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TR200101695T2 - Yüksek trihidroksi-etil-rütozid oranına sahip trokserütin ve onu hazırlama usulü - Google Patents

Yüksek trihidroksi-etil-rütozid oranına sahip trokserütin ve onu hazırlama usulü

Info

Publication number
TR200101695T2
TR200101695T2 TR2001/01695T TR200101695T TR200101695T2 TR 200101695 T2 TR200101695 T2 TR 200101695T2 TR 2001/01695 T TR2001/01695 T TR 2001/01695T TR 200101695 T TR200101695 T TR 200101695T TR 200101695 T2 TR200101695 T2 TR 200101695T2
Authority
TR
Turkey
Prior art keywords
troxerutine
rütoside
ratio
trihydroxy
ethyl
Prior art date
Application number
TR2001/01695T
Other languages
English (en)
Inventor
Estanove Cyril
Pruvost Fran�Ois
Original Assignee
Negma-Lerads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Negma-Lerads filed Critical Negma-Lerads
Publication of TR200101695T2 publication Critical patent/TR200101695T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bulus, yüksek trihidroksi-etil-rütozid oranina sahip yeni bir trokserütin ile ilgilidir. Söz konusu trokserütin, agirlik olarak en az %92 oraninda 7,3Æ,4Æ-trihidroksietil-rütozid oranina ve bu zenginlestirilmis trokserütin tozunun 3,5 grami 20 C sabit sicaklikta, 100 ml. su ihtiva eden bir deney kabinin içine atildigi taktirde beherin yüzeyini terketmek için 10 dakikadan az bir süreye veya yine söz konusu zenginlestirilmis trokserütin karisimi 20 C sabit sicaklikta, 63 2 mg. agirliginda ve 2 ve 3 mm. büyüklügünde topaklar halinde su yüzeyine birakildigi zaman sulandirilabilme süresi olarak 100 saniyeden az bir süreye sahiptir. Trokserütin, suda daha iyi sulandirilabilme ve eriyebilme özellikleri arzeder.
TR2001/01695T 1998-12-11 1999-12-10 Yüksek trihidroksi-etil-rütozid oranına sahip trokserütin ve onu hazırlama usulü TR200101695T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9815710A FR2787111B1 (fr) 1998-12-11 1998-12-11 Troxerutine a forte teneur en trihydroxy-ethyl-rutoside, a mouillabilite elevee, et procede de preparation

Publications (1)

Publication Number Publication Date
TR200101695T2 true TR200101695T2 (tr) 2002-04-22

Family

ID=9533903

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01695T TR200101695T2 (tr) 1998-12-11 1999-12-10 Yüksek trihidroksi-etil-rütozid oranına sahip trokserütin ve onu hazırlama usulü

Country Status (21)

Country Link
US (1) US6855697B1 (tr)
EP (1) EP1137653B1 (tr)
JP (1) JP2003505338A (tr)
KR (1) KR100644478B1 (tr)
CN (1) CN1196709C (tr)
AT (1) ATE276265T1 (tr)
AU (1) AU1569300A (tr)
BR (1) BR9916130A (tr)
CA (1) CA2354574C (tr)
CZ (1) CZ20011998A3 (tr)
DE (1) DE69920263T2 (tr)
ES (1) ES2229795T3 (tr)
FR (1) FR2787111B1 (tr)
HU (1) HUP0104689A3 (tr)
IL (1) IL143660A0 (tr)
PL (1) PL195116B1 (tr)
RU (1) RU2242478C2 (tr)
SK (1) SK7822001A3 (tr)
TR (1) TR200101695T2 (tr)
WO (1) WO2000035933A1 (tr)
ZA (1) ZA200105072B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1302774C (zh) * 2003-11-07 2007-03-07 邱学良 一种含有曲克芦丁的泡腾片及制法
RU2295970C1 (ru) * 2006-05-23 2007-03-27 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, повышающий резистентность капилляров, фармацевтическая композиция на его основе и способ ее применения
CN103113437A (zh) * 2013-01-05 2013-05-22 河北联合大学 曲克芦丁的制备方法
CN104177461B (zh) * 2013-05-21 2016-11-09 济南新力特科技有限公司 三羟乙基芦丁的制备方法
KR101809943B1 (ko) * 2014-05-23 2017-12-18 지난 신라이트 테크놀로지 컴퍼니 리미티드 트리하이드록시에틸 루토사이드의 제조방법
CN104628799B (zh) * 2014-12-24 2017-10-03 苏州亚宝药物研发有限公司 一种曲克芦丁中杂质a及其分离方法
CN111333602B (zh) * 2020-04-16 2022-12-16 四川协力制药股份有限公司 一种曲克芦丁生产废弃母液的回收转化工艺
CN112057424B (zh) * 2020-09-18 2022-09-16 开封康诺药业有限公司 一种曲克芦丁冻干粉针剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH423808A (fr) * 1964-03-26 1966-11-15 Zyma Sa Procédé pour la préparation d'éthers O-B-hydroxyéthylés de la rutine
FR5072M (tr) * 1965-10-25 1967-05-16
US4153788A (en) * 1974-04-09 1979-05-08 Zyma S.A. Process of preparing mono-O-β-hydroxyethyl-7 rutoside
CH581127A5 (tr) * 1974-04-09 1976-10-29 Zyma Sa
CS225440B1 (cs) * 1982-04-06 1984-02-13 Frantisek Ing Kvis Způsob přípravy směsi 0-hydroxyethylovaných derivátů rutinu
CN1032658A (zh) * 1987-10-19 1989-05-03 烟台人民制药厂 芦丁羟乙基衍生物的精制方法

Also Published As

Publication number Publication date
EP1137653B1 (fr) 2004-09-15
WO2000035933A1 (fr) 2000-06-22
KR100644478B1 (ko) 2006-11-10
PL195116B1 (pl) 2007-08-31
PL348200A1 (en) 2002-05-06
CA2354574A1 (fr) 2000-06-22
JP2003505338A (ja) 2003-02-12
CN1196709C (zh) 2005-04-13
HUP0104689A3 (en) 2003-12-29
HUP0104689A2 (hu) 2002-04-29
RU2242478C2 (ru) 2004-12-20
IL143660A0 (en) 2002-04-21
FR2787111B1 (fr) 2001-02-23
ES2229795T3 (es) 2005-04-16
CN1331697A (zh) 2002-01-16
ATE276265T1 (de) 2004-10-15
BR9916130A (pt) 2001-09-04
KR20010101173A (ko) 2001-11-14
AU1569300A (en) 2000-07-03
SK7822001A3 (en) 2002-01-07
DE69920263D1 (de) 2004-10-21
EP1137653A1 (fr) 2001-10-04
FR2787111A1 (fr) 2000-06-16
DE69920263T2 (de) 2005-09-29
US6855697B1 (en) 2005-02-15
CZ20011998A3 (cs) 2001-10-17
CA2354574C (fr) 2009-07-28
ZA200105072B (en) 2002-12-20

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