UA27252C2 - Похідні піразоло[1,5-а]піридину, які є антагоністами аденозину, та спосіб їх отримання - Google Patents
Похідні піразоло[1,5-а]піридину, які є антагоністами аденозину, та спосіб їх отриманняInfo
- Publication number
- UA27252C2 UA27252C2 UA93002532A UA93002532A UA27252C2 UA 27252 C2 UA27252 C2 UA 27252C2 UA 93002532 A UA93002532 A UA 93002532A UA 93002532 A UA93002532 A UA 93002532A UA 27252 C2 UA27252 C2 UA 27252C2
- Authority
- UA
- Ukraine
- Prior art keywords
- adenozine
- pyrazolo
- antagonists
- obtaining
- pyridine derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Developing Agents For Electrophotography (AREA)
Abstract
Даний винахід направлений на створення способів отримання нової сполуки піразолопіридину і його фармацевтично прийнятної солі. Він стосується і способу застосування споолуки піразолопіридину, який передбачає введення її людині або тваринам. Нова сполука піразолопіридину відповідно до даного винаходу може бути представлена такою формулою де R1 означає арил, R2 означає ацил(нижчий) алкіл і А означає нижчий алкенілен.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919107513A GB9107513D0 (en) | 1991-04-10 | 1991-04-10 | Pyrazolopyridine compound and processes for preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
UA27252C2 true UA27252C2 (uk) | 2000-08-15 |
Family
ID=10692949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002532A UA27252C2 (uk) | 1991-04-10 | 1993-06-18 | Похідні піразоло[1,5-а]піридину, які є антагоністами аденозину, та спосіб їх отримання |
Country Status (23)
Country | Link |
---|---|
US (1) | US5234930A (uk) |
EP (1) | EP0516941B1 (uk) |
JP (2) | JP2546470B2 (uk) |
KR (1) | KR100248700B1 (uk) |
CN (2) | CN1041203C (uk) |
AT (1) | ATE146473T1 (uk) |
AU (1) | AU653007B2 (uk) |
CA (1) | CA2065644C (uk) |
DE (1) | DE69215965T2 (uk) |
DK (1) | DK0516941T3 (uk) |
ES (1) | ES2095976T3 (uk) |
FI (1) | FI100969B (uk) |
GB (1) | GB9107513D0 (uk) |
GR (1) | GR3022113T3 (uk) |
HU (2) | HU214871B (uk) |
IE (1) | IE921086A1 (uk) |
IL (1) | IL101544A (uk) |
MX (1) | MX9201672A (uk) |
NO (1) | NO300271B1 (uk) |
RU (1) | RU2069662C1 (uk) |
SG (1) | SG43917A1 (uk) |
TW (1) | TW205550B (uk) |
UA (1) | UA27252C2 (uk) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5541213A (en) * | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
HUT76280A (en) * | 1993-12-29 | 1997-07-28 | Fujisawa Pharmaceutical Co | Pyrazolopyridine derivatives, pharmaceutical compositions containing them, process for proiducing them and their use |
EP0900796B1 (en) * | 1996-04-25 | 2004-12-15 | Fujisawa Pharmaceutical Co., Ltd. | Preventives and remedies for ischemic intestinal lesion and ileus |
AUPO111096A0 (en) * | 1996-07-18 | 1996-08-08 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
WO1998041237A1 (fr) | 1997-03-18 | 1998-09-24 | Fujisawa Pharmaceutical Co., Ltd. | Medicaments pour la prevention et la therapie de l'hyperphosphatemie |
CA2333947C (en) * | 1998-06-01 | 2010-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compounds as adenosine a1 antagonist for male sterility |
US20040152659A1 (en) * | 1999-05-12 | 2004-08-05 | Fujisawa Pharmaceutical Co. Ltd. | Method for the treatment of parkinson's disease comprising administering an A1A2a receptor dual antagonist |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
ES2245380T3 (es) * | 2000-12-15 | 2006-01-01 | Glaxo Group Limited | Pirazolopiridinas. |
AU2002239348A1 (en) * | 2000-12-15 | 2002-06-24 | Glaxo Group Limited | Pyrazolopyridine derivatives |
JP2004529119A (ja) * | 2001-03-08 | 2004-09-24 | スミスクライン ビーチャム コーポレーション | ピラゾロピリジン誘導体 |
