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SU635875A3 - Способ получени -гомостероидов - Google Patents

Способ получени -гомостероидов

Info

Publication number
SU635875A3
SU635875A3 SU752145940A SU2145940A SU635875A3 SU 635875 A3 SU635875 A3 SU 635875A3 SU 752145940 A SU752145940 A SU 752145940A SU 2145940 A SU2145940 A SU 2145940A SU 635875 A3 SU635875 A3 SU 635875A3
Authority
SU
USSR - Soviet Union
Prior art keywords
homosteroids
obtaining
dione
solution
chloro
Prior art date
Application number
SU752145940A
Other languages
English (en)
Inventor
Алиг Лео
Фюрст Андор
Мюллер Марсель
Original Assignee
Ф.Гоффманн-Ля Рош И Ко Аг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK170673AA external-priority patent/DK135722B/da
Priority claimed from CH1376473A external-priority patent/CH596237A5/xx
Application filed by Ф.Гоффманн-Ля Рош И Ко Аг (Фирма) filed Critical Ф.Гоффманн-Ля Рош И Ко Аг (Фирма)
Application granted granted Critical
Publication of SU635875A3 publication Critical patent/SU635875A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

она и 200 мг N-хлорсукцинимида перемешивают 1 ч при комнатной температуре в 4 мл раствора мочевины в плавиковой кислоте в соотношении по весу 1,25 : 1. Реакционную смесь выливают в водный раствор бикарбоната натри  и сульфита натри  и э-;чстрагир,уют хлористым метиленом. Растзор .ы хлористого метилена промывают водой, высушивают и упаривают. Хроматографированием в смеси хлористый метилен - ацетон выдел ют 270 мг 21-ацетокси-9 ,а-хлор-1р-фтор-17а-окси-1)-гомопрегна К4-диен-3 ,20-диона; т. пл. 266-268° С.
УФ-спектр: 6237 15250. (,104%, диоксан.)
Пример 3. К 470 мг 21-ацетокси-9ахлор-11р-фтор-17а-окси-/ ) - гомоирегна - 1,4диен- 3,20-диона в 10 мл метанола в атмосфере аргона добавл ют раствор 130 мг поташа в 2 мл воды, затем перемешивают 1 ч при комнатной температуре. Реакционную смесь выливают в раствор поваренной соли и экстрагируют хлористым метиленом. Экстракты промывают, высушивают, упаривают , получают чистый 9а-хлор-11р-фторI Та, 21 -диокси-О-гомопрегна-1,4-диен-3,20дион .
УФ -спектр: 8237 15150.
Пример 4. Аналогично примеру 2 из 400 мг 21-ацетоксн-17а-окси-1)-гомопрегна1 ,4,9(11)-триен-3,20-диона получают 270 мг 21-ацето.кси-9о:-хлор-11р-фтор - 17а-окси-Огоыопрегна-1 ,4 - диен - 3,20 - диона с т. пл. 266-268° С.
УФ-спектр: 6237 15250.
аЬ + 120 (с 0,104%, диоксан).

Claims (1)

1. Бюлер К-, Пирсон Д. синтезы, М., «Мир, 1973, ч.
SU752145940A 1973-03-28 1975-06-20 Способ получени -гомостероидов SU635875A3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK170673AA DK135722B (da) 1972-03-29 1973-03-28 Analogifremgangsmåde til fremstilling af 11beta,17aalfa,21-trihydroxy-D-homopregn-4-en-3,20-dioner.
CH1376473A CH596237A5 (en) 1973-09-26 1973-09-26 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones
DK531173AA DK142289B (da) 1973-03-28 1973-09-28 Analogifremgangsmåde til fremstilling af D-homopregn-4-en-3,20-dioner.

Publications (1)

Publication Number Publication Date
SU635875A3 true SU635875A3 (ru) 1978-11-30

Family

ID=27177053

Family Applications (6)

Application Number Title Priority Date Filing Date
SU752145939A SU612638A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU7502145936A SU564814A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU752145938A SU867316A3 (ru) 1973-03-28 1975-06-20 Способ получени д-гомостероидов
SU752145930A SU634676A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU752145940A SU635875A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU752145928A SU683630A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов

Family Applications Before (4)

Application Number Title Priority Date Filing Date
SU752145939A SU612638A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU7502145936A SU564814A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов
SU752145938A SU867316A3 (ru) 1973-03-28 1975-06-20 Способ получени д-гомостероидов
SU752145930A SU634676A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU752145928A SU683630A3 (ru) 1973-03-28 1975-06-20 Способ получени -гомостероидов

Country Status (26)

