[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SMT201300078B - Nucleosidi di uracile spiroossietano - Google Patents

Nucleosidi di uracile spiroossietano

Info

Publication number
SMT201300078B
SMT201300078B SM201300078T SM201300078T SMT201300078B SM T201300078 B SMT201300078 B SM T201300078B SM 201300078 T SM201300078 T SM 201300078T SM 201300078 T SM201300078 T SM 201300078T SM T201300078 B SMT201300078 B SM T201300078B
Authority
SM
San Marino
Prior art keywords
spiroossietano
nucleosides
uracil
uracil spiroossietano
spiroossietano nucleosides
Prior art date
Application number
SM201300078T
Other languages
English (en)
Inventor
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Steven Maurice Paula Van Hoof
Lili Hu
Abdellag Tahri
Original Assignee
Janssen Products
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Products, Medivir Ab filed Critical Janssen Products
Publication of SMT201300078B publication Critical patent/SMT201300078B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SM201300078T 2009-05-14 2013-07-04 Nucleosidi di uracile spiroossietano SMT201300078B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160215 2009-05-14
PCT/EP2010/056438 WO2010130726A1 (en) 2009-05-14 2010-05-11 Uracyl spirooxetane nucleosides

Publications (1)

Publication Number Publication Date
SMT201300078B true SMT201300078B (it) 2013-09-06

Family

ID=40823307

Family Applications (2)

Application Number Title Priority Date Filing Date
SM201300078T SMT201300078B (it) 2009-05-14 2013-07-04 Nucleosidi di uracile spiroossietano
SM201400085T SMT201400085B (it) 2009-05-14 2014-06-30 Nucleosidi di uracile spiroosietano

Family Applications After (1)

Application Number Title Priority Date Filing Date
SM201400085T SMT201400085B (it) 2009-05-14 2014-06-30 Nucleosidi di uracile spiroosietano

Country Status (39)

