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UA111475C2 - Способи лікування із застосуванням ліпідних сполук - Google Patents

Способи лікування із застосуванням ліпідних сполук

Info

Publication number
UA111475C2
UA111475C2 UAA201305822A UAA201305822A UA111475C2 UA 111475 C2 UA111475 C2 UA 111475C2 UA A201305822 A UAA201305822 A UA A201305822A UA A201305822 A UAA201305822 A UA A201305822A UA 111475 C2 UA111475 C2 UA 111475C2
Authority
UA
Ukraine
Prior art keywords
treatment
methods
application
lipid compounds
lipid
Prior art date
Application number
UAA201305822A
Other languages
English (en)
Russian (ru)
Inventor
Рагнар Ховланн
Туре Ск'єрет
Дейвід А. Фрейзер
Original Assignee
Пронова Байофарма Нордж Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пронова Байофарма Нордж Ас filed Critical Пронова Байофарма Нордж Ас
Publication of UA111475C2 publication Critical patent/UA111475C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Розкриті способи лікування або профілактики щонайменше одного захворювання або хворобливого стану у суб'єкта, якому це необхідно, які включають введення сполуки Формули (І):Формула (І)або її фармацевтично прийнятної солі або складного ефіру,у якій Rта Rнезалежно вибирають з атома водню або лінійних, розгалужених та/або циклічних С-Салкільних груп, за умови, що Rта Rобидва не являють собою водень. Такі захворювання або хворобливі стани можуть належати до коронарної хвороби серця (КХС), наприклад атеросклерозу; метаболічного синдрому/резистентності до інсуліну; та/або дисліпідемічного стану, такого як гіпертригліцеридемія (ГТГ), підвищений ЛНГ-холестерин, підвищений загальний холестерин, підвищений Аро В та низький ЛВГ-холестерин. Дане розкриття додатково забезпечує спосіб зменшення розвитку атеросклерозу. Також розкриті фармацевтичні композиції, що включають сполуку Формули (І).
UAA201305822A 2010-11-05 2011-11-03 Способи лікування із застосуванням ліпідних сполук UA111475C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41044510P 2010-11-05 2010-11-05
PCT/IB2011/002925 WO2012059818A1 (en) 2010-11-05 2011-11-03 Methods of treatment using lipid compounds

Publications (1)

Publication Number Publication Date
UA111475C2 true UA111475C2 (uk) 2016-05-10

Family

ID=46024069

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201305822A UA111475C2 (uk) 2010-11-05 2011-11-03 Способи лікування із застосуванням ліпідних сполук

Country Status (22)

Country Link
US (1) US9394228B2 (uk)
EP (1) EP2635270B1 (uk)
JP (1) JP2014505017A (uk)
KR (3) KR20130132836A (uk)
CN (2) CN103347508A (uk)
AR (1) AR083772A1 (uk)
AU (1) AU2011324909B2 (uk)
BR (1) BR112013010890B1 (uk)
CA (1) CA2816949C (uk)
CO (1) CO6771414A2 (uk)
EA (1) EA028535B1 (uk)
ES (1) ES2618604T3 (uk)
IL (1) IL226116B (uk)
MX (1) MX350720B (uk)
MY (1) MY170076A (uk)
NZ (1) NZ610705A (uk)
PH (1) PH12013500893A1 (uk)
SG (2) SG190114A1 (uk)
TW (2) TW201701875A (uk)
UA (1) UA111475C2 (uk)
WO (1) WO2012059818A1 (uk)
ZA (1) ZA201303813B (uk)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
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EP2147910A1 (en) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
AR078507A1 (es) 2009-05-08 2011-11-16 Pronova Biopharma Norge As Compuestos lipidicos, composiciones farmaceuticas, usos y metodo de preparacion
SG190114A1 (en) 2010-11-05 2013-07-31 Pronova Biopharma Norge As Methods of treatment using lipid compounds
AU2014222389B2 (en) * 2013-02-28 2018-11-29 Pronova Biopharma Norge As A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
PL2961727T3 (pl) 2013-02-28 2017-06-30 Pronova Biopharma Norge As Sposób wytwarzania kwasu 2-((5Z,8Z, 11Z,14Z,17Z)-ejkoza-5,8,11,14,17-pentaenyloksy)butanowego
JP7341916B2 (ja) * 2015-04-01 2023-09-11 ビーエーエスエフ エーエス アポｃ３を低下させるためのチアオキソ化合物の使用
WO2016156912A1 (en) * 2015-04-01 2016-10-06 Pronova Biopharma Norge As Use of thia oxo compounds for lowering apo c3
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JP2023554524A (ja) * 2020-12-22 2023-12-27 ノースシー セラピューティクス ベスローテン フェンノートシャップ 非アルコール性脂肪性肝炎の治療のための酸素含有構造強化脂肪酸を含む組合せ療法

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EP2635270A4 (en) 2014-03-26
KR20200034814A (ko) 2020-03-31
SG190114A1 (en) 2013-07-31
CA2816949A1 (en) 2012-05-10
EA201390659A1 (ru) 2013-11-29
TW201701875A (zh) 2017-01-16
KR102265409B1 (ko) 2021-06-16
WO2012059818A1 (en) 2012-05-10
ZA201303813B (en) 2015-06-24
AU2011324909A1 (en) 2013-06-13
CA2816949C (en) 2017-07-04
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MX2013005022A (es) 2013-06-03
BR112013010890A2 (pt) 2016-08-02
AU2011324909B2 (en) 2016-09-08
CN107496395A (zh) 2017-12-22
US9394228B2 (en) 2016-07-19
AR083772A1 (es) 2013-03-20
IL226116A0 (en) 2013-06-27
IL226116B (en) 2018-01-31
US20130345269A1 (en) 2013-12-26
EP2635270A1 (en) 2013-09-11
NZ610705A (en) 2014-10-31
CN103347508A (zh) 2013-10-09
BR112013010890B1 (pt) 2020-03-10
MY170076A (en) 2019-07-03
KR20130132836A (ko) 2013-12-05
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EP2635270B1 (en) 2016-12-21
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MX350720B (es) 2017-09-14
TW201233388A (en) 2012-08-16
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EA028535B1 (ru) 2017-11-30

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