TWI780802B - Biochemical assay device - Google Patents

Abstract

The present invention relates to a biochemical assay device in which a cap body and a body are provided at the two ends of a test tube, and a drive member is provided in the body, a specimen holding hole and a test paper holder are separated inside the test tube. In this way, after the specimen is taken, the specimen is placed into the specimen holding hole and mixed with the extracting liquid inside the specimen holding hole, and then the driving member punctures the membrane at the end of the specimen holding hole to make the extracting solution mixed with the specimen flow into the chamber of the test tube and react with the test paper strip in the test paper holder. According to this simple structure and easy operation, it can effectively save testing cost and improve testing efficiency. In addition, during and after the test, the specimen and the extraction solution are sealed inside the test tube, so that the virus can be prevented from spreading improperly and causing pollution to the environment.

Description

Biochemical detection device

The invention relates to the technical field of biological and chemical detection, in particular to a detection device with simple structure and easy operation, which can effectively save detection cost and improve detection efficiency, and can avoid environmental pollution caused by improper leakage of samples and extracts.

Press, the easiest way to determine whether you are infected with new coronary pneumonia [Covid-19] is to measure body temperature, but there may be infected people with new coronary pneumonia who will not have symptoms of elevated body temperature and fever. As the epidemic expands, more stringent screening is necessary , and the government has approved a variety of rapid screening reagents for the public to use for self-screening.

The test set of the existing rapid screening reagent mainly includes a pick-up stick, a test tube, a drip tip and a test cassette. Put the test stick into the test tube and stir it with the extract, then let it stand for a few minutes, then install a drip nozzle on the test tube, so that the extract mixed with the sample in the test tube will drop into the slot of the test cartridge, and then wait for 15 minutes After reading the test result, the inspection cassette is marked with a control line C and a test line T. If the control line does not appear in the test result, the result is invalid, and another set of test kits must be used to test again. If the control line appears and If the test line does not appear, the test result is negative; if both the control line and the test line appear, the test result is positive, indicating possible infection with new coronary pneumonia.

However, it can be seen from the above description that the test kits of existing rapid screening reagents have many parts and high cost, and the operation procedures are complicated. During the operation, attention must be paid to whether the test cassette is placed flat and the dripping of the mixed sample extract. Injection, etc., slight operational errors will affect the accuracy of the test results and require re-testing, so the detection efficiency is low, and if the extract of the mixed sample is accidentally dropped to other places during the operation, it may cause the virus to spread. After the test is completed, it is time-consuming to put the test stick, test tube, drip tip and test cassette into plastic bags one by one, so as to avoid polluting the environment and affecting the convenience of use.

The reason is that, in view of the fact that the existing detection devices for new coronary pneumonia still have the above-mentioned deficiencies in use and implementation, with the assistance of years of manufacturing and design experience and knowledge in related fields, and through many ingenuity, the inventor has developed this invention.

The present invention relates to a biochemical detection device, the main purpose of which is to provide a biochemical detection device with a simple structure and easy operation, which can effectively save detection costs and improve detection efficiency, and can avoid improper leakage of samples and extracts from polluting the environment device.

In order to achieve the above-mentioned purpose of implementation, the present inventor is to develop the following biochemical detection device, which includes: a test tube, so that a first cavity and a second cavity are respectively formed at the upper and lower ends of the test tube, A separate sample container and a test paper container are formed in the test tube between the first cavity and the second cavity, and the upper end of the sample hole communicates with the first cavity. Make the lower end of the sample container communicate with the second container, and cover the lower end of the sample container with a thin film, and make the notch of the test paper container face the second container, and make the test paper container and the second container The second cavity is connected, and the sample cavity is provided with an extraction solution, and a test strip is provided in the test paper container; A cover body, which is to form a cover cavity on the cover body to correspond to the upper end of the test tube, and a first plunger is formed in the cover cavity of the cover body to correspond to the second plunger plugged on the upper end of the test tube. In a chamber; a seat body is provided with a recessed groove at the upper end of the seat body, so that the lower end of the test tube is correspondingly arranged in the chamber of the seat body, and a through hole is provided at the bottom of the chamber , and make the through hole correspond to the position of the lower end of the sample container hole of the test tube, and also provide a safety pull ring, which is arranged around the lower end of the seat body, and is disconnected from the lower end of the seat body, and At least one stopper edge is formed on the inner side of the safety ring, and a pulling part is protruded on the outer side of the safety ring, and at least one first clamping part is formed on the lower end of the seat body; a driving part is The driver is located at the lower end of the seat, the driver is provided with a chassis, and the chassis is positioned against the stop edge of the safety ring at the lower end of the seat, and a puncture rod is formed on the chassis , and make the puncture rod correspond to the through hole of the base body, and make the puncture rod of the driving part pierce the film set at the lower end of the sample container hole, and set the bottom plate of the driving part There is at least one second clamping part, which is engaged with the first clamping part corresponding to the lower end of the seat body, so as to fix the piercing state of the piercing rod into the sample container, and the piercing rod pierces into the The rod diameter at one end of the film is smaller than the aperture at the lower end of the sample container, and the middle section of the puncture rod does not block the aperture at the lower end of the sample container and leaves a gap, so that the sample container and the test paper container It communicates with the second cavity of the test tube, so that the sample-containing extract in the sample well flows into the second cavity of the test tube, so as to contact the test paper strip arranged in the test paper container.

