SK2952003A3 - Biphenyl derivatives and the use thereof as integrin inhibitors - Google Patents

Biphenyl derivatives and the use thereof as integrin inhibitors Download PDF

Info

Publication number: SK2952003A3
Authority: SK; Slovakia
Prior art keywords: group; formula; pyridin; acid; solvates
Prior art date: 2000-08-23

Application number

SK295-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Wolfgang Staehle

Simon Goodman

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-23

Filing date

2001-07-24

Publication date

2003-06-03

2001-07-24 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-06-03 Publication of SK2952003A3 publication Critical patent/SK2952003A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

SK295-2003A 2000-08-23 2001-07-24 Biphenyl derivatives and the use thereof as integrin inhibitors SK2952003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10041428A DE10041428A1 (de)	2000-08-23	2000-08-23	Biphenylderivate
PCT/EP2001/008514 WO2002016323A1 (de)	2000-08-23	2001-07-24	Biphenylderivate und ihre verwendung als intigrininhibitoren

Publications (1)

Publication Number	Publication Date
SK2952003A3 true SK2952003A3 (en)	2003-06-03

Family

ID=7653542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK295-2003A SK2952003A3 (en)	2000-08-23	2001-07-24	Biphenyl derivatives and the use thereof as integrin inhibitors

Country Status (17)

Country	Link
US (1)	US20030187289A1 (de)
EP (1)	EP1311484A1 (de)
JP (1)	JP2004506717A (de)
KR (1)	KR20030022419A (de)
CN (1)	CN1447795A (de)
AU (1)	AU8973201A (de)
BR (1)	BR0113373A (de)
CA (1)	CA2420205A1 (de)
CZ (1)	CZ2003670A3 (de)
DE (1)	DE10041428A1 (de)
HU (1)	HUP0302822A3 (de)
MX (1)	MXPA03001556A (de)
NO (1)	NO20030812L (de)
PL (1)	PL359154A1 (de)
SK (1)	SK2952003A3 (de)
WO (1)	WO2002016323A1 (de)
ZA (1)	ZA200302253B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10127041A1 (de) *	2001-06-02	2002-12-05	Merck Patent Gmbh	Integrinantagonisten
WO2018046610A1 (en)	2016-09-08	2018-03-15	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for diagnosing and treating nephrotic syndrome

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999026921A1 (en) *	1997-11-24	1999-06-03	Merck & Co., Inc.	SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS
AU3561099A (en) *	1998-04-14	1999-11-01	American Home Products Corporation	Acylresorcinol derivatives as selective vitronectin receptor inhibitors
EP0960882A1 (de) *	1998-05-19	1999-12-01	Hoechst Marion Roussel Deutschland GmbH	Thienyl substituiertre Acylguanidine und ihre Verwendung als Knochenresorptionhemmer und als Vitronectinrezeptor-Antagoniste

2000
- 2000-08-23 DE DE10041428A patent/DE10041428A1/de not_active Withdrawn
2001
- 2001-07-24 CA CA002420205A patent/CA2420205A1/en not_active Abandoned
- 2001-07-24 BR BR0113373-0A patent/BR0113373A/pt not_active Application Discontinuation
- 2001-07-24 KR KR10-2003-7002578A patent/KR20030022419A/ko not_active Application Discontinuation
- 2001-07-24 SK SK295-2003A patent/SK2952003A3/sk unknown
- 2001-07-24 EP EP01969486A patent/EP1311484A1/de not_active Withdrawn
- 2001-07-24 MX MXPA03001556A patent/MXPA03001556A/es unknown
- 2001-07-24 HU HU0302822A patent/HUP0302822A3/hu unknown
- 2001-07-24 WO PCT/EP2001/008514 patent/WO2002016323A1/de not_active Application Discontinuation
- 2001-07-24 US US10/362,235 patent/US20030187289A1/en not_active Abandoned
- 2001-07-24 CZ CZ2003670A patent/CZ2003670A3/cs unknown
- 2001-07-24 PL PL01359154A patent/PL359154A1/xx unknown
- 2001-07-24 JP JP2002521199A patent/JP2004506717A/ja active Pending
- 2001-07-24 CN CN01814415A patent/CN1447795A/zh active Pending
- 2001-08-23 AU AU8973201A patent/AU8973201A/xx active Pending
2003
- 2003-02-21 NO NO20030812A patent/NO20030812L/no unknown
- 2003-03-20 ZA ZA200302253A patent/ZA200302253B/en unknown

Also Published As

Publication number	Publication date
HUP0302822A2 (hu)	2003-12-29
WO2002016323A1 (de)	2002-02-28
KR20030022419A (ko)	2003-03-15
AU8973201A (en)	2002-03-04
EP1311484A1 (de)	2003-05-21
BR0113373A (pt)	2003-07-15
HUP0302822A3 (en)	2004-07-28
US20030187289A1 (en)	2003-10-02
PL359154A1 (en)	2004-08-23
CA2420205A1 (en)	2003-02-21
CN1447795A (zh)	2003-10-08
NO20030812D0 (no)	2003-02-21
NO20030812L (no)	2003-02-21
MXPA03001556A (es)	2003-06-06
CZ2003670A3 (cs)	2003-06-18
JP2004506717A (ja)	2004-03-04
ZA200302253B (en)	2004-06-28
DE10041428A1 (de)	2002-03-07

Publication	Publication Date	Title
US20040092454A1 (en)	2004-05-13	Inhibitors of integrin alphavbeta6
RU2234505C2 (ru)	2004-08-20	Производные хроменона и хроманона в качестве ингибиторов интегринов
US7138417B2 (en)	2006-11-21	Inhibitors of integrin αvβ6
JP4216071B2 (ja)	2009-01-28	インテグリン阻害剤としての尿素およびウレタン誘導体
US20030171304A1 (en)	2003-09-11	Pyridine-2-yl-aminoalkyl carbonyl glycyl-$g(b)-alanine and derivatives thereof
US6649613B1 (en)	2003-11-18	Diacylhydrazine derivatives
SK2962003A3 (en)	2003-06-03	Biphenyl derivatives and the use thereof as integrin inhibitors
CZ20033000A3 (cs)	2004-02-18	Inhibitory integrinů a(v)B6
SK2952003A3 (en)	2003-06-03	Biphenyl derivatives and the use thereof as integrin inhibitors
US20040157902A1 (en)	2004-08-12	Integrin antagonists