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TW200730495A - Process for producing 2-oxindole compound - Google Patents

Process for producing 2-oxindole compound

Info

Publication number
TW200730495A
TW200730495A TW095147843A TW95147843A TW200730495A TW 200730495 A TW200730495 A TW 200730495A TW 095147843 A TW095147843 A TW 095147843A TW 95147843 A TW95147843 A TW 95147843A TW 200730495 A TW200730495 A TW 200730495A
Authority
TW
Taiwan
Prior art keywords
group
oxindole compound
general formula
compound represented
producing
Prior art date
Application number
TW095147843A
Other languages
Chinese (zh)
Inventor
Shigeyoshi Nishino
Kenji Hirotsu
Takeshi Takahashi
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of TW200730495A publication Critical patent/TW200730495A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to a process for producing 2-oxindole compound, characterized by reacting an isatin compound represented by the following general formula (1): (wherein, R represents a group selected from the group consisting of hydrocarbon group, alkoxy group, aryl group, aryloxy group, arylalkoxy group, halogen atom, amino group and nitro group, each of which may be substituted; and n represents an integer of 0 to 4) with hydrazine to give 3-hydrazono-2-oxindole compound represented by the general formula (2): (wherein, R and n have the same meanings as described above) or isosters thereof, and then reacting this with an organic base to produce 2-oxindole compound represented by the general formula (3): (wherein, R and n have the same meanings as described above).
TW095147843A 2005-12-20 2006-12-20 Process for producing 2-oxindole compound TW200730495A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005365718 2005-12-20

Publications (1)

Publication Number Publication Date
TW200730495A true TW200730495A (en) 2007-08-16

Family

ID=38188618

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095147843A TW200730495A (en) 2005-12-20 2006-12-20 Process for producing 2-oxindole compound

Country Status (3)

Country Link
JP (1) JP5119927B2 (en)
TW (1) TW200730495A (en)
WO (1) WO2007072841A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106854173A (en) * 2016-12-23 2017-06-16 山东轩德医药科技有限公司 A kind of preparation method of the carboxylate methyl ester of 2 carbonyl indolone 6

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115304536B (en) * 2022-07-26 2023-09-22 合肥工业大学 Preparation and application of indoline-2-one compound derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196610A (en) * 1993-12-28 1995-08-01 Kuraray Co Ltd Production of 5-chloro-2-oxyindole
TW550257B (en) * 1999-01-16 2003-09-01 Sinon Corp A process for preparing 2-oxindole
US5973165A (en) * 1999-03-17 1999-10-26 Sinon Corporation Process for preparing 2-oxindole
AT408223B (en) * 1999-12-27 2001-09-25 Dsm Fine Chem Austria Gmbh METHOD FOR THE PRODUCTION OF OXINDOLS
JP4078328B2 (en) * 2004-03-31 2008-04-23 大日本印刷株式会社 Method for producing 2-oxindole derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106854173A (en) * 2016-12-23 2017-06-16 山东轩德医药科技有限公司 A kind of preparation method of the carboxylate methyl ester of 2 carbonyl indolone 6

Also Published As

Publication number Publication date
JPWO2007072841A1 (en) 2009-05-28
WO2007072841A1 (en) 2007-06-28
JP5119927B2 (en) 2013-01-16

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