The biochemical detection device as described above, wherein the diameter of the sample well of the test tube is tapered from the upper end to the lower end to form a cone shape.

The above-mentioned biochemical detection device, wherein, the test tube is formed with a first embedding portion on the outer wall of the lower end, and at least one second embedding portion is formed on the wall of the container of the base body to match the test tube The first embedding part at the lower end is correspondingly embedded and combined.

The above-mentioned biochemical detection device, wherein, the seat system has a second plunger formed on the bottom of the container to correspond to block the second cavity at the lower end of the test tube, and to set the through hole on the second plunger.

The above-mentioned biochemical detection device, wherein, the base system forms a pit at its lower end opposite to the second plunger, and the through hole communicates with the pit, and the drive member is provided at the center of the chassis. There is a protruding block, and the protruding block is correspondingly accommodated in the recess, and the puncture rod is molded on the protruding block.

The above-mentioned biochemical detection device, wherein, the test tube is formed with two positioning blocks on the outer wall of its lower end, and a positioning concave part is formed between the two positioning blocks, and a positioning convex line is provided on the outside of the seat to match the The positioning concave part provided on the outer wall of the test tube corresponds to the embedded positioning.

In this way, after the sample is taken, the sample is placed into the sample container to stir and mix with the extract liquid in the sample container, and then the film at the end of the sample container is pierced by the driving member, so that the mixture can be effectively extracted. The extract of the sample flows into the cavity of the test tube, and reacts accordingly after contacting the test strip in the test paper container. According to the simple structure and simple operation mode, the detection cost can be effectively saved and the detection efficiency can be improved. During and after the test, since the sample and the extract mixed with it are all sealed in the test tube, it is possible to avoid the improper spread of the virus and pollute the environment.

1: test tube

11: The first cavity

12: Second cavity

13: Sample well

131: film

14: Test paper container

15: external thread segment

16: The first embedding part

17: Positioning block

171: positioning recess

2: cover body

21: Cover cavity

22: The first plunger

23: Internal thread segment

3: seat body

31: storage tank

32: Second embedding part

33: Second plunger

34: through hole

35: Pit

36: The first clamping part

37:Positioning convex strip

38: safety ring

381: stop edge

382: Pull Department

4: Driver

41: Chassis

42: Bump

43: piercing rod

44: The second clamping part

5: Test strips

6: Extract

7: Picking stick

71: Sampling Department

72: Handpiece

The first figure: three-dimensional exploded view of the present invention

Figure 2: Stereoscopic view of the present invention

The third figure: the sectional view of the present invention

Figure 4: Sectional view of the use state of the present invention (1)

Figure 5: Sectional view of the present invention in use state (2)

Figure 6: Sectional view of the present invention in use state (3)

The seventh figure: the sectional view of the use state of the present invention (four)

The eighth figure: the use state sectional view of the present invention (five)