Country Link
US (1) US3939193A (ru)
JP (3) JPS595600B2 (ru)
AR (1) AR211000A1 (ru)
AT (1) AT335087B (ru)
BE (1) BE820304A (ru)
CA (1) CA1031323A (ru)
CS (4) CS179927B2 (ru)
DD (1) DD115354A5 (ru)
DE (1) DE2445817C2 (ru)
DK (1) DK142289B (ru)
EG (1) EG11212A (ru)
ES (9) ES430370A1 (ru)
FI (1) FI54604C (ru)
FR (1) FR2244474B1 (ru)
GB (1) GB1445945A (ru)
HU (1) HU172657B (ru)
IE (1) IE40178B1 (ru)
IL (1) IL45516A (ru)
LU (1) LU70979A1 (ru)
NO (1) NO140672C (ru)
PH (1) PH11410A (ru)
PL (5) PL95272B1 (ru)
SE (1) SE418402B (ru)
SU (6) SU612638A3 (ru)
YU (3) YU36745B (ru)
ZA (1) ZA745316B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036874A (en) * 1972-03-29 1977-07-19 Hoffmann-La Roche Inc. D-homopregnanes
US4026923A (en) * 1973-03-28 1977-05-31 Hoffmann-La Roche Inc. D-Homosteroids
DE2349023A1 (de) * 1973-09-26 1975-04-10 Schering Ag Neue d-homo-steroide
DE2349022A1 (de) * 1973-09-26 1975-04-10 Schering Ag Neue d-homo-steroide
SE427276B (sv) * 1975-04-03 1983-03-21 Hoffmann La Roche Forfarande for framstellning av d-homosteroider
US4139716A (en) * 1975-04-09 1979-02-13 Hoffmann-La Roche Inc. 19-Nor-D-homopregnanes
DE2526372C2 (de) * 1975-06-11 1983-12-08 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Δ↑9↑↑(↑↑1↑↑1↑↑)↑-5α-D-Homo-20-ketosteroiden
NL7611162A (nl) * 1975-10-22 1977-04-26 Hoffmann La Roche Nieuwe d-homosteroiden.
AT356301B (de) * 1976-09-03 1980-04-25 Hoffmann La Roche Verfahren zur herstellung von neuen d-homo- steroiden
NL7802905A (nl) * 1977-04-21 1978-10-24 Hoffmann La Roche Werkwijze voor het bereiden van d-homosteroiden.
US4202841A (en) * 1977-08-25 1980-05-13 Hoffmann-La Roche Inc. D-Homopregnanes
DE3038855A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue d-homo-kortikoide, ihre herstellung und verwendung
JPS59181878U (ja) * 1983-05-24 1984-12-04 東芝機械株式会社 半導体結晶引上機用シ−ドホルダ連結金具
DE3409554A1 (de) * 1984-03-13 1985-09-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methyl-d-homo-kortikoide
JPS61115907U (ru) * 1984-12-30 1986-07-22
CN106831920B (zh) * 2016-12-03 2019-03-05 丽江映华生物药业有限公司 一种合成6-亚甲基-17α-羟基-19-去甲孕甾-4-烯-3,20-二酮的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860158A (en) * 1954-10-18 1958-11-11 Sterling Drug Inc Compounds of the perhydrochrysene series and preparation thereof
US3686223A (en) * 1968-12-26 1972-08-22 Sterling Drug Inc D-homoestratrienes
US3833621A (en) * 1972-03-20 1974-09-03 Richardson Merrell Inc 3-keto-7(alpha,beta)-loweralkyl-delta5 steroids and process for preparing same
CH571018A5 (ru) * 1972-03-29 1975-12-31 Hoffmann La Roche

Also Published As

Publication number Publication date
LU70979A1 (ru) 1976-08-19
FI54604B (fi) 1978-09-29
YU296680A (en) 1982-06-18
YU36979B (en) 1984-08-31
ES455104A1 (es) 1977-12-16
IL45516A0 (en) 1974-12-31
JPS5928560B2 (ja) 1984-07-13
YU36980B (en) 1984-08-31
YU243074A (en) 1982-06-18
DK142289C (ru) 1981-02-23
JPS5844000A (ja) 1983-03-14
SE418402B (sv) 1981-05-25
JPS596880B2 (ja) 1984-02-15
DD115354A5 (ru) 1975-09-20
SU683630A3 (ru) 1979-08-30
ES455103A1 (es) 1977-12-16
ES455106A1 (es) 1978-01-01
NO140672C (no) 1979-10-17
US3939193A (en) 1976-02-17
IE40178B1 (en) 1979-03-28
ES455102A1 (es) 1978-01-01
BE820304A (fr) 1975-03-25
JPS595600B2 (ja) 1984-02-06
CA1031323A (en) 1978-05-16
PL95273B1 (pl) 1977-10-31
FI54604C (fi) 1979-01-10
ES455105A1 (es) 1977-12-16
ES430370A1 (es) 1977-06-01
DE2445817A1 (de) 1975-04-03
AU7263374A (en) 1976-02-26
SU634676A3 (ru) 1978-11-25
PH11410A (en) 1977-12-27
DK142289B (da) 1980-10-06
SU564814A3 (ru) 1977-07-05
PL95271B1 (pl) 1977-10-31
GB1445945A (en) 1976-08-11
SU867316A3 (ru) 1981-09-23
NO140672B (no) 1979-07-09
FI276774A (ru) 1975-03-27
ES455107A1 (es) 1977-12-16
PL95291B1 (pl) 1977-10-31
PL95270B1 (ru) 1977-10-31
YU296780A (en) 1982-06-18
ES455100A1 (es) 1977-12-16
CS179948B2 (en) 1977-12-30
IE40178L (en) 1975-03-26
SU612638A3 (ru) 1978-06-25
IL45516A (en) 1978-03-10
SE7313269L (ru) 1975-03-27
ATA771974A (de) 1976-06-15
AR211000A1 (es) 1977-10-14
FR2244474A1 (ru) 1975-04-18
AT335087B (de) 1977-02-25
PL95272B1 (pl) 1977-10-31
NO380073L (ru) 1975-04-28
HU172657B (hu) 1978-11-28
YU36745B (en) 1984-08-31
CS179927B2 (en) 1977-12-30
ZA745316B (en) 1975-08-27
ES455101A1 (es) 1977-12-16
DE2445817C2 (de) 1985-09-05
DK531173A (ru) 1975-06-23
JPS5843999A (ja) 1983-03-14
CS179950B2 (en) 1977-12-30
FR2244474B1 (ru) 1978-06-30
JPS5058052A (ru) 1975-05-20
EG11212A (en) 1977-01-31
CS179949B2 (en) 1977-12-30

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