[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

TN2011000201A1 - Aminotetrahydropyrans as dipeptidyl peptidase - iv inhibitors for the treatment or prevention of diabetes - Google Patents

Aminotetrahydropyrans as dipeptidyl peptidase - iv inhibitors for the treatment or prevention of diabetes

Info

Publication number
TN2011000201A1
TN2011000201A1 TN2011000201A TN2011000201A TN2011000201A1 TN 2011000201 A1 TN2011000201 A1 TN 2011000201A1 TN 2011000201 A TN2011000201 A TN 2011000201A TN 2011000201 A TN2011000201 A TN 2011000201A TN 2011000201 A1 TN2011000201 A1 TN 2011000201A1
Authority
TN
Tunisia
Prior art keywords
dipeptidyl peptidase
diabetes
prevention
treatment
inhibitors
Prior art date
Application number
TN2011000201A
Other languages
English (en)
Inventor
Tesfaye Biftu
Ping Chen
Jason M Cox
Ann E Weber
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41559521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2011000201(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of TN2011000201A1 publication Critical patent/TN2011000201A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TN2011000201A 2008-11-13 2011-04-21 Aminotetrahydropyrans as dipeptidyl peptidase - iv inhibitors for the treatment or prevention of diabetes TN2011000201A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19917908P 2008-11-13 2008-11-13
PCT/US2009/063976 WO2010056708A1 (fr) 2008-11-13 2009-11-11 Aminotétrahydropyranes en tant qu’inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prévention du diabète

Publications (1)

Publication Number Publication Date
TN2011000201A1 true TN2011000201A1 (en) 2012-12-17

Family

ID=41559521

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2011000201A TN2011000201A1 (en) 2008-11-13 2011-04-21 Aminotetrahydropyrans as dipeptidyl peptidase - iv inhibitors for the treatment or prevention of diabetes

Country Status (40)

