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UA105053C2 - Азетидинонові сполуки і медичне застосування зазначених сполук - Google Patents

Азетидинонові сполуки і медичне застосування зазначених сполук

Info

Publication number
UA105053C2
UA105053C2 UAA201202735A UAA201202735A UA105053C2 UA 105053 C2 UA105053 C2 UA 105053C2 UA A201202735 A UAA201202735 A UA A201202735A UA A201202735 A UAA201202735 A UA A201202735A UA 105053 C2 UA105053 C2 UA 105053C2
Authority
UA
Ukraine
Prior art keywords
compounds
present
medical use
preparation
azetidinone
Prior art date
Application number
UAA201202735A
Other languages
English (en)
Russian (ru)
Inventor
Хуа Бай
Сяоцзе Сюй
Сюйян Чжао
Сяу Лю
Юнкай Чжан
Ін Чен
Сяохе Чжен
Маоцзян Гу
Цюфен Чжу
Юн Чжан
Хайрон Ло
Original Assignee
Чжецзян Хісун Фармасьютікал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чжецзян Хісун Фармасьютікал Ко., Лтд. filed Critical Чжецзян Хісун Фармасьютікал Ко., Лтд.
Publication of UA105053C2 publication Critical patent/UA105053C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даним винаходом запропоноване одержання азетидинонових сполук і медичне застосування зазначених сполук. Конкретніше, в описі запропоновані азетидинонові сполуки, представлені формулою (І), де R, R, R, R, Rі Rвизначені в описі, і способи одержання таких сполук.Сполуки за даним винаходом можуть знижувати рівні загального холестерину (ТС) і холестерину ліпопротеїнів низької густини (LDL-C) у плазмі і можуть бути використані для лікування або профілактики атеросклерозу, какергазії кровоносних судин, серцевої недостатності, хвороби коронарних артерій, ангіокардіопатії, інфаркту міокарда, стенокардії і гіперліпідемії і гіперхолестеринемії, і такого іншого.Даним винаходом також запропонований спосіб одержання сполук формули (І) і проміжних сполук.(I)
UAA201202735A 2009-08-11 2010-08-09 Азетидинонові сполуки і медичне застосування зазначених сполук UA105053C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2009101628888A CN101993403B (zh) 2009-08-11 2009-08-11 氮杂环丁酮类化合物及医药应用
PCT/CN2010/001206 WO2011017907A1 (zh) 2009-08-11 2010-08-09 氮杂环丁酮类化合物及医药应用

Publications (1)

Publication Number Publication Date
UA105053C2 true UA105053C2 (uk) 2014-04-10

Family

ID=43585888

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201202735A UA105053C2 (uk) 2009-08-11 2010-08-09 Азетидинонові сполуки і медичне застосування зазначених сполук

Country Status (18)

Country Link
US (1) US8623855B2 (uk)
EP (1) EP2465847B1 (uk)
JP (1) JP5706896B2 (uk)
KR (1) KR101394993B1 (uk)
CN (2) CN101993403B (uk)
CA (1) CA2770793C (uk)
CL (1) CL2012000351A1 (uk)
EA (1) EA021484B1 (uk)
IL (1) IL218045A (uk)
IN (1) IN2012DN01132A (uk)
MX (1) MX2012001829A (uk)
MY (1) MY157237A (uk)
NZ (1) NZ598050A (uk)
PE (1) PE20121086A1 (uk)
SG (1) SG178313A1 (uk)
UA (1) UA105053C2 (uk)
WO (1) WO2011017907A1 (uk)
ZA (1) ZA201201676B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101993403B (zh) * 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
EP2905276A4 (en) * 2012-09-05 2016-03-09 Zhejiang Hisun Pharm Co Ltd CRYSTALLINE FORMS OF AZETIDINONE COMPOUNDS AND METHODS FOR PREPARING THE SAME
CN104780918B (zh) * 2013-03-01 2017-03-08 浙江海正药业股份有限公司 用于预防和/或治疗丙型肝炎的氮杂环丁酮化合物及其组合物
CN105294426B (zh) 2014-06-09 2019-05-14 浙江海正药业股份有限公司 氮杂环丁酮化合物制备方法及其中间体
WO2019101150A1 (zh) * 2017-11-23 2019-05-31 浙江海正药业股份有限公司 一种海泽麦布片剂及其制备方法
WO2019101151A1 (zh) * 2017-11-23 2019-05-31 浙江海正药业股份有限公司 一种海泽麦布和HMG-CoA还原酶抑制剂的药物组合物
KR20240010494A (ko) * 2021-06-17 2024-01-23 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 하이뷰티마이브 중간체 및 이의 제조 방법

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ES2107548T3 (es) 1991-07-23 1997-12-01 Schering Corp Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
WO1995035277A1 (en) 1994-06-20 1995-12-28 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
CN1103780C (zh) 1995-10-31 2003-03-26 先灵公司 用作降低血胆固醇药剂的糖取代2－氮杂环丁酮
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IL155771A0 (en) 2000-12-20 2003-12-23 Schering Corp Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
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TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
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TW200726746A (en) * 2005-05-06 2007-07-16 Microbia Inc Processes for production of 4-biphenylylazetidin-2-ones
JP2008543837A (ja) * 2005-06-15 2008-12-04 メルク エンド カムパニー インコーポレーテッド 抗高コレステロール血症化合物
CN101134739A (zh) * 2006-09-01 2008-03-05 长春吉大天元化学技术股份有限公司 新的β-内酰胺类化合物及其制备方法及其药物用途
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US20080280836A1 (en) * 2007-05-08 2008-11-13 Morriello Gregori J Anti-hypercholesterolemic biaryl azetidinone compounds
CN101423511A (zh) * 2007-11-05 2009-05-06 中山奕安泰医药科技有限公司 依泽替米贝中间体及依泽替米贝的合成方法
CN101993403B (zh) * 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用

Also Published As

Publication number Publication date
CA2770793C (en) 2017-06-13
EP2465847B1 (en) 2016-10-12
MX2012001829A (es) 2012-07-23
MY157237A (en) 2016-05-13
KR101394993B1 (ko) 2014-05-15
CA2770793A1 (en) 2011-02-17
EP2465847A4 (en) 2013-04-17
IN2012DN01132A (uk) 2015-04-10
IL218045A0 (en) 2012-04-30
EP2465847A1 (en) 2012-06-20
ZA201201676B (en) 2012-11-28
EA201270248A1 (ru) 2012-07-30
US20120208994A1 (en) 2012-08-16
IL218045A (en) 2017-05-29
AU2010282097A1 (en) 2012-04-05
CN102448932B (zh) 2014-08-13
JP5706896B2 (ja) 2015-04-22
CN101993403A (zh) 2011-03-30
NZ598050A (en) 2013-03-28
JP2013501734A (ja) 2013-01-17
SG178313A1 (en) 2012-03-29
US8623855B2 (en) 2014-01-07
CN101993403B (zh) 2012-07-11
CN102448932A (zh) 2012-05-09
KR20120047969A (ko) 2012-05-14
CL2012000351A1 (es) 2012-08-10
WO2011017907A1 (zh) 2011-02-17
EA021484B1 (ru) 2015-06-30
PE20121086A1 (es) 2012-08-17

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