TWI737457B - Syringe - Google Patents

Abstract

The present invention provides a syringe comprises a barrel and a plunger component, wherein the plunger component is plugged into the bottom opening of the barrel and the plunger is disposed in the barrel in a movable push-pull reciprocating airtight manner, wherein the plunger component comprises a plunger with an open hole in the front end; a threaded component having a threaded rod and a upper part disposed at one end of the threaded rod, wherein the other end of the threaded rod is inserted into the open hole; a spring, whose two ends are respectively connected to the front end of the plunger and the upper part of the threaded component; and at least one stirring blade components disposed on the upper part of the threaded component, wherein the stirring blade component have at least two blades and each of the blades have a groove and a through-hole. When force is applied to move the plunger, the threaded rod is screwed in or out from the open hole, the spring is thus deformed, and the threaded rod drive the stirring blade component to rotate, so that the object to be injected is stirred.

Description

Injection device

The present invention relates to an injection device, and more specifically, to an injection device for delivering microspheres and/or granular drugs. When an external force is applied to the injection plunger, turbulence is generated in the syringe to disturb the microspheres and/or Granular drugs can avoid aggregation and sedimentation.

Selective internal radiation therapy (SIRT) is a method to treat cancer cells and tumors through targeted radiation therapy in the body. Most patients who use SIRT have the problem that their tumors cannot be surgically removed, especially those with hepatocellular carcinoma or liver metastases.

Traditional radiotherapy irradiates the human body with external radiation sources. The radiation penetrates the human skin, fat and other barriers and enters the body, which can destroy or eliminate cancer cells and tumors in the body. However, the energy of radiation will be greatly attenuated after being shielded by the human body. Generally, a larger radiation measurement must be applied by calculation. However, excessive radiation measurement will also cause damage to neighboring normal cells. This problem often leads to a decline in patient survival. In order to overcome this problem, SIRT was derived from the idea and derivation of traditional chemical embolization (chemoembolization), which directly transmits radioactive microspheres into the tumor through the blood. The small blood vessels are restricted by their size and get stuck in the small blood vessels inside the tumor, thereby directly releasing high-dose radioactivity at the site.

In SIRT, the use of microspheres injected into the blood to directly irradiate has clear clinical advantages: First, after microspheres are injected into the arteries, they use the characteristics of tumor vascular proliferation to deliver radioactive microspheres to the target organ tumor for radiation. Treatment; second, as the residence time of the radioactive microspheres increases, the radioactive substances in the microspheres gradually attenuate, and eventually the microspheres lose their radioactivity and become harmless substances remaining in the body; third, drugs such as vasodilators can be used to further control the arteries The high blood flow allows the radioactive microspheres to enter the tumor preferentially, and the damage to the normal tissues of other organs is relatively reduced.

However, SIRT still has many potential harm risks and needs to be improved.

First, the radioactive microspheres on the market are made of glass and resin. Among them, the radiation measurement of resin microspheres is far inferior to that of glass microspheres. In order to achieve the effect, a larger number of resin microspheres must be injected. The balls tend to gather and push against each other, resulting in the resin microspheres remaining in the syringe and the guide tube, making the operation difficult or the amount of radiation injected into the body insufficient. On the other hand, although glass microspheres have a relatively high radiometric measurement, the specific gravity of glass microspheres is quite large, and they are very easy to settle in the extraction bottle, syringe and infusion line. It is also easy to cause the accumulation of radioactive microspheres to remain in the extraction bottle and block. Or remain in the syringe and guide tube, as shown in Figure 1A and Figure 1B.

Second, in order to prevent radioactive microspheres from remaining in the syringe and guide tube, the current clinically available SIRT injection components must be combined with an external pump pressure system to force the radioactive microspheres into the artery. However, according to the 2015 U.S. Emergency Medical Research Agency, among the top ten medical technology hazards that need urgent response, there is confusion in the arterial/venous injection pipeline (such as the pipeline of the pump pressurization system), which causes the wrong medicine and infusion to be given. The harm. Due to the complexity of the pipeline in the treatment area, for example, the intensive care unit or the surgical patient may have up to 12 injection lines at the same time. If the SIRT injection component must be combined with an additional pump The pressure system will inevitably increase the risk of connecting the injection line to the wrong infusion pump or frequency band, and the injection line to the wrong infusion container or dosing line.