Country Link
US (2) US8481510B2 (it)
EP (2) EP2430035B1 (it)
JP (2) JP5778135B2 (it)
KR (1) KR101806837B1 (it)
CN (1) CN102439024B (it)
AP (1) AP2783A (it)
AR (1) AR076579A1 (it)
AU (1) AU2010247439B2 (it)
BR (1) BRPI1010579A2 (it)
CA (1) CA2760329C (it)
CL (1) CL2011002859A1 (it)
CO (1) CO6440533A2 (it)
CR (1) CR20120297A (it)
CY (2) CY1114081T1 (it)
DK (2) DK2511282T3 (it)
EA (1) EA022084B1 (it)
EC (1) ECSP11011461A (it)
ES (2) ES2411086T3 (it)
HK (1) HK1166326A1 (it)
HN (1) HN2011003014A (it)
HR (2) HRP20130554T1 (it)
IL (1) IL215955A (it)
JO (1) JO3027B1 (it)
ME (1) ME01478B (it)
MX (1) MX2011012027A (it)
MY (1) MY157018A (it)
NI (1) NI201100197A (it)
NZ (1) NZ596073A (it)
PL (2) PL2430035T3 (it)
PT (2) PT2430035E (it)
RS (1) RS52822B (it)
SG (1) SG175981A1 (it)
SI (2) SI2511282T1 (it)
SM (2) SMT201300078B (it)
TW (1) TWI461432B (it)
UA (1) UA105790C2 (it)
UY (1) UY32642A (it)
WO (1) WO2010130726A1 (it)
ZA (1) ZA201108309B (it)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PA8855801A1 (es) 2008-12-23 2010-07-27 Sintesis de nucleosidos de purina
JO3027B1 (ar) * 2009-05-14 2016-09-05 Janssen Products Lp نيوكليوسيدات يوراسيل سبيرواوكسيتان
DK2638054T3 (en) * 2010-11-10 2015-03-09 Janssen Products Lp URACYLSPIROOXETANNUCLEOSIDE PHOSPHORAMIDATES
EP2638053B1 (en) * 2010-11-10 2016-08-31 Janssen Products, L.P. Uracyl spirooxetane nucleoside phosphoramidates
WO2012075140A1 (en) 2010-11-30 2012-06-07 Pharmasset, Inc. Compounds
AU2015252113B2 (en) * 2010-11-30 2017-05-04 Gilead Pharmasset Llc Compounds
BR112013026219A2 (pt) * 2011-04-13 2016-07-26 Gilead Sciences Inc análogos de n-nucleosídeo 1'-substituída pirimidina para tratamento antiviral
CA2860234A1 (en) * 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
AP3545A (en) 2012-05-25 2016-01-14 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
JP6219414B2 (ja) * 2013-03-08 2017-10-25 ナンジン・サンホーム・ファーマシューティカル・カンパニー・リミテッドＮａｎｊｉｎｇ Ｓａｎｈｏｍｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． 新規なヌクレオシドホスホロアミデート化合物およびその使用
AU2014250762A1 (en) 2013-04-12 2015-10-29 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV
WO2014194826A1 (zh) * 2013-06-06 2014-12-11 南京圣和药业有限公司 三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用
EP3074412A4 (en) * 2013-11-28 2017-05-31 Janssen Sciences Ireland UC Crystal form of nucleoside inhibitor of hcv
EA037098B1 (ru) 2015-03-06 2021-02-05 Atea Фармасьютикалс, Инк. -d-2'-дезокси-2'--фтор-2'--c-замещенные-2-модифицированные-n6-замещенные пуриновые нуклеотиды для лечения вызванных hcv заболеваний
LU100724B1 (en) 2016-07-14 2018-07-31 Atea Pharmaceuticals Inc Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
BR112019004297A2 (pt) 2016-09-07 2019-05-28 Atea Pharmaceuticals Inc método, uso de uma quantidade eficaz de um composto, composto, e, composição farmacêutica.
KR102693011B1 (ko) 2017-02-01 2024-08-08 아테아 파마슈티컬즈, 인크. C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염
JP7181938B2 (ja) 2018-01-10 2022-12-01 ヌクオリオン ファーマシューティカルズ インコーポレイテッド ホスホロ（ン）アミダートアセタールおよびホスファ（ホナ）ートアルセタール化合物
EP3773753A4 (en) 2018-04-10 2021-12-22 ATEA Pharmaceuticals, Inc. TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS
US12110311B2 (en) 2019-07-17 2024-10-08 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
US20230201236A1 (en) * 2020-04-14 2023-06-29 Janssen Pharmaceuticals, Inc. Spirocyclic nucleoside analogues for the treatment of hepatitis e

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007491B1 (ru) * 2001-01-22 2006-10-27 Мерк Энд Ко., Инк. Производные нуклеозидов в качестве ингибиторов рнк-зависимой рнк вирусной полимеразы
CA2571079A1 (en) * 2004-06-24 2006-02-02 Merck & Co., Inc. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
JP2009504704A (ja) * 2005-08-15 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート
JP2009526850A (ja) * 2006-02-14 2009-07-23 メルク エンド カムパニー インコーポレーテッド Ｒｎａ依存性ｒｎａウイルス感染を治療するためのヌクレオシドアリールホスホルアミデート
PA8852101A1 (es) * 2008-12-08 2010-07-27 Medivir Ab Nucleótidos uracil ciclopropílicos
JO3027B1 (ar) * 2009-05-14 2016-09-05 Janssen Products Lp نيوكليوسيدات يوراسيل سبيرواوكسيتان