Country Link
US (8) US8143289B2 (fr)
EP (4) EP2358717B1 (fr)
JP (2) JP4854825B1 (fr)
KR (2) KR101260162B1 (fr)
CN (1) CN102272136B (fr)
AR (1) AR074306A1 (fr)
AU (1) AU2009314191B2 (fr)
BR (1) BRPI0921375B8 (fr)
CA (1) CA2742783C (fr)
CL (1) CL2011001082A1 (fr)
CO (1) CO6382129A2 (fr)
CR (1) CR20110257A (fr)
CY (1) CY1114617T1 (fr)
DK (1) DK2358717T3 (fr)
DO (1) DOP2011000128A (fr)
EA (1) EA018613B1 (fr)
EC (1) ECSP11011044A (fr)
ES (1) ES2432191T3 (fr)
GE (1) GEP20135724B (fr)
HK (1) HK1154849A1 (fr)
HN (1) HN2011001256A (fr)
HR (1) HRP20130924T1 (fr)
IL (2) IL212485A (fr)
JO (1) JO2870B1 (fr)
MA (1) MA32887B1 (fr)
MX (1) MX2011005044A (fr)
MY (1) MY150787A (fr)
NI (1) NI201100081A (fr)
NZ (1) NZ592826A (fr)
PA (1) PA8848201A1 (fr)
PE (1) PE20120027A1 (fr)
PL (1) PL2358717T3 (fr)
PT (1) PT2358717E (fr)
RS (1) RS52946B (fr)
SI (1) SI2358717T1 (fr)
SV (1) SV2011003903A (fr)
TN (1) TN2011000201A1 (fr)
TW (1) TWI398443B (fr)
UA (1) UA101414C2 (fr)
WO (1) WO2010056708A1 (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ589532A (en) 2008-06-12 2012-02-24 Janssen Pharmaceutica Nv Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor
JO2870B1 (en) 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
BR112012004335A8 (pt) 2009-09-02 2016-06-21 Merck Sharp & Dohme Composto, composição farmacêutica, e, uso do composto.
US8716482B2 (en) 2009-09-25 2014-05-06 Merck Sharp & Dohme Corp. Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
US8853212B2 (en) 2010-02-22 2014-10-07 Merck Sharp & Dohme Corp Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
EP2571876B1 (fr) 2010-05-21 2016-09-07 Merck Sharp & Dohme Corp. Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète
US8691832B2 (en) 2010-12-06 2014-04-08 Merck Sharp & Dohme Corp. Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
US20140221282A1 (en) * 2011-05-25 2014-08-07 Astrazeneca Pharmaceuticals Lp Long duration dual hormone conjugates
US8895603B2 (en) 2011-06-29 2014-11-25 Merck Sharp & Dohme Corp. Crystalline forms of a dipeptidyl peptidase-IV inhibitor
EP2729468A4 (fr) 2011-07-05 2015-03-18 Merck Sharp & Dohme Hétérocycles tricycliques utiles comme inhibiteurs de la dipeptidyl peptidase-iv
EP2814485A4 (fr) 2012-02-17 2015-08-26 Merck Sharp & Dohme Inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prévention du diabète
US9156848B2 (en) 2012-07-23 2015-10-13 Merck Sharp & Dohme Corp. Treating diabetes with dipeptidyl peptidase-IV inhibitors
EP2874622A4 (fr) 2012-07-23 2015-12-30 Merck Sharp & Dohme Traitement du diabète par administration d'inhibiteurs de dipeptidyl peptidase-iv
TWI500613B (zh) * 2012-10-17 2015-09-21 Cadila Healthcare Ltd 新穎之雜環化合物
US9937153B2 (en) 2013-08-30 2018-04-10 Merck Sharp & Dohme Ltd. Oral pharmaceutical formulation of omarigliptin
CN105392772B (zh) * 2014-03-20 2017-09-15 意大利合成制造有限公司 奥格列汀的关键中间体的制备方法
CN105037367A (zh) * 2014-04-18 2015-11-11 四川海思科制药有限公司 氨基六元环类衍生物及其在医药上的应用
CN105085528A (zh) * 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
CN105085530B (zh) * 2014-05-23 2019-01-04 四川海思科制药有限公司 三元稠合环取代的氨基六元环类衍生物及其在医药上的应用
JP6535034B2 (ja) * 2014-06-17 2019-06-26 スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド アミノピラン環誘導体及びその組成物と用途
CN105294694B (zh) * 2014-06-18 2019-01-04 四川海思科制药有限公司 氨基六元环类衍生物及其在医药上的应用
WO2016014324A1 (fr) * 2014-07-21 2016-01-28 Merck Sharp & Dohme Corp. Procédé de préparation d'inhibiteurs chiraux de dipeptidyl peptidase-iv
CN105985357A (zh) * 2015-02-12 2016-10-05 北京赛林泰医药技术有限公司 取代的氨基六元饱和杂脂环类长效dpp-iv抑制剂
WO2017031918A1 (fr) * 2015-08-24 2017-03-02 四川科伦药物研究院有限公司 Inhibiteur de dipeptidyl-peptidase-iv à action prolongée, ses applications, et un procédé de préparation d'un intermédiaire de celui-ci
CN106478631B (zh) * 2015-08-24 2019-04-05 四川科伦药物研究院有限公司 长效二肽基肽酶-iv抑制剂、用途及其中间体的制备方法
WO2017032705A1 (fr) 2015-08-25 2017-03-02 Sandoz Ag Forme cristalline d'omarigliptine
TWI681962B (zh) * 2015-08-26 2020-01-11 大陸商四川海思科製藥有限公司 胺基六員環類衍生物及其在醫藥上的應用
TWI640524B (zh) * 2015-08-27 2018-11-11 四川海思科製藥有限公司 Aminopyran ring derivatives and compositions and uses thereof
CN105198847B (zh) * 2015-10-28 2017-05-17 四川凯科医药科技有限公司 一种化合物的制备方法
WO2017093209A1 (fr) * 2015-12-03 2017-06-08 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Procédé de préparation d'aminotétrahydropyranes
CN105399744B (zh) * 2015-12-17 2017-07-18 黄燕鸽 一种奥格列汀的合成方法
EP3181565A1 (fr) 2015-12-18 2017-06-21 Sandoz Ag Sels cristallins d'omarigliptin
EP3395819B1 (fr) * 2015-12-25 2023-05-31 Sichuan Haisco Pharmaceutical Co., Ltd. Forme cristalline de dérivé aminopyrane substitué
CN106916158A (zh) * 2015-12-25 2017-07-04 四川海思科制药有限公司 一种吡喃衍生物盐酸盐水合物及其中间体的制备方法
CN106928228B (zh) * 2015-12-29 2019-08-30 杭州普晒医药科技有限公司 奥格列汀盐及其晶型、它们的制备方法和药物组合物
CN107337674B (zh) * 2016-04-29 2019-09-20 江苏吉贝尔药业股份有限公司 用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
WO2017202357A1 (fr) * 2016-05-25 2017-11-30 四川海思科制药有限公司 Procédé de préparation d'un dérivé de pyranne substitué par un trifluorométhyle
CN108699068B (zh) * 2016-05-25 2021-01-08 四川海思科制药有限公司 一种三氟甲基取代的吡喃衍生物制备方法
CN107652291B (zh) * 2016-07-26 2020-07-14 中国科学院上海药物研究所 一种制备手性四氢吡喃衍生物的方法
CN109874304B (zh) * 2016-08-12 2021-06-25 正大天晴药业集团股份有限公司 Dpp-iv长效抑制剂的结晶及其盐
CN106674227B (zh) * 2016-12-06 2019-03-19 上海博志研新药物技术有限公司 一种奥格列汀及其中间体的制备方法
EP3335703A1 (fr) 2016-12-16 2018-06-20 Hexal AG Composition pharmaceutique contenant de l'omarigliptine
EP3335701A1 (fr) 2016-12-16 2018-06-20 Hexal AG Composition pharmaceutique contenant de l'omarigliptine
EP3335704A1 (fr) 2016-12-16 2018-06-20 Hexal AG Composition pharmaceutique comprenant de l'omarigliptine
EP3335702A1 (fr) 2016-12-16 2018-06-20 Hexal AG Compositions pharmaceutiques comprenant de l'omarigliptine
CN107024590A (zh) * 2017-03-13 2017-08-08 新疆医科大学 一种诊断1型和2型糖尿病的血清蛋白标志物组
US11020412B2 (en) 2017-03-16 2021-06-01 Inventia Healthcare Limited Pharmaceutical composition comprising dapagliflozin
ES2747768T3 (es) 2017-03-20 2020-03-11 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR)
CN109796455B (zh) * 2017-11-17 2021-02-26 四川海思科制药有限公司 一种氨基吡喃衍生物的盐、其晶型及其制备方法和用途
CN111683659B (zh) * 2018-02-06 2023-08-29 四川海思科制药有限公司 一种氨基吡喃衍生物的组合物
CN113166060B (zh) 2018-09-19 2024-01-09 诺沃挪第克健康护理股份公司 用丙酮酸激酶激活化合物治疗镰状细胞病
CN113226356A (zh) 2018-09-19 2021-08-06 福马治疗股份有限公司 活化丙酮酸激酶r
MX2022001044A (es) * 2019-07-26 2022-04-06 Medshine Discovery Inc Inhibidor de sglt2/dpp4 y su aplicacion.
CN110568100B (zh) * 2019-09-12 2022-05-31 江西金水宝制药有限公司 一种米格列奈钙r-异构体的检测方法
CN111793071B (zh) * 2020-07-06 2021-06-04 四川凯科医药科技有限公司 奥格列汀的合成工艺
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US5232929A (en) 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
WO1998039342A1 (fr) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Nouveaux composes d'indole et d'azaindole inhibiteurs de fructose-1,6-biophosphatase
WO1998039344A1 (fr) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Nouveaux composes de purine inhibiteurs de fructose-1,6-biophasphatase
ZA981936B (en) 1997-03-07 1999-09-06 Metabasis Therapeutics Inc Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
AU749271B2 (en) 1997-07-01 2002-06-20 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
PA8469501A1 (es) * 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
EP1075266A1 (fr) 1998-05-04 2001-02-14 Point Therapeutics, Inc. Stimulation hematopoietique
HUP0103143A3 (en) 1998-09-09 2003-01-28 Metabasis Therapeutics Inc San Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase, process for their preparation and their use
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
GB9906715D0 (en) 1999-03-23 1999-05-19 Ferring Bv Compositions for promoting growth
IL146006A0 (en) 1999-05-17 2002-07-25 Novo Nordisk As Glucagon antagonists/inverse agonists
EP1305285B1 (fr) 2000-07-25 2007-05-16 Merck & Co., Inc. Indoles n-substitues utiles pour le traitement du diabete
CA2424475A1 (fr) 2000-10-27 2002-05-02 Probiodrug Ag Procede pour le traitement de troubles neurologiques et neuropsychologiques
JP4181408B2 (ja) 2001-01-30 2008-11-12 メルク エンド カムパニー インコーポレーテッド 肥満、糖尿病及び脂質異常を治療するためのアシルスルファミド類
ATE370943T1 (de) 2001-06-27 2007-09-15 Smithkline Beecham Corp Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
US7186746B2 (en) 2002-08-29 2007-03-06 Merck & Co., Inc. Indoles having anti-diabetic activity
US7393960B2 (en) 2002-08-29 2008-07-01 Merck & Co., Inc. Indoles having anti-diabetic activity
WO2004037159A2 (fr) 2002-10-23 2004-05-06 Obetherapy Biotechnology Composes, compositions et methodes permettant de moduler le metabolisme des graisses
US7192922B2 (en) 2002-11-19 2007-03-20 Allegheny-Singer Research Institute Method of treating left ventricular dysfunction
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
