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TNSN05082A1 - PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF) - Google Patents

PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF)

Info

Publication number
TNSN05082A1
TNSN05082A1 TNP2005000082A TNSN05082A TNSN05082A1 TN SN05082 A1 TNSN05082 A1 TN SN05082A1 TN P2005000082 A TNP2005000082 A TN P2005000082A TN SN05082 A TNSN05082 A TN SN05082A TN SN05082 A1 TNSN05082 A1 TN SN05082A1
Authority
TN
Tunisia
Prior art keywords
tgf
growth factor
transforming growth
pyrazole derivatives
inhibitors
Prior art date
Application number
TNP2005000082A
Other languages
French (fr)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2003/003933 external-priority patent/WO2004026306A2/en
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN05082A1 publication Critical patent/TNSN05082A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des dérivés de pyrazole nouveaux de formule (Ia), Des intermédiaires pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")- beta . Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF, comprenant, par exemple, le cancer et des maladies fibrotiques.Novel pyrazole derivatives of formula (Ia), intermediates for their preparation, pharmaceutical compositions containing them and their use in medicine are described. The compounds of the present invention are potent inhibitors of the transforming growth factor ("TGF") - beta signaling pathway. They are useful in the treatment of various disease states related to TGF, including, for example, cancer and fibrotic diseases.

TNP2005000082A 2002-09-18 2005-03-18 PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF) TNSN05082A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41214602P 2002-09-18 2002-09-18
PCT/IB2003/003933 WO2004026306A2 (en) 2002-09-18 2003-09-08 Pyrazole derivatives as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number Publication Date
TNSN05082A1 true TNSN05082A1 (en) 2007-05-14

Family

ID=47043989

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2005000082A TNSN05082A1 (en) 2002-09-18 2005-03-18 PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF)

Country Status (2)

Country Link
GT (1) GT200300203A (en)
TN (1) TNSN05082A1 (en)

Also Published As

Publication number Publication date
GT200300203A (en) 2004-06-23

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