TW202023597A - Composition, tablet, and capsule containing ampelopsis grossedentata extract - Google Patents

Abstract

The present invention provides a composition and a tablet or capsule in which an unusual odor (odor that is evaluated as malodor) unique to grossedentata is suppressed while containing a high amount of grossedentata extract.

The present invention prepares a composition and used it as a tablet or capsule; the composition contains chitosan and grossedentata extract, each of the composition contains 10 to 35 mass% of chitosan and 5 to 22 mass% of amperopsin, and the mass ratio of chitosan/amperopsin is 0.6 to 3.5.

Description

Compositions, tablets and capsules containing Tengcha extract

The present invention relates to a composition that suppresses the odor of a rattan tea extract and a tablet or capsule containing the composition.

Tengcha is a plant belonging to the genus Snake grape in the grape family, and it is called Xiantooth grape in China. The scientific name is Ampelopsis grossedentata. Mainly distributed in China's Guangxi, Guangdong, Yunnan, Guizhou, Hunan, Hubei, Jiangxi and Fujian provinces and autonomous regions. People of Zhuang or Yao nationality in Guangxi, Hunan and other provinces or autonomous regions in China often drink beverages made from its stems and leaves, and are also used for colds and sore throats.

A variety of physiological activities have been found for rattan tea extracts, and medical or health food applications containing rattan tea extracts have been proposed. For example, it has been proposed for the treatment of liver disease (Patent Document 1), lipase inhibition (Patent Document 2), matrix protease inhibition (Patent Document 3), antibacterial use (Patent Document 4), and prevention of perfume deterioration (Patent Document 2). Document 5) and for preventing the fading of pigments (Patent Document 6).

Regarding the vine tea extract, ampelopsin, a flavonoid compound, was identified as a component for the various functions described above, and a large amount of extracts containing the substance were obtained. This substance is extracted from dried rattan tea stems and leaves through a solvent such as water or hydroalcohol, and is further commercially available as a concentrated paste-like concentrate or spray-dried or freeze-dried powder.

Tengcha extracts are known to produce unique unpleasant odors (unpleasant odors) possessed by Tengcha extracts in the preparation step for capsules or tablets containing the Tengcha extracts. Since this peculiar smell will increase during long-term storage, the shelf life must be shortened.

Therefore, looking for a preparation that contains a large amount of vine tea extract, and is easy to drink with little odor after long-term storage.

[Prior Art Document] [Patent Document]

[Patent Document 1] Japanese Patent Application Publication No. 2003-026584

[Patent Document 2] JP 2003-012536 A

[Patent Document 3] JP 2002-173424 A

[Patent Document 4] JP 2002-159566 A

[Patent Document 5] JP 2004-018756 A

[Patent Document 6] JP 2002-065201 A

The inventors of the present invention conducted research on the basis of the above-mentioned background technology, and conducted research on Tengcha extract under various formulation conditions, and found that if chitosan and Tengcha extract are contained Formulation of the composition of the extract can suppress the peculiar smell of Tengcha extract. Based on such insights, the present invention proposes a composition containing chitosan and rattan tea extract and a tablet or capsule containing the composition.

That is, the subject of the present invention is to provide a composition, a lozenge, or a capsule that contains a large amount of rattan tea extract and suppresses the peculiar smell of rattan tea (an odor evaluated as a bad smell).

The main structure of the present invention is as follows.

(1) A composition containing chitosan and rattan tea extract, each composition containing 10 to 35% by mass of chitosan, 5 to 22% by mass of leucocephaly, and chitosan/leucocephaly The mass ratio is 0.6 to 3.5.

(2) A tablet containing the composition described in (1).

(3) A capsule containing the composition described in (1).

According to the present invention, there is provided a composition, lozenges, and capsules in which the peculiar smell of Tengcha extract is suppressed. In particular, according to the present invention, long-term storage is possible, and since the generation of peculiar smell from the vine tea extract is suppressed, it can be a preparation that is easy to swallow even if it is not resistant to the elderly or children.

The present invention relates to a composition containing chitosan and rattan tea extract, and a tablet or capsule containing the composition.

One of the main constituents of the composition of the present invention is chitosan. The so-called chitosan is a polysaccharide that mainly has a structure connected to glucosamine via a β1,4 bond, and sometimes contains N-acetylglucosamine as a constituent in addition to glucosamine.

The source of chitosan used in the present invention is not particularly limited. For example, chitin obtained by removing calcium or protein from crustaceans such as shrimps, crabs, etc., cuttlefish bones, etc. can be used Substances obtained by acylation.

In addition, the degree of deacetylation of chitosan used in the present invention is not particularly limited. Usually, a substance with a degree of deacetylation of 50 to 100% is sufficient. In addition, the degree of deacetylation of chitosan is a value measured by a colloidal titration method.

Furthermore, the average molecular weight of chitosan used in the present invention is not particularly limited.

The chitosan used in the present invention preferably uses powder that meets the specifications of commercially available food materials.

As the Tengcha extract, any one or more of the leaves, stems, flowers and roots of Tengcha can be used. Particularly good use of stem or leaf extracts.

