TW200904327A - Rodent repellent and method for repelling rodents using the same - Google Patents
Rodent repellent and method for repelling rodents using the same Download PDFInfo
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- TW200904327A TW200904327A TW097114594A TW97114594A TW200904327A TW 200904327 A TW200904327 A TW 200904327A TW 097114594 A TW097114594 A TW 097114594A TW 97114594 A TW97114594 A TW 97114594A TW 200904327 A TW200904327 A TW 200904327A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-nitrogen bonds, e.g. azides, diazo-amino compounds, diazonium compounds, hydrazine derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
Abstract
Description
200904327 九、發明說明： 【發明所屬之技術領域】 -本發明係關於一種對老鼠等，齒類為有效之忌避劑及 . 使用該忌避劑之忌避方法。 【先前技術】 一：人1 *鹿鼬叭、臭鼬等嚆齒類動物會損害農作物、 广什0此’習知方法係使用薄荷油、辣椒驗 利文獻υ。 丨有大㈣油作為針對鼠之忌避劑（專 果===職存在忌避效果不充分或者其效 (專利文獻1)日本專利特開平7_285821號公報 【發明内容】 (發明所欲解決之問題） i 本土月係有4L於上述狀況而完成者，本發明之目的係 供-種發揮充分的針對鼠㈣齒類的忌避效果而且其效 果的持續性為優異之.齒類忌避劑、及使用其之忌避方 法。 々 (解決問題之手段） 本發明之嚅齒類忌避劑之特徵在於，包含具有選自 架内有2個或3個氮原子的雜環（A)、Ν-Ν單鍵（Β)及偶^ 基⑹所組成之群組中的至少u之含氮化合物（1= 效成分。 97114594 200904327 於上述構成中，上述雜環（A )較佳為選自由吼β坐環、吼 〇坐咬（pyrazolidine)環、°比°坐淋環、°比°坐β定酮 (pyrazolidinone)環、吼唑 ^(pyrazolone)環、咪唑環、 〇等二唾環、17等二《坐„定（〇別(^犯〇11(^116)環、《等二《坐°定酮 (oxadiazolidinone)環、三唑環所組成之群組中之至少1 種。又’上述偶氮基（C)，較佳為選自由萘基偶氮基、苯 基偶氮基、甲苯基偶氮基、雙偶氮基、異丙苯基偶氮基、 一甲本基偶氮基及大菌香基偶氮基所組成之群組中之任 意者。又，上述含氮化合物，較佳為選自由噁蟲酮 (1^1；0又3(11820116)、吡唑噚橙（？71^2〇1〇116〇1^11代）、偶氮 笨（azobenzene)及偶氮二甲醯胺（az〇dicarb〇namide)所 組成之群組。 本發明之嘯齒類之忌避方法之特徵在於使用上述本發 明之嚅齒类員忌避齊j。於上述構成中之丨述嚅齒類忌避劑， 2佳的是採用散佈、喷霧（氣溶膠（aer〇s〇1)、全量喷射氣 /合膠等）、塗佈、加熱蒸散、送風式揮發或者煙燻中之任 意手段而使用。又，於上述構成中，較佳的是使用每卜 使用場所的有效成分量為卜別g量之屬齒類忌避 (發明效果） :::發明’可提供對老鼠等嚅齒類發揮充分 果的持續性亦優異之忌避劑。藉此獲得可 内更確貫地忌避鼠等嗡齒類之效果。 ： 【實施方式】 97114594 200904327 本發明之嚅齒類忌避劑，係含有選自由骨架内有2個或 3個氮原子的雜環（a)、n-N單鍵（B)及偶氮基（〇所組成之 - 群組中的至少1種之含氮化合物（以下亦稱為「特定含氮 • 化s物」）作為必需之有效成分者。詳細而言，該特定含 氮化合物，係具有至少2個氮原子者’藉由此種含氮結構 而發揮針對嚅齒類之優異的忌避效果。再者，作為必需有 效成分之特定含氮化合物，可僅為1種，亦可為2種以上。 ^ 關於上述雜環（A) ’例如較佳為α比唾環（下述結構式 (&1)) °比唑啶環（下述結構式（a2))、11比唑啉環（下述結構 弋（a3))吡唑喷_環（下述結構式（a4))、吡唑噚環（下述 結構式〔a 、ι, ))、咪唑環（下述結構式（a6 ) )、σ号二唑環述 結構式（a 7))、π _ ,、 τ二唑啶（oxadiazolidine)環（下述結構式 (a8))、π号二 0企 一主啶鲷（oxadiazolidinone)環（下述結構式 、三 4 择,__ , — 衣（下述結構式（alO))所組成之群組中的至少 1種之五員雜璟 、 及’進而較佳為崎二唑啶酮環或吼峻噚環。 i 97U4594 8 200904327 [化1]200904327 IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to a repellent which is effective for teeth and the like, and a repellent method for using the repellent. [Prior Art] A: People 1 * Deer scorpion, skunk and other caries will damage crops, and the traditional method is to use peppermint oil and pepper to test the literature.丨 大 大 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四i. The local monthly system has 4L in the above-mentioned situation, and the object of the present invention is to provide a sufficient repellent effect against the rat (four) teeth, and the durability of the effect is excellent. The tooth repellent and the use thereof忌 々 手段 手段 手段 手段 手段 手段 手段 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本含) and at least u of the nitrogen-containing compound in the group consisting of (6) (1 = active ingredient. 97114594 200904327 In the above constitution, the above heterocyclic ring (A) is preferably selected from the group consisting of 吼β, 吼Py 咬 py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py py定(〇别((^犯〇11(^116)环,《等二《坐°的酮酮(oxadiazolidinone)环And at least one of the group consisting of triazole rings. Further, the above azo group (C) is preferably selected from the group consisting of naphthylazo, phenylazo, tolylazo, and bis. Any one of the group consisting of a nitrogen group, a cumylazo group, a monomethyl azo group, and a large auxyl azo group. Further, the above nitrogen-containing compound is preferably selected from the group consisting of Ketone (1^1; 0 and 3 (11820116), pyrazole orange (?71^2〇1〇116〇1^11 generation), azobenzene and azomethine (az〇dicarb) A group consisting of 〇namide). The method of repelling the whistling tooth of the present invention is characterized in that the caries of the present invention are used in the above-mentioned configuration. It is used by any means such as spreading, spraying (aerosol (aer〇s〇1), full-spray gas/gluing, etc.), coating, heating and evapotranspiration, air-flowing volatilization or smoking. Among them, it is preferable to use the amount of the active ingredient per use place as the tooth type repellent (the effect of the invention) ::: the invention can provide the caries such as the mouse The repellent which is excellent in the persistence of the fruit is also obtained, thereby obtaining the effect of repelling the caries and the like more accurately. [Embodiment] 97114594 200904327 The caries-type repellent of the present invention is selected from the group consisting of a nitrogen-containing compound having at least one of a heterocyclic ring (a), an nN single bond (B), and an azo group (composed of 〇) in the skeleton (hereinafter also referred to as " Specifically, the specific nitrogen-containing compound is an essential active component. Specifically, the specific nitrogen-containing compound having at least two nitrogen atoms is excellent in caries by such a nitrogen-containing structure. The repellent effect. In addition, the specific nitrogen-containing compound which is an essential effective component may be used alone or in combination of two or more. ^ Regarding the above heterocyclic ring (A) 'for example, α is preferably a ratio of a salivary ring (the following structural formula (& 1)) to a pyrazolidine ring (the following structural formula (a2)), and 11 a oxazoline ring (below) Structure 弋(a3)) Pyrazole spray_ring (the following structural formula (a4)), pyrazolium ring (the following structural formula [a, ι, )), imidazole ring (the following structural formula (a6)) Σ-number diazole ring structure formula (a 7)), π _ , τ oxadiazolidine ring (the following structural formula (a8)), π No. 2 oxadiazolidinone ring (The following structural formula, three, four, __, - clothing (the following structural formula (alO)) of at least one of the five members of the group, and 'further preferably soxazolidinone Ring or 噚 噚 ring. i 97U4594 8 200904327 [Chemical 1]
r>r>
N-N (al)N-N (al)
NN
N- 上述罝細,D、 ’ (a10) 所表示結構中之鍅。1列如較佳為包含於如下述通式（b) 不同，例如可舉出：中，R1〜R、可分別相同亦可 具有取代基之燒基及:二二有：基(具體而言為可 .R3 R2 R4 (b) 97114594 200904327 上述偶氮基（C)係N原子與！^原 佳的是於如下述通式（c ” 又鍵而鍵結者，較 中U可分別相同亦可不^結構中含有。該式（〇 自由萘基==氮r而::如可較佳地舉出選 苯基偶氮基、二甲c、二唾基、雙偶氮基、異丙 群组中的任音其茵香基偶氮基所組成之 .^ ，议土般偶氮色素中包含此處所舉出之偶氮 ί’。偶氮色她如後述者）可適宜作為特定含氮化合= [化3] R5-Ν=：ν·-R6 (C) 至於上述特定含氮化合物之具體例，例如可舉出： 具有上述於骨架内具有2個或3個氮原子之雜環（Α) 者如心**酮（下述結構式（I ))或吼嗤脊（下述結構式 (Π ))等； 具有上述Ν-Ν單鍵（Β)者，如肼、苯基肼、L2 —二苯肼 等； 具有上述偶氮基（C)者’如偶氮苯（下述結構式（m ))、 偶氮二曱醯胺（下述結構式（jy ))、偶氮雙異丁腈、各種偶 氮色素（莧菜紅（Amaranth)、新胭脂紅（New Cocci ne) '曰 落黃（Sunset Yellow)、紅寶石顏料 B(Lithol Rubine B)、 紅寶石顏料（Lithol Rubine)、色殿紅（Lake Red)、色殿 97114594 10 200904327 紅CBA、立索紅（Lithol Red)、立索紅CA、立索紅BA、 立索紅SR、豔色澱紅R(Briinant Lake Red R)、深粟色 (Deep Maroon) ' 甲苯胺紅、蘇丹瓜（sudan ΠΙ )、Permaton Red、永固橙（permanent 0range)、聯苯胺橙g、橙色π、 間本一紛标、餘牢獲紅（Bri 11 iant Fast Scar let)、永固 紅 F5R、猩紅 N. F(Scarlet Red Ν· F)、麗春紅 3R(Ponceau 3R)、麗春紅R、麗春紅sx、油溶紅χ〇(〇η Red x〇)、固 紅 S(Fast Red S)、漢薩撥（Hanza 〇range)、橙色 j、橙 色SS、漢薩黃、polar Yell〇w 5G、黃色AB、黃色〇B、 f 黃（Metanil Yeliow)、耐曬黃（Fast Ught YeU〇w)3G、 奈酚藍黑（Naphthol Blue Black)等）等。再者，上述特定 含氮化合物例如亦可為如具有作為雜環（A)的吼唑哜環與 偶氮基⑹兩者之吼㈣撥般之具有2種以上上述含氮結 構之化合物。 [化4] 97114594 200904327 ο. ch3 •ο Ν.N- The above is fine, and D, ' (a10) is the structure in the structure. The first column is preferably contained in the following formula (b), and examples thereof include R1 to R, a group which may be the same or may have a substituent, and a group: (in particular, It can be .R3 R2 R4 (b) 97114594 200904327 The above azo (C) N atom is preferably the same as the following formula (c ”, which is the same as the U. It may be contained in the structure. The formula (〇 free naphthyl == nitrogen r: and preferably phenyl azo, dimethyl c, di-sal, bis-azo, isopropyl group) In the group, the octyl group consists of oxalic acid azo. ^, the earth-like azo pigment contains the azo ί '. The azo color as described later can be suitable as a specific nitrogen. In the specific examples of the above-mentioned specific nitrogen-containing compound, for example, the above-mentioned heterocyclic ring having two or three nitrogen atoms in the skeleton (for example) may be mentioned. Α) such as ketone (the following structural formula (I)) or ridge (the following structural formula (Π)); etc.; having the above Ν-Ν single bond (Β), such as 肼, phenyl hydrazine , L2 - diphenyl hydrazine, etc.; The base (C) such as azobenzene (the following structural formula (m)), azodiamine (the following structural formula (jy)), azobisisobutyronitrile, various azo pigments (amaranth) (Amaranth), New Cocci ne 'Sunset Yellow, Lithol Rubine B, Lithol Rubine, Lake Red, Hall 97114594 10 200904327 Red CBA, Lithol Red, Lisuo Red CA, Lisuo Red BA, Lisuo Red SR, Brinnant Lake Red R, Deep Maroon 'Toluidine Red, Sudan ΠΙ, Permaton Red, permanent 0range, benzidine orange g, orange π, bis, Bri 11 iant Fast Scar let Scarlet N. F (Scarlet Red Ν· F), Ponceau 3R (Ponceau 3R), Ponceau R, Ponceau sx, oil soluble red χ〇 (〇η Red x〇), solid red S (Fast Red S), Hanza 〇range, orange j, orange SS, Hansa yellow, polar Yell〇w 5G, yellow AB, yellow 〇B, f yellow (Metanil Yeliow), light fast yellow (Fast Ught YeU 〇w) 3G, Naphthol Blue Black, etc.). Further, the specific nitrogen-containing compound may be, for example, a compound having two or more kinds of the above-described nitrogen-containing structures, such as a ruthenium ring having a heterocyclic ring (A) and an azo group (6). [化4] 97114594 200904327 ο. ch3 •ο Ν.
