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TN2013000160A1 - Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors - Google Patents

Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

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Publication number
TN2013000160A1
TN2013000160A1 TNP2013000160A TN2013000160A TN2013000160A1 TN 2013000160 A1 TN2013000160 A1 TN 2013000160A1 TN P2013000160 A TNP2013000160 A TN P2013000160A TN 2013000160 A TN2013000160 A TN 2013000160A TN 2013000160 A1 TN2013000160 A1 TN 2013000160A1
Authority
TN
Tunisia
Prior art keywords
hsd
inhibitors
benzoimidazole
indeno
carbonitrile
Prior art date
Application number
TNP2013000160A
Other languages
French (fr)
Inventor
Matthias Eckhardt
Hans-Juergen Martin
Martin Schuehle
Sandra Sick
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/059331 external-priority patent/WO2012061708A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TN2013000160A1 publication Critical patent/TN2013000160A1/en

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Abstract

The present invention relates to crystalline compounds of the following structural formula (II) possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 รข-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
TNP2013000160A 2011-11-04 2013-04-12 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors TN2013000160A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/059331 WO2012061708A1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (1)

Publication Number Publication Date
TN2013000160A1 true TN2013000160A1 (en) 2014-11-10

Family

ID=54360601

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000160A TN2013000160A1 (en) 2011-11-04 2013-04-12 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Country Status (1)

Country Link
TN (1) TN2013000160A1 (en)

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