Therefore, during the SIRT injection process, how to prevent the radioactive microspheres from agglomerating and sedimenting each other, resulting in the radioactive microspheres remaining in the syringe and the guide tube, and reducing the use of additional tubing to reduce the confusion of the injection tubing The problem is an important issue facing SIRT.

In view of this, the present invention provides an injection device including:

A containing tube including a top opening and a bottom opening is used to contain the object to be injected; and

The push rod component is inserted into the accommodating cylinder from the bottom opening in an airtight manner that can be pushed back and forth, and the push rod component includes:

The push rod has an opening at the front end;

The screw is provided with a screw shaft and an abutment portion provided at one end of the screw shaft, the other end of the screw shaft is inserted into the opening of the push rod, so that the screw shaft is partially contained in the opening, and the other part Then highlight the opening;

The spring has two ends respectively connected to the front end of the push rod and the abutting part of the spiral member; and

At least one set of mixing blade assembly is arranged on the abutting part of the spiral element, the mixing blade assembly has at least two blades, and each of the blades has a groove and a through hole,

Wherein, when a force is applied to move the push rod along the axial direction of the accommodating cylinder, the screw shaft is driven to rotate out or screw in from the opening to deform the spring, and the screw drives the stirring blade assembly to rotate, To stir the to be injected.

In a specific embodiment, when no force is applied to the push rod, the deformed spring drives the screw shaft to rotate in or out of the opening and drives the stirring blade assembly to rotate to stir the object to be injected, At the same time, the push rod moves to the original position.

In a specific embodiment, the inner wall of the opening of the push rod has an internal thread, and the side wall of the screw shaft has an external thread that matches the internal thread. When the screw shaft slides in the opening At this time, the screw shaft rotates due to the matching internal thread and the external thread.

In a specific embodiment, the screw shaft and the opening of the push rod are combined with a rotating structure.

In a specific implementation aspect, the rotating structure is a sealed waterproof bearing.

In a specific embodiment, the push rod component further includes a chassis, which is arranged at the front end of the push rod, so that the two ends of the spring are respectively connected to the chassis and the abutment portion of the spiral member.

In a specific embodiment, the chassis has a central through hole for the screw shaft to pass through, and the inner wall of the central through hole of the chassis has an internal thread that matches the external thread on the side wall of the spiral shaft.

In a specific embodiment, the push rod component further includes a top cone disc, which is arranged on the abutting portion of the spiral element.

In a specific embodiment, when no force is applied to the push rod, the distance between the top opening of the accommodating cylinder and the top cone is less than the distance between the top opening and the bottom opening of the accommodating cylinder A quarter.

In a specific embodiment, based on the total length of the blade, the groove of the blade is set within a quarter of the total length starting from the tip of the blade.

In a specific embodiment, based on the total length of the blade, the through hole of the blade is located outside the range of three-quarters of the total length starting from the tip of the blade.

In a specific embodiment, the aperture of the through hole is 50 μm to 200 μm.

In a specific embodiment, the angle between the horizontal plane of the blade and the radial direction of the spiral shaft is 30 to 45 degrees.

In one embodiment, the push rod component includes two sets of stirring blade assemblies, and in another embodiment, the two sets of stirring blade assemblies are formed to be connected to the spiral member in opposite rotation directions.

In a specific embodiment, the stirring blade assembly has three blades.

In a specific implementation aspect, the outer wall of the accommodating cylinder has a spiral protrusion, and the spiral protrusion functions to strengthen the front end finger support during the injection operation, so as to achieve the purpose of stable injection.

In a specific implementation aspect, a chassis gasket is provided at the connection between the chassis and the front end of the push rod.

In a specific embodiment, the injection device further includes a top nozzle connected to the top opening.

In a specific embodiment, the injection device further includes a top opening stopper, which is sleeved in the top opening of the accommodating cylinder, and the top opening stopper has an opening for the ejector and the top opening stopper connect.

In a specific implementation aspect, the accommodating cylinder includes a side opening, which is connected to an injection line, so that the injection liquid is injected into the accommodating cylinder through the injection line.

In a specific implementation aspect, the accommodating cylinder further includes a side opening plug, which is arranged in the side opening of the accommodating cylinder to seal the side opening.

As in a specific embodiment, the substance to be injected is loaded with microspheres and/or granular drugs.

