20040004614A1 (en) * 2002-02-22 2004-01-08 Bacus Laboratories, Inc. Focusable virtual microscopy apparatus and method
US20030228053A1 (en) * 2002-05-03 2003-12-11 Creatv Microtech, Inc. Apparatus and method for three-dimensional image reconstruction
US20030210262A1 (en) * 2002-05-10 2003-11-13 Tripath Imaging, Inc. Video microscopy system and multi-view virtual slide viewer capable of simultaneously acquiring and displaying various digital views of an area of interest located on a microscopic slide
US20030231791A1 (en) * 2002-06-12 2003-12-18 Torre-Bueno Jose De La Automated system for combining bright field and fluorescent microscopy
US20040047033A1 (en) * 2002-09-10 2004-03-11 Olympus Optical Co., Ltd. Microscopic image capture apparatus and microscopic image capturing method

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100073472A1 (en) * 1998-06-01 2010-03-25 Carl Zeiss Microlmaging Ais, Inc. Intergrated virtual slide and live microscope system
US20100067759A1 (en) * 1998-06-01 2010-03-18 Zeineh Jack A System and Method for Remote Navigation of a Specimen
US20060251331A1 (en) * 1998-06-01 2006-11-09 Trestle Acquisition Corp. System and method for reconstructing a diagnostic trajectory
US8036868B2 (en) 1998-06-01 2011-10-11 Carl Zeiss Microimaging Gmbh Intergrated systems and methods of virtual or live microscope slide presentation
US7916916B2 (en) 1998-06-01 2011-03-29 Carl Zeiss Microimaging Gmbh System and method for remote navigation of a specimen
US7391894B2 (en) 1998-06-01 2008-06-24 Carl Zeiss Microimaging Ais, Inc. System and method for remote navigation of a specimen
US20060251309A1 (en) * 1998-06-01 2006-11-09 Trestle Acquisition Corp. System and method for remote navigation of a specimen
US7505616B2 (en) 1998-06-01 2009-03-17 Carl Zeiss Microimaging Ais, Inc. System and method for reconstructing a diagnostic trajectory
US7916913B2 (en) 1998-06-01 2011-03-29 Carl Zeiss Microimaging Gmbh System and method for reconstructing a diagnostic trajectory
US20100034437A1 (en) * 1998-06-01 2010-02-11 Zeineh Jack A System and method for reconstructing a diagnostic trajectory
US7027628B1 (en) * 2000-11-14 2006-04-11 The United States Of America As Represented By The Department Of Health And Human Services Automated microscopic image acquisition, compositing, and display
US7305109B1 (en) 2000-11-14 2007-12-04 The Government of the United States of America as represented by the Secretary of Health and Human Services, Centers for Disease Control and Prevention Automated microscopic image acquisition compositing, and display
US20110187846A1 (en) * 2003-07-14 2011-08-04 Carl Zeiss Microimaging Gmbh System for remote viewing and display of a slide
US20060276974A1 (en) * 2003-07-14 2006-12-07 Trestle Acquisition Corp. System for remote viewing and display of a slide

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