h3cH3c
ClCl
ΟΟ
,0,0
H3CT (I) (Π) ί^Ί (III) οH3CT (I) (Π) ί^Ί (III) ο
ο νη2 (IV) 作為上述特定含氮化合物，於上述具體例中，就發揮高 忌避效果而言，尤其以選自由以結構式（I )〜（IV )所表示 之噁蟲酮、吡唑11弄橙、偶氮苯及偶氮二曱醯胺所組成之群 組者為佳。 於本發明之嚅齒類忌避劑中，除上述例示的特定含氮化 合物以外，例如亦可使用1種或2種以上之以下所舉出的 化合物作為有效成分。亦即，可將咪唑系化合物（噻苯噠 口坐（thiapendazole)、依普同（iprodione)、富馬酸惡 口米口坐 鹽 (oxpoconazole fumarate)等） 、 得福隆 (teflubenzuron)、氟蟲脲（flufenoxuron)、六伏隆 97114594 12 200904327 (hexaflumuron)、克福隆（chlorfluazuron)、二福隆 (diflubenzuron)、硫敵克（thiodicarb)、免扶克 (benfuracarb)、棉鈴威（alanylcarb)、furathiocarb、 亞滅培（acetamipr id)、福拉比（f urametpyr)、新類尼古 丁（neonicotinoid)系化合物（益達胺（imidacloprid)、 MTI-446、賽速安（thiamethoxiam)等）、滅大松 (methidathion)、白克松（pyraclofos)、賽滅淨 (cyromazine)、乙蟲清（ethiprole)、唑蟲醯胺 (tolfenpyrad)、diacloden、芬普螨（fenproximate)、因 得克（indoxacarb)、芬普尼（fipronil)、得芬瑞 (tebufenpyrad)、畢達本（pyridaben)、畢汰芬 (pyrimidifen)、克芬蟎（cl〇fentezine)、嘧蟎酯 (fluacrypyrim) > molantale tartrate 、免賴得 (benomyl)、賽福座（triflumizole)、撲克拉 (prochloraz)、稻瘟酯（pefrazoate)、三泰芬 (triadimefon)、比多農（bitertanol)、芬克座 (fenbuconazole)、邁克尼（mycl〇butanil)、菲克利 (hexaconazole)、得克利（tebuconazole)、普克利 (propiconazole)、待克利（difenoconazole)、種菌唑 (ipconazole)、易胺座（imibenconazole)、環克座 (cyproconazole)、四克利（tetraconazole)、石夕氟口垒 (simeconazole)、echlomezole、赛座滅（cyazofamid)等 作為有效成分。 本發明之屬齒類忌避劑之劑型，根據成為有效成分之化 97114594 13 200904327 合物的物性等加以適當設計即可，並無特別限定；例如可 將上述有效成分溶解或分散於溶劑（液體載體）中，或者將 上述有效成分與固體載體混合以使其吸附或含浸於固體 載體中等，而製成製劑。當然，亦可單獨使用上述有效成 分而製成製劑。 可適用於本發日㈣齒類忌避劑之劑型的具體例，例如可 牛出喷霧劑、使用喷射劑進行喷霧之氣溶膠、泵劑 ng f_)、塗佈劑、加熱蒸散用或送風式揮發用或 =燻用等之墊片（薄片）劑、膠帶劑、蜂巢 粉 劑、顆粒劑等。 a 物 作為上述溶劑，一般而言例如可 之醇類，·二醇類’·丙，、甲基乙基心類甲 二哼烷等之醚類；己烷、煤油、石蜱 虱夫喃、 甲苯等之芳香族烴類；醋酸乙^之日肪族烴類；苯、 溶劑可單獨使用，亦可併用2種以上。曰、’燈油等。該等 作為上述固體載體’一般而言例如可 粉、膨濁土、黏土、石夕藻土、碳_ 用：嶺土、滑石 之礦物質或無機質粉末；木粉、大豆粉：=、沸石等 之植物質粉末；紙漿、齡樹脂、聚酿胺、^夕H粉等 偶氮雙異丁氰（廟）、纖維或橡膠之粉末.；：烯等塑膠； 二氣苯、三異丙基-s_三噚烷、環、，知腦、萘、對 華性粉末等。該等固體載體可單獨使燒金剛炫等之昇 上。又，上述固體載體之形一 ，亦可併用2種以 氣性好者，例如可舉出蜂 ^ 乂旮為構造簡單且通 97Π4594 蜂桌狀、網狀、狹縫狀、格子狀或 14 200904327 者設有開孔之紙類等之構造。 以下’按代表性的劑型舉出本發明嚙齒類忌避劑之製備 例0 、（1)喷務別·使作為必需有效成分之吼唑哜撥1重量 知及作為其他成分之笨氧基乙醇0.2重量份溶解或分散 於作為載體之二醇類/水混合溶劑（丙二醇/水= 10/88.8(重里比））98 8重量份中，再將其收容於喷霧容 器中。 (2)喷務劑·使作為必需有效成分之噁蟲酮1重量份、 2為其他成分之乙酸丙二醇酯Μ重量份溶解或分散於 作為載體之乙醇89重量份中，再將其收容於喷霧容器中。 ^ :溶膠：使作為必需有效成分之。惡蟲酮1重量份、 他成分之乙酸丙二醇醋15重量份溶解或分散於 5〇重量广重量份中，加入作為喷射劑之二曱峻 伤，再將其填充於喷射容器中。 膠：使作為必需有效成分之爾橙 知、及作為其他成分之對 里1 或八私Μ ^、、 尨基本甲酸丁酯〇· 3重量份溶解 一刀政於作為载體之二醇類/ k、、g \γ 28 5/91 ΰ子類/水此合溶劑（乙醇/水二 — 量份，再將其填充於噴射容器中。 之 重量份、及作為其他成分之=需有效成分之偶氮 量份、乳酸辛醋19.5重量份溶解;㈣甲苯）〇.5重 量”，再將其容置於配設;?入於二為載體之燈心重 97114594 於，又入该溶液的位置處之具備 200904327 吸液芯及加熱裝置（例如電加熱裝置）之容器中。 (曰6)加熱蒸散用液劑：使作為必需有效成分之嗯蟲酮5 份、及作為其他成分之BHT〇. 5重量份、油酸〇·5重 置份、脂肪酸鋁5重量份、及醋酸丙二醇酯25重量份溶 解^作為載體之燈油64重量份中，或者在不使用擔體的 狀悲下（亦即’使用添加彳〇〇1重量％濃度的色素（綠色 202唬）作為添加原體之噁蟲酮），將其容置於具敎 置（例如電加熱裝置）之薄型板上。ο νη2 (IV) The above-mentioned specific nitrogen-containing compound is particularly selected from the group consisting of the insecticides represented by the structural formulae (I) to (IV), and pyrazole 11 in the above specific examples. It is preferred to use a group consisting of orange, azobenzene and azodiamine. In addition to the specific nitrogen-containing compound exemplified above, for example, one or two or more of the compounds exemplified below may be used as the active ingredient. That is, an imidazole-based compound (thiapendazole, iprodione, oxpoconazole fumarate, etc.), teflubenzuron, flubene may be used. Urea (flufenoxuron), hexaflulon 97114594 12 200904327 (hexaflumuron), chlorfluazuron, diflubenzuron, thiodicarb, benfuracarb, alanylcarb, furathiocarb , acetamipr id, f urametpyr, neonicotinoid compounds (imidacloprid, MTI-446, thiamethoxiam, etc.), methasone ), pyraclofos, cyromazine, ethiprole, tolfenpyrad, diacloden, fenproximate, indoxacarb, fipronil ), tebufenpyrad, pyridaben, pyrimidifen, cl〇fentezine, fluacrypyrim > molantale tartrate, benomyl, Triflumizole, prochloraz, pefrazoate, triadimefon, bitertanol, fenbuconazole, mycl〇butanil, phenanthrene Hexaconazole, tebuconazole, propiconazole, difenoconazole, ipconazole, imibenconazole, cyproconazole, tetraconazole, stone As an active ingredient, simeconazole, echlomezole, and cyazofamid are used. The dosage form of the dentate repellent of the present invention is not particularly limited as long as it is appropriately designed according to the physical properties of the compound 97112594 13 200904327 which is