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TWI561245B - Conjugate comprising erythropoietin and a branched polymeric structure - Google Patents

Conjugate comprising erythropoietin and a branched polymeric structure

Info

Publication number
TWI561245B
TWI561245B TW104100285A TW104100285A TWI561245B TW I561245 B TWI561245 B TW I561245B TW 104100285 A TW104100285 A TW 104100285A TW 104100285 A TW104100285 A TW 104100285A TW I561245 B TWI561245 B TW I561245B
Authority
TW
Taiwan
Prior art keywords
erythropoietin
conjugate
polymeric structure
branched polymeric
branched
Prior art date
Application number
TW104100285A
Other languages
Chinese (zh)
Other versions
TW201538168A (en
Inventor
Meireles Rolando Paez
Gonzalez Daniel Enrique Amaro
Odio Fidel Raul Castro
Valdes Yenisel Hernandez
Estrada Gladys Amalia Ruiz
Original Assignee
Ct De Ingenjeria Gernetica Y Biotecnologia
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Ingenjeria Gernetica Y Biotecnologia, Centro Inmunologia Molecular filed Critical Ct De Ingenjeria Gernetica Y Biotecnologia
Publication of TW201538168A publication Critical patent/TW201538168A/en
Application granted granted Critical
Publication of TWI561245B publication Critical patent/TWI561245B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
TW104100285A 2014-01-08 2015-01-06 Conjugate comprising erythropoietin and a branched polymeric structure TWI561245B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CUP2014000003A CU20140003A7 (en) 2014-01-08 2014-01-08 CONJUGATE UNDERSTANDING ERYTHROPOYETIN AND A RAMIFIED POLYMER STRUCTURE

Publications (2)

Publication Number Publication Date
TW201538168A TW201538168A (en) 2015-10-16
TWI561245B true TWI561245B (en) 2016-12-11

Family

ID=52573994

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104100285A TWI561245B (en) 2014-01-08 2015-01-06 Conjugate comprising erythropoietin and a branched polymeric structure

Country Status (17)

Country Link
US (1) US20160317674A1 (en)
EP (1) EP3093024A1 (en)
JP (1) JP6367952B2 (en)
KR (1) KR20160105811A (en)
CN (1) CN106163541A (en)
AR (1) AR099045A1 (en)
AU (1) AU2015205774B2 (en)
CA (1) CA2935306A1 (en)
CU (1) CU20140003A7 (en)
EA (1) EA201691386A1 (en)
IL (1) IL246526A0 (en)
MX (1) MX2016008928A (en)
NZ (1) NZ722092A (en)
SG (1) SG11201604984TA (en)
TW (1) TWI561245B (en)
WO (1) WO2015104008A1 (en)
ZA (1) ZA201604636B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479711A1 (en) * 2002-01-15 2004-11-24 Pan Asia Bio (Shanghai) Co., Ltd Multidrop tree branching functional polyethylene glycol, the preparation method and the use of it

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
DE60109625T3 (en) 2000-05-15 2017-08-03 F. Hoffmann-La Roche Ag LIQUID MEDICINE PREPARATION CONTAINING AN ERYTHROPOIETIN DERIVATIVE
EA013535B1 (en) * 2002-12-26 2010-06-30 Маунтин Вью Фамэсьютикэлс, Инк. Polymer conjugate of bioactive component (variants), method for producing and use thereof, pharmaceutical products on the base thereof
WO2006061853A2 (en) * 2004-12-10 2006-06-15 Serum Institute Of India Limited Novel erythropoietic compounds and a process for producing erythropoietic compounds
CU23556A1 (en) * 2005-11-30 2010-07-20 Ct Ingenieria Genetica Biotech POLYMER STRUCTURE SIMILAR TO DENDRÍMERO FOR THE OBTAINING OF CONJUGATES OF PHARMACEUTICAL INTEREST
PT2054074E (en) * 2006-08-04 2014-11-07 Prolong Pharmaceuticals Llc Modified erythropoietin
WO2008056654A1 (en) * 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101376676B (en) * 2008-10-09 2012-04-25 天津派格生物技术有限公司 PEGylated erythropoietin protein long-acting preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479711A1 (en) * 2002-01-15 2004-11-24 Pan Asia Bio (Shanghai) Co., Ltd Multidrop tree branching functional polyethylene glycol, the preparation method and the use of it

Also Published As

Publication number Publication date
US20160317674A1 (en) 2016-11-03
WO2015104008A1 (en) 2015-07-16
AU2015205774B2 (en) 2017-11-30
TW201538168A (en) 2015-10-16
JP2017506619A (en) 2017-03-09
KR20160105811A (en) 2016-09-07
ZA201604636B (en) 2018-05-30
EP3093024A1 (en) 2016-11-16
IL246526A0 (en) 2016-08-31
SG11201604984TA (en) 2016-07-28
EA201691386A1 (en) 2016-11-30
CN106163541A (en) 2016-11-23
MX2016008928A (en) 2016-10-04
WO2015104008A8 (en) 2016-08-25
NZ722092A (en) 2017-11-24
AU2015205774A1 (en) 2016-07-28
AR099045A1 (en) 2016-06-22
CU20140003A7 (en) 2015-08-27
CA2935306A1 (en) 2015-07-16
JP6367952B2 (en) 2018-08-01

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees