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TR201907147T4 - Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. - Google Patents

Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. Download PDF

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Publication number
TR201907147T4
TR201907147T4 TR2019/07147T TR201907147T TR201907147T4 TR 201907147 T4 TR201907147 T4 TR 201907147T4 TR 2019/07147 T TR2019/07147 T TR 2019/07147T TR 201907147 T TR201907147 T TR 201907147T TR 201907147 T4 TR201907147 T4 TR 201907147T4
Authority
TR
Turkey
Prior art keywords
fgfr inhibitor
tumor drug
intermittent administration
present
salt
Prior art date
Application number
TR2019/07147T
Other languages
English (en)
Inventor
Ochiiwa Hiroaki
Hirai Hiroshi
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of TR201907147T4 publication Critical patent/TR201907147T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut buluş aracılığıyla çözülecek problem, FGFR inhibitörünün antitümör etkisi muhafaza edilirken yüksek kan fosfor seviyeleri gibi azaltılmış yan etkilere sahip olan güçlü ve yüksek derecede seçici yeni bir FGFR inhibitörü ve bir antitümör ajan sağlamaktır. Mevcut buluş, Formül (I) ile temsil edilen bir 3,5-disübstitüe benzen alkinil bileşiğini veya kullanılan bir tuzunu içeren bir antitümör ajanı sağlar böylece 3,5-disübstitüe benzen alkinil bileşiği veya bunun bir tuzu, haftada en az iki kere ve en az bir günlük bir dozlama aralığı olmak üzere bir uygulama programıyla uygulanır.
TR2019/07147T 2013-07-18 2014-07-17 Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. TR201907147T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013149963 2013-07-18

Publications (1)

Publication Number Publication Date
TR201907147T4 true TR201907147T4 (tr) 2019-06-21

Family

ID=52346281

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/07147T TR201907147T4 (tr) 2013-07-18 2014-07-17 Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç.

Country Status (14)

Country Link
US (2) US20160193210A1 (tr)
EP (1) EP3023100B1 (tr)
JP (1) JP6084291B2 (tr)
KR (1) KR101974254B1 (tr)
AU (1) AU2014291161B2 (tr)
DK (1) DK3023100T3 (tr)
ES (1) ES2724929T3 (tr)
HU (1) HUE044273T2 (tr)
PL (1) PL3023100T3 (tr)
PT (1) PT3023100T (tr)
RU (1) RU2664118C2 (tr)
TR (1) TR201907147T4 (tr)
TW (1) TWI574691B (tr)
WO (1) WO2015008839A1 (tr)

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Also Published As

Publication number Publication date
RU2016105133A3 (tr) 2018-02-28
US20190183897A1 (en) 2019-06-20
EP3023100B1 (en) 2019-03-13
KR101974254B1 (ko) 2019-04-30
PT3023100T (pt) 2019-05-29
KR20160032186A (ko) 2016-03-23
ES2724929T3 (es) 2019-09-17
US20160193210A1 (en) 2016-07-07
TWI574691B (zh) 2017-03-21
DK3023100T3 (da) 2019-05-27
RU2016105133A (ru) 2017-08-23
US10894048B2 (en) 2021-01-19
JP6084291B2 (ja) 2017-02-22
JPWO2015008839A1 (ja) 2017-03-02
PL3023100T3 (pl) 2019-07-31
RU2664118C2 (ru) 2018-08-15
AU2014291161A1 (en) 2016-02-25
EP3023100A1 (en) 2016-05-25
AU2014291161B2 (en) 2018-04-26
HUE044273T2 (hu) 2019-10-28
WO2015008839A1 (ja) 2015-01-22
EP3023100A4 (en) 2017-01-04
TW201536294A (zh) 2015-10-01

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