CA2512879A1 (fr) 2003-01-17 2004-08-12 Soumya P. Sahoo Derives de n-cyclohexylaminocarbonyl benzenesulfonamide
US7691603B2 (en) 2003-04-09 2010-04-06 Novo Nordisk A/S Intracellular formation of peptide conjugates
US20040214856A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7145012B2 (en) * 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
WO2005030751A2 (fr) * 2003-09-08 2005-04-07 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
EP1699806A1 (fr) 2003-12-23 2006-09-13 Progen Industries Limited Composes mimetiques du glycosaminoglycane (gag)
JP4963671B2 (ja) 2004-06-21 2012-06-27 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療または予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としてのアミノシクロヘキサン
US20090292110A1 (en) 2004-07-23 2009-11-26 Defrees Shawn Enzymatic modification of glycopeptides
US7718667B2 (en) * 2004-09-28 2010-05-18 Merck Sharp & Dohme Corp. Fused aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1796669B1 (fr) 2004-10-01 2010-09-22 Merck Sharp & Dohme Corp. Aminopiperidines utilisees comme inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete
EP1807066A1 (fr) 2004-10-25 2007-07-18 Novartis AG Combinaison d'inhibiteur de la dpp-iv, d'antidiabetique ppar et de metformine
JP4999698B2 (ja) 2004-11-29 2012-08-15 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療または予防用のジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合アミノピペリジン
WO2007024993A2 (fr) 2005-08-26 2007-03-01 Merck & Co., Inc. Aminopiperidines fusionnees utilisees comme inhibiteurs de dipeptidyl-peptidase-iv pour le traitement ou la prevention du diabete
US7411093B2 (en) 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
CN101090888A (zh) 2004-12-20 2007-12-19 霍夫曼-拉罗奇有限公司 4－氨基哌啶衍生物
EP1702916A1 (fr) 2005-03-18 2006-09-20 Santhera Pharmaceuticals (Schweiz) GmbH Inhibiteurs de DPP-IV
TWI357902B (en) * 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth
US7906649B2 (en) 2005-05-25 2011-03-15 Merck Sharp & Dohme Corp. Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
ATE553124T1 (de) 2005-06-13 2012-04-15 Imp Innovations Ltd Oxyntomodulinanaloga und ihre wirkungen auf das fressverhalten
WO2007070434A2 (fr) 2005-12-14 2007-06-21 Merck & Co., Inc. Amino-piperidines fusionnees en tant qu'inhibiteurs de la dipeptidyl peptidase-4 pour le traitement ou la prevention du diabete
US7750034B2 (en) * 2006-01-25 2010-07-06 Merck Sharp & Dohme Corp. Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1986652B1 (fr) 2006-02-15 2013-03-20 Merck Sharp & Dohme Corp. Aminotétrahydropyrannes en tant qu'inhibiteurs de dipeptidylpeptidase-iv dans le traitement prophylactique ou thérapeutique du diabète
CA2638800A1 (fr) 2006-02-22 2007-09-07 Merck & Co., Inc. Derives d'oxyntomoduline
WO2007109135A2 (fr) 2006-03-20 2007-09-27 Merck & Co., Inc. Agonistes du récepteur de neuromédine u et leurs utilisations
TW200806669A (en) * 2006-03-28 2008-02-01 Merck & Co Inc Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
AU2007254357B2 (en) 2006-05-16 2011-07-21 Merck Sharp & Dohme Corp. Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
MX2009000748A (es) 2006-07-18 2009-03-31 Centocor Inc Mimeticuerpos de peptido-1 similar a glucagon de humano, composiciones, metodos y usos.
WO2008060488A1 (fr) 2006-11-14 2008-05-22 Merck & Co., Inc. Composés hétéroaromatiques tricycliques en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prévention de diabètes
GEP20135944B (en) 2007-02-15 2013-10-25 Indiana Unversity Research And Tech Corporation Glucagon/glp-1 receptor co-agonists
JP2010531307A (ja) 2007-06-28 2010-09-24 メルク フロスト カナダ リミテツド Ｇｐｒ１０５活性のアンタゴニストとしての置換縮合ピリミジン
AU2008276568A1 (en) 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
WO2009014676A1 (fr) * 2007-07-23 2009-01-29 Merck & Co., Inc. Nouvelle forme cristalline d'un sel de dichlorhydrate d'un inhibiteur de la dipeptidyle peptidase iv
US8653059B2 (en) 2007-08-21 2014-02-18 Merck Sharp & Dohme Corp. Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
WO2009042053A2 (fr) 2007-09-21 2009-04-02 Merck & Co., Inc. Agonistes du récepteur de la neuromédine u et leurs utilisations
US7902376B2 (en) * 2008-01-23 2011-03-08 Merck Sharp & Dohme Corp. Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates
CN102272135A (zh) 2008-10-08 2011-12-07 百时美施贵宝公司 唑并吡咯酮黑色素浓集激素受体-1拮抗剂
JO2870B1 (en) * 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes

