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TN2014000147A1 - Derives de (4-phenylimidazol-2-yl) ethylamine utiles comme modulateurs de canal sodique - Google Patents

Derives de (4-phenylimidazol-2-yl) ethylamine utiles comme modulateurs de canal sodique

Info

Publication number
TN2014000147A1
TN2014000147A1 TNP2014000147A TN2014000147A TN2014000147A1 TN 2014000147 A1 TN2014000147 A1 TN 2014000147A1 TN P2014000147 A TNP2014000147 A TN P2014000147A TN 2014000147 A TN2014000147 A TN 2014000147A TN 2014000147 A1 TN2014000147 A1 TN 2014000147A1
Authority
TN
Tunisia
Prior art keywords
phenylimidazol
sodium channel
derivatives useful
channel modulators
ethylamine derivatives
Prior art date
Application number
TNP2014000147A
Other languages
English (en)
Inventor
Sharanjeet Kaur Bagal
Mark Ian Kemp
Duncan Charles Miller
Yoshihisa Murata
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000147(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of TN2014000147A1 publication Critical patent/TN2014000147A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des dérivés d'imidazole, leur utilisation en médecine, des compositions les contenant, des procédés pour leur préparation et des intermédiaires utilisés dans de tels procédés. L'invention concerne plus particulièrement de nouveaux modulateurs imidazole du Nav1.8 de formule (I) ou un sel pharmaceutiquement acceptable de ceux-ci, les R1, R2, R3, R4 et R5 étant tels que définis dans la description. Les modulateurs du Nav1.8 sont potentiellement utiles dans le traitement d'une large gamme de troubles, en particulier de la douleur.
TNP2014000147A 2011-10-26 2014-04-08 Derives de (4-phenylimidazol-2-yl) ethylamine utiles comme modulateurs de canal sodique TN2014000147A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161551628P 2011-10-26 2011-10-26
PCT/IB2012/055610 WO2013061205A2 (fr) 2011-10-26 2012-10-15 Composés chimiques

Publications (1)

Publication Number Publication Date
TN2014000147A1 true TN2014000147A1 (fr) 2015-09-30

Family

ID=47278356

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2014000147A TN2014000147A1 (fr) 2011-10-26 2014-04-08 Derives de (4-phenylimidazol-2-yl) ethylamine utiles comme modulateurs de canal sodique

Country Status (28)

Country Link
US (1) US9079878B2 (fr)
EP (1) EP2771335A2 (fr)
JP (1) JP5946538B2 (fr)
KR (1) KR101586966B1 (fr)
CN (1) CN103906746B (fr)
AP (1) AP2014007579A0 (fr)
AU (1) AU2012328034B2 (fr)
BR (1) BR112014009102A2 (fr)
CA (1) CA2850925C (fr)
CL (1) CL2014000956A1 (fr)
CO (1) CO6940427A2 (fr)
CR (1) CR20140185A (fr)
CU (1) CU20140046A7 (fr)
DO (1) DOP2014000085A (fr)
EA (1) EA023375B1 (fr)
EC (1) ECSP14013324A (fr)
GT (1) GT201400079A (fr)
HK (1) HK1198650A1 (fr)
IL (1) IL232267A (fr)
MD (1) MD20140037A2 (fr)
MX (1) MX337469B (fr)
NI (1) NI201400031A (fr)
PE (1) PE20141682A1 (fr)
SG (1) SG11201401032YA (fr)
TN (1) TN2014000147A1 (fr)
UA (1) UA109220C2 (fr)
WO (1) WO2013061205A2 (fr)
ZA (1) ZA201402281B (fr)

