TH133899A - Acid sodium salt 5-cyclo-propyl-2 - {[2- (2,6-difluorophenyl) pyrimidin -5-il] amino} benzoic As a DHODH inhibitor - Google Patents
Acid sodium salt 5-cyclo-propyl-2 - {[2- (2,6-difluorophenyl) pyrimidin -5-il] amino} benzoic As a DHODH inhibitorInfo
- Publication number
- TH133899A TH133899A TH1101001984A TH1101001984A TH133899A TH 133899 A TH133899 A TH 133899A TH 1101001984 A TH1101001984 A TH 1101001984A TH 1101001984 A TH1101001984 A TH 1101001984A TH 133899 A TH133899 A TH 133899A
- Authority
- TH
- Thailand
- Prior art keywords
- pyrimidin
- amino
- benzoic
- difluorophenyl
- sodium salt
- Prior art date
Links
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims abstract 4
- 159000000000 sodium salts Chemical class 0.000 title claims abstract 4
- -1 2,6-difluorophenyl Chemical group 0.000 title claims abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N 289-95-2 Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 2
- 102100002130 DHODH Human genes 0.000 title 1
- 101710035145 DHODH Proteins 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- SLSURDZCCVUGLR-UHFFFAOYSA-N 5-cyclopropyl-2-[[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino]benzoic acid Chemical compound OC(=O)C1=CC(C2CC2)=CC=C1NC(C=N1)=CN=C1C1=C(F)C=CC=C1F SLSURDZCCVUGLR-UHFFFAOYSA-N 0.000 claims abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
Abstract
DC60 (14/03/56) การประดิษฐ์นี้ถูกชี้นำกับเกลือโซเดียมของกรด 5- ไซโคลโพรพิล-2-{[2-(2,6-ไดฟลูออ- โรฟีนิล)ไพริมิดิน-5-อิล]อะมิโน}เบนโซอิค (5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5- yl]amino}benzoic acid) และโซลเวทของสารนี้ที่ยอมรับได้ทางเภสัชกรรม การประดิษฐ์นี้ถูกชี้นำกับเกลือโซเดียมของกรด5-ไซโคลโพรพิล-2-{[2-(2,6-ไดฟลูออ- โรฟีนิล)ไพริมิดิน-5-อิล]อะมิโน}เบนโซอิค(5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5- yl]amino)}benzoic acid)และโซลเวทของสารนี้ที่ยอมรับได้ทางเภสัชกรรม สิทธิบัตรยา DC60 (14/03/56) This invention was directed to the sodium salt of 5-cyclopropyl-2 - ((2- (2,6-diplo-rophenyl) pyrimidine). -5-il] amino} benzoic (5-cyclopropyl-2 - {[2- (2,6-difluorophenyl) pyrimidin-5- yl] amino} benzoic acid) and solvate of this substance are pharmacologically acceptable. This invention was directed to the sodium salt of 5-cyclopropyl-2 - ([2- (2,6-dipflu-rophenyl) pyrimidin-5-il] ami. No} benzoic (5-cyclopropyl-2 - {[2- (2,6-difluorophenyl) pyrimidin-5- yl] amino)} benzoic acid) and solvate of this substance, which is acceptable for pharmaceuticals, drug patents.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH133899B TH133899B (en) | 2014-05-26 |
| TH133899A true TH133899A (en) | 2014-05-26 |
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