In a specific embodiment, the injection device is composed of silicone rubber, polyethylene, acrylic resin, polyurethane, polypropylene, polymethyl methacrylate, polyethylene glycol, polyhydroxyethyl methacrylate, polyethylene Made of at least one material of lactide, polylactic acid, chitosan, hyaluronic acid and hydrogel.

In a specific embodiment, the inner wall of the accommodating cylinder and the surface of the stirring blade assembly are coated with a hydrophobic polymer film, and in another embodiment, the hydrophobic polymer film is polymerized Methylsiloxane (PDMS) or polytetrafluoroethylene (PTFE).

The injection device of the present invention is a push rod component with a special structure, wherein, when a force is applied to move the push rod along the axial direction of the accommodating cylinder, the screw in the push rod component is screwed out from the opening of the push rod through the screw shaft Or screw in, the rotating motion of the screw out or screw in drives the stirring blade assembly to rotate, so that the to-be-injected material is stirred by the stirring blade assembly. On the other hand, due to the movement of the screw shaft, the spring is deformed by compression or tension. Therefore, when no force is applied to the push rod, the deformed spring will drive the push screw to unscrew or rotate from the opening of the push rod again. Into and drive the mixing blade assembly to rotate, and at the same time move the push rod to the original position.

Secondly, in the injection device of the present invention, the blade of the mixing blade assembly has special structures, such as grooves and through holes, which can cause irregular turbulence in the surrounding fluid when the mixing blade assembly rotates, thereby avoiding microspheres. And/or granular medicine aggregates, settles, and improves dispersion.

Therefore, when a force is applied to the push rod component of the injection device of the present invention, the microspheres and/or granular medicine in the container can be dispersed by the turbulence generated by the stirring blade assembly, and pass through the top opening of the container. It is pushed out, easy to operate and does not require an external pump pressure system.

1: Conventional injection components used for SIRT

10: Containment tube

11: Top opening

12: bottom opening

13: side opening

130: Side opening plug

22: putter

220: open hole

23: Chassis

24: Spiral

241: Spiral shaft

242: contact part

26: Spring

28: Mixing blade assembly

29: Top cone

30: talk back

301: Top opening plug

40: Spiral shaft

41,41’,41”: Blade

410,410’,410”: groove

411,411’,411”: Through hole

412: Leaf Tip

h,h’,t,t’: distance

L: total length

Fig. 1A is a schematic diagram of the appearance and structure of a conventional injection assembly used for SIRT; Fig. 1B is a schematic diagram of the cross-sectional structure.

2A and 2B are schematic cross-sectional structure diagrams of specific embodiments of the injection device of the present invention, wherein FIG. 2A is a schematic cross-sectional structure diagram when no force is applied to the push rod, and FIG. 2B is a schematic cross-sectional structure diagram when force is applied to the push rod .

Fig. 3 is an exploded schematic view of a cross-sectional structure of a specific embodiment of the injection device of the present invention.

4A to 4D are schematic top views of specific embodiments of the stirring blade assembly of the injection device of the present invention; FIGS. 4E and 4F are schematic side views of the implementation of the stirring blade assembly.

The following specific examples illustrate the implementation of the present invention. Those familiar with the art can easily understand the other advantages and effects of the present invention from the contents disclosed in this specification.

It should be noted that the structure, ratio, size, etc. shown in the drawings in this manual are only used to match the content disclosed in the manual for the understanding and reading of those who are familiar with the art, and are not intended to limit the implementation of the present invention. Therefore, it does not have any technical significance. Any structural modification, proportional relationship change or size adjustment should still fall within the original The technical content disclosed by the invention can be covered.

Also refer to Fig. 2A and Fig. 3, which are the structural schematic diagrams of the specific embodiment of the injection device of the present invention.

In this embodiment, the injection device includes a accommodating barrel 10 and a push rod component. The container 10 includes a top opening 11, a side opening 13 and a bottom opening 12. Although the accommodating cylinder 10 in this embodiment includes a side opening 13, in other embodiments, the side opening 13 may not be provided. In this embodiment, the top opening 11 is the ejection port of the object to be injected, and the top opening 11 is used to connect the ejector nozzle 30. In order to tightly connect and prevent gas or liquid from infiltrating or leaking from the gap, a top opening plug can be further provided 301 is in the top opening 11 of the containing barrel 10, and the top opening plug 301 has an opening for inserting the ejection nozzle 30 and communicating with the containing barrel 10, so as to lift the top opening 11 and the ejection nozzle 30. The tightness of the connection between.

