SK500332020U1 - Disinfectant, method of its preparation and its use - Google Patents

Abstract

The technical solution describes a long-term stable disinfectant, suitable in particular for large-scale disinfection, disinfection of objects and / or spaces, in the form of an aqueous solution with bactericidal, sporocidal, virocidal and fungicidal disinfectant activity. The disinfectant contains 0.5 to 20 wt. % of hypochlorous acid and / or its salts, 1 to 5,000 ppm of silver nanoparticles with a size of 500 nm to 15 nm, 0.05 to 3.5 wt. % of at least one quaternary ammonium compound selected from the group consisting of N-C8-C16-alkylbenzyldimethylammonium chloride, N-C8-C16-alkyldimethylammonium chloride, N-di (C8-C16-alkyl) dimethylammonium chloride and polyhexamethylene-guanidine hydrochloride, and weight. % of excipients and stabilizers, the remainder in the total weight of the composition being water.

Description

Technical field

The invention relates to a disinfectant suitable for personal disinfection and for large-scale disinfection in the form of an aqueous solution with bactericidal, sporocidal, virocidal and fungicidal disinfectant activity consisting of chloric acid and silver nanoparticles and a quaternary ammonium compound.

Prior art

Disinfection is a targeted process of elimination of microorganisms: bacteria, viruses, fungi, yeasts. Disinfection is performed chemically or physically. The effectiveness of the disinfection depends on the composition, the application, the pH value and the stability of the disinfectant. The doses of chlorine needed to disinfect the water depend mainly on the temperature, pH value, organic matter content. The effect of pH is that as it decreases, the proportions of the more potent form (HCl) increase, compared to the less effective form of the hypochlorite anion. The effectiveness of the disinfection is determined by the pH value of the water, the optimal effectiveness is achieved at a pH of the water between 5.5 and 7.5. Chloric acid is approximately 100 times more potent oxidizing agent than hypochlorite ion CIO and in this pH range it is maximally represented. For the chloric acid salt, the pH is recommended as the effective acidic value. However, this causes problems with surface corrosion. In addition, commonly used disinfectants based on hypochlorites contain a high percentage of hypochlorite ions and chloride anion, which causes problems with salinity and salinity, respectively. reduces the desired effect of synergistically acting materials. Therefore, it is particularly suitable to use commercial equipment generating chlorine directly.

CN 109907069 describes a disinfectant composition comprising as components chloric acid, crustacean amine, chitosan, EDTA, PVP, SiO2, polyhexamethylene guanidine, inositol, lauric acid, polyoxyethylene octyl ether, quaternized poly ether amine and ethanol.

CN110268115 describes sterilization in a papermaking process with chloric acid, chlorine dioxide, haloamines and polyhexamethylene guanidine.

JP2009160580 describes a biofilm inhibitor for microorganisms formed in situ by mixing solutions of chloric acid and ammonium salts.

U.S. Pat. No. 5,070,200 protects the process for preparing N-chloramines by reacting an amine and an aqueous 5% solution of chloric acid in an organic solvent.

NZ578582 protects the process for the preparation of N-halogen amines electrochemically.

JP2001247898 protects a composition against fungal contamination consisting of chloric acid and a cyclic secondary amine.

Patent document KR20020067082 protects a deodorizing soap consisting of plant extracts, perchloric acid, amino acid, ethanolamine, cellulose and a coconut soap base.

WO2018202897 relates to compositions consisting of oxidizing agents such as perchloric acid or its salts and artemisin compounds.

JP 2001302425 protects a sterilization method comprising mixing a solution of chloric acid and an amine oxide, an alcohol and a pH adjuster.

A granulate of a fungicidally active composition consisting of a resin, perchloric acid, a fatty acid ester, an alcohol and an amine is protected by KR20090127700.

U.S. Pat. No. 2019083373 protects a low-alcohol disinfectant foam by mixing water, a foaming agent and an organic solution of silver reindeer with polyethylene imine.

