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UA107583C2 - Спироциклические нитрилы как ингибиторы протеазы - Google Patents

Спироциклические нитрилы как ингибиторы протеазы

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Publication number
UA107583C2
UA107583C2 UAA201209494A UAA201209494A UA107583C2 UA 107583 C2 UA107583 C2 UA 107583C2 UA A201209494 A UAA201209494 A UA A201209494A UA A201209494 A UAA201209494 A UA A201209494A UA 107583 C2 UA107583 C2 UA 107583C2
Authority
UA
Ukraine
Prior art keywords
protease inhibitors
spiro cyclic
cyclic nitriles
nitriles
spiro
Prior art date
Application number
UAA201209494A
Other languages
English (en)
Ukrainian (uk)
Inventor
Манфред ШУДОК
Міхель Вагнер
Армін Бауер
Анна Кольманн
Original Assignee
Санофі-Авентіс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофі-Авентіс filed Critical Санофі-Авентіс
Publication of UA107583C2 publication Critical patent/UA107583C2/ru

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

Изобретение относится к замещенным гетероциклическим спиросоединениям формулы (I), которые ингибируют катепсин, способа их получения и их применение в качестве лекарственного средства. EMBED ISISServer (l)
UAA201209494A 2006-06-01 2007-05-23 Спироциклические нитрилы как ингибиторы протеазы UA107583C2 (ru)

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UAA201209494A UA107583C2 (ru) 2006-06-01 2007-05-23 Спироциклические нитрилы как ингибиторы протеазы

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WO2012047703A2 (en) * 2010-10-04 2012-04-12 Schering Corporation Cyclopropyl-spiro-piperidines useful as sodium channel blockers
FR2967673B1 (fr) 2010-11-24 2012-12-28 Minakem Synthese de n-heterocycles par alkylation reductrice de derives cyanes
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
CN103304571B (zh) * 2012-03-06 2018-02-16 凯惠科技发展(上海)有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
RU2016149812A (ru) 2014-06-06 2018-07-17 Флексус Байосайенсиз, Инк. Иммунорегулирующие средства
CN104250233B (zh) * 2014-08-29 2016-03-16 湖南华腾制药有限公司 一种4-叔丁氧羰基-2-环丙基吗啉的制备方法
SI3191487T1 (sl) * 2014-09-12 2019-12-31 Boehringer Ingelheim International Gmbh Spirociklični inhibitorji katepsina C
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
US10709692B2 (en) * 2015-12-04 2020-07-14 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1)
US20220193048A1 (en) 2019-04-05 2022-06-23 Universite De Bretagne Occidentale Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
WO2021147882A1 (zh) * 2020-01-21 2021-07-29 深圳信立泰药业股份有限公司 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途

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UA100669C2 (ru) 2013-01-25
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US8039480B2 (en) 2011-10-18
CN101460462B (zh) 2013-07-31
HK1133255A1 (en) 2010-03-19
RU2012144638A (ru) 2014-04-27
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MX2008014800A (es) 2008-12-02
CN102417480B (zh) 2015-08-26
US20140073662A1 (en) 2014-03-13
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EP2032535A1 (de) 2009-03-11
SI2032535T1 (sl) 2012-12-31
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ES2392675T3 (es) 2012-12-12
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KR20090015949A (ko) 2009-02-12
HN2008001723A (es) 2010-12-27
RU2478620C2 (ru) 2013-04-10
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