In this embodiment, the side opening 13 may be provided with a side opening stopper 130 to seal the side opening 13 to avoid gas or liquid leakage or infiltration from the outside. Or, in other embodiments, the side opening The port 13 can be connected to an injection line, so that the injection liquid can be injected into the accommodating cylinder 10 through the injection line. For example, the side opening 13 is sealed with the side opening plug 130 to perform the first injection. If there is still residue in the container 10 after the injection, the side opening plug 130 can be removed. , And connect the injection line, introduce the injection liquid to extract the residue in the containing cylinder 10, and make the push rod member described later reciprocate in the containing cylinder 10 to suspend and disperse the residue in the injection In the liquid, make a second injection.

The bottom opening 12 is used to pass into the push rod component, so that the push rod component is disposed in the accommodating cylinder 10, so that the push rod component and the accommodating cylinder 10 are airtightly It can be combined with reciprocating push and pull.

The internal space of the accommodating cylinder 10 is loaded with the object to be injected. In this embodiment, the object to be injected is microspheres and/or granular drugs. During the advancing movement, the microspheres and/or granular drugs are pushed out to the ejector nozzle 30 through the top opening 11, and the ejector nozzle 30 can be connected to an injection line such as a guide tube to connect to the body. In this way, the microspheres and/or granular drugs It passes through the top opening 11, the top nozzle 30, and the guide tube to the body.

The outer wall of the accommodating cylinder may also have spiral protrusions, and the protrusions can be used as supporting parts of the fingers during injection operation to facilitate stable injection.

In this embodiment, the push rod component includes a push rod 22, a spiral member 24, a spring 26 and at least one set of mixing blade assemblies 28. The push rod component can also include a chassis 23 and a top cone 29.

The front end of the push rod 22 has an opening 220, and the screw 24 has a screw shaft 241 and an abutment portion 242 provided at one end of the screw shaft 241. The other end of the screw shaft 241 is inserted into the opening of the push rod 22. The hole 220 allows a part of the screw shaft 241 to be contained in the opening 220 and the other part to protrude from the opening 220. The two ends of the spring 26 are respectively connected to the front end of the push rod 22 and the abutting portion 242 of the spiral member 24. The mixing blade assembly 28 is attached to the abutting portion 242 of the spiral element 24.

The inner wall of the opening 220 has an internal thread, and the side wall of the screw shaft 241 also has an external thread that matches the internal thread. Therefore, when the screw shaft 241 slips in the opening 220, it matches the The internal thread and the external thread make the screw shaft rotate while moving, that is, screw out or screw in. When a force is applied to move the push rod 22, the screw shaft 241 is screwed out or screwed in from the opening 220, driving the stirring blade assembly 28 to rotate, so that the object to be injected is stirred. Specifically, as shown in FIG. 2B, when a force is applied to push the push rod 22 along the axial direction of the accommodating cylinder 10, the screw shaft 241 is screwed out of the opening 220, between the end of the screw shaft 241 and the bottom of the opening 220 The distance t becomes longer, from the distance t to the distance t'.

The spring 26 surrounds the screw shaft 241. The function of the spring 26 is to provide a source of feedback power, and also to avoid the problem that the mixing blade assembly 28 is stuck and cannot function during the sliding process of the push rod component. As shown in FIG. 2A, when no force is applied to the push rod 22, the spring 26 is not compressed. When an external force is applied to the push rod 22, the screw shaft 241 is screwed out or screwed in from the opening 220, and the screw shaft 241 is exposed to the length of the opening 220 (that is, the distance from the front end of the push rod 22 to the abutment portion 242 of the screw 24) The change occurs, so that the spring 26 is compressed or stretched and deformed. When no force is applied to the push rod 22, the deformed spring 26 drives the push rod 22 to move, and the screw shaft 241 is simultaneously screwed in or out of the opening 220 and driven The stirring blade assembly 28 rotates. Specifically, as shown in FIG. 2B to FIG. 2A, the deformed spring 26 drives the push rod 22 to move, the screw shaft 241 is screwed in from the opening 220, and the distance t'between the end of the screw shaft 241 and the bottom of the opening 220 becomes shorter , From the distance t'to the distance t. In addition, the spring 26 can also prevent the spiral member 24 from being damaged due to excessive rotation.