JP20192188436 discloses a composition with exceptional stability consisting of a quaternary ammonium compound, chloric acid and chloride ions.

U.S. Pat. No. 9,327,750 describes a composition based on peroxides and chlorides in which chlorine and oxygen are generated at pH 2-3 for disinfection.

GB 2078522 further stabilizes such an oxidation system using amidosulfonic acid and succinic acid.

Utility model SK 1682 protects a water-soluble biocidal and cleaning agent containing said alkali metal phosphate oxidation system.

Disinfectants containing chlorine-based oxidants prepared at the site of application are known, e.g. by electrochemical decomposition of sodium chloride e.g. SK 5216Y1.

Although they state half a year for the stability of the preparation, said application of a membrane system with a current of several amperes is impractical for the average user.

Combinations of several disinfectant active ingredients are known. Thus, the utility model SK 9-93 solves the disinfection using a combination of at least three active substances. However, the use of concentrated components reacts with each other and consequently reduces the effectiveness of the biocidal effect.

SK 3463-92 describes a combination of starch grease, polyethylene glycol, sodium hypochlorite, hydrochloric acid, benzyldimethyllaurylammonium chloride and water.

S K 50033-2020 U1

The oligodynamic effects (bactericidal ability) of some metals (Ag, Cu) have long been known. Oligodynamic effects are manifested in trace amounts of metals, the time of their contact with the material must be relatively long, often several hours. E.g. in the sterilization process with the aid of silver ions, silver ions are dosed into the water in a concentration of from 0.05 to 0.1 mg. k ¹ .

Czechoslovak patent no. 83637 from 1952 states the preparation of the so-called colloidal silver, where to stabilize the system uses e.g. water-soluble proteins (gelatin, albumin), for the effectiveness of the aqueous suspension of the preparation used for water disinfection indicates half a year.

Utility model SK 7250 protects a disinfectant consisting of chloric acid or its salts and silver nanoparticles and excipients and stabilizers selected from nonionic and ionic surfactants, water-soluble alcohols and polyols, polysaccharides, hydrogen peroxide, orthophthalaldehyde, formaldehyde, glutenaldehyde.

Despite this information, there is a lack of broad-spectrum disinfectants providing not only immediate disinfection but also effective long-term disinfection, which should show long-term stability, i. j. required effectiveness in a matter of months.

These shortcomings are eliminated by the utility model which ensures such disinfection by the action of a long-lasting disinfectant composition consisting of chlorine-free chloric acid, silver nanoparticles of an aquatic ammonium compound.