Also Published As

Publication number Publication date
HRP20130924T1 (hr) 2013-11-08
BRPI0921375A2 (pt) 2015-12-29
US8415297B2 (en) 2013-04-09
CR20110257A (es) 2011-07-01
KR20120107133A (ko) 2012-09-28
WO2010056708A1 (fr) 2010-05-20
JP4854825B1 (ja) 2012-01-18
JP5537507B2 (ja) 2014-07-02
GEP20135724B (en) 2013-01-10
US20130157940A1 (en) 2013-06-20
EP2358717B1 (fr) 2013-08-21
NI201100081A (es) 2011-11-03
MA32887B1 (fr) 2011-12-01
HK1154849A1 (en) 2012-05-04
ECSP11011044A (es) 2011-06-30
AU2009314191B2 (en) 2012-02-16
EP2676960A1 (fr) 2013-12-25
US9403790B2 (en) 2016-08-02
CN102272136A (zh) 2011-12-07
US20140287993A1 (en) 2014-09-25
MX2011005044A (es) 2011-06-17
EP2676960B1 (fr) 2017-04-19
US20150344487A1 (en) 2015-12-03
EP2676961B1 (fr) 2017-04-19
CN102272136B (zh) 2015-01-14
KR101260162B1 (ko) 2013-05-09
MY150787A (en) 2014-02-28
SI2358717T1 (sl) 2014-02-28
US8951965B2 (en) 2015-02-10
DOP2011000128A (es) 2011-06-30
EP2676961A1 (fr) 2013-12-25
EA201170670A1 (ru) 2011-12-30
PE20120027A1 (es) 2012-02-05
UA101414C2 (uk) 2013-03-25
EP2676959A1 (fr) 2013-12-25
SV2011003903A (es) 2011-10-13
US8772328B2 (en) 2014-07-08
DK2358717T3 (da) 2013-11-18
TWI398443B (zh) 2013-06-11
EP2358717A1 (fr) 2011-08-24
JP2012508746A (ja) 2012-04-12
IL225198A (en) 2016-02-29
NZ592826A (en) 2012-06-29
US20120149637A1 (en) 2012-06-14
CO6382129A2 (es) 2012-02-15
US20140051740A1 (en) 2014-02-20
CY1114617T1 (el) 2016-10-05
EA018613B1 (ru) 2013-09-30
AU2009314191A1 (en) 2010-05-20
JP2011251973A (ja) 2011-12-15
US8143289B2 (en) 2012-03-27
IL212485A0 (en) 2011-06-30
HN2011001256A (es) 2013-10-14
BRPI0921375B8 (pt) 2021-05-25
KR20110074581A (ko) 2011-06-30
KR101454093B1 (ko) 2014-10-27
CL2011001082A1 (es) 2012-02-24
BRPI0921375B1 (pt) 2020-11-03
PT2358717E (pt) 2013-11-26
US9138426B2 (en) 2015-09-22
TW201024299A (en) 2010-07-01
US9278976B2 (en) 2016-03-08
US8592371B2 (en) 2013-11-26
IL212485A (en) 2013-08-29
CA2742783A1 (fr) 2010-05-20
US20150126443A1 (en) 2015-05-07
ES2432191T3 (es) 2013-12-02
US20160137622A1 (en) 2016-05-19
US20100120863A1 (en) 2010-05-13
PA8848201A1 (es) 2010-06-28
JO2870B1 (en) 2015-03-15
PL2358717T3 (pl) 2014-01-31
CA2742783C (fr) 2013-01-08
RS52946B (en) 2014-02-28
AR074306A1 (es) 2011-01-05

