TR200100906T2 - Trombin inhibitörleri olarak benzamid türevleri - Google Patents
Trombin inhibitörleri olarak benzamid türevleriInfo
- Publication number
- TR200100906T2 TR200100906T2 TR2001/00906T TR200100906T TR200100906T2 TR 200100906 T2 TR200100906 T2 TR 200100906T2 TR 2001/00906 T TR2001/00906 T TR 2001/00906T TR 200100906 T TR200100906 T TR 200100906T TR 200100906 T2 TR200100906 T2 TR 200100906T2
- Authority
- TR
- Turkey
- Prior art keywords
- thrombin inhibitors
- benzamide derivatives
- 4alkyl
- 4alkenyl
- 3alkyl
- Prior art date
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title abstract 2
- 239000003868 thrombin inhibitor Substances 0.000 title abstract 2
- 150000003936 benzamides Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Bulusa göre yeni formül (I) bilesikleri, ki burada R1 C1-4alkili veya C3-8sikloalkili temsil eder, R2 C1-4alkili veya C3-4alkenil temsil eder R3, hidrojen, C1-3alkil veya halojeni temsil eder; R4 C1-6alkili temsil eder, bunlarin hazirlanmasi için islemler, bunlari içeren farmasötik formülasyonlar ve bunlarin özellikle trombin intibitörleri olarak tedavi için kullanimlari saglanmaktadir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821483.6A GB9821483D0 (en) | 1998-10-03 | 1998-10-03 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200100906T2 true TR200100906T2 (tr) | 2001-07-23 |
Family
ID=10839873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00906T TR200100906T2 (tr) | 1998-10-03 | 1999-09-30 | Trombin inhibitörleri olarak benzamid türevleri |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6441008B1 (tr) |
| EP (1) | EP1117644A1 (tr) |
| JP (1) | JP3457281B2 (tr) |
| KR (1) | KR20010075546A (tr) |
| CN (1) | CN1328548A (tr) |
| AR (1) | AR023332A1 (tr) |
| AU (1) | AU758007B2 (tr) |
| BR (1) | BR9914267A (tr) |
| CA (1) | CA2345997A1 (tr) |
| CO (1) | CO5140085A1 (tr) |
| CZ (1) | CZ20011216A3 (tr) |
| GB (1) | GB9821483D0 (tr) |
| HU (1) | HUP0103744A3 (tr) |
| IL (1) | IL142301A0 (tr) |
| MA (1) | MA26695A1 (tr) |
| NO (1) | NO20011654L (tr) |
| NZ (1) | NZ510839A (tr) |
| PE (1) | PE20001059A1 (tr) |
| PL (1) | PL347152A1 (tr) |
| TR (1) | TR200100906T2 (tr) |
| WO (1) | WO2000020394A1 (tr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117144D0 (en) * | 2001-07-13 | 2001-09-05 | Glaxo Group Ltd | Process |
| PL1637141T3 (pl) | 2004-09-21 | 2012-04-30 | Trobio Ab | Stabilizowana kompozycja proteazy zawierająca proteazę serynową, pochodne morfoliny i odwracalne inhibitory tej proteazy serynowej |
| JP5080476B2 (ja) * | 2005-09-22 | 2012-11-21 | トルービオ・アーベー | 安定化プロテアーゼ組成物 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW257757B (tr) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| ATE168678T1 (de) | 1993-03-29 | 1998-08-15 | Zeneca Ltd | Heterozyklische derivate als plätchenaggregationsinhibitoren |
| GB9525620D0 (en) | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
-
1998
- 1998-10-03 GB GBGB9821483.6A patent/GB9821483D0/en not_active Ceased
-
1999
- 1999-09-29 AR ARP990104910A patent/AR023332A1/es not_active Application Discontinuation
- 1999-09-30 CN CN99813786A patent/CN1328548A/zh active Pending
- 1999-09-30 AU AU64670/99A patent/AU758007B2/en not_active Ceased
- 1999-09-30 JP JP2000574511A patent/JP3457281B2/ja not_active Expired - Fee Related
- 1999-09-30 PL PL99347152A patent/PL347152A1/xx not_active Application Discontinuation
- 1999-09-30 BR BR9914267-8A patent/BR9914267A/pt not_active IP Right Cessation
- 1999-09-30 EP EP99952472A patent/EP1117644A1/en not_active Withdrawn
- 1999-09-30 WO PCT/EP1999/007194 patent/WO2000020394A1/en not_active Application Discontinuation
- 1999-09-30 HU HU0103744A patent/HUP0103744A3/hu unknown
- 1999-09-30 NZ NZ510839A patent/NZ510839A/en unknown
- 1999-09-30 US US09/806,407 patent/US6441008B1/en not_active Expired - Fee Related
- 1999-09-30 KR KR1020017004191A patent/KR20010075546A/ko not_active Withdrawn
- 1999-09-30 CZ CZ20011216A patent/CZ20011216A3/cs unknown
- 1999-09-30 TR TR2001/00906T patent/TR200100906T2/tr unknown
- 1999-09-30 CO CO99061898A patent/CO5140085A1/es unknown
- 1999-09-30 PE PE1999000995A patent/PE20001059A1/es not_active Application Discontinuation
- 1999-09-30 CA CA002345997A patent/CA2345997A1/en not_active Abandoned
- 1999-09-30 IL IL14230199A patent/IL142301A0/xx unknown
- 1999-10-01 MA MA25797A patent/MA26695A1/fr unknown
-
2001
- 2001-04-02 NO NO20011654A patent/NO20011654L/no not_active Application Discontinuation
-
2002
- 2002-01-10 US US10/044,769 patent/US6670381B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20011654L (no) | 2001-05-30 |
| CA2345997A1 (en) | 2000-04-13 |
| EP1117644A1 (en) | 2001-07-25 |
| PE20001059A1 (es) | 2000-10-23 |
| IL142301A0 (en) | 2002-03-10 |
| CN1328548A (zh) | 2001-12-26 |
| JP3457281B2 (ja) | 2003-10-14 |
| US20020169189A1 (en) | 2002-11-14 |
| MA26695A1 (fr) | 2004-12-20 |
| HUP0103744A3 (en) | 2002-03-28 |
| HUP0103744A2 (hu) | 2002-02-28 |
| NZ510839A (en) | 2003-08-29 |
| BR9914267A (pt) | 2001-07-03 |
| AR023332A1 (es) | 2002-09-04 |
| AU6467099A (en) | 2000-04-26 |
| KR20010075546A (ko) | 2001-08-09 |
| US6441008B1 (en) | 2002-08-27 |
| CO5140085A1 (es) | 2002-03-22 |
| PL347152A1 (en) | 2002-03-25 |
| GB9821483D0 (en) | 1998-11-25 |
| JP2002526531A (ja) | 2002-08-20 |
| AU758007B2 (en) | 2003-03-13 |
| CZ20011216A3 (cs) | 2001-09-12 |
| NO20011654D0 (no) | 2001-04-02 |
| WO2000020394A1 (en) | 2000-04-13 |
| US6670381B2 (en) | 2003-12-30 |
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