TWM656940U - Liposome-coated structure with plant-derived bioactive peptides - Google Patents

Abstract

A liposome coating structure of a plant-derived bioactive peptide with whitening effect, comprising: a core part, wherein the core part contains a plant-derived bioactive peptide, and the plant-derived bioactive peptide can inhibit the production of melanin; and a liposome protective layer, wherein the liposome protective layer comprises a first coating layer and a second coating layer, wherein the first coating layer and the second coating layer constitute a hollow spherical space, and the hollow spherical space is used to accommodate the core part, the first coating layer constitutes the inner layer of the liposome protective layer, and the second coating layer constitutes the outer layer of the liposome protective layer.

Description

Liposomal encapsulation structure of plant-derived bioactive peptides

This work is related to a liposome encapsulation structure, especially a liposome encapsulation structure of a plant-derived bioactive peptide with whitening effect.

The production of melanin in human skin is a complex physiological process that originates from melanocytes in the basal layer of the epidermis. When the skin is exposed to ultraviolet radiation, emotional fluctuations, stress or endocrine changes, this series of factors causes keratinocytes to release free radicals. Free radicals are unstable substances produced by metabolism when the body maintains physiological functions. Their extremely high activity triggers a series of redox reactions. These free radicals interact with substances in the skin, further stimulating peripheral nerves to release cytokines, including interleukin (interleukin), prostaglandin (prostaglandin), etc., triggering an inflammatory response. At the same time, this process stimulates the pituitary gland to secrete α-melanocyte-stimulating hormone (α-MSH). The function of α-MSH is to activate tyrosinase in melanocytes. This tyrosinase reacts with tyrosine in the blood, generates dopa through oxidation, and then oxidizes to dopaquinone, and finally releases melanin and melaninoids. These melanin-filled melanosomes transmit melanin to surrounding keratinocytes through the synapses of melanocytes to protect skin cells. The released melanin is gradually transported to the epidermis, causing the skin to gradually darken and eventually be metabolized. Therefore, the key steps to reduce the production of melanin and achieve whitening effects include reducing the stimulation of active free radicals, inhibiting the action of peripheral nerves, and slowing down the inflammatory response caused by interleukins, prostaglandins, etc., or inhibiting the activity of tyrosinase.

It is currently known that tyrosinase is one of the important enzymes that regulates melanin production. It not only participates in many reactions in the melanin production process, but is also a key enzyme that catalyzes the rate-limiting step in the reaction. Therefore, the content of tyrosinase can be used as an indicator of the melanin production reaction. Although melanin has a photoprotective effect, when there is too much melanin or abnormal distribution, it will cause excessive melanin deposition and plaques, affecting beauty. Therefore, how to effectively inhibit tyrosinase activity and prevent abnormal melanin deposition such as dark spots and age spots has become the focus of research and development for related industries.

In recent years, with the rise of the global health and natural lifestyle trend, people's demand for natural and non-toxic skin care ingredients has increased. Behind this trend is the concern about the allergies or other side effects that may be caused by chemically synthesized beauty products in the past. Therefore, skin care products with natural extracts as the main raw materials have gradually gained favor among consumers. At present, studies have proven that some natural substances such as vitamin C (L-ascorbic acid), kojic acid, azelaic acid and arbutin have significant effects in whitening and anti-oxidation. These ingredients are valued for their natural sources and effectiveness. However, these substances also face many challenges in application. For example, vitamin C is easily oxidized when exposed to air or sunlight, and high concentrations may irritate the skin. Kojic acid has poor stability and is easily oxidized and discolored. Long-term excessive use may also cause cytotoxicity. In addition, the mechanism of action of some whitening agents may involve direct destruction of melanocytes, which may not only cause cytotoxicity but also affect the overall health of the skin. Therefore, in the development and use of these ingredients, safety and determination of appropriate concentrations have become key factors. Consumers and manufacturers need to have a deeper understanding of the characteristics and limitations of these ingredients to ensure that the products are both effective and safe.

This creation is a liposome-encapsulated structure of a plant-derived bioactive peptide with whitening effect. The liposome is used to encapsulate a natural plant-derived bioactive peptide with whitening function. The plant-derived bioactive peptide with whitening function is a small molecule protein fragment extracted from plants. It has the characteristics of promoting skin whitening and brightening the skin color, which can ensure that consumers can use it with peace of mind.