In order to enable a more complete and clear disclosure of the technical means of the present invention and the effects it can achieve, the detailed description is as follows. Please refer to the disclosed drawings and figure numbers: first, please refer to the first to third As shown in the figure, it is the biochemical detection device of the present invention, which mainly includes: a test tube (1), so that a first cavity (11) and a first cavity (11) and a first cavity (11) and a first cavity (11) and a first cavity (11) are respectively formed at the upper and lower ends of the test tube (1) in the test tube (1). The second cavity (12), and the test tube (1) is positioned between the first cavity (11) and the second cavity (12) to form a separate sample cavity (13) and a test paper cavity (14), and make the upper end of the sample container hole (13) communicate with the first cavity (11), and make the lower end of the sample container hole (13) communicate with the second cavity (12), and make the sample The aperture of the container hole (13) is tapered from the upper end to the lower end, and a thin film (131) is covered at the lower end of the sample container hole (13), and the notch of the test paper container (14) faces This second chamber (12), and this test paper chamber (14) communicates with this second chamber (12), forms an external thread section (15) on the outer wall of the upper end of this test tube (1), in addition A first embedding part (16) is formed on the outer wall of the lower end of the test tube (1), and two positioning blocks (17) are formed on the outer wall of the test tube (1) above the first embedding part (16). A positioning recess (171) is formed between the positioning blocks (17); a cover (2), which forms a covering cavity (21) on the cover (2), and is arranged on the upper end of the test tube (1) correspondingly , and a first plunger (22) is formed in the cover cavity (21) to correspond to plugging in the first cavity (11) at the upper end of the test tube (1). The wall is formed with an internal thread section (23) to be screwed correspondingly with the external thread section (15) provided on the outer wall of the upper end of the test tube (1); Groove (31), so that the lower end of the test tube (1) is correspondingly arranged in the container (31) of the seat (3), and at least one second embedding part is formed on the wall of the container (31) (32), to be embedded and combined with the first embedding portion (16) of the lower end of the test tube (1), and form a second plunger ( 33), to correspond to the second container blocked at the lower end of the test tube (1) In the cavity (12), a through hole (34) is provided on the second plunger (33) to correspond to the lower end position of the sample holding hole (13) of the test tube (1), and the base ( 3) A pit (35) is formed at the lower end relative to the second plunger (33), and the through hole (34) is communicated with the pit (35), and the lower end of the base (3) is shaped at least A tenon-shaped first clamping part (36), the present invention forms a first clamping part (36) on both sides of the pit (35), and a second clamping part (36) is formed on the outside of the base (3). There is a positioning convex strip (37) to be embedded and positioned corresponding to the positioning recess (171) set on the outer wall of the test tube (1), and a safety pull ring (38) is also provided, and the safety pull ring (38) surrounds the seat body (3) lower end, and is connected with the lower end of the seat body (3), and at least one stop edge (381) is formed on the inner side of the safety pull ring (38), and the safety pull ring (38) ) is protrudingly provided with a pulling part (382) on the outside; a driving part (4), which makes the driving part (4) located at the lower end of the base (3), and the driving part (4) is provided with a chassis ( 41), and the chassis (41) is positioned against the stop edge (381) of the safety pull ring (38) at the lower end of the base (3), and a projection (42) is provided at the center of the chassis (41) , and the protrusion (42) is correspondingly accommodated in the recess (35) of the seat (3), and a piercing rod (43) is formed on the protrusion (42), and the piercing rod ( 43) Correspondingly set in the through hole (34) of the seat body (3), at least one second clamping part (44) in the shape of a clamping hole is provided on the chassis (41). The present invention uses The chassis (41) is provided with a second engaging portion (44) on both sides of the protruding block (42), for respectively engaging with the two first engaging portions (36) at the lower end of the base (3) Combining; a test strip (5), the test strip (5) is set in the test paper container (14) of the test tube (1), and one end of the test strip (5) protrudes to the test tube (1) at the second chamber (12); an extraction solution (6), the extraction solution (6) is accommodated in the sample well (13) of the test tube (1).

According to this, when testing for viruses such as new coronary pneumonia, the user inserts the front-end sampling part (71) of a sampling stick (7) into his left and right nostrils in sequence and rotates it several times to collect samples in his nasal cavity , please also refer to the fourth figure, and then insert the sampling part (71) after passing the sampling stick (7) with the sample through the first cavity (11) at the upper end of the test tube (1) In the sample container (13), it can be stirred with the extract (6) pre-contained in the sample container (13), and then please refer to the fifth figure, the user can take the sample The handle part (72) of the stick (7) was broken off, and only the sampling part (71) was left in the test tube (1). Then please refer to the sixth As shown in the figure, the cover body (2) can be placed on the upper end of the test tube (1), and the external thread segment (15) provided on the upper end of the cover body (2) and the inner thread section (23) of the test tube (1) can be used. The screw connection is fixed, and the first plunger (22) set on the cover (2) is correspondingly blocked in the first cavity (11) of the test tube (1), so as to prevent the extraction liquid mixed with the sample from (6) Seep out.