The screw shaft 241 and the opening 220 of the push rod 22 can be combined with a rotating structure, and the rotating structure is, for example, a sealed waterproof bearing.

The push rod component may further include a chassis 23 provided at the front end of the push rod 22, so that the two ends of the spring 26 are respectively connected to the chassis 23 and the abutment portion 242 of the spiral member 24. The chassis 23 has a central through hole, so the screw shaft 241 can pass through the central through hole and be inserted into the opening 220 of the push rod 22. The inner wall of the central through hole of the chassis 23 may also have an internal thread that matches the external thread on the side wall of the screw shaft 241. In addition, a chassis gasket can be provided at the connection between the chassis 23 and the front end of the push rod 22.

The push rod component may further include a top cone 29 provided on the abutting portion 242 of the screw 24.

In this embodiment, when no force is applied to the push rod as shown in FIG. 2A, the distance h between the top opening 11 of the accommodating tube 10 and the top cone 29 of the push rod component is smaller than the top opening of the accommodating tube 10 One-fourth of the distance between 11 and the bottom opening 12 to prevent the mixing blade assembly 28 from being stuck in the opening of the accommodating cylinder 10 and unable to function, resulting in damage to the screw shaft 241.

When force is applied to push the push rod 22 along the axial direction of the accommodating cylinder 10 as shown in FIG. 2B, the entire push rod component together with the push rod 22 and the screw 24 are pushed into the housing cylinder 10, and at the same time, the screw shaft 241 is also self-propelled from the push rod 22. The opening 220 is screwed out. Therefore, the top cone 29 provided on the abutment portion 242 of the spiral member 24 approaches the top opening 11, and the top opening 11 of the accommodating cylinder 10 reaches the top cone 29 of the push rod member. The distance h between them is shortened, and the distance h becomes the distance h′, so that the object to be injected is pushed out from the top opening 11.

The mixing blade assembly 28 will be further described in detail below.

In this embodiment, the stirring blade assembly 28 is in contact with the abutting portion 242 of the screw 24. Specifically, the mixing blade assembly 24 is sleeved on the abutting portion 242 of the spiral element 24. When the screw shaft 241 is screwed in or out of the opening 220, the rotation of the screw 24 drives the mixing blade assembly 28 to rotate together. The present invention disturbs the microspheres or granular medicines in the container 10 by the turbulence caused by the rotation of the stirring blade assembly 28, so as to prevent the microspheres or granular medicines from settling, agglomerating, agglomerating, etc. due to their high specific gravity.

As shown in FIG. 4A, the blade 41 is connected to the screw shaft 40. Specifically, the mixing blade assembly 28 has at least two blades, such as two blades, three blades, four blades, five blades, etc., as shown in FIG. 4A, which is a specific implementation of the mixing blade assembly 28 having three blades. example.

In other embodiments, each blade of the mixing blade assembly 28 may be further designed. 4B and 4E, the blade 41 has grooves 410, 410', the grooves 410, 410' can be provided near the end of the blade 41, for example, can be provided in the total length L starting from the tip 412 of the blade 41 Within a quarter. The grooves 410, 410' may have a zigzag groove structure, and may have a plurality of grooves. When the blade 41 rotates, the grooves 410, 410' make the turbulence generated by the blade 41 more irregular and increase the shearing force, which can destroy the agglomeration of microspheres or granular drugs and improve the dispersibility.

In other embodiments, as shown in FIGS. 4C and 4E, the blade 41 may be provided with through holes 411, 411', and the through holes 411, 411' may provide arc, axial, and radial turbulence and vortex when the blade 41 rotates. And the vortex can prevent the microspheres or granular medicine from remaining on the wall or bottom of the container 10, and at the same time, it can provide a flow channel for the microspheres or granular medicine. Specifically, the through holes 411, 411' may be located at the front end of each blade 41, for example, may be provided outside the range of three-quarters of the total length L starting from the tip 412 of the blade 41. The pore size of the through holes 411, 411' may be 50 μm to 200 μm, such as 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, or 200 μm, but is not limited thereto. The grooves 410, 410' and the through holes 411, 411' can also be provided on the blade 41 at the same time to improve the dispersion effect.