One of the purposes of this invention is to provide a liposome-encapsulated structure of plant-derived bioactive peptides with whitening effects.

A liposome coating structure of a plant-derived bioactive peptide with whitening effect, comprising: a core part, wherein the core part contains a plant-derived bioactive peptide, and the plant-derived bioactive peptide can inhibit the production of melanin; and a liposome protective layer, wherein the liposome protective layer comprises a first coating layer and a second coating layer, wherein the first coating layer and the second coating layer constitute a hollow spherical space, and the hollow spherical space is used to accommodate the core part, the first coating layer constitutes the inner layer of the liposome protective layer, and the second coating layer constitutes the outer layer of the liposome protective layer.

This creation uses a liposome coating structure to encapsulate plant-derived bioactive peptides, which allows the plant-derived bioactive peptides to more easily penetrate the skin and exert their effects. It can also effectively protect the activity of the plant-derived bioactive peptides and enhance their stability and effectiveness in application.

The core contains a plant-derived bioactive peptide with a whitening effect. The plant-derived bioactive peptide with a whitening function is a small molecule protein fragment extracted from plants, which has the characteristics of promoting skin whitening and brightening skin color. These bioactive peptides usually contain a specific amino acid sequence that can effectively penetrate the skin barrier and reach the deep layers of the skin. The whitening effect of plant-derived bioactive peptides is mainly achieved by inhibiting the production of melanin, which is usually achieved by affecting the activity of tyrosinase in the skin. Tyrosinase is a key enzyme in the melanin production process and controls the production of melanin. In addition to directly inhibiting the production of melanin, these plant-derived bioactive peptides may also have antioxidant effects, helping to protect the skin from free radical damage, thereby reducing skin dullness and pigmentation caused by UV exposure or environmental stress, thereby preventing skin aging and pigmentation. In addition, they can promote the renewal and repair of skin cells, helping to maintain the health and youthfulness of the skin and help repair skin damage caused by UV exposure or environmental factors.

The above-mentioned plant-derived bioactive peptides not only have the effect of promoting skin whitening, but also because of their low molecular weight, they are more efficiently absorbed and utilized in skin care. This smaller molecular structure allows plant-derived bioactive peptides to quickly penetrate the skin layer and reach the deep layers of the skin more effectively than large molecular proteins or single amino acids. When these plant-derived bioactive peptides enter the human body, they are quickly absorbed by skin cells through a special transport mechanism. This efficient penetration and absorption ability means that plant-derived bioactive peptides can quickly concentrate in specific parts of the skin, thereby exerting their whitening and skin texture improvement effects in these areas. Another important feature of plant-derived bioactive peptides is that they are generally gentler and less likely to cause skin sensitivity or irritation than chemically synthesized whitening agents, making them an ideal choice for people with sensitive skin. As consumers' demand for natural and gentle skin care ingredients grows, plant-derived bioactive peptides with whitening effects will be more widely used in beauty care products.

The above-mentioned plant-derived bioactive peptides are susceptible to oxidation under certain conditions, which in turn weakens their activity and affects their ability to inhibit melanin production. In order to protect the activity of plant-derived bioactive peptides and prolong their stability, this invention uses a liposome protective layer to protect the activity of plant-derived bioactive peptides. Liposomes are tiny spherical structures composed of a double-layer structure that can encapsulate plant-derived bioactive peptides to form a protective layer. This structure can reduce the direct contact between plant-derived bioactive peptides and the external environment under adverse environmental conditions, thereby reducing the occurrence of oxidation, thermal denaturation and other reactions. At the same time, the hydrophilic and lipophilic properties of liposomes also help to improve the stability and solubility of plant-derived bioactive peptides, making them easier to be absorbed by the skin.

The liposome protective layer can be made of phospholipid compounds, wherein the phospholipid compounds are selected from lecithin (e.g., soybean lecithin, corn lecithin, cottonseed oil lecithin, egg yolk lecithin, egg white lecithin, etc.), phosphatidylcholines (PC), phosphatidylethanolamines (PE), phosphatidylglycerols (PG), phosphatidylinositols, sphingomyelins (SM), phosphatidic acids, phosphatidylinositols, phosphatidylserine. One or more phospholipid compounds can be selected according to different applications and purposes to adjust the properties of the liposome. The selection of appropriate phospholipid components can affect the stability, solubility, biocompatibility of the stable phospholipid bilayer membrane structure and its application in drug carriers.