After waiting for about one minute to fully mix the sample and the extract (6), please also refer to the seventh figure, the user can hold the safety ring (38) of the base (3) and pull it part (382) to tear off the safety pull ring (38) connected with the base body (3) from the base body (3), so as to release the chassis (41) and safety pull ring of the driving part (4) (38) The locking position of the stop edge (381) provided on the inner side. Please also refer to the eighth figure, and then the user can push the driver (4) upwards, so that the piercing rod (43) provided by the driver (4) will push the lower end of the sample container hole (13) The established film (131) is pierced, and when the driver (4) is pushed up, the second clamping part (44) set on the chassis (41) of the driver (4) is connected to the base (3 ) at the lower end of the first clamping portion (36) is clamped and combined to fix the state of the piercing rod (43) piercing into the sample container hole (13).

And after this puncture rod (43) pierces this sample container hole (13), because this puncture rod (43) it pierces the rod diameter of this film (131) one end is less than this sample container hole (13) lower end. Aperture, in addition this puncture rod (43) middle section shaft system does not correspond to block the aperture of this sample container hole (13) lower end and leaves a gap, can make this sample container hole (13) and test paper container (14) and test tube The second cavity (12) of (1) communicates, at this moment, the extract solution (6) mixed with the sample in the sample cavity (13) will flow into the second cavity (12) of the test tube (1) , so as to be in contact with the test strip (5) set in the test paper container (14), when the test strip (5) is fully soaked, the test strip (5) will produce a corresponding change reaction, and use The tester can observe the change of the test strip (5) through the test tube (1), so as to determine the test result.

In addition, if it is negative after the test is completed, the present invention can be directly thrown into the trash can, and if it is positive, it must be further screened at the community laboratory, and the present invention will be delivered to the laboratory as medical waste. The sampling part (71) of the stick (7), the sample and the extract (6) mixed with the sample are sealed and contained in the test tube (1) of the present invention during the detection operation, so the user does not need to It takes time to tidy up and organize to improve the convenience of use. Furthermore, the present invention has a simple structure, few components and low cost, so it can save detection cost, and the operation procedure is simple, and it is not easy for operation errors to affect the correctness of the detection results. Therefore, retesting can be avoided to improve detection efficiency. In addition, the sampling part (71), the sample and the extract (6) mixed with the sample are all sealed in the test tube (1) during and after the test, so that the improper transmission of the virus and the pollution to the environment can be prevented, and the Improve the safety of use.

The above-mentioned embodiments or diagrams do not limit the implementation of the biochemical detection device of the present invention. In addition to providing detection of new coronary pneumonia virus, the present invention can also provide detection of pathogens such as influenza virus and bacteria, biological tissues, body fluids, and chemical substances. For detection, any appropriate changes or modifications made by those with ordinary knowledge in the technical field shall be considered as not departing from the patent scope of the present invention.

As can be seen from the above structure and implementation, the present invention has the following advantages:

1. The biochemical detection device of the present invention has a simple structure, few components and low cost, so the detection cost can be effectively saved.

2. The biochemical detection device of the present invention has a simple operation procedure, and is not prone to operating errors that affect the accuracy of the detection results. Therefore, it can effectively reduce the number of re-tests and improve detection efficiency.

3. The biochemical detection device of the present invention seals the sampling part of the sampling stick, the sample, and the extract mixed with the sample in the test tube during and after the detection, so it can truly prevent the improper spread of the virus and pollute the environment , in order to improve the security of use.

4. In the biochemical detection device of the present invention, the sampling part, the sample, and the extract mixed with the sample are placed in the test tube during the detection operation, so that the user does not need to waste time cleaning up after the detection. Ease of use can be further improved.

In summary, the embodiment of the present invention can indeed achieve the expected effect, and the specific structure disclosed by it has not only never been seen in similar products, nor has it been disclosed before the application. It has fully complied with the provisions of the Patent Law and It is really convenient to file an application for a patent for invention according to the law, to ask for the review, and to grant the patent.