an active ingredient; for example, the above active ingredient may be dissolved or dispersed in a solvent (liquid carrier) The preparation is prepared by mixing the above active ingredient with a solid carrier to adsorb or impregnate it in a solid carrier. Of course, the above-mentioned effective ingredients can also be used alone to prepare a preparation. Specific examples of the dosage form applicable to the tooth repellent of the present day (4), such as a bovine spray, an aerosol sprayed with a propellant, a pump ng f_), a coating agent, a heating evapotranspiration or a supply air A gasket (sheet) agent, a tape agent, a honeycomb powder, a granule, etc., for volatilization or = fumigation. a substance as the above-mentioned solvent is generally an ether such as an alcohol, a glycol '·propyl, a methyl ethyl heart methane dioxane or the like; a hexane, a kerosene, a sulphur, and a sulphur, The aromatic hydrocarbons such as toluene; the aliphatic hydrocarbons of the acetic acid; the benzene and the solvent may be used singly or in combination of two or more.曰, 'light oil, etc. Such as the above solid carrier 'generally, for example, powder, turbid soil, clay, shixia soil, carbon _: shale, talc mineral or inorganic powder; wood powder, soybean powder: =, zeolite, etc. Vegetable powder; pulp, age resin, poly-tank, 夕 H powder, etc. azobisisobutyronitrile (miao), fiber or rubber powder;; olefin and other plastics; di-benzene, triisopropyl- S_trioxane, ring, brain, naphthalene, Chinese powder, etc. These solid carriers can be individually raised to the like. Further, the shape of the solid carrier may be two or more, and the gas may be used in combination. For example, the structure of the bee is simple, and the structure is 97Π4594, which is a bee-like shape, a mesh shape, a slit shape, a lattice shape or 14 200904327 The structure is provided with a paper such as a hole. In the following, a representative example of the rodent repellent of the present invention is given as a representative dosage form. (1) Spraying is carried out, and the weight of the carbazole compound as an essential active ingredient is 1 weight. The parts by weight were dissolved or dispersed in 98 8 parts by weight of a glycol/water mixed solvent (propylene glycol/water = 10/88.8 (heavy ratio)) as a carrier, and then contained in a spray container. (2) Spraying agent: 1 part by weight of oxycodone as an essential active ingredient, and 2 parts by weight of propylene glycol acetate as a component, dissolved or dispersed in 89 parts by weight of ethanol as a carrier, and then contained in a spray In the fog container. ^ : Sol: Made as an essential active ingredient. 1 part by weight of the insecticidal ketone and 15 parts by weight of the propylene glycol vinegar of the other component were dissolved or dispersed in 5 parts by weight of the weight portion, and the second emulsion as a propellant was added, and then filled in a spray container. Glue: dissolves as an essential active ingredient, and as a further component, 1 or 8 Μ, 尨 尨 尨 尨 尨 3 3 3 3 3 3 3 3 3 3 二醇 二醇 二醇 二醇 二醇 二醇, g \γ 28 5/91 scorpion / water this solvent (ethanol / water two - parts, and then filled in the spray container. The weight of the part, and as other ingredients = need active ingredients even Nitrogen content, 19.5 parts by weight of lactic acid octanoic acid dissolved; (4) toluene) 5.5 weight", and then placed in the arrangement; into the carrier of the second weight of 97114594, and into the solution at the position It has a container of 200904327 wick and heating device (such as electric heating device). (曰6) Liquid for heating and ebling: 5 parts of chlorfenapyr as an essential active ingredient, and BHT 作为 as other ingredients. 5 weight a portion, a bismuth oleate 5 reset portion, 5 parts by weight of fatty acid aluminum, and 25 parts by weight of propylene glycol acetate dissolved in 64 parts by weight of the kerosene as a carrier, or in the absence of a carrier (ie, 'use Adding a pigment of 1% by weight concentration (green 202唬) as an additive The metoxadiazone), which is housed in a thin plate having opposing objective for (e.g., an electrical heating device) of.
