SK122199A3 - Methods and compositions for modulating responsiveness to corticosteroids - Google Patents
Methods and compositions for modulating responsiveness to corticosteroids Download PDFInfo
- Publication number
- SK122199A3 SK122199A3 SK1221-99A SK122199A SK122199A3 SK 122199 A3 SK122199 A3 SK 122199A3 SK 122199 A SK122199 A SK 122199A SK 122199 A3 SK122199 A3 SK 122199A3
- Authority
- SK
- Slovakia
- Prior art keywords
- corticosteroid
- subject
- oxo
- agent
- modulating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/820,692 US6054487A (en) | 1997-03-18 | 1997-03-18 | Methods and compositions for modulating responsiveness to corticosteroids |
US1634698A | 1998-01-30 | 1998-01-30 | |
PCT/US1998/004916 WO1998041232A2 (en) | 1997-03-18 | 1998-03-12 | Compositions for modulating responsiveness to corticosteroids |
Publications (1)
Publication Number | Publication Date |
---|---|
SK122199A3 true SK122199A3 (en) | 2000-12-11 |
Family
ID=26688484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1221-99A SK122199A3 (en) | 1997-03-18 | 1998-03-12 | Methods and compositions for modulating responsiveness to corticosteroids |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0998300A1 (hu) |
JP (1) | JP2002504091A (hu) |
KR (1) | KR20000076420A (hu) |
CN (1) | CN1269722A (hu) |
AU (1) | AU734756B2 (hu) |
BG (1) | BG103808A (hu) |
BR (1) | BR9810409A (hu) |
CA (1) | CA2282845A1 (hu) |
DE (1) | DE998300T1 (hu) |
ES (1) | ES2146192T1 (hu) |
HU (1) | HUP0104439A3 (hu) |
ID (1) | ID22975A (hu) |
IL (1) | IL131815A0 (hu) |
NO (1) | NO994506L (hu) |
NZ (1) | NZ337769A (hu) |
PL (1) | PL336464A1 (hu) |
SI (1) | SI20110A (hu) |
SK (1) | SK122199A3 (hu) |
TR (1) | TR199902615T2 (hu) |
WO (1) | WO1998041232A2 (hu) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US6706264B1 (en) | 1994-03-14 | 2004-03-16 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y |
ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
US7704944B2 (en) | 1997-08-14 | 2010-04-27 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
US6184210B1 (en) | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
AR015966A1 (es) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
EP1516630A3 (en) * | 1997-10-31 | 2006-05-03 | Wyeth | Use of anti-il-12 antibodies in transplantation rejection |
ATE274920T1 (de) * | 1997-10-31 | 2004-09-15 | Wyeth Corp | Verwendung von anti-il-12 antikörpern bei transplantationsabstossungen |
WO1999025737A1 (en) * | 1997-11-19 | 1999-05-27 | Tanox Pharma B.V. | Compositions and methods for treatment of autoimmune diseases, using a monoclonal antibody to the interleukin-12 beta2-chain |
AU755273B2 (en) * | 1998-03-16 | 2002-12-05 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
CA2355345A1 (en) * | 1998-11-27 | 2001-06-28 | Technion Research & Development Foundation Ltd. | Interferon gamma inducing factor based vaccine and use of same for protective immunity against multiple sclerosis |
EP1137766B1 (en) * | 1998-12-09 | 2005-09-28 | Protein Design Labs, Inc. | Use of il-12 antibodies to treat psoriasis |
CN1346344A (zh) | 1999-03-16 | 2002-04-24 | 西托维亚公司 | 取代的2-氨基苯甲酰胺天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其应用 |
US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
DE19915465A1 (de) * | 1999-04-06 | 2000-10-19 | Apotech Res & Dev Ltd | Verwendung eines Caspase-Inhibitors zur Proliferationshemmung von Zellen und Verwendung eines oder mehrerer Caspase-Inhibitors/en zur Behandlung von Erkrankungen beruhend auf Lymphozyten-Hyperproliferation oder zur Suppression einer Immunantwort durch Lymphozyten |
ATE363465T1 (de) | 1999-04-09 | 2007-06-15 | Cytovia Inc | Caspase inhibitoren und ihre verwendung |
IL131047A0 (en) * | 1999-07-22 | 2001-01-28 | Yeda Res & Dev | Use of il-18 inhibitors |
DE60040397D1 (de) | 1999-08-27 | 2008-11-13 | Cytovia Inc | Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung |
WO2001019373A2 (en) * | 1999-09-17 | 2001-03-22 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