In addition to phospholipid compounds, the above-mentioned liposome protective layer can be added with molecules that are compatible with liposomes and have no negative effects on the human body, such as proteins, carbohydrates, sterols, etc., as needed. The physical and chemical properties of the liposome protective layer can be adjusted by the added ingredients, thereby adjusting the rate at which the liposome structure is absorbed by human tissues, or making the liposome particles easier to be absorbed by specific types of cells.

The core may further include hydrolyzed yeast extract, which is a multifunctional skin care ingredient that has significant effects in whitening, moisturizing and protecting the skin. Hydrolyzed yeast extract contains ingredients that can promote skin brightness and even skin tone, help reduce pigmentation and improve uneven skin tone, so that the skin looks brighter and clearer. The vitamins and minerals contained in hydrolyzed yeast help reduce skin dullness caused by ultraviolet exposure or other environmental factors. At the same time, hydrolyzed yeast extract is also an effective moisturizer that can help the skin retain moisture, making the skin look plumper and healthier, strengthening the skin barrier, improving the skin's resistance to environmental stress, reducing water loss, and protecting the skin from harmful substances. In addition, hydrolyzed yeast extract is rich in nutrients, which helps repair and regenerate skin cells, promotes the healing of damaged skin, and speeds up the repair process. It is particularly beneficial for skin damaged by UV rays or other external factors. In summary, hydrolyzed yeast extract is widely used in modern skin care and beauty products due to its unique ingredients and multiple functions. Not only does it improve the skin's tone and brightness, it also provides deep hydration and strengthens the skin barrier while promoting the repair and restoration of damaged skin. This makes Hydrolyzed Yeast Extract an ideal ingredient for maintaining healthy skin.

The core may further include sodium ascorbyl phosphate, which is a derivative of vitamin C and provides multiple benefits for whitening and skin care. Sodium ascorbyl phosphate can effectively reduce skin pigmentation, fight against dullness and spots caused by ultraviolet exposure or hormonal changes, and help inhibit the production of melanin, thereby reducing existing spots and preventing the formation of new spots. Sodium ascorbate phosphate has significant antioxidant capacity and is able to neutralize free radicals, which are generated by UV exposure, environmental pollution, stress and unhealthy lifestyles in daily life. By reducing the damage of free radicals to skin cells, sodium ascorbate phosphate helps to prevent skin aging and inflammation caused by these factors. Sodium ascorbate phosphate can also create a protective barrier, reducing the direct impact of environmental pollutants on the skin, thereby protecting the skin from harmful substances. Pollutants in the environment, such as smoke and heavy metals, may accelerate the skin aging process. Using sodium ascorbate phosphate can effectively combat these negative effects. In addition, sodium ascorbate phosphate helps fight signs of skin aging due to oxidative stress, such as fine lines, wrinkles, loss of elasticity and lack of radiance, promotes collagen synthesis, enhances the structure and elasticity of the skin, thereby helping to reduce the appearance of fine lines and wrinkles. In addition, sodium ascorbate phosphate has a positive impact on the overall health and appearance of the skin. It helps to improve the skin's ability to retain moisture, making the skin more plump and smooth. In summary, sodium ascorbate phosphate plays an important role in beauty and skin care products as a highly effective skin care ingredient. Not only does it provide whitening and brightening effects, it also effectively protects the skin from external environmental damage and helps slow down signs of skin aging, keeping the skin young and healthy.

The core may further include green tea extract, which is a natural ingredient extracted from green tea leaves that has a variety of skin-beneficial properties. Green tea extract is rich in antioxidants, especially catechins, which are powerful free radical scavengers. Free radicals are unstable molecules that may attack skin cells, causing skin aging and damage. Epicatechins can help protect skin cells from environmental stressors such as UV rays and pollution, thereby preventing signs of skin aging such as fine lines, wrinkles and spots. Green tea extract can act as a natural sunscreen to help reduce direct damage to the skin due to UV rays, such as sunburn and redness. It can also prevent and repair DNA damage caused by UV rays, and reduce the signs of aging caused by skin exposure to the sun, such as pigmentation and uneven skin tone. The anti-inflammatory properties of green tea extract can help reduce skin inflammation, including acne, erythema and sensitivity reactions, thereby promoting healthy and soothing skin. In addition, the vitamin E and vitamin B2 contained in green tea extract help maintain the health of skin cells and enhance the skin's natural barrier function. It can also increase the moisture content of the skin, help maintain the skin's elasticity and moisture, and prevent dryness and roughness.