(υ加熱蒸散用墊片··使作為必需有效成分之〇比唑噚橙 2重量份、及作為其他成分< 黯（二丁基㈣甲苯）〇 5 重量份溶解於作為載體之二醇類/水混合溶劑（乙醇/水= 25/25(重量比））5〇重量份中，再將作為載體之紙聚塾片 浸潰於該溶財藉以含浸有效成分，_於常溫下自缺乾 燥，而獲得含有有效成分之塾片。此時，將所獲得塾片載 置於用加熱裝置(例如電加熱裝置)保持於高溫之板 此可將有效成分穩定地加熱蒸發。 ⑻加熱蒸散用顆粒劑：使作為必需有效成分之偶 1重量份、及作為其他成分之十二酸己醋5重量份溶解於 乙醇94重量份中，再將該溶液嘴霧至作為載體之 異丁腈OUM)上藉以含浸有效成分，然後於常溫下自⑼ ^ ’而獲得含有有效成分之顆粒。此時，將所獲得顆 置於用峨置(例如電加熱裝置)保持於高溫之板上， 此可將有效成分穩定地加熱蒸發。 (9)送風式揮發料巢狀劑：使作為必需有效成分之伯 97114594 16 200904327 ^苯5重量份、及作為其他成分之十二酸己酯25重量份 ^解π於乙醇7〇重量份中，再將作為載體之蜂巢狀成形體 • ^材質：紙）浸潰於該溶液中藉以含浸有效成分，然後於常 -μ下自然乾燥，而獲得含有有效成分之蜂巢狀體。此時， Ϊ ^用由驅動馬達驅動的送風裝置（風扇等）而產生之氣 人向所獲得蜂巢狀體，藉此可使有效成分穩定地揮發。 酮式揮發用顆粒劑：使作為必需有效成分之喔蟲 …、和 里刀及作為其他成分之乙酸丙二醇酯30重量份 於乙_ 25重量份中’再將該溶液喷霧至作為載體之 二=上藉，含浸有效成分，職於常溫下自純燥，而 2 3有有效成分之紙漿粒（顆粒）。此時，將利用由驅動 二將動的送風叙置（風扇等）而產生之氣流吹向所獲得 立(顆粒），藉此可使有效成分穩定地揮發。 =煙燻用顆粒劑：將作為必需有效成分之。比唾。弄撥 及蘇Γ ^與作為其他成分之偶氮二甲酿胺87.5重量份 二=基纖維素2 5重量份進行混合水練，成 溫下自㈣燥，而獲得含有有效成分之顆 地揮將所得顆粒進行煙燦，藉此可使有效成分穩定 本發明嚅齒類忌避劑中 -定含氮化合物）之含量H有之上述有效成分（上述特 •定即可，並無特別限制。:/Γ劑的劑型等而適當碟 或溶液狀態之劑型二^ 送風式揮發用或煙燻用液劑月，佈:卜加熱条散用、 文月j專）之情形時，若含有0. 1〜 97114594 200904327 40重量％、較佳為1〜Μ重量％之有效成分即可；於製成 氣溶膠或泵劑之劑型之情形時，若含有〇1〜2〇重量％、 較佳為0.5〜1〇重量％之有效成分即可；於 成固體狀態之劑型（例如，加熱蒸散用、送風式揮^用^ 煙燻用等之塾片（薄片）劑、膠帶劑、蜂巢 粒劑等）之情形日寺，若含有〇.〇1〜4〇重量 ^ 〜20重量％之有效成分即可。 馬. 為了製成所需之劑型，相愛盈可机士 視需要了於本發明之嚅齒類忌避 劑中調配入塗膜形成劑、乳化劑、分散劑 劑、穩定化劑、喷射劑等之添加劑。至於該等添加劑:例 如可调配入乙基纖維素、經基丙基纖維素、石夕酉同、丙稀酸 _、:氮化橡膠、石油樹脂、甲基纖維素、醋酸乙烯醋' 聚乙烯醉、乳膠液等之塗膜形成劑；脂肪族單缓酸趟 鏈烷基苯磺酸鹽、烷基硫酸鹽、山梨醇酐脂肪酸酯、聚氧 乙烯烧基_、聚乙二醇脂肪酸醋、脂肪酸烧醇酿胺等之界 面活性劑；赂蛋白、明膠、海藻酸、羧基甲基纖維素、液 =油軋、二甲醚、氟碳、壓縮氣體等。又，例如於將劑 里衣成煙燒劑之情形時，發熱物質（硝基脈、硝化纖維素 等）、促進燃燒之氧化劑(過氯酸鹽、氯酸鹽、次氯酸鹽 等）凋正煙燻劑燃燒之燃燒調整劑（碳粉、澱粉、糖類、 纖維素等）等作為添加劑。該等添加劑，可單獨使用，、 可併用2種以上。 本叙明之嚅齒類忌避劑中，視需要可進一步含有嚅 防除劑、殺蟲劑、腹足類防除劑、害蟲忌避劑、殺菌制、 97114594 18 200904327 防黴劑、香料、抗氧化劑、撥水/撥油劑等。例如，可含 有··華法令（warfarin)等之嚙齒類防除劑；除蟲菊 ^pyrethroid)系殺蟲劑、胺基甲酸酯系殺蟲劑、有機磷系 =蟲劑、氟系殺蟲劑、昆蟲成長控制劑等之殺蟲劑；& 二乙基-間苯乙醯胺、鄰苯二子酸二甲酯、醯胺基胺等之 害蟲忌:避劑’·四聚乙醛(ffletaldehyde)等之腹足類防除 氯 3,5 一甲苯酚（para_chl〇r〇ietha 殺菌劑；丁基經基苯w、二丁絲基？苯、生育j = :、：H("rizanol)等之抗氧化劑；檸檬系、玫瑰 南i等I撥尺/撥之山各種香料’· €、油脂、金屬卷、氟系撥油 d 4之撥水/撥油劑等中的！種或2種以上。 本發明之忌避方法，俜佶 者。在使用該方法時，在:齒類忌避劑 所或侵入舍幻曰# 求 避之屬齒類的生存場 所Μ入食害％所，例如農作物 田、果樹園、花卉箄味4沾—产 飞裁。辰作物的小塊 — 等生長的化壇、植木銖及 、一 豕庭或食堂等的廚房、洗面處、陽么^圍一般 或煙燒等裝置使=1二熱蒸散或送風式揮發 有效成分或者含有其之紙、 而、’:可以另外途徑將 網等設置於上述場所或農作物、==、金屬線、棚、 本發明之忌避方法中所使用之 使用量，若根㈣齒類忌避財的有效成ϋ忌避劑之 的劑型或使用方法、使用場所等作適4=置、忌避劑 別限制，但通常若將每 =確疋印可，並無特 97114594 m使用場所之有效成分量為 19 200904327 1 20 g、較佳為3〜ίο g左右的量作為標準即可。 於=¾明中，作為忌避對象之餐齒類並無特別限定，例 士可牛出老既、兎、鹿、鼬鼠、臭鼬等嚅齒類。 (實施例） 、 利用貝把例具體說明本發明，但本發明並不限定 於該等實施例。 (實施例1) 將偶氮,曱醯胺88重量份與噁蟲酮(3-(2-曱氧基苯 土）T氧基1，3,4-崎二唾_2 —g同）i2重量份之g混 練物作為有效成分，向其中添加2gM基丙基纖維素，再 加入水進行練合，成形為顆粒狀，而獲得忌避劑。 (實施例2) 除將1.0 g噁蟲酮（3_(2_甲氧基苯基）_5_曱氧基 -1，3’4-哼二唑_2__)作為有效成分以外，其餘以與實施 例1同樣之方式’獲得顆粒狀 之忌避劑。 (實施例3) 除將0.3 g吡唑噚橙作為有效成分以外，其餘以與實施 例1同樣之方式，獲得顆粒狀之忌避劑。 (實施例4) 除將0.3 g偶氮笨作為有效成分以外，其餘以與實施例 1同樣之方式’獲得顆粒狀之忌避劑。 (實施例5) 除將1 〇 g偶氮二曱醯胺作為有效成分以外，其餘以與 實施例1同樣之方式，獲得顆粒狀之忌避劑。 97114594 20 200904327 (比較例1) 將以百滅寧（Permethr iη)為有效成分且利用水使其發 熱之市售煙燻式忌避劑作為比較用忌避劑。 -藉由下述試驗來評價以上實施例丨〜5及比較例丨中所 獲得忌避劑之忌避效力。 〈忌避效力試驗〉 使用以如下方式而形成之嚅齒類忌避試驗裝置進行忌 避效力試驗：將暗室即Α室（高度i mx寬度】似深度 m)與以300 W照明進行照射的明室即B室（高度〇2似寬 度0. 23 mx深度〇. 38m)用導管（内徑7 cm、長度5〇⑽） 相連接，使小白鼠可在兩室間自由地往復。 預先確遇於上述嚷齒類忌避試驗裝置中，小白鼠採取如 下的行動。即，在通常情況下，小白鼠因具有忌避光的性 貝而不進入B室，但當在a室中受到忌避劑的刺激時，則 會進入⑽動）到B室側。但是，在A室中受到忌避劑的刺 激而向6至移動之小白鼠，因忌避B室中的光，通常會在 片刻後再次向A室移動。 庐】中_系小白鼠(雄)放置於上述嚙齒類忌避 ;起至”使用各忌避劑。然後’自開始使用忌避 β室之總計進人缝室之進出，測定向 人數（亦即，進入Β室後返回至Α宮的小 白鼠再次向Β室移動之情形，亦同樣計為二至： 次進…B室滞留時間(自進入，室：直=)、及1 之％間）。將各滞留時間之進入β室的次數集令示於表！。 97114594 21 200904327 再者，在使用忌避劑時，於鲁心7 r 1 愔报+ 於實施例1、5及比較例1之 障$進仃煙燻，於該等以外 卜丄也 于乂外之情形則於加熱至450〇C之板 上進仃加熱而使其揮發。 [表1](υ υ υ υ υ υ υ υ υ υ υ υ υ υ υ υ υ υ υ 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 / water mixed solvent (ethanol / water = 25 / 25 (weight ratio)) 5 parts by weight, and then used as a carrier paper, the tablet is impregnated with the solution to impregnate the active ingredient, _ dry at room temperature The ruthenium sheet containing the active ingredient is obtained. At this time, the obtained ruthenium sheet is placed on a plate maintained at a high temperature by a heating device (for example, an electric heating device), whereby the active ingredient can be stably heated and evaporated. (8) Heating evapotranspiration particles Agent: Dissolve 1 part by weight of the essential active ingredient and 5 parts by weight of other components of dodecanoic hexanoic acid in 94 parts by weight of ethanol, and then spray the solution onto the isobutyronitrile OUM as a carrier. By impregnating the active ingredient, the particles containing the active ingredient are obtained from (9) ^ ' at room temperature. At this time, the obtained particles are placed on a plate maintained at a high temperature by means of a crucible (e.g., an electric heating device), whereby the active ingredient is stably heated and evaporated. (9) Air-type volatile material nesting agent: 5 parts by weight of benzene as a necessary active ingredient, and 5 parts by weight of hexyl hexanoate as other components, and π in an amount of 7 parts by weight of ethanol Then, the honeycomb shaped body as