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KR102062323B1 (ko) * 2011-09-14 2020-01-03 다우 아그로사이언시즈 엘엘씨 보론산 및 이의 중간체 형성 방법 및 시스템
PL3080134T3 (pl) 2013-12-13 2019-01-31 Vertex Pharmaceuticals Incorporated Proleki pirydonoamidów nadające się do stosowania jako modulatory kanałów sodowych
KR102192572B1 (ko) 2014-06-09 2020-12-18 삼성전자주식회사 광원 모듈의 불량 검사방법, 광원 모듈의 제조 방법 및 광원 모듈 검사장치
EP3209303A4 (fr) * 2014-10-24 2017-08-30 Avectas Limited Administration à travers des membranes plasmiques de cellules
US9763955B2 (en) 2015-02-19 2017-09-19 Purdue Pharma L.P. Methods and compositions for decreasing gastric emptying
IS2977B (is) 2015-02-23 2017-07-15 Actavis Group Ptc Ehf. Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni
WO2017115128A2 (fr) 2015-12-30 2017-07-06 Avectas Limited Administration sans vecteur de protéines et de compositions d'édition de gènes dans des cellules et des tissus
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
EP3481856A1 (fr) 2016-07-06 2019-05-15 Crispr Therapeutics AG Matériaux et procédés de traitement de troubles liés à la douleur
MA49137A (fr) 2017-05-16 2021-04-21 Vertex Pharma Amides de pyridone deutérés et leurs promédicaments utilisés en tant que modulateurs de canaux sodiques
UY37806A (es) 2017-07-11 2020-01-31 Vertex Pharma Carboxamidas como moduladores de los canales de sodio
AU2019218387A1 (en) 2018-02-12 2020-08-27 Vertex Pharmaceuticals Incorporated A method of treating pain
WO2020146612A1 (fr) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters et carbamates utilisés en tant que modulateurs de canaux sodiques
WO2020146682A1 (fr) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides utilisés en tant que modulateurs de canaux sodiques
WO2020176763A1 (fr) 2019-02-27 2020-09-03 Vertex Pharmaceuticals Incorporated Forme posologique comprenant un promédicament inhibiteur de canal sodique na 1,8
WO2020219867A1 (fr) 2019-04-25 2020-10-29 Vertex Pharmaceuticals Incorporated Compositions de co-cristaux d'amide de pyridone pour le traitement de la douleur
PE20230300A1 (es) 2019-12-06 2023-02-13 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
WO2022256708A1 (fr) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Formes galéniques solides et schémas posologiques comprenant du (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-méthoxy-phényl)-4,5-diméthyl-5-(trifluorométhyl)tétrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide
CA3221960A1 (fr) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Tetrahydrofuranes a substitution hydroxy et (halo)alkoxy utiles en tant que modulateurs de canaux sodiques
WO2022256702A1 (fr) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Tétrahydrofuran-2-carboxamides substitués utiles en tant que modulateurs de canaux sodiques
EP4347583A1 (fr) 2021-06-04 2024-04-10 Vertex Pharmaceuticals Incorporated Analogues de tétrahydrofurane substitués utiles en tant que modulateurs de canaux sodiques
CA3221939A1 (fr) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Analogues de n-(hydroxyalkyl(hetero)aryl)tetrahydrofurane carboxamide en tant que modulateurs de canaux sodiques
PE20241335A1 (es) 2021-06-04 2024-07-03 Vertex Pharma N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio
WO2023205465A1 (fr) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Composés hétéroaryles pour le traitement de la douleur
WO2023205468A1 (fr) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Composés hétéroaryle pour le traitement de la douleur
AU2023255771A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20230373925A1 (en) 2022-04-22 2023-11-23 Vertex Pharma Heteroaryl compounds for the treatment of pain
WO2023211990A1 (fr) 2022-04-25 2023-11-02 Siteone Therapeutics, Inc. Inhibiteurs d'amides hétérocycliques bicycliques de na v1.8 pour le traitement de la douleur
CN115656380A (zh) * 2022-11-09 2023-01-31 武汉海特生物创新医药研究有限公司 一种mtv对映异构体的hplc-uv检测方法
WO2024123815A1 (fr) 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Procédé de synthèse de modulateurs de tétrahydrofurane substitués de canaux sodiques

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US7112366B2 (en) 2001-01-05 2006-09-26 The Ohio State University Chemical monolayer and micro-electronic junctions and devices containing same
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
FR2842808B1 (fr) * 2002-07-25 2004-09-10 Sod Conseils Rech Applic Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques
EP1747210B1 (fr) * 2004-05-07 2010-06-30 Warner-Lambert Company LLC Dérivés de phénol 3- ou 4-monosubstitués utiles comme ligands de h3
US7456164B2 (en) * 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
KR20070083828A (ko) * 2004-10-27 2007-08-24 쉐링 코포레이션 Ｎａｖ１．８의 짧은 간섭 핵산 억제를 위한 조성물 및방법
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Also Published As

Publication number Publication date
US9079878B2 (en) 2015-07-14
JP2014530900A (ja) 2014-11-20
US20140296313A1 (en) 2014-10-02
CN103906746A (zh) 2014-07-02
JP5946538B2 (ja) 2016-07-06
CA2850925A1 (fr) 2013-05-02
WO2013061205A8 (fr) 2014-03-27
NZ623090A (en) 2015-10-30
ZA201402281B (en) 2015-11-25
AU2012328034B2 (en) 2015-04-23
IL232267A (en) 2016-10-31
EP2771335A2 (fr) 2014-09-03
MX2014004738A (es) 2014-08-01
PE20141682A1 (es) 2014-11-14
CA2850925C (fr) 2017-01-10
CU20140046A7 (es) 2014-10-02
DOP2014000085A (es) 2014-08-31
MX337469B (es) 2016-03-02
GT201400079A (es) 2015-06-02
ECSP14013324A (es) 2014-05-31
UA109220C2 (uk) 2015-07-27
WO2013061205A2 (fr) 2013-05-02
CL2014000956A1 (es) 2014-07-18
CR20140185A (es) 2014-06-03
WO2013061205A3 (fr) 2013-06-27
KR101586966B1 (ko) 2016-01-19
SG11201401032YA (en) 2014-07-30
CN103906746B (zh) 2015-12-09
KR20140069234A (ko) 2014-06-09
IL232267A0 (en) 2014-06-30
EA023375B1 (ru) 2016-05-31
BR112014009102A2 (pt) 2017-04-18
CO6940427A2 (es) 2014-05-09
AP2014007579A0 (en) 2014-04-30
EA201490864A1 (ru) 2014-08-29
HK1198650A1 (en) 2015-05-22
AU2012328034A1 (en) 2014-05-15
MD20140037A2 (ro) 2014-08-31
NI201400031A (es) 2014-10-01

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