The core may further comprise hyaluronic acid, which is a polysaccharide naturally found in the human body and widely used in skin care products. The main benefit of hyaluronic acid is its strong moisturizing ability. It attracts and locks in water, with each gram of hyaluronic acid being able to bind up to 6 liters of water, making it an ideal ingredient for keeping the skin moisturized and reducing dryness, especially for dry, dehydrated or mature skin. Hyaluronic acid helps increase the elasticity of the skin, making it look more resilient and smooth. It can also fill in fine lines and wrinkles, reducing signs of skin aging caused by age and environmental factors. Hyaluronic acid plays an important role in the skin repair process, promoting wound healing and cell regeneration. It helps reduce inflammation and has a soothing and restorative effect on damaged or sensitive skin. Hyaluronic acid can maintain a good moisture balance, which is essential for promoting more even and bright skin. Good hydration can also enhance the effects of other whitening ingredients, making the skin look brighter.

The core may further include polyglutamic acid (PGA), which is a biopolymer produced by natural microbial fermentation and has multiple benefits in skin care. PGA has a strong water adsorption capacity and can effectively absorb and retain a large amount of water, even several times more than its own weight. It can form a moisturizing film on the surface of the skin, locking in moisture for a long time, thereby keeping the skin hydrated for a long time. By strengthening the skin's natural barrier, PGA helps reduce the adverse effects of environmental factors on the skin, such as damage caused by pollution and ultraviolet rays. It improves the elasticity and softness of the skin, makes the skin texture more delicate, and helps reduce the appearance of fine lines and wrinkles. PGA can promote the metabolism and repair of skin cells, accelerate wound healing, and help restore the skin to a healthy state. This property makes it particularly effective in treating dry, damaged or aging skin. PGA can enhance the skin's ability to absorb other skin care ingredients, such as antioxidants, vitamins and other moisturizing ingredients, thereby improving the overall skin care effect. It acts as a carrier to help these ingredients penetrate deeper into the skin and exert their maximum effectiveness. PGA is suitable for all skin types, including sensitive and inflammatory skin, because it is very gentle and will not cause irritation. In skin care products, it is commonly found in creams, essences, masks and skin care oils to provide deep moisturizing and repairing effects. In summary, as a highly effective moisturizing ingredient, polyglutamic acid plays an important role in modern skin care, especially in enhancing skin moisture, improving skin texture and promoting skin health. Due to its excellent performance and versatility, PGA has become a key ingredient in many high-end skin care products.

The core may further include xanthan gum, which is a polysaccharide fermented from sugars. Its multiple functions in skin care products make it a key ingredient in skin care formulas. One of the main functions of xanthan gum is to act as a thickener, which gives skin care products a richer and smoother texture, making the product easier to apply and evenly applied to the skin. It can improve the spreadability of skin care products, ensure that the skin care products have better ductility and touch on the skin, and enhance the user experience. As a stabilizer, xanthan gum can help maintain the homogeneity of skin care products, ensure that water and oil are not easily separated, thereby maintaining the consistency and effectiveness of the product. It helps prevent the active ingredients from settling or decomposing during storage and use, thereby extending the shelf life of the product and maintaining its effectiveness. Although xanthan gum does not have direct whitening or other effects on the skin, it can improve the skin stability and absorption of other active ingredients. By enhancing the distribution and stability of active ingredients, xanthan gum allows these ingredients to work more effectively on the skin. Xanthan gum also provides a moisturizing effect, helping the skin retain moisture and making the skin look more moisturized. Xanthan gum is a gentle ingredient for sensitive skin, is not likely to cause irritation or allergic reactions, and helps soothe and protect the skin. Xanthan gum is widely used in various skin care products, including facial cleansers, creams, serums, facial masks and body lotions. As a non-toxic and biodegradable natural ingredient, it meets the modern demand for natural and environmentally friendly skin care products.