a carrier, ^ material: paper, is impregnated in the solution to impregnate the active ingredient, and then naturally dried under normal-μ to obtain a honeycomb body containing the active ingredient. At this time, the honeycomb body obtained by the air blower (fan or the like) driven by the drive motor is used to obtain the honeycomb body, whereby the active ingredient can be stably volatilized. Granules for ketone volatilization: 30 parts by weight of acetaminophen as a necessary active ingredient, and lining of propylene glycol and other components as a component, and then spraying the solution to the carrier 2 = borrowed, impregnated with active ingredients, working at room temperature from pure dry, and 23 with active ingredients of pulp particles (granules). At this time, the airflow generated by the air supply (fan or the like) that is driven by the drive 2 is blown toward the obtained particles (particles), whereby the active component can be stably volatilized. = granules for smoking: will be used as an essential active ingredient. More than saliva. And Γ Γ 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 与 8 与 与 与 与 与The obtained granules are smouldering, whereby the active ingredient can be stabilized by the content of the nitric acid compound in the dentate repellent of the present invention, and the above-mentioned effective ingredient is present (the above-mentioned special composition is not particularly limited. The dosage form of the sputum agent, etc., and the dosage form of the appropriate dish or solution state, the air supply type, or the smog liquid, the liquid, the cloth, the heating element, the 97114594 200904327 40% by weight, preferably 1% by weight to 5% by weight of the active ingredient; in the case of a dosage form for making an aerosol or a pump, if it contains 〜1~2〇% by weight, preferably 0.5~1 5% by weight of the active ingredient; in the form of a solid state (for example, for heating and transpiration, air supply type, smear, etc., smear (slice), tape, honeycomb granules, etc.) Japanese temple, if it contains 〇.〇1~4〇 weight ^~20% by weight of active ingredient Can. In order to prepare the desired dosage form, Aiyu Yingkeji is required to be formulated into a coating film forming agent, an emulsifier, a dispersing agent, a stabilizer, a propellant, etc. in the caries-type repellent of the present invention. additive. As for the additives: for example, it can be blended with ethyl cellulose, propyl propyl cellulose, lycopene, acrylic acid, nitriding rubber, petroleum resin, methyl cellulose, vinyl acetate vinegar Coating agent for drunkenness, latex solution, etc.; aliphatic monosodium sulfonate alkyl benzene sulfonate, alkyl sulfate, sorbitan fatty acid ester, polyoxyethylene alkyl _, polyethylene glycol fatty acid vinegar , surfactants such as fatty acid calcined amine; brix protein, gelatin, alginic acid, carboxymethyl cellulose, liquid = oil rolling, dimethyl ether, fluorocarbon, compressed gas, and the like. Further, for example, when the agent is made into a smoked agent, the heat generating substance (nitrocellulose, nitrocellulose, etc.) and the oxidizing agent (perchlorate, chlorate, hypochlorite, etc.) which promote combustion are withered. A combustion modifier (carbon powder, starch, sugar, cellulose, etc.) that burns a positive fuming agent is used as an additive. These additives may be used singly or in combination of two or more. The caries-type repellents described in the present invention may further contain a cockroach control agent, an insecticide, a gastropod control agent, a pest repellent, and a bactericidal system, as required, 97114594 18 200904327 anti-mold agent, perfume, antioxidant, water/dial Oil and so on. For example, it may contain a rodent control agent such as warfarin; pyrethrum pyrythroid is an insecticide, a urethane-based insecticide, an organophosphorus-based insecticide, or a fluorine-based insecticide. Insecticides such as agents and insect growth control agents; & pests such as diethyl-m-phenylethylamine, dimethyl phthalate, guanamine, etc.: avoidant'·tetraacetaldehyde ( Ffletaldehyde) and other gastropods for the prevention of chlorine 3,5-cresol (para_chl〇r〇ietha fungicide; butyl-based benzene w, dibutyl-based benzene, fertility j = :, :H ("rizanol), etc. Antioxidant; lemon system, rose south i, etc. I dialing / dialing the mountain various spices '· €, grease, metal coils, fluorine-based oil d 4 water / oiling agent, etc.! In the method of repelling the present invention, when the method is used, in the survival place of the tooth type, such as the crop field or the fruit tree, in the living place where the teeth are invaded or invaded. Garden, flower smell 4 dip - production fly cut. Small pieces of Chen crop - such as growing altar, planting wood and kitchen, washing room, canteen, wash At the place, the yang, the circumstance, or the smouldering, etc., so that the 1-2 escaping or air-steaming active ingredient or the paper containing the same, and ': another way, the net or the like can be placed in the above-mentioned place or crop, ==, The amount of use of the metal wire, the shed, and the repellent method of the present invention is limited to the dosage form, the method of use, the place of use, etc. of the root (4) tooth repellent. However, if the amount of the effective ingredient of the 97114594 m use place is 19 200904327 1 20 g, preferably about 3 to ίο g, the amount of the active ingredient is usually as standard. In the =3⁄4 明, The tooth form of the tooth to be repelled is not particularly limited, and the case may be a cow, a scorpion, a deer, a squirrel, a skunk, or the like. (Example) The present invention will be specifically described using a shell example. The invention is not limited to the examples. (Example 1) 88 parts by weight of azo, decylamine and trimethoprim (3-(2-decyloxyphenyl) T-oxy 1,3,4- 2 g parts by weight of the i2 part by weight of the kneaded material as an active ingredient, and 2 g of M-propylcellulose was added thereto. Water was added for blending, and it was shaped into granules to obtain a repellent. (Example 2) In addition to 1.0 g of triammonal (3_(2-methoxyphenyl)_5_decyloxy-1,3'4 In the same manner as in Example 1, except that the oxadiazole-2__) was used as an active ingredient, a granular repellent was obtained. (Example 3) Except that 0.3 g of pyrazole orange was used as an active ingredient, In the same manner as in Example 1, a particulate repellent was obtained. (Example 4) A granular repellent was obtained in the same manner as in Example 1 except that 0.3 g of azobenzene was used as an active ingredient. (Example 5) A particulate repellent was obtained in the same manner as in Example 1 except that 1 〇 g azodiamine was used as an active ingredient. 97114594 20 200904327 (Comparative Example 1) A commercially available smokable repellent containing Permethrium as an active ingredient and heated by water was used as a comparative repellent. - The repellent effect of the repellents obtained in the above Examples 丨 to 5 and Comparative Examples was evaluated by the following test. <Repellent effect test> The repellent effect test was performed using a caries-type repelling test device formed as follows: a dark room, that is, a diverticulum (h i mx width) like a depth m), and a bright room that is irradiated with 300 W illumination, that is, B The chamber (height 似 2 like width 0. 23 mx depth 〇. 38 m) is connected by a catheter (inner diameter 7 cm, length 5 〇 (10)) so that the mouse can freely reciprocate between the two chambers. In the above-mentioned dental caries repellent test device, the mouse took the following action. That is, under normal circumstances, the mouse does not enter the B room because of the repellent sex, but when it is stimulated by the repellent in the a chamber, it enters the (10) movement to the B chamber side. However, in the room A, the stimuli of the repellent are moved to the moving mouse 6 to avoid moving the light in the room B, and usually move to the room A again after a while.庐 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中 中After the diverticulum returns to the palace, the mouse is moved to the diverticulum again, which is also counted as two to: sub-into...B room retention time (from entry, room: straight =), and 1%). The order of the number of times of entering the β chamber for each residence time is shown in the table! 97114594 21 200904327 Furthermore, when the repellent is used, it is reported in Lu Xin 7 r 1 + in the obstacles of Examples 1, 5 and Comparative Example 1 Into the smoke, in the case of other than the other, the heat is heated to 450 ° C on the plate to heat and volatilize. [Table 1]
(實施例6) 將噁蟲酮(3-(2-曱氧基苯基)_5_甲氧基^,3,4一等二唑 2「酉同）〇.4 g溶解於50 mL乙醇中，將小白鼠用固體飼料 小白鼠、大白鼠、倉鼠用CE2」Cleajapan製造）浸漬 於所獲得溶液中60分鐘藉以充分含浸作為有效成分之噁 蟲酮’然後於40 C下乾燥1 〇分鐘，而獲得含有忌避劑之 固體飼料。 i (實施例7) 除將°惡轰_之量自0.4 g變更為2.0 ga外，其餘以與 實施例6同樣之方式，獲得含有忌避劑之固體飼料。 使用以上實施例6及7中所獲得之固體飼料’藉由下述 試驗來評價攝食忌避效果。 〈攝食忌避試驗〉 5又置與小白鼠飼育用籠内為相同環境條件之藥劑區與 對照區，以與實施例6相同的條件（浸潰時間、乾燥溫度、 97114594 22 200904327 ί燥時間），於藥劑區將實施例中所獲得固體飼料浸潰於 早獨的乙醇溶液中，於對照區將上述實施例6中所使用的 小白鼠用固體飼料浸潰於單獨的乙醇溶液中，再進行乾燥 而獲侍固體飼料(無毒餌），將各固體飼料约⑼忌進行精 確秤量，併置（將此時之重量作為初期重量，於該籠 :士使小白鼠每當想要飲水時即可攝取水。在此種狀態的 :中’放置4隻7週齢之小白鼠(雄），於15小時後回收 時後重量)。‘，、八：將此時之重量作為15小 舌旦曰…臭刀別异出樂劑區及對照區中偏離初期 m里ϋ夏分作為攝食量’基於下述式求出攝食忌避率 二 驗係…進行，使用平均重量之值。 食量率（％)~ 1GG —[(藥劑區之攝食量/對照區之攝 [表2 ] 初期重量 (gl 15小時後重量 __(g) 攝食量 攝食忌避率 (g) (%) 6. 03 58. 61 14. 57 2. 50 87. 32 19. 71 一藥劑區 藥劑區 20.^08 jM6~ "2M0 14. 05(Example 6) The insecticidal ketone (3-(2-decyloxyphenyl)-5-methoxy^,3,4-isodazole 2" 酉.4 g was dissolved in 50 mL of ethanol. The mice were immersed in the obtained solution with solid feed mice, rats, and hamsters (manufactured by CE2" Cleajapan) for 60 minutes to sufficiently impregnate the asparagus ketone as an active ingredient, and then dried at 40 C for 1 minute, and A solid feed containing a repellent is obtained. i (Example 7) A solid feed containing a repellent was obtained in the same manner as in Example 6 except that the amount of sulphur was changed from 0.4 g to 2.0 ga. The food repellent effect was evaluated by the following test using the solid feed obtained in the above Examples 6 and 7. <Ingestion Repellent Test> 5 The drug area and the control area which are the same environmental conditions in the cage for the breeding of the white rats are set to the same conditions as in Example 6 (impregnation time, drying temperature, 97114594 22 200904327 ί dry time), The solid feed obtained in the example was immersed in the early ethanol solution in the pharmaceutical area, and the mouse used in the above Example 6 was immersed in a separate ethanol solution in a control solution, and then dried. The solid feed (non-toxic bait) is obtained, and each solid feed is about to be accurately weighed and juxtaposed (the weight at this time is used as the initial weight, in the cage: the cow can take water whenever he wants to drink water) In this state: '4 weeks of white rats (male) were placed, and the weight was recovered after 15 hours). ',, eight: the weight of this time as 15 small tongues 曰 臭 臭 别 别 别 别 别 别 及 及 及 及 及 及 及 及 及 及 及 及 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离 偏离Performed by... using the average weight value. Food consumption rate (%) ~ 1GG - [(Food intake in the drug area / control area [Table 2] Initial weight (g 15 hours after weight __ (g) food intake repellent rate (g) (%) 6. 03 58. 61 14. 57 2. 50 87. 32 19. 71 Pharmacy area of a pharmacy area 20.^08 jM6~ "2M0 14. 05
實施例6 (有效成分0. 4 g) 實施例， (有效成分2.0 g) 其效果係濃度依賴性 (實施例8) 基/Η量份與 為有效成分，向其中添酮）2〇重量份之混練物作 〃、工基丙基纖維素3重量份，加入 97114594 23 200904327 水進行練合’成形為顆粒狀，而獲得忌避劑。 除使用暗室即A室的大小不同之嚆齒類忌避試驗裝置 以外’其餘藉由與實施例1〜5同樣的忌避效力試驗，來 s平價上述所得忌避劑及比較例1之忌避劑之忌避效力。亦 即’此處所使用之嚅齒類忌避試驗裝置係以如下方式而形 成之裝置··將暗室即A室（高度2.4 mx寬度3.6 mx深度 2,7 m)與以3〇〇 W照明進行照射之明室即B室（高度〇 2爪 X寬度0. 23 mx深度〇. 38 m)用導管（内徑7 cm、長度50 cm) 相連接，且小白鼠可自由地在兩室間往復。在使用忌避劑 時，使用加熱煙燻裝置使1〇 g忌避劑蒸發。結果示於表 以上 分鐘 3分鐘以上 合計 4 48 1 [表3 ] 按滯留時間之谁入 未滿1分鐘 h ·-_ _ —— 1分鐘以上 未滿2分鐘 2分查 未滿 實施例8 Γ --ψ- .^哎剛及便用該忍避劑，之嚅 類忌避方法進行詳細說明 _ ^ ^ 仁本發明之範圍並不侷限於 该#說明，在不損及本發明之I t ώ 之要曰之範圍内可作適當改變 或改良。 97114594 24Example 6 (Active ingredient: 0.4 g) Example, (Active ingredient: 2.0 g) The effect is concentration-dependent (Example 8) The base/twist amount and the active ingredient, and the ketone is added thereto) 2 parts by weight The kneaded material was used as hydrazine and 3 parts by weight of propyl propyl cellulose, and was added to 97,214, 594, 23, 2009, 427, and water to form a granule, and a repellent was obtained. The repellent efficacy test of the above-mentioned repellent and the repellent of Comparative Example 1 was performed by using the same repellent efficacy test as in Examples 1 to 5 except that the dark room, that is, the caries-type repelling test device having the same size of the A-chamber, was used. . That is, the caries-type repelling test device used here is a device formed as follows: • A chamber (a height of 2.4 mx, a width of 3.6 mx, a depth of 2,7 m) and a 3 〇〇W illumination are irradiated in a dark room. The chamber B (height 〇 2 claw X width 0. 23 mx depth 〇. 38 m) is connected by a catheter (inner diameter 7 cm, length 50 cm), and the mouse is free to reciprocate between the two chambers. When using a repellent, a heating fuming device is used to evaporate the 1〇g repellent. The results are shown in the table above 3 minutes or more for a total of 4 48 1 [Table 3] According to the retention time who entered less than 1 minute h ·-_ _ —— 1 minute or more less than 2 minutes 2 points check not full Example 8 Γ - ψ - . 哎 哎 及 及 该 该 该 该 该 忍 忍 忍 忍 忍 忍 忍 忍 忍 忍 忍 _ _ _ 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本Appropriate changes or improvements can be made within the scope of the key points. 97114594 24
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| CN109892333A (en) * | 2017-12-08 | 2019-06-18 | 宁波三江益农化学有限公司 | Application, bird repellent agent prescription and dosage form of the zinc dibutyl dithiocarbamate as bird repellent |
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| JP6068712B2 (en) * | 2015-06-18 | 2017-01-25 | アース製薬株式会社 | Disinfectant |
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| JPS5534016A (en) * | 1978-08-28 | 1980-03-10 | Earth Chemical Co | Repeling of rodent animal and pests |
| JP2004196684A (en) * | 2002-12-17 | 2004-07-15 | Ebara Corp | Animal repellent |
| JP2006096686A (en) * | 2004-09-28 | 2006-04-13 | Kazuyoshi Hoshino | Small animal-repelling agent |
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