US6566338B1 (en) | 1999-10-12 | 2003-05-20 | Cytovia, Inc. | Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death |
JP2004500086A (ja) | 2000-02-10 | 2004-01-08 | アボット・ラボラトリーズ | ヒトインターロイキン18に結合する抗体とその調整方法および使用方法 |
AU2001275228A1 (en) * | 2000-06-06 | 2001-12-17 | Glaxo Group Limited | Cancer treatment composition containing an anti-neoplastic agent and a pde4 inhibitor |
AU7250301A (en) * | 2000-06-22 | 2002-01-02 | Willy Ben Moussa Ben Mohammed | Use of glucocorticosteroids for producing a medicament to treat oligotrichia |
US20020025317A1 (en) * | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
WO2002022127A1 (en) * | 2000-09-13 | 2002-03-21 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
EP1188438A1 (en) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
EP1199074A1 (en) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production |
JP4860897B2 (ja) * | 2001-01-29 | 2012-01-25 | メルク セロノ ソシエテ アノニム | 心疾患の治療および/または予防のためのil−18阻害剤の使用 |
BR0210904A (pt) * | 2001-05-16 | 2005-08-16 | Yeda Res & Dev | Uso de inibidores de il-18 para o tratamento ou prevenção de sepse |
ES2706902T3 (es) | 2001-06-26 | 2019-04-01 | Amgen Inc | Anticuerpos para OPGL |
KR100824491B1 (ko) * | 2001-10-05 | 2008-04-22 | 콤비네이토릭스, 인코포레이티드 | 면역염증 질환의 치료를 위한 조합 |
JP2003342196A (ja) * | 2002-05-31 | 2003-12-03 | Mukku:Kk | 静脈注射用組成物、その製造法およびその製剤 |
EP1553955A4 (en) * | 2002-09-24 | 2008-11-05 | Combinatorx Inc | METHODS AND REAGENTS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH INCREASED LEVELS OF PRO-INFLAMMATORY CYTOKINES |
AU2003263717A1 (en) * | 2002-09-25 | 2004-04-19 | Astrazeneca Ab | A COMBINATION OF A LONG-ACTING Beta2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES |
WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
EP1752159A4 (en) * | 2004-05-17 | 2009-07-01 | Univ Keio | MEDICAL COMPOSITION AND THERAPEUTIC PROCEDURE |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
AU2005264453B2 (en) * | 2004-07-16 | 2011-07-14 | Atsuo Sekiyama | IL-18 receptor antagonist and pharmaceutical composition containing the antagonist |
JPWO2006041121A1 (ja) * | 2004-10-13 | 2008-05-15 | 協和醗酵工業株式会社 | 慢性皮膚疾患の治療および/または予防剤 |
CN106075449A (zh) | 2005-07-14 | 2016-11-09 | 尼奥塞蒂克斯公司 | 用于局部脂肪组织治疗的持续释放的增强性脂肪分解性制剂 |
CA2666612C (en) * | 2006-10-17 | 2012-11-27 | Lipothera, Inc. | Methods, compositions, and formulations for the treatment of thyroid eye disease |
SG177982A1 (en) | 2007-01-16 | 2012-02-28 | Abbott Lab | Methods for treating psoriasis |
CA2681752A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
TWI461210B (zh) | 2008-03-18 | 2014-11-21 | Abbvie Inc | 治療牛皮癬的方法 |
US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
KR20140025312A (ko) | 2010-11-24 | 2014-03-04 | 리쎄라 인코오포레이티드 | 지방증 및 윤곽 팽창의 미용적 치료를 위한 선택적인, 친유성, 및 지속성 베타 작용제 단일치료 제형 및 방법 |
WO2015063669A1 (en) | 2013-10-30 | 2015-05-07 | Wockhardt Limited | Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof |
WO2022173923A1 (en) | 2021-02-10 | 2022-08-18 | Iolyx Therapeutics, Inc. | Methods for ophthalmic delivery of roflumilast |
JP2024534570A (ja) * | 2021-09-22 | 2024-09-20 | イオリクス セラピューティクス,インコーポレーテッド | 眼炎症性疾患を処置する方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3320125A (en) * | 1964-04-28 | 1967-05-16 | Merck & Co Inc | Inhalation aerosol composition |
EP0416950B1 (en) * | 1989-09-08 | 1993-08-11 | Glaxo Group Limited | Medicaments |
IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
GB9202519D0 (en) * | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
MX9304585A (es) * | 1992-07-31 | 1994-03-31 | Glaxo Group Ltd | Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata. |
GB9426252D0 (en) * | 1994-12-24 | 1995-02-22 | Glaxo Group Ltd | Pharmaceutical composition |
US6149892A (en) * | 1995-04-14 | 2000-11-21 | Glaxowellcome, Inc. | Metered dose inhaler for beclomethasone dipropionate |
-
1998
- 1998-03-12 NZ NZ337769A patent/NZ337769A/xx unknown
