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UA72934C2 - Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція - Google Patents

Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція

Info

Publication number
UA72934C2
UA72934C2 UA2002043167A UA200243167A UA72934C2 UA 72934 C2 UA72934 C2 UA 72934C2 UA 2002043167 A UA2002043167 A UA 2002043167A UA 200243167 A UA200243167 A UA 200243167A UA 72934 C2 UA72934 C2 UA 72934C2
Authority
UA
Ukraine
Prior art keywords
group
preparing
tetrahydropiridines
piperidyl
phenyl
Prior art date
Application number
UA2002043167A
Other languages
English (en)
Russian (ru)
Inventor
Марко БАРОНІ
Бернар Буррі
Бернар Бурри
Розанна КАРДАМОНЕ
П'єр Казелла
Пьер Казелла
Умберто Гуцці
Original Assignee
Санофі-Авантіс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9913206A external-priority patent/FR2800071B1/fr
Priority claimed from FR0008328A external-priority patent/FR2810984B1/fr
Application filed by Санофі-Авантіс filed Critical Санофі-Авантіс
Publication of UA72934C2 publication Critical patent/UA72934C2/uk

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A43—FOOTWEAR
    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B7/00—Footwear with health or hygienic arrangements
    • A43B7/12—Special watertight footwear
    • A43B7/125—Special watertight footwear provided with a vapour permeable member, e.g. a membrane
    • A—HUMAN NECESSITIES
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    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B9/00—Footwear characterised by the assembling of the individual parts
    • A43B9/02—Footwear stitched or nailed through
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29D35/061—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding
    • B29D35/062—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding using means to bond the moulding material to the preformed uppers
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    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29D35/00—Producing footwear
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    • B29D35/128—Moulds or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/14—Multilayered parts
    • B29D35/142—Soles
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B29C45/14836—Preventing damage of inserts during injection, e.g. collapse of hollow inserts, breakage
    • B29C2045/14844—Layers protecting the insert from injected material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
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Abstract

Винахід стосується сполук формули (І) , (I) де Х - N або СН; R1 - атом гідрогену або галогену або CF3; R2 та R3 - незалежно, атом гідрогену або метил; n - 0 або 1; А - група формули (а) або (b) , (a) , (b) де R4 - атом гідрогену або галогену, (С1-С4)алкіл, CF3, аміногрупа, моно(С1-С4)алкіламіногрупа або ді(С1-С4)алкіламіногрупа; R5 - атом гідрогену або галогену, (С1-С4)алкоксил, (С1-С4)алкіл або CF3; R6 - атом гідрогену, (С1-С4)алкіл або (С1-С4)алкоксил; а також їх солей або сольватів, фармацевтичної композиції, що їх містять, способу їх одержання та синтезу інтермедіатів за цим способом.
UA2002043167A 1999-10-22 2000-10-19 Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція UA72934C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9913206A FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR0008328A FR2810984B1 (fr) 2000-06-28 2000-06-28 Pyridyl-tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/002910 WO2001029026A1 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt

Publications (1)

Publication Number Publication Date
UA72934C2 true UA72934C2 (uk) 2005-05-16

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UA2002043167A UA72934C2 (uk) 1999-10-22 2000-10-19 Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція

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EP (1) EP1226137B8 (uk)
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FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP2426120A1 (en) 2003-08-18 2012-03-07 Fujifilm Finechemicals Co., Ltd. Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

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EP1226137B1 (fr) 2004-07-21
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EP1226137A1 (fr) 2002-07-31
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NO20021872L (no) 2002-06-21
MXPA02003979A (es) 2003-01-28
KR100755115B1 (ko) 2007-09-04
RS50399B (sr) 2009-12-31
YU28902A (sh) 2004-11-25
HK1046532A1 (en) 2003-01-17
DE60012355T2 (de) 2005-12-22
IS2308B (is) 2007-10-15
IS6336A (is) 2002-04-09
IL149250A (en) 2007-08-19
HUP0204444A2 (en) 2003-05-28
MEP25108A (en) 2011-12-20
ME01727B (me) 2010-05-07
EA004508B1 (ru) 2004-04-29
HK1046532B (zh) 2005-03-18
NO20021872D0 (no) 2002-04-19
PL354922A1 (en) 2004-03-22
SK287098B6 (sk) 2009-12-07
BR0014871A (pt) 2002-06-11
BG106613A (en) 2003-02-28
PL198421B1 (pl) 2008-06-30
US6509351B1 (en) 2003-01-21
TWI224097B (en) 2004-11-21
AU7931300A (en) 2001-04-30
SI1226137T1 (en) 2005-02-28
AR026188A1 (es) 2003-01-29
EE200200210A (et) 2003-06-16
CA2386417A1 (en) 2001-04-26
HRP20020347B1 (en) 2010-10-31
WO2001029026A1 (fr) 2001-04-26
EA200200352A1 (ru) 2002-10-31
TR200201075T2 (tr) 2002-11-21
NO322596B1 (no) 2006-10-30
CA2386417C (en) 2010-09-28
AU778306B2 (en) 2004-11-25
KR20020040904A (ko) 2002-05-30
JP2003512370A (ja) 2003-04-02
NZ518112A (en) 2003-11-28
EP1226137B8 (fr) 2004-12-15
CZ20021382A3 (cs) 2002-07-17
PT1226137E (pt) 2004-11-30
IL149250A0 (en) 2002-11-10
CZ301566B6 (cs) 2010-04-21
HRP20020347A2 (en) 2003-08-31
ATE271554T1 (de) 2004-08-15
HUP0204444A3 (en) 2004-07-28
DK1226137T3 (da) 2004-11-22
DE60012355D1 (de) 2004-08-26
JP4831908B2 (ja) 2011-12-07
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BG65564B1 (bg) 2008-12-30
EE05055B1 (et) 2008-08-15

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