The method of extraction from Tengcha is not particularly limited. Tengcha can be used directly during extraction, or its dried product can be used. In terms of extraction efficiency, the dried product is preferred. In addition, the method of crushing to granular or powder for extraction can extract the effective ingredients in a short time and with high extraction efficiency under stable conditions. The extraction temperature is not particularly limited, and it can be appropriately set according to the particle size of the pulverized product of Tengcha or the type of solvent.

The kind of solvent is not particularly limited. It is preferably a lower alcohol such as water and ethanol, or a mixed solvent thereof. The extraction can be carried out at room temperature. It can also be performed under heating conditions (for example, using a heated solvent such as warm water or hot water).

According to the above extraction operation, the effective ingredients of the present invention can be extracted from Tengcha and dissolved in a solvent. The solvent containing the extract can be used directly. Preferably, it is used after performing common purification treatments such as sterilization, washing, filtration, decolorization, and deodorization as needed. Furthermore, all the solvents were volatilized to obtain a solid state (dried product). The dried product can be re-dissolved in any solvent, and powdered and used by performing operations such as spray drying. In the present invention, it is preferable to use the above-mentioned powder.

In addition, Maruzen Pharmaceutical Co., Ltd. has rattan tea extracts (extracts) commercially available, and these can also be used. The commercially available Tengcha extract is a powder that uses as an index, a kind of flavonoid compound, which is a large amount of flavonoids contained in the leaves of Tengcha, and regulates the extraction rate. This powder can also be used in the present invention.

In addition, the Tengcha extract produces extremely specific and undesirable odors (unpleasant odors) during the above-mentioned encapsulation and tablet formulation steps.

For the composition containing chitosan and rattan tea extract, in order to suppress the smell of rattan tea, the powder of chitosan and rattan tea extract is uniformly mixed. For the powder of chitosan and rattan tea extract, the blending amount and blending ratio are very important. Preferably, each component contains 10 to 35% by mass of chitosan. In addition, it is preferable that the concentration of leucocephalin in each part of the composition is 5 to 22% by mass and the rattan tea extract is contained. In addition, the mass ratio of chitosan/leucocylin is adjusted to 0.6 to 3.5 and blended.

In addition, the composition containing chitosan and rattan tea extract can be mixed with various excipients, such as sugar or starch, in order to be made into tablets by the squeezing method, and can be granulated according to needs. Agent. By pressing the granule or powder into a tablet according to a conventional method, a tablet can be obtained that suppresses the peculiar smell of Tengcha extract.

When making a capsule, the composition is filled into a hard capsule according to a conventional method to make a capsule. At this time, when forming a capsule, various excipients such as sugar or starch may be mixed, and granulation may be performed as needed to form a granule. By filling the granule or powder composition into hard capsules in accordance with a conventional method, a capsule with suppressed peculiar smell of Tengcha extract can be obtained.

In addition, in formulation, the substances that can be used as excipients are cellulose, starch, lactose, maltitol, cyclodextrin, hemicellulose, guar gum, konjak mannan, alginic acid, agar, carrageenan , Chitin, carboxymethyl cellulose and polydextrose. Especially preferred is cellulose or starch.

In addition, as long as it does not hinder the purpose of the present invention, edible oil, calcium, iron, sodium, zinc, copper, potassium, phosphorus, magnesium, iodine, manganese, selenium and other minerals, vitamin A, vitamin C, vitamin D, vitamin E can be formulated , Vitamin K, niacin, folic acid and pantothenic acid and other fat-soluble or water-soluble vitamins, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, phospholipid, gum arabic, xanthan gum , Tragacanth gum, locust bean gum, preservatives and antioxidants, flavoring agents or spices, sodium chloride, sodium glutamate, glycine, succinic acid and sodium lactate and other flavoring agents, citric acid, sodium citrate, acetic acid, hexyl Diacid, fumaric acid and malic acid and other sour agents, aspartame and other low-calorie sweeteners and coloring agents.

(Example)

<Lozenges>

Hereinafter, test examples carried out using the lozenges of the examples and comparative examples are shown, and the effects of the present invention are explained.

1. Evaluation method of odor

8mm、250mg/粒的錠劑，在將原料混合後，使用單沖式壓錠機(岡田精工公司製)以打擊壓1000kgf進行製備。 Since the nature of the odor of Tengcha extract is still unclear, it was decided to quantify it based on sensory evaluation. Numericalization is judged by a skilled professional sensory evaluator by two comparison methods with standard products, and a score is given. Regarding the standard product, a tablet having the composition shown in Table 1 below was prepared and used as a standard product. In addition, the evaluation criteria are clearly indicated in the column of the form. The standard lozenge setting is

A tablet of 8 mm and 250 mg/tablet was prepared after mixing the raw materials using a single-punch tablet press (manufactured by Okada Seiko Co., Ltd.) at a shock pressure of 1000 kgf.

[Table 1]

In addition, the odor intensity of the criteria 5 to 1 is based on the content described in the above-mentioned Table 1, which corresponds to the following expression in sense.