Also Published As

Publication number Publication date
ME01478B (me) 2014-04-20
AU2010247439A1 (en) 2011-12-01
JP5778135B2 (ja) 2015-09-16
US20120065156A1 (en) 2012-03-15
BRPI1010579A2 (pt) 2016-03-15
UY32642A (es) 2010-11-30
US20130217648A1 (en) 2013-08-22
PL2511282T3 (pl) 2014-09-30
EA022084B1 (ru) 2015-10-30
CA2760329A1 (en) 2010-11-18
EA201171406A1 (ru) 2012-05-30
TW201100442A (en) 2011-01-01
SI2511282T1 (sl) 2014-09-30
ECSP11011461A (es) 2012-02-29
TWI461432B (zh) 2014-11-21
SI2430035T1 (sl) 2013-08-30
US8933052B2 (en) 2015-01-13
HN2011003014A (es) 2014-06-30
CA2760329C (en) 2017-10-31
MY157018A (en) 2016-04-15
KR101806837B1 (ko) 2017-12-08
US8481510B2 (en) 2013-07-09
DK2511282T3 (da) 2014-07-07
CY1114081T1 (el) 2016-07-27
EP2430035A1 (en) 2012-03-21
AR076579A1 (es) 2011-06-22
SMT201400085B (it) 2014-09-08
JP2012526764A (ja) 2012-11-01
AU2010247439B2 (en) 2014-09-25
PT2430035E (pt) 2013-05-22
HK1166326A1 (en) 2012-10-26
CL2011002859A1 (es) 2012-07-20
CR20120297A (es) 2012-10-25
CN102439024B (zh) 2014-09-17
JP2015180692A (ja) 2015-10-15
NI201100197A (es) 2012-05-28
ES2477598T3 (es) 2014-07-17
IL215955A0 (en) 2012-01-31
MX2011012027A (es) 2012-02-28
DK2430035T3 (da) 2013-05-27
HRP20130554T1 (en) 2013-07-31
NZ596073A (en) 2013-02-22
PL2430035T3 (pl) 2013-08-30
CO6440533A2 (es) 2012-05-15
SG175981A1 (en) 2011-12-29
EP2430035B1 (en) 2013-04-03
KR20120018355A (ko) 2012-03-02
WO2010130726A1 (en) 2010-11-18
ES2411086T3 (es) 2013-07-04
UA105790C2 (uk) 2014-06-25
PT2511282E (pt) 2014-07-11
CY1115383T1 (el) 2017-01-04
AP2783A (en) 2013-10-31
JO3027B1 (ar) 2016-09-05
AP2011005958A0 (en) 2011-10-31
EP2511282B1 (en) 2014-04-02
CN102439024A (zh) 2012-05-02
RS52822B (en) 2013-10-31
EP2511282A1 (en) 2012-10-17
HRP20140605T1 (hr) 2014-09-26
IL215955A (en) 2015-03-31
ZA201108309B (en) 2013-04-24

Similar Documents

Publication Publication Date Title
SMT201400085B (it) Nucleosidi di uracile spiroosietano
SMT201600351B (it) Composti antivirali
BR112012007122A2 (pt) derivados de fosforamidatos de nucleosídeos
BRPI0922681A2 (pt) nucleiotídeos de uracil ciclopropila
BRPI0907435A2 (pt) Derivados de 5-flúor pirimidina
ZA201008829B (en) Nucleoside cyclicphosphates
DK2154967T3 (da) Pyrimidinderivater
ZA201106827B (en) Substituted nucleoside and nucleotide analogs
BRPI0922508A2 (pt) Análogos de nucleosídeo
BRPI0819797A2 (pt) compostos de nucleosídeos antivirais
BR112012005616A2 (pt) compostos antivirais heterocíclicos
BRPI1010852A2 (pt) compostos antivirais heterocíclicos
BRPI1013493A2 (pt) composto de pirimidina
BRPI1016266A2 (pt) compostos antivirais heterocíclicos
BRPI0811115A2 (pt) Compostos de heteroarilamida pirimidona
DK2373644T3 (da) Pyridazinonderivater
BRPI1010900A2 (pt) compostos antivirais heterocíclicos
BRPI0923903A2 (pt) Derivados de piridazinona
TH104960B (th) อนุพันธ์ซับสทิทิวเต็ดอะริลลาไมด์ออกซาเซพิโนไพริมิโดน
FI20090160A0 (fi) Avaruusalus
FR2942717B1 (fr) Nouvel agent antiviral
FIU20090270U0 (fi) Oligonukleotidikonjugaatteja
TH114434B (th) คาร์บอไฮเดรต
TH94206B (th) ปากกา
TH105862B (th) ปากกา