- 1998-03-12 TR TR1999/02615T patent/TR199902615T2/xx unknown
- 1998-03-12 AU AU67604/98A patent/AU734756B2/en not_active Ceased
- 1998-03-12 JP JP54063398A patent/JP2002504091A/ja active Pending
- 1998-03-12 HU HU0104439A patent/HUP0104439A3/hu unknown
- 1998-03-12 CN CN98805124A patent/CN1269722A/zh active Pending
- 1998-03-12 DE DE0998300T patent/DE998300T1/de active Pending
- 1998-03-12 EP EP98912929A patent/EP0998300A1/en not_active Withdrawn
- 1998-03-12 CA CA002282845A patent/CA2282845A1/en not_active Abandoned
- 1998-03-12 IL IL13181598A patent/IL131815A0/xx unknown
- 1998-03-12 ES ES98912929T patent/ES2146192T1/es active Pending
- 1998-03-12 KR KR1019997008524A patent/KR20000076420A/ko not_active Application Discontinuation
- 1998-03-12 PL PL98336464A patent/PL336464A1/xx unknown
- 1998-03-12 ID IDW991185A patent/ID22975A/id unknown
- 1998-03-12 SI SI9820032A patent/SI20110A/sl unknown
- 1998-03-12 SK SK1221-99A patent/SK122199A3/sk unknown
- 1998-03-12 BR BR9810409-8A patent/BR9810409A/pt not_active IP Right Cessation
- 1998-03-12 WO PCT/US1998/004916 patent/WO1998041232A2/en not_active Application Discontinuation
-
1999
- 1999-09-17 NO NO994506A patent/NO994506L/no unknown
- 1999-10-13 BG BG103808A patent/BG103808A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998041232A2 (en) | 1998-09-24 |
SI20110A (sl) | 2000-06-30 |
HUP0104439A2 (hu) | 2002-04-29 |
HUP0104439A3 (en) | 2002-08-28 |
CA2282845A1 (en) | 1998-09-24 |
PL336464A1 (en) | 2000-06-19 |
WO1998041232A3 (en) | 2000-10-05 |
AU734756B2 (en) | 2001-06-21 |
IL131815A0 (en) | 2001-03-19 |
ES2146192T1 (es) | 2000-08-01 |
NO994506D0 (no) | 1999-09-17 |
JP2002504091A (ja) | 2002-02-05 |
AU6760498A (en) | 1998-10-12 |
DE998300T1 (de) | 2001-03-01 |
TR199902615T2 (xx) | 2000-03-21 |
BR9810409A (pt) | 2000-08-22 |
ID22975A (id) | 1999-12-23 |
NO994506L (no) | 1999-11-17 |
NZ337769A (en) | 2002-09-27 |
CN1269722A (zh) | 2000-10-11 |
KR20000076420A (ko) | 2000-12-26 |
BG103808A (en) | 2000-07-31 |
EP0998300A1 (en) | 2000-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK122199A3 (en) | Methods and compositions for modulating responsiveness to corticosteroids | |
US6054487A (en) | Methods and compositions for modulating responsiveness to corticosteroids | |
WO2001019373A2 (en) | Methods and compositions for modulating responsiveness to corticosteroids | |
JP4748912B2 (ja) | アルキルおよびアリールアラニンp2部分を含むc型肝炎ウイルスに対する大員環ns3−セリンプロテアーゼ阻害剤 | |
US7169760B2 (en) | Peptides as NS3-serine protease inhibitors of hepatitis C virus | |
CA2405521C (en) | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties | |
JP4563033B2 (ja) | C型肝炎ウイルスのns3−セリンプロテアーゼ阻害剤としての新規ペプチド | |
KR20000064454A (ko) | 인터류킨-1베타전환효소의억제제 | |
AU2006276246A1 (en) | Novel macrocyclic inhibitors of hepatitis C virus replication | |
EP0356223A2 (en) | HIV protease inhibitors useful for the treatment of aids | |
JP3112327B2 (ja) | Aceの阻害剤として有用な新規なアミノ及びニトロ含有三環式化合物類 | |
AU2005219859A1 (en) | Inhibitors of hepatitis C virus NS3 protease | |
CA2540031A1 (en) | Macrocyclic inhibitors of hepatitis c virus ns3 serine protease | |
JPH10501244A (ja) | インターロイキン−1β変換酵素の二環式ラクタム阻害剤 | |
JP2019214574A (ja) | 環状ペプチドおよび医薬としてのその使用 | |
CZ312799A3 (cs) | Přípravky pro modulaci reakce na kortikosteroidy | |
JP2003512450A (ja) | 可溶性ヒトcd23形成阻害剤としてのヒドロキサム酸誘導体 | |
MXPA99008433A (en) | Methods and compositions for modulating responsiveness to corticosteroids | |
RU2820150C2 (ru) | Нитрилсодержащие противовирусные соединения | |
RU2786722C1 (ru) | Нитрилсодержащие противовирусные соединения | |
US6613880B2 (en) | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | |
AU2001280637B2 (en) | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | |
ES2344890T3 (es) | Nuevos peptidos como inhibidores de la serina proteasa ns3 del virus de la hepatitis c. | |
US20040204367A1 (en) | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | |
AU2001280637A1 (en) | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |