TR200102779T2 - Antikor ve kemokin yapìlarìnìn oto baĞìçìklìk hastalìklarìnìn tedavisinde kullanìmì - Google Patents
Antikor ve kemokin yapìlarìnìn oto baĞìçìklìk hastalìklarìnìn tedavisinde kullanìmìInfo
- Publication number
- TR200102779T2 TR200102779T2 TR2001/02779T TR200102779T TR200102779T2 TR 200102779 T2 TR200102779 T2 TR 200102779T2 TR 2001/02779 T TR2001/02779 T TR 2001/02779T TR 200102779 T TR200102779 T TR 200102779T TR 200102779 T2 TR200102779 T2 TR 200102779T2
- Authority
- TR
- Turkey
- Prior art keywords
- treatment
- chemokine
- structures
- antibody
- diseases
- Prior art date
Links
- 102000019034 Chemokines Human genes 0.000 title abstract 4
- 108010012236 Chemokines Proteins 0.000 title abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 102000009410 Chemokine receptor Human genes 0.000 abstract 3
- 108050000299 Chemokine receptor Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 abstract 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 abstract 2
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mevcut buluç, kemokin al c lar na karç eksprime eden hücrelere, özellikle de kemokin al c s CCR5' e karç eksprime eden monozit/makrofajlar ve CCR5+ T hücrelerine karç olan antikor ve kemokin yap lar yla ilgilidir. Öte yandan bu buluç öz baG ç kl k hastal klar n n ve alerjik hastal klar n tedavisi, özellikle de kronik olarak iltihaplanan eklem hastal klar n n tedavisine yönelik olarak antikor ve kemokin yap lar n n, kemokin al c lar na karç eksprime eden hücrelerin imhas nda kullan lmas yla ilgilidir. Buluçun anlay ç ndaki antikor ve kemokin yap lar sayesinde kemokin al c lar na karç eksprime eden hücrelerin seçici bir çekilde de azalt lmas mümkün olduGu için öz baG ç kl k hastal klar nda baG ç kl k sistemini bask layan bir tedavi mümkün olmaktad r.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19910891 | 1999-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200102779T2 true TR200102779T2 (tr) | 2002-03-21 |
Family
ID=7900625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/02779T TR200102779T2 (tr) | 1999-03-11 | 2000-03-10 | Antikor ve kemokin yapìlarìnìn oto baĞìçìklìk hastalìklarìnìn tedavisinde kullanìmì |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1161456B1 (tr) |
| JP (1) | JP2002540771A (tr) |
| CN (1) | CN1345336A (tr) |
| AT (1) | ATE286074T1 (tr) |
| AU (1) | AU4104700A (tr) |
| CA (1) | CA2366713A1 (tr) |
| CZ (1) | CZ20013270A3 (tr) |
| DE (1) | DE50009113D1 (tr) |
| ES (1) | ES2233359T3 (tr) |
| HU (1) | HUP0200484A2 (tr) |
| IL (1) | IL145335A0 (tr) |
| NO (1) | NO316916B1 (tr) |
| SK (1) | SK12782001A3 (tr) |
| TR (1) | TR200102779T2 (tr) |
| WO (1) | WO2000053633A2 (tr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528625B1 (en) | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| EP1317284A2 (en) * | 2000-09-08 | 2003-06-11 | Micromet AG | Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders |
| DE60203324T2 (de) * | 2001-12-21 | 2006-04-06 | Micromet Ag | Einzelne und duale anti-cd4-rantes chemokin/zytokin konstrukte |
| TW200720289A (en) | 2005-04-01 | 2007-06-01 | Hoffmann La Roche | Antibodies against CCR5 and uses thereof |
| KR101105610B1 (ko) | 2006-08-17 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | Ｃｃｒ５ 에 대한 항체 및 항푸소제닉 펩타이드의 컨쥬게이트 |
| TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| EP2074147B1 (en) | 2006-09-29 | 2012-03-21 | F. Hoffmann-La Roche AG | Antibodies against ccr5 and uses thereof |
| CL2008000707A1 (es) | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion. |
| AR084053A1 (es) | 2010-11-30 | 2013-04-17 | Chugai Pharmaceutical Co Ltd | Agente terapeutico que induce citotoxicidad |
| WO2013024022A1 (en) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| ES2900898T3 (es) | 2014-04-07 | 2022-03-18 | Chugai Pharmaceutical Co Ltd | Anticuerpos biespecíficos inmunoactivadores |
| AU2015260230A1 (en) | 2014-05-13 | 2016-11-17 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| JP6931329B2 (ja) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法 |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428788B1 (en) * | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| US6528625B1 (en) * | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| ZA985542B (en) * | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
| WO2000004926A2 (en) * | 1998-07-22 | 2000-02-03 | Osprey Pharmaceuticals Limited | Conjugates for treating inflammatory disorders and associated tissue damage |
-
2000
- 2000-03-10 TR TR2001/02779T patent/TR200102779T2/tr unknown
- 2000-03-10 DE DE50009113T patent/DE50009113D1/de not_active Expired - Fee Related
- 2000-03-10 AU AU41047/00A patent/AU4104700A/en not_active Abandoned
- 2000-03-10 CA CA002366713A patent/CA2366713A1/en not_active Abandoned
- 2000-03-10 AT AT00920490T patent/ATE286074T1/de not_active IP Right Cessation
- 2000-03-10 HU HU0200484A patent/HUP0200484A2/hu unknown
- 2000-03-10 SK SK1278-2001A patent/SK12782001A3/sk not_active Application Discontinuation
- 2000-03-10 IL IL14533500A patent/IL145335A0/xx unknown
- 2000-03-10 ES ES00920490T patent/ES2233359T3/es not_active Expired - Lifetime
- 2000-03-10 WO PCT/EP2000/002154 patent/WO2000053633A2/de active IP Right Grant
- 2000-03-10 CN CN00804846A patent/CN1345336A/zh active Pending
- 2000-03-10 EP EP00920490A patent/EP1161456B1/de not_active Expired - Lifetime
- 2000-03-10 JP JP2000604068A patent/JP2002540771A/ja active Pending
- 2000-03-10 CZ CZ20013270A patent/CZ20013270A3/cs unknown
-
2001
- 2001-09-06 NO NO20014346A patent/NO316916B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013270A3 (cs) | 2002-02-13 |
| ES2233359T3 (es) | 2005-06-16 |
| DE50009113D1 (de) | 2005-02-03 |
| NO20014346L (no) | 2001-09-27 |
| WO2000053633A3 (de) | 2000-11-16 |
| WO2000053633A2 (de) | 2000-09-14 |
| SK12782001A3 (sk) | 2002-03-05 |
| NO20014346D0 (no) | 2001-09-06 |
| EP1161456B1 (de) | 2004-12-29 |
| NO316916B1 (no) | 2004-06-21 |
| CA2366713A1 (en) | 2000-09-14 |
| HUP0200484A2 (en) | 2002-06-29 |
| AU4104700A (en) | 2000-09-28 |
| ATE286074T1 (de) | 2005-01-15 |
| EP1161456A2 (de) | 2001-12-12 |
| JP2002540771A (ja) | 2002-12-03 |
| IL145335A0 (en) | 2002-06-30 |
| CN1345336A (zh) | 2002-04-17 |
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