The blades of the mixing blade assembly 28 can also be arranged in an inclined manner to provide better shearing force. Specifically, the angle between the horizontal plane of the blades and the radial direction of the screw shaft 40 is 30 to 45 degrees, such as 30, 35 , 40 or 45 degree angle, but not limited to this. As shown in Fig. 4F, the angle between the horizontal plane of the blade 41' and the radial direction of the screw axis G is 45 degrees.

The mixing blade assembly 28 can be one group, two groups, three groups, etc., and the combination of pumping rate and thrust can be changed by setting different pitches. As shown in Figures 4D and 4E, which show an embodiment of two sets of stirring blade assemblies 28, the two sets of stirring blade assemblies 28 are sleeved on the spiral shaft 40 of the spiral member 24 and connected with the spiral shaft 40. The stirring blade assembly 28 has three blades 41', and the lower stirring blade assembly 28 also has three blades 41", and the blades 41', 41" all have grooves 410', 410" and through holes 411', 411".

When more than two sets of stirring blade assemblies are provided, at least one stirring blade assembly rotates due to the rotation of the screw shaft, and the other stirring blade assemblies can be driven by the screw shaft or not driven by the screw shaft. The mixing blade assembly that is not driven by the screw shaft can be driven by the liquid flow caused by other mixing blade assemblies. Specifically, when two sets of stirring blade assemblies are provided, the upper stirring blade assembly is configured to rotate due to the drive of the screw shaft, and the lower stirring blade assembly is configured to rotate due to the liquid flow driven by the upper stirring blade assembly, and the lower stirring blade assembly The direction of rotation of the blade assembly is opposite to the direction of rotation of the upper mixing blade assembly.

The injection device of the present invention can be made of non-degradable materials including silicone rubber, polyethylene, acrylic resin, polyurethane, polypropylene or polymethyl methacrylate, or it can also be made of polyglycolide (PGA), polylactic acid , Chitosan, hyaluronic acid and at least one material of hydrogel. In other embodiments, the injection device of the present invention may be made of at least one material including polyhydroxyethyl methacrylate, polyethylene glycol, chitosan, and hyaluronic acid.

In this embodiment, the inner wall of the accommodating cylinder 10 and the surface of the stirring blade assembly 28 may be coated with a hydrophobic polymer film to avoid adhesion of microspheres or granular drugs, and reduce the risk of microspheres or granular drugs. The plastic particles generated by the collision prevent the plastic particles from being injected into the human body and causing harm. The hydrophobic polymer membrane is, for example, polydimethylsiloxane (PDMS) or polytetrafluoroethylene (PTFE).

It can be seen from the above that the injection device of the present invention is a push rod component with a special structure. When a force is applied to move the push rod along the axial direction of the accommodating cylinder, the screw in the push rod component passes through the screw shaft from the opening of the push rod. Rotating out or screwing in, the rotating motion of the screwing out or screwing in drives the stirring blade assembly to rotate, so that the to-be-injected material is stirred by the stirring blade assembly. On the other hand, due to the movement of the screw shaft, the spring is deformed by compression or tension. Therefore, when no force is applied to the push rod, the deformed spring will drive the push screw to unscrew or rotate from the opening of the push rod again. Enter and drive the mixing blade assembly to rotate, and at the same time move the push rod to the original position. The stirring blade assembly of the injection device of the present invention has a special structure, and the blades are provided with grooves and through holes. Therefore, when the stirring blade assembly rotates, the surrounding fluid can produce irregular turbulence, thereby avoiding the accumulation of microspheres and/or granular drugs. Settling and improving dispersion.

Therefore, when a force is applied to the push rod component of the injection device of the present invention, the microspheres and/or granular medicine in the container can be dispersed by the turbulence generated by the stirring blade assembly, and pass through the top opening of the container. It is pushed out, easy to operate and does not require an external pump pressure system.

It should be understood that, within the scope of the technical content disclosed in the present invention, various technical features (such as those disclosed in specific implementations and embodiments) can be freely combined with each other to form new or better technical solutions , For the sake of brevity, I won’t repeat it here. And what the present invention discloses is constructed by the end value As long as the value falls between the upper and lower ends of the numerical value range, it shall be included in the scope disclosed in the present invention, and the sub-range formed by it and the end points or other numerical values shall naturally be included in the present invention. Within the scope of the disclosure.

