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UA107336C2 - Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина - Google Patents

Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина

Info

Publication number
UA107336C2
UA107336C2 UAA201108206A UAA201108206A UA107336C2 UA 107336 C2 UA107336 C2 UA 107336C2 UA A201108206 A UAA201108206 A UA A201108206A UA A201108206 A UAA201108206 A UA A201108206A UA 107336 C2 UA107336 C2 UA 107336C2
Authority
UA
Ukraine
Prior art keywords
ylvinyl
pyrrolidin
pyrimidine
synthesis
salt forms
Prior art date
Application number
UAA201108206A
Other languages
English (en)
Ukrainian (uk)
Inventor
Срінівіса Рао Акіредді
Балвіндер Сінгх Бхатті
Тімоті Дж. Катбертсон
Гарі Моріс Далл
Крейг Харрісон Міллер
Джозеф Пайк Мітченер мол.
Хуліо А. Муньос
Пітер Альберт Оттен
Original Assignee
Таргасепт, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41650077&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA107336(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Таргасепт, Інк. filed Critical Таргасепт, Інк.
Publication of UA107336C2 publication Critical patent/UA107336C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к стереоспецифическому синтезу (R)-5-((E)-2-пирролидин-3-илвинил)пиримидина, его солевых форм и новых полиморфных форм этих солей.
UAA201108206A 2008-12-01 2009-11-30 Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина UA107336C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11879608P 2008-12-01 2008-12-01
PCT/US2009/066078 WO2010065443A1 (en) 2008-12-01 2009-11-30 Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine

Publications (1)

Publication Number Publication Date
UA107336C2 true UA107336C2 (ru) 2014-12-25

Family

ID=41650077

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108206A UA107336C2 (ru) 2008-12-01 2009-11-30 Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина

Country Status (26)

Country Link
US (1) US8604191B2 (ru)
EP (2) EP2364307B1 (ru)
JP (1) JP5710490B2 (ru)
KR (1) KR20110098763A (ru)
CN (1) CN102232070A (ru)
AU (1) AU2009322624B2 (ru)
BR (1) BRPI0922759A2 (ru)
CA (2) CA2742366C (ru)
CL (1) CL2011001258A1 (ru)
CO (1) CO6390106A2 (ru)
DK (1) DK3279195T3 (ru)
EC (1) ECSP11011167A (ru)
ES (2) ES2820857T3 (ru)
HK (1) HK1250572A1 (ru)
HU (1) HUE050540T2 (ru)
IL (2) IL266097B (ru)
MX (1) MX2011005611A (ru)
NZ (3) NZ592554A (ru)
PE (1) PE20110589A1 (ru)
PL (1) PL3279195T3 (ru)
PT (1) PT3279195T (ru)
RU (2) RU2533819C2 (ru)
SG (2) SG10201406410UA (ru)
UA (1) UA107336C2 (ru)
WO (1) WO2010065443A1 (ru)
ZA (1) ZA201103737B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
US20130237550A1 (en) * 2010-03-11 2013-09-12 Targacept, Inc. Arylvinylazacycloalkane compounds for constipation
ES2848977T5 (es) 2014-10-20 2024-06-06 Oyster Point Pharma Inc Métodos de tratamiento de afecciones oculares
PT3439661T (pt) * 2016-04-07 2021-09-30 Oyster Point Pharma Inc Métodos de tratamento de condições oculares
WO2020014232A1 (en) 2018-07-10 2020-01-16 Oyster Point Pharma, Inc. Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions
TW202019424A (zh) 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之方法
TW202206078A (zh) 2020-04-28 2022-02-16 美商奧伊斯特普安生物製藥公司 局部投與菸鹼乙醯膽鹼受體促效劑用以抑制冠狀病毒感染

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SU1605922A3 (ru) * 1987-05-01 1990-11-07 Фудзисава Фармасьютикал Ко., Лтд (Фирма) Способ получени производных пирролидина или их солей
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
IL107184A (en) 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
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US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
ES2097703B1 (es) * 1995-04-12 1997-12-01 Decox S L Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion.
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Also Published As

Publication number Publication date
IL212798B (en) 2019-05-30
SG10201902903RA (en) 2019-05-30
EP3279195A1 (en) 2018-02-07
CA3090738C (en) 2023-06-13
NZ611965A (en) 2015-01-30
RU2011127010A (ru) 2013-01-10
JP2012510471A (ja) 2012-05-10
CO6390106A2 (es) 2012-02-29
KR20110098763A (ko) 2011-09-01
EP2364307A1 (en) 2011-09-14
CN102232070A (zh) 2011-11-02
NZ703381A (en) 2016-03-31
IL212798A0 (en) 2011-07-31
US8604191B2 (en) 2013-12-10
PT3279195T (pt) 2020-09-29
EP3279195B1 (en) 2020-07-01
DK3279195T3 (en) 2020-08-17
NZ592554A (en) 2013-08-30
JP5710490B2 (ja) 2015-04-30
AU2009322624B2 (en) 2015-06-11
EP2364307B1 (en) 2017-07-05
ECSP11011167A (es) 2011-10-31
CA3090738A1 (en) 2010-06-10
SG10201406410UA (en) 2014-11-27
ZA201103737B (en) 2012-01-25
AU2009322624A1 (en) 2010-06-10
ES2641762T3 (es) 2017-11-13
MX2011005611A (es) 2011-09-15
HUE050540T2 (hu) 2020-12-28
IL266097A (en) 2019-06-30
BRPI0922759A2 (pt) 2016-01-05
CA2742366C (en) 2020-09-22
RU2700796C2 (ru) 2019-09-23
CL2011001258A1 (es) 2011-09-02
ES2820857T3 (es) 2021-04-22
HK1250572A1 (zh) 2018-12-28
WO2010065443A1 (en) 2010-06-10
RU2014136983A (ru) 2016-04-10
PL3279195T3 (pl) 2020-12-14
CA2742366A1 (en) 2010-06-10
IL266097B (en) 2022-07-01
PE20110589A1 (es) 2011-09-07
RU2533819C2 (ru) 2014-11-20
US20110281895A1 (en) 2011-11-17

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