TR200000310T2 - Bir 3-(2-değiştirilmiş-vinil)-sefalosporin' in z-izomeri' nin seçici üretimine mahsus bir yöntem. - Google Patents
Bir 3-(2-değiştirilmiş-vinil)-sefalosporin' in z-izomeri' nin seçici üretimine mahsus bir yöntem.Info
- Publication number
- TR200000310T2 TR200000310T2 TR2000/00310T TR200000310T TR200000310T2 TR 200000310 T2 TR200000310 T2 TR 200000310T2 TR 2000/00310 T TR2000/00310 T TR 2000/00310T TR 200000310 T TR200000310 T TR 200000310T TR 200000310 T2 TR200000310 T2 TR 200000310T2
- Authority
- TR
- Turkey
- Prior art keywords
- isomer
- cephalosporin
- vinyl
- modified
- selective production
- Prior art date
Links
- 229940124587 cephalosporin Drugs 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 aminothiazole -4-yl Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Asagidaki genel formül (IV)' e Formül (IV) ki burada, R1, bir hidrojen atomu'nu ya da bir tek-degerli amino-koruyan grubu göstermektedir, ya da, bir 2-(2-N-korunmus ya da korunmamis aminotiyazol-4-yl)-2-alkoksiiminoasetil grubu'nu göstermektedir, R2, bir hidrojen atomu'nu göstermektedir. Bu bulusun yöntemlerine göre, bilesik (IV) ' ün, Z-,izomeri' ninkinden, daha düsük anti bakteriyel tesirdeki türden olan E-izomeri' nin üretilmesi, fark edilir ölçüde önlenebilmektedir. Ilaveten, yüksek bir safliktaki Z-izomeri, etkin bir biçimde basit bir yoldan üretilebilmektedir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16694897 | 1997-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000310T2 true TR200000310T2 (tr) | 2000-08-21 |
Family
ID=15840609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00310T TR200000310T2 (tr) | 1997-06-24 | 1998-06-24 | Bir 3-(2-değiştirilmiş-vinil)-sefalosporin' in z-izomeri' nin seçici üretimine mahsus bir yöntem. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6288223B1 (tr) |
| EP (1) | EP1016665B1 (tr) |
| JP (1) | JP3713282B2 (tr) |
| KR (1) | KR100515273B1 (tr) |
| CN (1) | CN1107679C (tr) |
| AT (1) | ATE221890T1 (tr) |
| AU (1) | AU731265B2 (tr) |
| BR (1) | BR9810313B1 (tr) |
| CA (1) | CA2294178C (tr) |
| CZ (1) | CZ295599B6 (tr) |
| DE (1) | DE69807093T2 (tr) |
| EA (1) | EA002449B1 (tr) |
| ES (1) | ES2182330T3 (tr) |
| HU (1) | HU228767B1 (tr) |
| ID (1) | ID24210A (tr) |
| IL (1) | IL133681A (tr) |
| NZ (1) | NZ502234A (tr) |
| PL (1) | PL193367B1 (tr) |
| PT (1) | PT1016665E (tr) |
| RO (1) | RO120261B1 (tr) |
| SK (1) | SK283525B6 (tr) |
| TR (1) | TR200000310T2 (tr) |
| UA (1) | UA55463C2 (tr) |
| WO (1) | WO1998058932A1 (tr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4157177B2 (ja) * | 1997-06-04 | 2008-09-24 | 大塚化学ホールディングス株式会社 | ３−アルケニルセフェム化合物の製造法 |
| US7459550B2 (en) | 2003-07-04 | 2008-12-02 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of Cefditoren |
| EP1660505A2 (en) * | 2003-08-14 | 2006-05-31 | Ranbaxy Laboratories Limited | Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof |
| WO2005100367A1 (en) * | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins |
| WO2005100369A1 (en) * | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | Depletion of e-isomers in preparation of z-enriched 3-(2-substituted vinyl) cephalosporins |