The core may further include glycerin, which is a commonly used ingredient in skin care products. It can act as a highly effective humectant that attracts surrounding moisture and helps the skin stay hydrated. It absorbs moisture from the air to provide a lasting moisturizing effect for the skin. This water absorption ability is particularly effective for dry and dehydrated skin, and can significantly reduce the dryness and tightness of the skin. Glycerin not only provides moisture, but also helps strengthen the skin's natural barrier, protecting the skin from external irritation and pollutants. By improving the skin's barrier function, glycerin helps reduce water loss and maintain the skin's health. Regular use of skin care products containing glycerin can improve the texture of the skin, making the skin smoother and softer. Glycerin is also effective in reducing the appearance of fine lines and wrinkles in the skin, as it helps the skin retain moisture and elasticity. Glycerin is helpful in soothing skin irritation or inflammation caused by dryness, especially for skin conditions such as eczema and psoriasis, and it also helps speed up the skin's repair process, making it particularly beneficial for damaged or sensitive skin. Glycerin is used in a wide range of skincare products, from daily face creams and body lotions to hand creams and lip balms. It is a gentle, non-irritating ingredient that is suitable for all skin types, including sensitive skin.

This creation can further include 1,3-butylene glycol, which has the function of assisting percutaneous absorption. 1,3-butylene glycol can affect the arrangement of keratin cells in the skin, help break the barrier of the stratum corneum, and make it easier for plant-derived bioactive peptides to penetrate the skin and enter deep tissues. Secondly, 1,3-butylene glycol also has moisturizing properties, helping to maintain the hydration state of the skin, while reducing skin dryness, and further promoting the penetration of plant-derived bioactive peptides.

This creation can further include polyacrylamide, which, when added to the ointment to be applied, is mainly used for thickening, shaping and auxiliary functions, increasing the viscosity and concentration of the ointment to ensure that it can adhere evenly to the skin surface when applied, so that the ointment has appropriate texture, stability and performance, thereby achieving better ingredient delivery and absorption.

This creation may further include C13-14 isoalkane, which helps retain moisture in the skin and provides long-lasting moisturizing effects, thereby making the skin feel soft and smooth. It can also act as a dispersant to help mix different ingredients to ensure the uniformity and stability of the product. It can also act as a carrier for plant-derived bioactive peptides to help plant-derived bioactive peptides better penetrate the skin, thereby enhancing their effects.

This creation may further include Laureth-7, which acts as an emulsifier to create a stable emulsion texture, ensuring the uniformity and texture of the product, making it easier to apply and spread on the skin during use.

This creation can further include moisturizing particles, such as hydrolyzed collagen, sodium polyglutamine, ammonium glycyrrhizinate, and at least one of the small molecule hyaluronic acid. Among them, allantoin has anti-allergic, skin soothing, and anti-inflammatory effects in addition to moisturizing effects; hydrolyzed collagen can keep the skin supple and elastic, slow down aging, and improve oil secretion; sodium polyglutamine can restore skin elasticity and maintain long-term moisturizing, and its water retention capacity is 10 times that of hyaluronic acid; ammonium glycyrrhizinate can reduce skin sensitivity and eliminate skin dullness, thereby achieving a whitening effect; small molecule hyaluronic acid can achieve deep moisturizing of the skin.

The invention may further be formulated into external preparations suitable for topical application to the skin, including, but not limited to: emulsions, gels, ointments, creams, patches, liniments, powders, aerosols, sprays, lotions, serums, pastes, foams, drops, suspensions, salve, and bandages.

The composition may further comprise one or more additives selected from the group consisting of water, alcohols, glycols, hydrocarbons (such as petroleum jelly and white petrolatum), waxes, preserving agents, antioxidants, surfactants, absorption enhancers, stabilizing agents, gelling agents, active agents, humectants, odor absorbers, fragrances, pH adjusting agents, chelating agents, emulsifiers, occlusive agents, agents), emollients, thickeners, solubilizing agents, penetration enhancers, anti-irritants, colorants, and propellants, etc.

100: Liposome-encapsulated structure of plant-derived bioactive peptides with whitening effect

110: Core Department

120: Liposome protective layer

121: First coating layer

122: Second coating layer

130: Hollow spherical space

Figure 1 is a schematic diagram of a preferred embodiment of this invention.