1: test tube

11: The first cavity

12: Second cavity

13: Sample well

14: Test paper container

15: external thread segment

16: The first embedding part

17: Positioning block

171: positioning recess

2: cover body

21: Cover cavity

22: The first plunger

23: Internal thread segment

3: seat body

31: storage tank

32: Second embedding part

33: Second plunger

34: through hole

37:Positioning convex strip

38: safety ring

382: Pull Department

4: Driver

41: Chassis

42: Bump

43: piercing rod

44: The second clamping part

5: Test strips

Claims (6)

A biochemical detection device, comprising: a test tube, such that a first cavity and a second cavity are respectively formed at the upper and lower ends of the test tube, and the inside of the test tube is located in the first cavity And the second cavity is formed with a separate sample cavity and a test paper cavity, and the upper end of the sample cavity communicates with the first cavity, and the lower end of the sample cavity communicates with the second cavity. communicate with each other, and cover the lower end of the sample container with a thin film, and make the notch of the test paper container face the second cavity, so that the test paper container communicates with the second cavity, and in the sample container The hole is provided with an extraction solution, and a test strip is arranged in the test paper container; a cover body is used to make the cover body form a covering cavity, so as to correspond to the cover on the upper end of the test tube, and the cover cavity of the cover body A first plunger is formed in the inner system to block the first cavity at the upper end of the test tube; a seat is provided with a recess at the upper end of the seat so that the lower end of the test tube is correspondingly arranged on the seat In the container of the body, a through hole is provided at the bottom of the container, and the through hole corresponds to the position of the lower end of the sample container hole of the test tube, and a safety pull ring is provided, and the safety pull ring is It is arranged around the lower end of the seat body, and is disconnected from the lower end of the seat body. At least one stop edge is formed on the inner side of the safety ring, and a pulling part is protruded on the outer side of the safety ring. The lower end of the seat body is formed with at least one first clamping part; a driving part is to make the driving part be located at the lower end of the seat body, and the driving part is provided with a chassis, and the chassis and the bottom end of the seat body are connected to each other. The stop edge of the safety pull ring is positioned against each other, and a piercing rod is formed on the chassis, and the piercing rod is correspondingly installed in the through hole of the base body, and the piercing rod of the driving member is used to hold the sample The film at the lower end of the hole is pierced, and at least one second clamping part is provided on the chassis of the driving member to connect with the bottom of the seat body. The first clamping portion at the end is engaged with corresponding locking to fix the state of the puncture rod piercing into the sample container hole, and the diameter of the end of the puncture rod piercing the film is smaller than the diameter of the lower end of the sample container hole. In addition, the middle shaft of the puncture rod does not leave a gap corresponding to the aperture of the lower end of the sample container, so that the sample container and the test paper container communicate with the second cavity of the test tube, so that the The sample-containing extract in the sample container flows into the second cavity of the test tube to contact with the test paper strip arranged in the test paper container. The biochemical detection device according to claim 1, wherein the diameter of the sample well of the test tube is tapered from the upper end to the lower end in a tapered shape. The biochemical detection device as described in claim 1, wherein, the test tube is formed with a first embedding portion on the outer wall of the lower end, and at least one second embedding portion is formed on the wall of the container of the base body, so as to Correspondingly embedded and combined with the first embedding part at the lower end of the test tube. The biochemical detection device as described in Claim 1, wherein, the seat system forms a second plunger at the bottom of the container, so as to be correspondingly blocked in the second cavity at the lower end of the test tube, and make the transparent The hole is located on the second plunger. The biochemical detection device as described in Claim 4, wherein, the base system forms a recess at its lower end opposite to the second plunger, and the through hole communicates with the recess, and the driving member is positioned on the second plunger. A protruding block is arranged in the center of the chassis, and the protruding block is correspondingly accommodated in the recess, and the puncture rod is molded on the protruding block. The biochemical detection device as described in Claim 1, wherein, the test tube is formed with two positioning blocks on the outer wall of the lower end, and a positioning recess is formed between the two positioning blocks, and a positioning protrusion is provided on the outside of the base, The position is embedded and positioned corresponding to the positioning recess provided on the outer wall of the test tube.

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