| JP4064948B2 (ja) * | 2004-06-04 | 2008-03-19 | 明治製菓株式会社 | ３−アルケニルセフェム化合物及び製造方法 |
| JP4046708B2 (ja) * | 2004-06-04 | 2008-02-13 | 明治製菓株式会社 | ３−アルケニルセフェム化合物の製造方法 |
| TW200619222A (en) * | 2004-09-02 | 2006-06-16 | Rohm & Haas Elect Mat | Method for making organometallic compounds |
| JP2006096679A (ja) * | 2004-09-28 | 2006-04-13 | Meiji Seika Kaisha Ltd | セファロスポリン化合物の製造方法 |
| CN101665499A (zh) * | 2008-09-01 | 2010-03-10 | 日本化学工业株式会社 | 头孢烯化合物的制造方法 |
| EP2520578A1 (en) | 2011-05-06 | 2012-11-07 | Lupin Limited | Process for purification of cephalosporins |
| CN105622636B (zh) * | 2016-02-05 | 2017-08-25 | 河南理工大学 | 一种头孢妥仑匹酯中间体的制备方法 |
| CN113480491B (zh) * | 2021-09-08 | 2022-05-06 | 山东昌邑四方医药化工有限公司 | 一种从头孢托仑母核生产废液中回收4-甲基噻唑-5-甲醛和三苯基氧膦的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6219593A (ja) | 1985-07-18 | 1987-01-28 | Meiji Seika Kaisha Ltd | 新規セフエム化合物 |
| IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
| JPH03128382A (ja) * | 1989-07-18 | 1991-05-31 | Eisai Co Ltd | チアゾリルアセトアミドセフェム系化合物 |
| JPH06219593A (ja) * | 1993-01-21 | 1994-08-09 | Oki Electric Ind Co Ltd | 電子写真記録装置 |
| JP3128382B2 (ja) | 1993-03-11 | 2001-01-29 | 旭 中野 | 鉄道車両運行支援表示装置 |
| ES2155839T3 (es) * | 1993-11-17 | 2001-06-01 | Biochemie Gmbh | Separacion de isomeros de cefalosporina. |
| JPH0867684A (ja) * | 1994-08-31 | 1996-03-12 | Kyorin Pharmaceut Co Ltd | 新規セフェム化合物、その製造法及び抗菌剤 |
-
1998
- 1998-06-24 WO PCT/JP1998/002820 patent/WO1998058932A1/ja active IP Right Grant
- 1998-06-24 DE DE69807093T patent/DE69807093T2/de not_active Expired - Fee Related
- 1998-06-24 SK SK1857-99A patent/SK283525B6/sk not_active IP Right Cessation
- 1998-06-24 CN CN98807781A patent/CN1107679C/zh not_active Expired - Lifetime
- 1998-06-24 HU HU0002458A patent/HU228767B1/hu unknown
- 1998-06-24 AT AT98929666T patent/ATE221890T1/de not_active IP Right Cessation
- 1998-06-24 ID IDW991680A patent/ID24210A/id unknown
- 1998-06-24 BR BRPI9810313-0A patent/BR9810313B1/pt not_active IP Right Cessation
- 1998-06-24 EP EP98929666A patent/EP1016665B1/en not_active Expired - Lifetime
- 1998-06-24 PL PL339361A patent/PL193367B1/pl not_active IP Right Cessation
- 1998-06-24 ES ES98929666T patent/ES2182330T3/es not_active Expired - Lifetime
- 1998-06-24 JP JP50417799A patent/JP3713282B2/ja not_active Expired - Lifetime
- 1998-06-24 EA EA200000065A patent/EA002449B1/ru not_active IP Right Cessation
- 1998-06-24 CA CA002294178A patent/CA2294178C/en not_active Expired - Lifetime
- 1998-06-24 PT PT98929666T patent/PT1016665E/pt unknown
- 1998-06-24 RO RO99-01373A patent/RO120261B1/ro unknown
- 1998-06-24 CZ CZ19994718A patent/CZ295599B6/cs not_active IP Right Cessation
- 1998-06-24 AU AU79331/98A patent/AU731265B2/en not_active Ceased
- 1998-06-24 KR KR10-1999-7012110A patent/KR100515273B1/ko not_active IP Right Cessation
- 1998-06-24 UA UA2000010366A patent/UA55463C2/uk unknown
- 1998-06-24 TR TR2000/00310T patent/TR200000310T2/tr unknown
- 1998-06-24 NZ NZ502234A patent/NZ502234A/en not_active IP Right Cessation
- 1998-06-24 IL IL13368198A patent/IL133681A/xx not_active IP Right Cessation
- 1998-06-24 US US09/446,380 patent/US6288223B1/en not_active Expired - Lifetime
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