US7034030B2 (en) * | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
WO2002078701A1 (en) * | 2001-03-30 | 2002-10-10 | Smithkline Beecham Corporation | Use of pyrazolopyridines as therapeutic compounds |
WO2002083672A1 (en) | 2001-04-10 | 2002-10-24 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
ES2242028T3 (es) * | 2001-04-27 | 2005-11-01 | Smithkline Beecham Corporation | Derivados de pirazolo(1,5-a)piridina. |
AUPR548601A0 (en) * | 2001-06-06 | 2001-06-28 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyrazinecompound and pharmaceutical use thereof |
IL158667A0 (en) * | 2001-06-21 | 2004-05-12 | Smithkline Beecham Corp | Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
ATE364043T1 (de) * | 2001-09-07 | 2007-06-15 | Smithkline Beecham Corp | Pyrazolo-pyridine für die behandlung von herpes- ansteckungen |
JP2005508955A (ja) * | 2001-10-05 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | ヘルペスウイルス感染の治療で使用されるためのイミダゾ−ピリジン誘導体 |
US7199120B2 (en) * | 2001-12-11 | 2007-04-03 | Smithkline Beecham Corporation | Pyrazolo-pyridine derivatives as antiherpes agents |
EP1546148A1 (en) * | 2002-10-03 | 2005-06-29 | SmithKline Beecham Corporation | Therapeutic compounds based on pyrazolopyridine derivatives |
EP2038279A2 (en) | 2006-06-06 | 2009-03-25 | Avigen, Inc. | Substituted pyrazolo [1,5- alpha] pyridine compounds and their methods of use |
US9572528B1 (en) | 2012-08-06 | 2017-02-21 | Los Angeles Biomedical Research Insitute at Harbor-UCLA Medical Center | Monitor for SIDS research and prevention |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925849A (en) * | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
GB8901423D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
-
1991
- 1991-04-10 GB GB919107513A patent/GB9107513D0/en active Pending
-
1992
- 1992-04-02 TW TW081102547A patent/TW205550B/zh active
- 1992-04-02 AU AU13988/92A patent/AU653007B2/en not_active Expired
- 1992-04-03 IE IE108692A patent/IE921086A1/en not_active IP Right Cessation
- 1992-04-07 FI FI921522A patent/FI100969B/fi not_active IP Right Cessation
- 1992-04-08 DE DE69215965T patent/DE69215965T2/de not_active Expired - Lifetime
- 1992-04-08 DK DK92106028.1T patent/DK0516941T3/da active
- 1992-04-08 EP EP92106028A patent/EP0516941B1/en not_active Expired - Lifetime
- 1992-04-08 SG SG1996005302A patent/SG43917A1/en unknown
- 1992-04-08 ES ES92106028T patent/ES2095976T3/es not_active Expired - Lifetime
- 1992-04-08 AT AT92106028T patent/ATE146473T1/de active
- 1992-04-09 RU SU5011507/04A patent/RU2069662C1/ru active
- 1992-04-09 CA CA002065644A patent/CA2065644C/en not_active Expired - Lifetime
- 1992-04-09 US US07/866,215 patent/US5234930A/en not_active Expired - Lifetime
- 1992-04-09 JP JP4088735A patent/JP2546470B2/ja not_active Expired - Lifetime
- 1992-04-09 IL IL10154492A patent/IL101544A/en not_active IP Right Cessation
- 1992-04-09 CN CN92103372A patent/CN1041203C/zh not_active Expired - Lifetime
- 1992-04-09 KR KR1019920005893A patent/KR100248700B1/ko not_active IP Right Cessation
- 1992-04-09 HU HU9201213A patent/HU214871B/hu unknown
- 1992-04-09 NO NO19921413A patent/NO300271B1/no not_active IP Right Cessation
- 1992-04-09 CN CNB971253781A patent/CN100508975C/zh not_active Expired - Lifetime
- 1992-04-10 MX MX9201672A patent/MX9201672A/es unknown
-
1993
- 1993-06-18 UA UA93002532A patent/UA27252C2/uk unknown
-
1995
- 1995-06-22 HU HU95P/P00354P patent/HU211680A9/hu unknown
- 1995-11-16 JP JP7298193A patent/JP2903040B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-19 GR GR960403475T patent/GR3022113T3/el unknown
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