The essence of the technical solution

The essence of the technical solution is a long-term stable disinfectant suitable especially for disinfection of persons and large-scale disinfection and disinfection of objects and spaces in the form of aqueous solution with bactericidal, sporocidal, virocidal and fungicidal disinfecting activity containing 0.5 to 20% by weight of chloric acid and / or its sulfur chloride-free, 1 to 5000 ppm of silver nanoparticles with a size of 500 nm to 15 nm, 0.05 to 3.5 wt. % of at least one quaternary ammonium compound selected from the group consisting of N-GS-Glo-alkyl-benzyldimethylammonium chloride. N-C8-C16-alkyl-dimethylammonium chloride, N-di-C8-G16-alkyl-dimethylammonium chloride and polyhexamethylene guanidine hydrochloride, and 0.05 to 15 weight percent of excipients and stabilizers, the remainder being total water by weight of the composition. As excipients, substances selected from the group consisting of nonionic and ionic surfactants, fatty acid esters, water-soluble alcohols and polyols, hydrogen peroxide, aldehydes such as orthophthalaldehyde, formaldehyde or glutaraldehyde, and combinations thereof can be used. The surfactant is preferably sodium dodecylbenzenesulfonate and / or sodium lauryl sulfate and / or nonionic ethylene oxide or propylene oxide surfactants. As a silver stabilizer, it is possible to use a support on the polymer, preferably of natural origin, such as casein, albumin, gelatin, polysaccharides, polyactyl acid, polyvinylpyrrolidone or combinations thereof. Particularly suitable are polysaccharides such as e.g. arabinogalactan. The preparation of silver nanoparticles directly in a polyol-water and gelatin with formaldehyde medium is preferred, these forming part of the disinfectant formulation. Colloidal silver supplies e.g. Luma Systém as a Nanosilver product. The quality of the product is characterized by measuring the size of silver nanoparticles in aqueous dispersion, measuring polydispersity and measuring zeta potential. Surprisingly, it has been found that an aqueous solution of chloric acid not containing chloride anions in the pH range 6.5-7.5 containing silver nanoparticles and at least one quaternary ammonium compound selected from the group consisting of N-C8-C16-alkyl-benzyl Idimethylammonium chloride, N-C8 -C16-alkyldimethylammonium chloride, N-di (C8-C16-alkyl) dimethylammonium chloride and polyhexamethylene guanidine hydrochloride provide a long-lasting disinfectant. Chloric acid without chlorides is prepared e.g. by reacting chlorine oxide with water at a temperature of about 0 ° C (concentration about 5 mol dnr ³ ). Solutions of chloric acid salts are prepared by disproportionating chlorine in alkaline solutions. However, these solutions also contain chloride anions. Technologies for the preparation of perchloric acid are known e.g. Envirolyte, Envirolyte Industries intemational Ltd., Tallinn, Estonia, or by membrane electrolysis of soh solution Kohout engineering sro ČR. The quality of chloric acid salts is the stated content of "active chlorine". Suitable salts of chloric acid are LiClO (e.g. with 40% active chlorine), Ca (ClO) 2 (e.g. with 70% active chlorine), Ba (ClO) 2, NaOCl.

The advantage of the technical solution is the long-term effectiveness of the disinfectant, easy availability of starting materials (aqueous solution of chloric acid without chloride anions, colloidal silver suspension, commercially available ammonium salts) resp. their simple technology of preparation and handling of components. Another advantage is the wide range of disinfecting effect and its retention throughout the life of the product. In a solution of a preparation whose pH is neutral (6.5 - 7.5 pH), the concentration of chloric acid prevails over the hypochlorite anion Since the acidity of the solution of chloric acid is about ten times lower than the acidity of the carbonic acid solution, the preparation has no corrosive effects. The disinfectant is easy to handle, odorless after chlorine, without special storage requirements in terms of safety and maintaining a broad-spectrum effect. The advantage is the possibility of application in a wide concentration range of individual evils

With K 50033-2020 U1 of the final product, and thus also the influence of e.g. washing ability by adjusting the ratio of the individual components. The disinfectant can be applied undiluted or in a suitable dilution.

Other advantages as well as details of the formulation, application as well as the effectiveness of this technical solution are apparent from the examples of the technical solution without being limited thereto.

Examples of embodiments

Example 1

Demineralized water at a temperature of 15 to 20 ° C is introduced into a perfectly cleaned mixing vessel with a reaction volume of 1000 l. Chloric acid (produced on an Envirolyte) is fed from the chloric acid reservoir in an amount according to the desired final concentration, e.g. 2.5 weight percent. The mixture is stirred for 5 minutes and 150 ml of a 5,000 ppm aqueous suspension of colloidal silver in the form of nanoparticles (average particle size 25 nm) are added. The permissible deviation of the amount of water is ± 1%, of perchloric acid 0.1% and of colloidal silver 0.01%. Subsequently, 550 g of benzyldimethyllaurylammonium chloride are added with the fastener switched on. The mixing process takes 15 minutes. A stock solution of disinfectant is obtained as a clear, odorless, chlorine-free liquid with a pH of 6.7. The range of use is from +2 to +45 ° C. The original disinfection efficiency remained virtually unchanged within one year. Dosage of the product - diluted with water in the ratio 1:20 to 1:50, undiluted is applied to heavily contaminated places. Antibacterial efficacy is demonstrated by the test given in Table 1.