In the embodiment of FIG. 1 , the liposome coating structure 100 of the plant-derived bioactive peptide having whitening effect comprises a core portion 110 and a liposome protective layer 120. The liposome protective layer 120 is a double-layer structure having a first coating layer 121 and a second coating layer 122. The first coating layer 121 has two ends, one end is hydrophilic and the other end is hydrophobic. Similarly, the second coating layer 122 has two ends, one end is hydrophilic and the other end is hydrophobic. The coating 121 is the inner layer of the liposome protective layer 120, and the second coating 122 is the outer layer of the liposome protective layer 120. The hydrophilic end of the first coating 121 faces inward to form a hollow spherical space 130, and the hollow spherical space 130 is used to accommodate the core 110. The hydrophobic end of the first coating 121 faces outward and is arranged together with the hydrophobic end of the second coating 122. The hydrophilic end of the second coating 122 faces outward to form the outer layer of the liposome protective layer 120.

The double-layer structure of the liposome protective layer 120 can provide a stable hollow spherical space 130 to protect the plant-derived bioactive peptides in the core 110 from oxygen and other external factors, thereby maintaining the activity of the plant-derived bioactive peptides. Secondly, the liposome protective layer 120 can improve the stability of the plant-derived bioactive peptides and extend their service life in the product. In addition, the liposome protective layer 120 can also promote the absorption of the plant-derived bioactive peptides. Through its special structure and properties, it helps to improve the penetration rate of active ingredients in the skin or body, thereby allowing the plant-derived bioactive peptides to resist the effect of inhibiting melanin production.

The core 110 contains plant-derived bioactive peptides, which are small molecule fragments from plant proteins. These small molecules have a relatively low molecular weight, which allows the plant-derived bioactive peptides to pass through the skin and more easily reach deep areas, thereby exerting their efficacy in inhibiting the activity of tyrosinase in melanocytes. By reducing the activity of tyrosinase, the formation of melanin can be effectively reduced, thereby achieving a whitening effect, which is very effective in reducing pigmentation caused by sunlight and improving uneven skin color. At the same time, plant-derived bioactive peptides have antioxidant properties and can protect the skin from damage by free radicals, which are one of the main causes of skin aging and pigmentation. This antioxidant effect helps protect the skin from environmental factors such as ultraviolet rays and pollution. Plant-derived bioactive peptides also promote the repair and regeneration of skin cells, enhancing the skin's natural recovery ability. This is very important for restoring damaged skin and improving the overall health of the skin.

This invention can be made into different dosage forms, so that the liposome-encapsulated structure with plant-derived bioactive peptides can be conveniently applied to the skin. The dosage forms that can be made include: emulsion, gel, ointment, cream, patch, wipe, powder, aerosol, spray, lotion, emulsion, paste, foam, drop, suspension, ointment and bandage. Users can easily apply or use it according to their needs and preferences to achieve rapid absorption and whitening effects.

100: Liposome-encapsulated structure of plant-derived bioactive peptides with whitening effect

110: Core Department

120: Liposome protective layer

121: First coating layer

122: Second coating layer

130: Hollow spherical space

Claims (8)

A liposome coating structure of a plant-derived bioactive peptide comprises: a core portion, wherein the core portion contains a plant-derived bioactive peptide, and the plant-derived bioactive peptide can inhibit melanin production; and a liposome protective layer, wherein the liposome protective layer comprises a first coating layer and a second coating layer, wherein the first coating layer and the second coating layer constitute a hollow spherical space, and the hollow spherical space is used to accommodate the core portion, the first coating layer constitutes the inner layer of the liposome protective layer, and the second coating layer constitutes the outer layer of the liposome protective layer. The liposome-encapsulated structure of plant-derived bioactive peptides as described in claim 1, wherein the core portion comprises a hydrolyzed yeast extract. The liposome-encapsulated structure of the plant-derived bioactive peptide as described in claim 1, wherein the core portion contains sodium ascorbate phosphate. The liposome-encapsulated structure of plant-derived bioactive peptides as described in claim 1, wherein the core portion contains green tea extract. The liposome-encapsulated structure of the plant-derived bioactive peptide as described in claim 1, wherein the core portion comprises hyaluronic acid or polyglutamic acid. The liposome-encapsulated structure of the plant-derived bioactive peptide as described in claim 1, wherein the core portion contains xanthan gum or glycerol. The liposome-encapsulated structure of the plant-derived bioactive peptide as described in claim 1, wherein the liposome-encapsulated structure of the plant-derived bioactive peptide can be made into an external preparation for application on the skin. The liposome-encapsulated structure of plant-derived bioactive peptides as described in claim 7, wherein the dosage form of the external preparation is an emulsion, gel, ointment or cream.