Criterion 5: There is almost no smell.

Criterion 4: A slight smell is felt.

Criterion 3: A strong smell is felt but does not affect drinking.

Criterion 2: Feel a very strong smell, and feel resistant to drinking.

Criterion 1: An unpleasant smell is felt.

2. Preparation and evaluation of tablets of Examples 1 to 6 and Comparative Examples 1 to 6

8mm、250mg/粒的錠劑。將該錠劑20粒裝入鋁製袋中，在40℃75%RH的恆溫箱中保存2周後，由3名接受過專業的訓練的感官評估人員對開封時產生的臭味進行了評估。此外，以如上述製備的5種錠剤作為標準品，與此等藉由2種比較法對等同性進行了判斷。 According to the formula in Table 2, after mixing the raw materials, it is produced with a single punch press (manufactured by Okada Seiko Co., Ltd.)

8mm, 250mg/tablet tablets. The 20 tablets of the tablets were put into an aluminum bag and stored in an incubator at 40°C and 75%RH for 2 weeks. Three professionally trained sensory assessors evaluated the odor generated during opening. . In addition, five ingots prepared as described above were used as standard products, and the equivalence was judged by two comparison methods.

For the judgment of the evaluation, for example, if the test product has an unpleasant odor equivalent to standard 3, the score is 3. In addition, as a result of the sensory test, the average of the scores of 3 people was calculated. The results are shown in the last row of Table 2

The sensory evaluation average value 4 or more judged that the unpleasant odor can be reduced.

[Table 2]

From the experimental results using the tablets of Examples 1 to 6 and Comparative Examples 1 to 6, it can be seen that formulating chitosan is effective in suppressing the specific odor derived from the Tengcha extract in the tablets containing the Tengcha extract. In addition, in the composition before pressing the tablet containing chitosan and vine tea extract, if the composition is adjusted to contain 5 to 22% by mass of interleukin, 10 to 35% by mass of chitosan, and If the mass ratio of glycan/leucoside is 0.6 to 3.5, a tablet can be obtained without the specific odor from Tengcha.

<Capsules>

Hereinafter, test examples carried out using the capsules of the examples and comparative examples are shown to explain the effects of the present invention.

1. Evaluation method of odor

Similar to the tablet test, a skilled professional sensory assessor will judge by two comparison methods with the standard product and give a score. Regarding the standard product, a capsule having the composition shown in Table 3 below was prepared, and this was used as a standard product. In addition, the evaluation criteria are clearly indicated in the column of the form.

In addition, regarding the capsule, after mixing the raw materials, a hard capsule filling machine ("Profill 100" manufactured by Capsugel) was used to prepare a hard capsule of No. 2 capsule size (capsule shell manufactured by Capsugel).

[table 3]

In addition, the odor intensity of the criteria 5 to 1 is based on the content described in the above Table 3 as a criterion, and sensory corresponds to the following expression.

Criterion 5: There is almost no smell.

Criterion 4: A slight smell is felt.

Criterion 3: A strong smell is felt but does not affect drinking.

Criterion 2: Feel a very strong smell, and feel resistant to drinking.

Criterion 1: An unpleasant smell is felt.

2. Preparation and evaluation of capsules of Examples 7 to 12 and Comparative Examples 7 to 12

According to the formula of Table 4, the raw materials were mixed, and a hard capsule filling machine ("Profill 100" manufactured by Capsugel) was used in the same manner as the standard product to prepare a hard capsule (capsule shell manufactured by Capsugel) of No. 2 capsule size. The 20 capsules were sealed in an aluminum bag at 40℃75%RH After being stored in the incubator for 2 weeks, 3 professionally trained sensory evaluators evaluated the odor generated during opening.

In addition, the equivalence with the 5 standard capsules prepared above was judged by 2 comparison methods.

For the judgment of the evaluation, for example, if the test product has an unpleasant odor equivalent to standard 3, the score is 3. In addition, as a result of the sensory test, the average of the scores of 3 people was calculated. The results are shown in the last row of Table 4.

The sensory evaluation average value 4 or more judged that the unpleasant odor can be reduced.

[Table 4]

From the experimental results using the capsules of Examples 7 to 12 and Comparative Examples 7 to 12, it is known that formulating chitosan is effective in suppressing the specific odor derived from the Tengcha extract in the capsules containing the Tengcha extract. In addition, in the composition before filling the capsules containing chitosan and vine tea extract, if the composition is adjusted to contain 5 to 22% by mass of leucocein, 10 to 35 The mass% of chitosan, and the mass ratio of chitosan/bleachin is 0.6 to 3.5, the capsule can be obtained without the specific odor from Tengcha.

Claims (3)

A composition containing chitosan and rattan tea extract, each composition containing 10 to 35% by mass of chitosan, 5 to 22% by mass of leucocephaly, and the mass ratio of chitosan to leucocephaly From 0.6 to 3.5. A lozenge containing the composition described in item 1 of the scope of the patent application. A capsule containing the composition described in item 1 of the scope of patent application.