10: Containment tube

130: Side opening plug

22: putter

220: open hole

23: Chassis

24: Spiral

26: Spring

28: Mixing blade assembly

29: Top cone

30: talk back

301: Top opening plug

h: distance

t: distance

Claims (20)

An injection device, including: A containing tube including a top opening and a bottom opening is used to contain the object to be injected; and The push rod component is inserted into the accommodating cylinder from the bottom opening in an airtight manner that can be pushed back and forth, and the push rod component includes: The push rod has an opening at the front end; The screw is provided with a screw shaft and an abutment portion provided at one end of the screw shaft, the other end of the screw shaft is inserted into the opening of the push rod, so that the screw shaft is partially contained in the opening, and the other part Then highlight the opening; The spring has two ends respectively connected to the front end of the push rod and the abutting part of the spiral member; and At least one set of mixing blade assembly is arranged on the abutting part of the spiral member, and the mixing blade assembly has There are at least two blades, and each blade has a groove and a through hole, Wherein, when a force is applied to move the push rod along the axial direction of the accommodating cylinder, the screw shaft is driven to rotate out or screw in from the opening to deform the spring, and the screw drives the stirring blade assembly to rotate, To stir the to be injected. The injection device according to claim 1, wherein when no force is applied to the push rod, the deformed spring drives the screw shaft to rotate in or out of the opening and drives the stirring blade assembly to rotate to stir the While waiting for the injection, the push rod moves to the original position. The injection device according to claim 1, wherein the inner wall of the opening of the push rod has an internal thread, and the side wall of the screw shaft has an external thread matching the internal thread, and when the screw shaft is in the opening When sliding in the hole, the screw shaft rotates due to the matching internal thread and the external thread. The injection device according to claim 1, wherein the screw shaft and the opening of the push rod are combined in a rotating structure. The injection device according to claim 4, wherein the rotating structure is a sealed waterproof bearing. According to the injection device according to claim 3, the push rod component further includes a chassis, which is arranged at the front end of the push rod, so that the two ends of the spring are respectively connected to the chassis and the abutment part of the spiral member. The injection device according to claim 6, wherein the base plate has a central through hole through which the screw shaft passes, and the inner wall of the central through hole of the base plate has an inner thread that matches the outer thread on the side wall of the screw shaft. Thread. According to the injection device according to claim 1, the push rod component further includes a top cone disc, which is arranged on the abutting part of the spiral member. The injection device according to claim 8, wherein, when no force is applied to the push rod, the distance between the top opening of the accommodating cylinder and the top cone is less than the distance from the top opening to the bottom opening of the accommodating cylinder A quarter of the distance between. The injection device according to claim 1, wherein, based on the total length of the blades of the stirring blade assembly, the groove is provided within a range of a quarter of the total length starting from the tip of the blade. The injection device according to claim 1, wherein, based on the total length of the blades of the stirring blade assembly, the through hole is located outside the range of three-quarters of the total length from the tip of the blade as a starting point. The injection device according to claim 1, wherein the hole diameter of the through hole is 50 μm to 200 μm. The injection device according to claim 1, wherein the angle between the horizontal plane of the blade and the radial direction of the screw shaft is 30 to 45 degrees. The injection device according to claim 1, wherein the push rod component includes two sets of stirring blade assemblies, and the two sets of stirring blade assemblies are formed to be connected to the spiral member in a manner of opposite rotation directions. The injection device according to claim 1, further comprising a top nozzle connected to the top opening. According to the injection device according to claim 1, the accommodating cylinder includes a side opening, which is connected to an injection line, so that the injection liquid is injected into the accommodating cylinder through the injection line. The injection device according to claim 1, wherein the substance to be injected is loaded with microspheres and/or granular drugs. The injection device described in claim 1 is composed of silicone rubber, polyethylene, acrylic resin, polyurethane, polypropylene, polymethyl methacrylate, polyethylene glycol, polyhydroxyethyl methacrylate, polyethylene Made of at least one material of ester, polylactic acid, chitosan, hyaluronic acid and hydrogel. The injection device according to claim 1, wherein the inner wall of the accommodating cylinder and the surface of the stirring blade assembly are coated with a hydrophobic polymer film. The injection device according to claim 19, wherein the hydrophobic polymer film is polydimethylsiloxane (PDMS) or polytetrafluoroethylene (PTFE).

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