[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

TWI347847B - Drug delivery system for sub-tenon administration of fine particles - Google Patents

Drug delivery system for sub-tenon administration of fine particles

Info

Publication number
TWI347847B
TWI347847B TW093125059A TW93125059A TWI347847B TW I347847 B TWI347847 B TW I347847B TW 093125059 A TW093125059 A TW 093125059A TW 93125059 A TW93125059 A TW 93125059A TW I347847 B TWI347847 B TW I347847B
Authority
TW
Taiwan
Prior art keywords
sub
fine particles
delivery system
drug delivery
tenon administration
Prior art date
Application number
TW093125059A
Other languages
English (en)
Other versions
TW200509985A (en
Inventor
Kazuhito Yamada
Yasumasa Sasaki
Hiroyuki Sakai
Kiyohi Matsuno
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of TW200509985A publication Critical patent/TW200509985A/zh
Application granted granted Critical
Publication of TWI347847B publication Critical patent/TWI347847B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW093125059A 2003-08-20 2004-08-20 Drug delivery system for sub-tenon administration of fine particles TWI347847B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003296279 2003-08-20

Publications (2)

Publication Number Publication Date
TW200509985A TW200509985A (en) 2005-03-16
TWI347847B true TWI347847B (en) 2011-09-01

Family

ID=34213588

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093125059A TWI347847B (en) 2003-08-20 2004-08-20 Drug delivery system for sub-tenon administration of fine particles

Country Status (7)

Country Link
US (1) US20060286173A1 (zh)
EP (1) EP1666025A4 (zh)
KR (1) KR101160702B1 (zh)
CN (1) CN1835735B (zh)
CA (1) CA2536185C (zh)
TW (1) TWI347847B (zh)
WO (1) WO2005018608A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101119733A (zh) * 2005-02-18 2008-02-06 参天制药株式会社 减轻或避免甾族化合物副作用的方法
RU2414193C2 (ru) * 2005-07-29 2011-03-20 Сантен Фармасьютикал Ко., Лтд. Неинвазивная система доставки лекарственного средства к ткани заднего сегмента глаза с применением твердой композиции
US9693967B2 (en) 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP2396070A4 (en) 2009-02-12 2012-09-19 Incept Llc ACTIVE COMPOSITION WITH HYDROGEL PLUGS
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
JP6199883B2 (ja) 2011-12-05 2017-09-20 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 医療用オルガノゲルプロセス及び組成物
RU2540161C2 (ru) * 2012-12-27 2015-02-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ хирургии отслойки сетчатки
EP3984525A1 (en) * 2014-06-12 2022-04-20 Adare Pharmaceuticals USA, Inc. Extended-release drug delivery compositions

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
NL188266C (nl) * 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
GB2203039B (en) * 1987-03-02 1990-10-24 American Cyanamid Co Stable ophthalmic preparations containing acetazolamide
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US4946859A (en) * 1989-07-31 1990-08-07 Merck & Co., Inc. 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide
IL95942A0 (en) * 1989-10-13 1991-07-18 Syntex Inc Collagen-containing ophthalmic formulation
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
US5178635A (en) * 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
CA2142103C (en) * 1992-08-28 2003-07-08 Haim Aviv Submicron emulsions as ocular drug delivery vehicles
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
JPH06157294A (ja) * 1992-11-19 1994-06-03 Tanabe Seiyaku Co Ltd 脂肪微粒子製剤
EP0694310B1 (en) * 1993-04-16 2000-02-16 Wakamoto Pharmaceutical Co., Ltd. Reversible, thermally gelling water-base medicinal composition
WO1995003009A1 (en) * 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5538974A (en) * 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
US5773021A (en) * 1994-03-14 1998-06-30 Vetoquinol S.A. Bioadhesive ophthalmic insert
SE9401108D0 (sv) * 1994-03-31 1994-03-31 Leiras Oy Ophthalmic composition I
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
JPH08176016A (ja) * 1994-12-19 1996-07-09 Univ Miami 生分解可能で注射可能な薬物運搬ポリマー
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6264970B1 (en) * 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
CA2591581C (en) * 1996-12-20 2013-01-29 Alza Corporation Gel composition and methods
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
WO2001028473A1 (en) * 1999-10-21 2001-04-26 Alcon Universal Ltd. Sub-tenon drug delivery
EP1231936A2 (en) * 1999-10-27 2002-08-21 K-Quay Enterprises, LLC Methods and compositions for treatment of keratoconus using protease inhibitors
US6395294B1 (en) * 2000-01-13 2002-05-28 Gholam A. Peyman Method of visualization of the vitreous during vitrectomy
US6726918B1 (en) * 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
DK1380302T3 (da) * 2001-03-28 2008-12-08 Santen Pharmaceutical Co Ltd Medikamenter mod retina- og choroidea-sygdomme indeholdende ste-roider som aktiv bestanddel
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
JP4838968B2 (ja) * 2001-09-28 2011-12-14 参天製薬株式会社 薬物−ポリエチレングリコール結合体を含有する眼組織内注入剤
US20030194421A1 (en) * 2001-12-28 2003-10-16 Angiotech Pharmaceuticals, Inc. Treatment of uveitis
RU2004127577A (ru) * 2002-02-14 2005-05-27 Мерк Патент ГмбХ (DE) Способы и композиции для лечения заболеваний глаз
KR20040084931A (ko) * 2002-02-22 2004-10-06 산텐 세이야꾸 가부시키가이샤 미립자 결막하 투여를 위한 약물 수송 시스템
AU2003248624B2 (en) * 2002-06-05 2006-04-06 University Of Florida Opthalmic drug delivery system
JP2004196787A (ja) * 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd 結膜下デポによるドラッグデリバリーシステム
CN101119733A (zh) * 2005-02-18 2008-02-06 参天制药株式会社 减轻或避免甾族化合物副作用的方法
RU2414193C2 (ru) * 2005-07-29 2011-03-20 Сантен Фармасьютикал Ко., Лтд. Неинвазивная система доставки лекарственного средства к ткани заднего сегмента глаза с применением твердой композиции