Similar Documents

Publication Publication Date Title
JO2870B1 (en) Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
MX2012002633A (es) Aminotetrahidropiranos como inhibidores de la dipeptidil peptidasa iv para el tratamiento prevencion de la diabetes.
MX2008012490A (es) Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes.
EP2571876A4 (fr) Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète
WO2007097931A3 (fr) Aminotétrahydropyrannes en tant qu'inhibiteurs de dipeptidylpeptidase-iv dans le traitement prophylactique ou thérapeutique du diabète
WO2007136603A3 (fr) Aminotétrahydropyranes en tant qu'inhibiteurs de la dipeptidyl peptidase-iv pour le traitement ou la prévention du diabète
WO2007087231A3 (fr) Aminocyclohexanes utiles en tant qu'inhibiteurs de la dipeptidyl peptidase-iv pour traiter ou prévenir le diabète
EP1888066A4 (fr) Aminocyclohexanes en tant qu'inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete
EP1921917A4 (fr) Aminopiperidines fusionnees utilisees comme inhibiteurs de dipeptidyl-peptidase-iv pour le traitement ou la prevention du diabete
EP1796669A4 (fr) Aminopiperidines utilisees comme inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete
EP1819674A4 (fr) Aminopiperidines fusionnees utilisees comme inhibiteurs de la dipeptidyle peptidase-iv permettant de traiter ou de prevenir le diabete
WO2007070434A3 (fr) Amino-piperidines fusionnees en tant qu'inhibiteurs de la dipeptidyl peptidase-4 pour le traitement ou la prevention du diabete
EP1841770A4 (fr) Pyrimidines bicycliques en tant qu'inhibiteurs de la dipeptidyl-peptidase-iv dans le traitement ou la prevention de diabetes
EP1784188A4 (fr) Derives de triazole accoles inhibiteurs de la dipeptidyl peptidase-iv utilises dans le traitement ou la prevention du diabete
GEP20135785B (en) Pyrrolopyrimidine compounds as cdk inhibitors
EP1651623A4 (fr) Hexahydrodiazepinones utilises en tant qu'inhibiteurs de la dipeptidyl peptidase iv pour le traitement ou la prevention du diabete
GB2465132A (en) Novel compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
EP2091328A4 (fr) Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer
EA201070635A1 (ru) Соединения, ингибирующие дипептидилпептидазу-iv,способы их получения и фармацевтические композиции, содержащие их в качестве активного агента
WO2012118945A3 (fr) Hétérocycles bicycliques fondus, utilisés comme inhibiteurs de la dipeptidylpeptidase-4
EP2077719A4 (fr) Inhibiteurs pipéridines et pyrrolidines de la bêta-secrétase utilisés dans le traitement de la maladie d'alzheimer
WO2013006526A3 (fr) Hétérocycles tricycliques utiles comme inhibiteurs de la dipeptidyl peptidase-iv
EP2073635A4 (fr) Inhibiteurs de spiropipéridine macrocyclique de bêta-secrétase pour le traitement de la maladie d'alzheimer
WO2012017391A3 (fr) Nouveaux composés en tant qu'inhibiteurs de la dpp-iv et procédé de préparation associé
EP1912963A4 (fr) Inhibiteurs de beta-secretase a cetal cyclique destines au traitement de la maladie d'alzheimer