Table 1

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S K 50033-2020 U1

Examples 2 to 7

Modification of the stock solution according to Example 1 by the addition of auxiliaries resp. stabilizers are listed in Table 2.

Table 2

(wt.%) Tween 80 GA Hydrogen peroxide gelatin PEG AG EMK DSNA GL Example 2 - 0.1 0.05 1 - 0.5 0.5 1 2 Example 3 1 2 - 0.5 0.1 - 0.25 0.5 - Example 4 2 - - - 1 0.5 0.1 - 2 Example 5 - 0.25 - 1 - - 0.5 0.5 - Example 6 - - 2 - 5 - 0.5 5 - Example 7 - 0.5 1 - 0.1 - - 1 1

GA: glutaraldehyde, DS-Na: sodium dodecyl benzenesulfonate, AG: arabinogalactan, GL: glycerin, EMK: fatty acid esters,

Example 8

A hand disinfectant solution for routine and preventive hand disinfection is prepared by mixing a basic disinfectant with 60 wt. % alcohol in a ratio of 1: 0.5 to 1: 2 and the subsequent addition of 1 wt. % aloe vera and glycerin. How to use: the solution is applied to the hands, rubbed until it soaks into the skin, rinsed.

Industrial applicability

According to the mentioned technical solution, it is possible to industrially produce a disinfectant suitable for disinfecting persons and for large-scale disinfection, e.g. veterinary spaces, interiors of buildings, floors, workbenches but also swimming pools, wellness, saunas and for the preparation of products such as disinfectant soaps, etc., in the form of an aqueous solution with bactericidal, sporocidal, virocidal and fungicidal disinfecting efficacy. As the composition does not have corrosive effects, it can also be used effectively to disinfect small metal objects, e.g. refrigerators, and appliances, e.g. in healthcare and food.

Claims (7)

CLAIMS FOR PROTECTION Disinfectant, characterized in that it contains 0.5 to 20% by weight of chloric acid and / or its salts, 1 to 5000 ppm of silver nanoparticles with a size of 500 nm to 15 nm, 0.05 to 3.5% by weight. % of at least one quaternary ammonium compound selected from the group consisting of N-C8-C16-alkylbenzyldimethylammonium chloride, N-C8-C16-alkyldimethylammonium chloride, N-di (C8-C16-alkyl) dimethylammonium chloride and polyhexamethylene-guanidine 20 hydrochloride and weight percent of excipients and stabilizers, with the remainder in the total weight of the composition being water. Disinfectant according to claim 1, characterized in that the excipients are selected from the group consisting of nonionic and ionic surfactants, fatty acid esters, water-soluble alcohols and polyols, hydrogen peroxide, aldehydes such as orthophthalaldehyde, formaldehyde or glutaraldehyde, and combinations thereof . Disinfectant according to claim 1, characterized in that the stabilizers are selected from the group consisting of casein, albumin, gelatin, polysaccharides, polyacrylic acid, polyvinylpyrohdone and combinations thereof. Disinfectant according to Claim 2, characterized in that the surfactant is sodium dodecylbenzenesulfonate and / or sodium lauryl sulfate and / or nonionic surfactants based on ethylene oxide or propylene oxide. Process for preparing a disinfectant according to any one of claims 1 to 4, characterized in that a solution of chloric acid and / or its salts is mixed, an aqueous suspension of silver nanoparticles preferably stabilized by adding at least one substance selected from the group consisting of casein, albumin, gelatin, polysaccharides, polyacrylic acid, polyvinylpyrrolidone and combinations thereof, at least one quaternammonium compound and at least one monovalent. Method for disinfecting large areas, objects and / or spaces, characterized in that a disinfectant according to any one of claims 1 to 4 is applied to the disinfected large area, object and / or to the disinfected space. Use of a disinfectant according to any one of claims 1 to 4 for disinfecting large areas, objects and / or spaces.