Also Published As

Publication number Publication date
EP1666025A1 (en) 2006-06-07
US20060286173A1 (en) 2006-12-21
CN1835735A (zh) 2006-09-20
TW200509985A (en) 2005-03-16
KR20060066728A (ko) 2006-06-16
WO2005018608A1 (ja) 2005-03-03
CN1835735B (zh) 2010-05-12
EP1666025A4 (en) 2011-08-31
KR101160702B1 (ko) 2012-06-28
CA2536185A1 (en) 2005-03-03
CA2536185C (en) 2012-06-26

Similar Documents

Publication Publication Date Title
EP1484054A4 (en) DRUG DELIVERY SYSTEM FOR SUBCONJUNCTIVAL ADMINISTRATION OF FINE GRAINS
EP1624855A4 (en) PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR THE ADMINISTRATION OF HYDROPHOBIC MEDICINAL PRODUCTS
EP1871384A4 (en) PHARMACEUTICAL SUBSTANCE DELIVERY SYSTEMS FOR HYDROPHOBIC MEDICAMENTS AND COMPOSITIONS COMPRISING THE SAME
IL172223A0 (en) Drug delivery systems for tumor targeting ngr-molecules and uses thereof
HK1083688A1 (zh) 用於可調整預設劑量的給藥的藥物遞送系統
AU2003245368A1 (en) Delivery system for flowable medicinal or therapeutic substances
IL176108A0 (en) Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
WO2006060547A3 (en) Systems and methods for intra-oral drug delivery
PL1631255T3 (pl) System dostarczania leków
GB2391480B (en) Drug delivery system
IL174748A0 (en) Nanoparticles for drug delivery
IL177785A0 (en) Nanocell drug delivery system
AU2003239433A1 (en) Delivery of drug amines through an inhalation route
IL174396A0 (en) Oral drug delivery system
ZA200506240B (en) Coated particles and pharmaceutical dosage forms
AU2003222067A1 (en) System for delivery of therapeutic substances
AU2003217950A8 (en) Agglomerated particles for aerosol drug delivery
ZA200610770B (en) Dosage form for delivery of multiple drug forms
GB2400565B (en) Nasal drug delivery
EP1667619A4 (en) PHARMACEUTICAL FEEDING SYSTEM
EP1585500A4 (en) COATED PARTICLES INTENDED FOR THE PROLONGED DELIVERY OF PHARMACEUTICAL INGREDIENTS
TWI347847B (en) Drug delivery system for sub-tenon administration of fine particles
AU2003243439A1 (en) Medical device for intra-lumenal delivery of pharmaceutical agents
GB0304636D0 (en) Pharmaceutical composition for nasal delivery
GB2405094B (en) Pharmaceutical composition for controlled drug delivery system

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees